epirubicin / Generic mfg. 
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 217 Diseases   230 Trials   230 Trials   3979 News 


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  • ||||||||||  prednisone / generics, furosemide / generics, epirubicin / generics
    Journal:  Hypercalcemia of Malignancy in a Dog Diagnosed With Cholangiocellular Carcinoma. (Pubmed Central) -  Jul 12, 2019   
    Chemotherapy with intravenous epirubicin was initiated based on the cytological diagnosis...Postmortem examination confirmed a cholangiocellular carcinoma. To our knowledge, this is the first report of malignant hypercalcemia associated with cholangiocellular carcinoma in a dog.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Trial completion date, Trial primary completion date:  Reduced Chemotherapy in Low Risk DLBCL (clinicaltrials.gov) -  Jul 8, 2019   
    P4,  N=290, Recruiting, 
    Not yet recruiting --> Recruiting Trial completion date: Jun 2019 --> Jun 2020 | Trial primary completion date: Apr 2019 --> Apr 2020
  • ||||||||||  doxorubicin hydrochloride / generics
    Journal, IO Biomarker:  Activation of miR-34a-5p/Sirt1/p66shc pathway contributes to doxorubicin-induced cardiotoxicity. (Pubmed Central) -  Jun 28, 2019   
    Moreover, enforced expression of Sirt1 alleviated Dox-induced apoptosis of H9c2 cells, with suppressing levels of p66shc, Bax, the activated caspase-3 and miR-34a-5p, and enhancing Bcl-2 expression. Therefore, miR-34a-5p enhances cardiomyocyte apoptosis by targeting Sirt1, activation of miR-34a-5p/Sirt1/p66shc pathway contributes to Dox-induced cardiotoxicity, and blockage of this pathway represents a potential cardioprotective effect against anthracyclines.
  • ||||||||||  Ibrance (palbociclib) / Pfizer
    Enrollment open:  EORTC 1745-ETF-BCG: Adjuvant Palbociclib in Elderly Patients With Breast Cancer (clinicaltrials.gov) -  Jun 24, 2019   
    P2,  N=366, Recruiting, 
    These changes indicate on potential beneficial effects on neuronal functions associated with mild cognitive impairments in cancer chemotherapy. Not yet recruiting --> Recruiting
  • ||||||||||  epirubicin / generics
    Journal:  Gradiently degraded electrospun polyester scaffolds with cytostatic for urothelial carcinoma therapy. (Pubmed Central) -  Jun 17, 2019   
    ...The purpose of this study was to reveal the possibility of the controlled delivery of epirubicin (EPI) via gradiently degraded electrospun poly(ε-caprolactone) (PCL)/poly(lactide-co-glycolide) (PLGA) scaffolds to evaluate their antitumor activity against UTUC...The EPI-loaded PCL/PLGA scaffolds showed excellent antitumor activities both in vitro and in vivo without apparent systemic toxicity. Overall, the gradiently-degraded EPI-loaded electrospun polyester scaffolds are potential ureteral stent tubes for the local inhibition of the recurrence of UTUC, where the continued release of EPI can prevent the subsequent proliferation of residual tumor cells, and the gradient degradation is consistent with the repair of the ureter.
  • ||||||||||  epirubicin / generics
    Journal:  ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM. (Pubmed Central) -  Jun 15, 2019   
    ...At the molecular level, ectopic expression of ZEB1 impaired the responsiveness of breast cancer cells to genotoxic drug treatment, such as epirubicin (EPI)...Using a nude mouse xenograft model, we further confirmed that ectopic expression of ZEB1 decreased breast cancer responsiveness to EPI treatment in vivo. Collectively, our findings suggest that ZEB1 is a crucial determinant of chemotherapeutic resistance in breast cancer.
  • ||||||||||  Hervelous (trastuzumab biosimilar) / Hanwha Solutions, Alvogen, Prestige BioPharma, Mundipharma, Dr. Reddy's
    Trial completion date, Trial primary completion date:  TROIKA: A Phase III Trial to Compare the Efficacy, Safety and Pharmacokinetics of HD201 to Herceptin (clinicaltrials.gov) -  Jun 7, 2019   
    P3,  N=500, Active, not recruiting, 
    However, grades 2-3 alopecia was seen less often with prolonged post-infusion scalp cooling. Trial completion date: Apr 2020 --> Oct 2019 | Trial primary completion date: Apr 2019 --> Sep 2019
  • ||||||||||  epirubicin micelle formulation (NC-6300) / NanoCarrier
    Journal:  Function of Epirubicin-Conjugated Polymeric Micelles in Sonodynamic Therapy. (Pubmed Central) -  Jun 6, 2019   
    In conclusion, drug-conjugated micellar nanoparticles are more desirable for SDT because of accelerated ROS production and drug protection from ROS. Furthermore, a combination of NC-6300 and TP-HIFU is useful for minimally invasive cancer therapy with cooperative effects of HIFU-derived features, antitumor activity of EPI, and increased ROS generation to cause damage to cancer cells.
  • ||||||||||  paclitaxel / generics, cyclophosphamide intravenous / generics
    Clinical, Journal:  Primary breast cancer in a patient with Wilson disease: A case report. (Pubmed Central) -  Jun 5, 2019   
    We reviewed the literature for studies of patients with WD complicated with cancers, and to our knowledge, this is the first report on WD complicated with breast cancer. The patient received chemotherapy even with liver dysfunction, which suggests that patients with WD can be safely treated with paclitaxel chemotherapy under close surveillance.
  • ||||||||||  paclitaxel / generics
    Biomarker, Journal:  Glucose-Regulated Protein 94 Modulates the Response of Osteosarcoma to Chemotherapy. (Pubmed Central) -  May 30, 2019   
    Therefore, GRP94 silencing may increase the resistance of MG63 and 143B cells to paclitaxel, gemcitabine, and epirubicin treatments by inhibiting the induction of apoptosis. Thus, GRP94 may be a key biomarker for the chemotherapeutic response of OS.
  • ||||||||||  Endostar (recombinant human endostatin) / Simcere
    Clinical, Journal:  The effect of ifosfamide, epirubicin, and recombinant human endostatin therapy on a cardiac angiosarcoma: A case report. (Pubmed Central) -  May 29, 2019   
    This case shows us that operation on late stage cardiac angiosarcomas can alleviate a patient's symptoms; postoperative paclitaxel monotherapy was insufficient and ifosfamide and epirubicin plus recombinant human endostatin has a limited effect on late stage cardiac angiosarcoma. Studies with a larger sample size are needed for verification of these findings.
  • ||||||||||  paclitaxel / generics, doxorubicin hydrochloride / generics
    Clinical, Journal:  Jekyll and Hyde of chemotherapy treatment: method for patient specific dosing of chemotherapy medications. (Pubmed Central) -  May 29, 2019   
    A new method to dose chemotherapy based on a patients albumin will maintain the same effective free drug levels as in patients with normal albumin. This can reduce the severity of chemotherapy side-effects and may: ensure better outcomes for patients since it allows them to complete their course of chemotherapy without interruption, decrease the cost and complications associated with severe side-effects, and will allow for enhanced treatment options.
  • ||||||||||  Trial completion, Enrollment change, Trial completion date:  Haplo-identical HSCT Versus Chemotherapy for Adult Acute Lymphoblastic Leukemia Patients (clinicaltrials.gov) -  May 29, 2019   
    P3,  N=131, Completed, 
    This can reduce the severity of chemotherapy side-effects and may: ensure better outcomes for patients since it allows them to complete their course of chemotherapy without interruption, decrease the cost and complications associated with severe side-effects, and will allow for enhanced treatment options. Active, not recruiting --> Completed | N=300 --> 131 | Trial completion date: Dec 2018 --> Apr 2019
  • ||||||||||  temozolomide / generics, epirubicin / generics
    Journal:  Triple conjugated carbon dots as a nano-drug delivery model for glioblastoma brain tumors. (Pubmed Central) -  May 29, 2019   
    C-DT increased the cytotoxicity to 86% in SJGBM2 at 0.01 μM while C-ET and C-TT reduced it only to 33 and 8%, respectively. Not only did triple conjugated C-DT increase the cytotoxicity, but also the two-drug combination in C-DT displayed a synergistic effect.
  • ||||||||||  Baraclude (entecavir) / BMS
    Journal:  Long-term Histopathologic Follow-up of a Spherical Embolic Agent; Observation of the Transvascular Migration of HepaSphere. (Pubmed Central) -  May 28, 2019   
    ...A 60-year-old male with chronic hepatitis B was treated with entecavir and seroconversion was obtained...A 1.9  F preshaped microcatheter (ProgreatΣ, Terumo, Japan) was selectively inserted into the A3 and anterior segmental branch, 10  mg of epirubicin was injected into each artery, and the arteries were embolized with 7  mg and 13  mg of HepaSphere loaded with epirubicin, respectively...The largest and smallest HepaSphere diameters were 241.6  ±  52.5  µm and 186.5  ±  41.4  µm, respectively, and deformity was 22.6% ± 13.0 %. All the HepaSpheres detected in the examined pathological specimen were noted to be extravascular.
  • ||||||||||  Journal:  Determination of 16 antineoplastic drugs by capillary electrophoresis with UV detection: applications in quality control. (Pubmed Central) -  May 7, 2019   
    A micellar electrokinetic chromatography (MEKC) method coupled to UV was also developed for the determination of methotrexate, pemetrexed, etoposide, etoposide phosphate, fludarabine phosphate, and 5-fluorouracil...Both methods were validated and trueness values between 99.4% and 101.3% were obtained with repeatability and intermediate precision values of 0.5-1.8% for all drugs. These methods were found appropriate for controlling injectable pharmaceutical formulations containing antineoplastic drugs and successfully applied in quality control.