rivastigmine / Generic mfg. 
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 65 Diseases   14 Trials   14 Trials   1875 News 


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  • ||||||||||  atomoxetine / Generic mfg., rivastigmine / Generic mfg.
    Trial completion, Enrollment change:  Cognitive Decline in Non-demented PD (clinicaltrials.gov) -  Jul 7, 2020   
    P4,  N=9, Completed, 
    The findings of this study can be of a significant benefit to the drug-designing industry in this disease-prone era. Recruiting --> Completed | N=50 --> 9
  • ||||||||||  rivastigmine / Generic mfg.
    Trial initiation date:  Toward a Computationally-Informed, Personalized Treatment for Hallucinations (clinicaltrials.gov) -  Jun 29, 2020   
    P1,  N=35, Not yet recruiting, 
    QbD was demonstrated to be a useful approach for the optimization of NLC formulations for which specific physicochemical requisites can be identified. Initiation date: May 2020 --> Apr 2021
  • ||||||||||  rivastigmine / Generic mfg.
    Journal:  Novel biocompatible poly(acrylamide)-grafted-dextran hydrogels: Synthesis, characterization and biomedical applications. (Pubmed Central) -  Jun 15, 2020   
    Further, we developed an electro-responsive transdermal drug delivery system (ETDS) utilizing PAAm-g-Dxt copolymer for rivastigmine tartarate delivery through skin...The drug permeability characteristics studied under "on-off" stimuli suggested that there was faster drug permeation when electrical stimuli was 'on' and it decreased when electrical stimuli was 'off.' The histopathology study confirmed the altered skin structural integrity after application of electrical stimuli. Hence, the PAAm-g-Dxt based ETDS are useful for transdermal drug delivery triggered by an electric stimulus to deliver on-demand release of drug into systemic circulation.
  • ||||||||||  donepezil / Generic mfg., rivastigmine / Generic mfg., quetiapine / Generic mfg.
    Retrospective data, Journal:  Treatment Options for Dementia with Lewy Bodies: A Network Meta-Analysis of Randomised Control Trials. (Pubmed Central) -  Jun 6, 2020   
    Despite the lack of statistical significance, when assessing the efficacy and safety outcomes for each drug in the evidence network, donepezil appeared to have a more favourable overall benefit/risk profile for patients with DLB. Further comparative trials are required to improve understanding of the true difference between existing and potential future treatment options.
  • ||||||||||  rivastigmine / Generic mfg.
    Journal:  Gel-based microemulsion design and evaluation for rivastigmine topical application. (Pubmed Central) -  May 28, 2020   
    The drug-loaded experimental formulation did not cause skin irritation and had good stability at 20ºC and 40ºC storage for at least 3 months. The result showed that gel-based microemulsion formulation could be a promising approach for topical administration.
  • ||||||||||  donepezil / Generic mfg., memantine / Generic mfg., rivastigmine / Generic mfg.
    Journal:  Factors Associated With Deprescribing Acetylcholinesterase Inhibitors in Older Nursing Home Residents With Severe Dementia. (Pubmed Central) -  May 15, 2020   
    Among NH residents with severe dementia being treated with AChEIs, the cumulative incidence of AChEI discontinuation was just under 30% at 1 year of follow-up. Our findings provide insight into potential drivers of deprescribing AChEIs, identify system-level barriers to deprescribing, and help to inform covariates that are needed to address potential confounding in studies evaluating the potential risks and benefits associated with deprescribing.
  • ||||||||||  donepezil / Generic mfg., memantine / Generic mfg., rivastigmine / Generic mfg.
    Review, Journal:  Available and future treatments for atypical parkinsonism. A systematic review. (Pubmed Central) -  Apr 29, 2020   
    However, the improvements were modest, and the results should be replicated and above all balanced against side effects. A detailed knowledge of the pathological mechanism underlying the disorders is needed, and disease-modifying therapies are required to offer better therapeutic options to physician and caregivers of APS patients.
  • ||||||||||  donepezil / Generic mfg., rivastigmine / Generic mfg.
    Journal:  Donepezil, a drug for Alzheimer's disease, promotes oligodendrocyte generation and remyelination. (Pubmed Central) -  Apr 14, 2020   
    More interestingly, donepezil also promotes the repair of the myelin sheaths in vivo and provides significant therapeutic effect in a cuprizone-mediated demyelination animal model. Donepezil is a drug that has been used to treat AD safely for many years; our findings suggest that it might be repurposed to treat CNS demyelinating diseases such as MS by promoting OPC to OL differentiation and remyelination.
  • ||||||||||  Kinaction (masitinib) / AB Science
    Trial completion date, Trial primary completion date:  Masitinib in Patients With Mild to Moderate Alzheimer's Disease (clinicaltrials.gov) -  Apr 7, 2020   
    P3,  N=721, Active, not recruiting, 
    Overall, ADD+AP treatment was well tolerated. Trial completion date: Sep 2020 --> Jun 2020 | Trial primary completion date: Sep 2020 --> Dec 2019
  • ||||||||||  The Dopamine (D1) Positive Allosteric modulator, DETQ, Restored Cognitive Performance and Social Interaction in Sub-Chronic Phencyclidine (PCP)-Treated Mice (Spadolini - Ground Floor) -  Apr 4, 2020 - Abstract #SIRS2020SIRS_1268;    
    P1
    LY3154207, a novel DA D1 positive allosteric modulator (D1PAM) is currently in phase 2 development for Lewy Body Dementias (NCT02603861)...Sub-effective doses (SEDs) of DETQ and the AAPD olanzapine, or SED-DETQ + the ACh esterase inhibitor, rivastigmine, reversed the NOR deficit...Clozapine, but not lurasidone, rescued SI in the sc-PCP+CUS mice...The blockade of its efficacy by gabazine, and haloperidol, and the dialysis data, indicate the importance of D1/D2 effects on adenylate cyclase, and the contribution of GABAAR stimulation, to the efficacy of DETQ. Overall, these data support future studies with D1PAM in a range of neuropsychiatric disorders, including schizophrenia.
  • ||||||||||  tacrolimus / Generic mfg., rivastigmine / Generic mfg.
    Journal:  Optimization of chromatography to overcome matrix effect for reliable estimation of four small molecular drugs from biological fluids using LC-MS/MS. (Pubmed Central) -  Apr 1, 2020   
    The best chromatographic conditions established were, Acquity BEH C18 (50 × 2.1 mm, 1.7 μm) column with 5.0 mm ammonium acetate, pH 6.0: methanol as the mobile phase under gradient program for gemfibrozil; Luna CN (50 × 2.0 mm, 3 μm) column with a mobile phase consisting of acetonitrile-10 mM ammonium acetate, pH 7.0 (90:10, v/v) for rivastigmine; Inertsustain C18 (100 × 2.0 mm, 5 μm) column using methanol-2.0 mM ammonium formate, pH 5.5 (80: 20, v/v) as the mobile phase for isocratic elution of telmisartan; and Acquity BEH C18 (50 × 2.1 mm, 1.7 μm) with methanol-10 mM ammonium acetate, pH 6.0 (95:5, v/v) as mobile phase for tacrolimus. The methods were thoroughly validated as per EMA and USFDA guidance and were successfully applied for pharmacokinetic studies in healthy subjects.
  • ||||||||||  Kinaction (masitinib) / AB Science
    Trial completion date, Trial primary completion date:  Masitinib in Patients With Mild to Moderate Alzheimer's Disease (clinicaltrials.gov) -  Apr 1, 2020   
    P3,  N=721, Active, not recruiting, 
    The methods were thoroughly validated as per EMA and USFDA guidance and were successfully applied for pharmacokinetic studies in healthy subjects. Trial completion date: Dec 2019 --> Sep 2020 | Trial primary completion date: Dec 2019 --> Sep 2020
  • ||||||||||  rivastigmine / Generic mfg.
    Journal:  SAR-mediated Similarity Assessment of the Property Profile for New, Silicon-Based AChE/BChE Inhibitors. (Pubmed Central) -  Mar 29, 2020   
    In fact, some of the newly prepared molecules revealed comparable or even better inhibitory activities compared to the marketed drugs (rivastigmine or galanthamine) and commercially applied pesticide Diuron, respectively...The stochastic model validation was used to generate an 'average' 3D-QSAR pharmacophore pattern. Finally, the target-oriented molecular docking was employed to (re)arrange the spatial distribution of the ligand property space for BChE and photosystem II (PSII).
  • ||||||||||  rivastigmine / Generic mfg., reboxetine / Generic mfg.
    Enrollment open:  Noradrenaline, Acetylcholine and Dynamic Learning in Healthy Humans (clinicaltrials.gov) -  Mar 25, 2020   
    P=N/A,  N=120, Recruiting, 
    Finally, the target-oriented molecular docking was employed to (re)arrange the spatial distribution of the ligand property space for BChE and photosystem II (PSII). Not yet recruiting --> Recruiting
  • ||||||||||  rivastigmine / Generic mfg.
    Biomarker, Clinical, Journal:  FDG-PET in suspected dementia with Lewy bodies: a case report. (Pubmed Central) -  Mar 18, 2020   
    In conclusion, core CSF biomarkers reflect pathophysiology of AD in the early and late stages; the application of approved radiotracers have potential in amyloid-PET brain imaging to detect early AD. This case highlights the challenges in diagnosis of an elderly patient with DLB, the use of neuro-imaging as a diagnostic biomarker, the avoidance of the use of antipsychotic and the response to pharmacological treatment with Rivastigmine after a probable diagnosis of DLB.
  • ||||||||||  rivastigmine / Generic mfg.
    Preclinical, Journal:  An in vitro study on the interaction of the anti-Alzheimer drug rivastigmine with human erythrocytes. (Pubmed Central) -  Mar 17, 2020   
    Fluorescence spectroscopy results showed that rivastigmine produce a slight change in the acyl chain packing order and a weak displacement of the water molecules of the hydrophobic-hydrophilic membrane interface. On the other hand, observations by scanning electron microscopy (SEM) showed that the drug changed the normal biconcave shape of erythrocytes in stomatocytes (cup-shaped cells) and echinocytes (speculated shaped).
  • ||||||||||  rivastigmine / Generic mfg.
    Journal:  Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer's disease. (Pubmed Central) -  Mar 12, 2020   
    More interestingly, the metabolism of 3din vitro indicated that 4 metabolites in rat liver microsome metabolism, 2 metabolites in human liver microsome metabolism, and 4 metabolites in intestinal flora metabolism, which offered supports for the preclinical study of 3d. Overall, this study exhibited that compound 3d was a promising advanced compound targeted multiple factors associated with AD.
  • ||||||||||  donepezil / Generic mfg., galantamine hydrobromide / Generic mfg., rivastigmine / Generic mfg.
    Clinical, Journal:  An update on the utility and safety of cholinesterase inhibitors for the treatment of Alzheimer's disease. (Pubmed Central) -  Mar 2, 2020   
    The authors have reviewed all recent literature including review articles, meta-analyses, clinical trials and more.Expert opinion: These ChEIs differ subtly in their mechanisms of action, in their tolerability and safety and FDA-approved indications. All are considered first-line, symptomatic treatments of the various phases of AD and may even have potentially disease-modifying effects.
  • ||||||||||  donepezil / Generic mfg., rivastigmine / Generic mfg.
    Clinical, Journal:  Rivastigmine does not alter cocaine-induced subjective effects or self-administration. (Pubmed Central) -  Feb 28, 2020   
    Rivastigmine 3 or 6 mg had no significant effect on the subjective effects of cocaine after 9 days of treatment. This is an important finding as other drugs in the AChEi class (donepezil, Huperzine A) have produced significant results, but differ in their receptor specificity and PK parameters.
  • ||||||||||  rivastigmine / Generic mfg.
    Journal:  Design and synthesis of HS-donor hybrids: A new treatment for Alzheimer's disease? (Pubmed Central) -  Feb 21, 2020   
    In this work, we designed a small series of multitarget molecules combining the rivastigmine-scaffold, a well-established drug already approved for AD, with sulforaphane (SFN) and erucin (ERN), two natural products deriving from the enzymatic hydrolysis of glucosinolates contained in broccoli and rocket, respectively, endowed both with antioxidant and neuroprotective effects...Finally, the compounds showed neuroprotective and antioxidant activities in human neuronal cells. The most interesting compounds have been further investigated to elucidate the possible mechanism of action.