rivastigmine / Generic mfg. 
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 65 Diseases   14 Trials   14 Trials   1875 News 


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  • ||||||||||  donepezil / Generic mfg., galantamine hydrobromide / Generic mfg., rivastigmine / Generic mfg.
    Journal:  Is Combining an Anticholinergic with a Cholinesterase Inhibitor a Good Strategy for High-Level CNS Cholinesterase Inhibition? (Pubmed Central) -  Nov 12, 2020   
    The currently approved cholinesterase inhibitors (donepezil, rivastigmine, and galantamine) produce gastrointestinal toxicity which limits dosing to that which produces only about 25% to 35% CNS cholinesterase inhibition in Alzheimer's disease patients undergoing treatment, below the minimum therapeutic target of about 40% to 50% CNS inhibition considered necessary to treat cognitive impairment...Unfortunately, most common muscarinic anticholinergics, including solifenacin, readily penetrate the CNS and are directly associated with long-term exacerbation of the underlying neuropathology of Alzheimer's disease and increased brain atrophy...For long-term safety against accelerating the underlying disease processes in Alzheimer's disease, anticholinergics used to increase the tolerability of AChE inhibitors should not penetrate, or have very limited penetration, of the blood-brain barrier. Neurotrophic-mediated mechanisms by which cholinergic drugs may affect neurodegeneration in Alzheimer's disease are explored and improved treatment options are suggested.
  • ||||||||||  citalopram / Generic mfg., paroxetine / Generic mfg., rivastigmine / Generic mfg.
    Review, Journal:  Effectiveness of Pharmacological Interventions for Symptoms of Behavioral Variant Frontotemporal Dementia: A Systematic Review. (Pubmed Central) -  Oct 30, 2020   
    This review provides an overview of the pharmacological interventions that can be used to treat the main bvFTD symptoms as well as a guideline for managing bvFTD. More research is needed to investigate the efficacy of pharmacological interventions for bvFTD through use of a validated outcome and a focus on the specific behavioral problems associated with bvFTD.
  • ||||||||||  donepezil / Generic mfg., memantine / Generic mfg., rivastigmine / Generic mfg.
    Review, Journal:  Natural and synthetic drugs used for the treatment of the dementia. (Pubmed Central) -  Oct 21, 2020   
    Recently discovered by French scientists from Marseille triterpenoid hydroperoxides demonstrate high activity as potential therapeutic agents for the treatment of dementia. The information presented in this review is of great interest to pharmacologists, medical chemists, physiologists, neurologists and doctors, as well as for the pharmaceutical industry.
  • ||||||||||  rivastigmine / Generic mfg.
    Journal:  Butyrylcholinesterase Protein Ends in the Pathogenesis of Alzheimer's Disease-Could BCHE Genotyping Be Helpful in Alzheimer's Therapy? (Pubmed Central) -  Oct 3, 2020   
    Based on the results, we suggest that SNPs (rs1126680) and/or (rs55781031) genotyping should be performed to identify subjects at risk for lowered efficacy ChEIs therapy, and such patients should be treated with a lower rivastigmine dosage. Finally, our sequence analysis of the N-terminal end of N-BChE revealed evolutionarily conserved amino acid residues that can be involved in disulfide bond formation and anchoring of N-BChE in the cell membrane.
  • ||||||||||  Clinical, Journal:  Anticholinergic medicines use among older adults before and after initiating dementia medicines. (Pubmed Central) -  Sep 23, 2020   
    Use of anticholinergic medicines is common among persons initiating dementia medicines and this occurs against a backdrop of widespread campaigns to reduce irrational medicine combinations in this vulnerable population. Decisions about deprescribing medicines with questionable benefit among persons with dementia may be complicated by conflicting recommendations in prescribing guidelines.
  • ||||||||||  Review, Journal:  Drugs Modulating CD4+ T Cells Blood-Brain Barrier Interaction in Alzheimer's Disease. (Pubmed Central) -  Sep 22, 2020   
    Donepezil reduces the numbers of Th1 but not Th2, Rivastigmine inhibits Th1 and Th17 but not Th2, and memantine reduces Th1 but not Treg. However, none of the current AD drugs is specifically designed to target the dysregulated balance in the Th17/Treg axis. Future drug design approaches should specifically consider inhibiting CD4+ Th17 to improve AD prognosis.
  • ||||||||||  rivastigmine / Generic mfg.
    [VIRTUAL] CHIEF-PD: Cholinesterase Inhibitor to prEvent Falls in Parkinson’s Disease () -  Sep 20, 2020 - Abstract #MDSCongress2020MDS Congress_963;    
    This Phase III, blinded, randomised, placebo-controlled trial will assess the clinical and cost effectiveness of rivastigmine in reducing the rate of falls in people with Parkinson’s disease. If successful this would offer a novel, acceptable and effective intervention to tackle a common and particularly debilitating complication of the disease.
  • ||||||||||  donepezil / Generic mfg., rivastigmine / Generic mfg.
    [VIRTUAL] Donepezil for mild cognitive impairment in Parkinson’s disease: A 48-week follow-up study () -  Sep 20, 2020 - Abstract #MDSCongress2020MDS Congress_909;    
    Donepezil and rivastigmine, acetylcholinesterase inhibitors (AChEIs), increase acetylcholine level and duration of the neurotransmitter action in the synaptic cleft. Although we could not demonstrate improvement in the cognitive functions, Donepezil treatment could be beneficial in PD patients with MCI by decreasing the slow-wave relative to the fast wave in EEG, which could reflect the enhancement of brain connectivity.
  • ||||||||||  Clinical, Journal, HEOR:  Effect of drug compliance on health care costs in newly-diagnosed dementia: Analysis of nationwide population-based data. (Pubmed Central) -  Sep 9, 2020   
    Although we could not demonstrate improvement in the cognitive functions, Donepezil treatment could be beneficial in PD patients with MCI by decreasing the slow-wave relative to the fast wave in EEG, which could reflect the enhancement of brain connectivity. This population-based retrospective cohort study provides evidence that patients newly-diagnosed with dementia who showed higher initial drug compliance or maintained antidementia drugs (Cholinesterase inhibitors and memantine) would benefit in total health-care costs.
  • ||||||||||  donepezil / Generic mfg., galantamine hydrobromide / Generic mfg., rivastigmine / Generic mfg.
    Journal:  QT interval prolongation and Torsades de Pointes with donepezil, rivastigmine and galantamine. (Pubmed Central) -  Sep 4, 2020   
    Attention to risk factors for QT prolongation/TdP should be exercised when prescribing donepezil and modifiable risk factors corrected. Owing to the low number of cases with galantamine and rivastigmine, further work is needed to establish whether these drugs may be more suitable than donepezil for patients with other risk factors for TdP.
  • ||||||||||  risperidone / Generic mfg., Egis, rivastigmine / Generic mfg.
    Review, Journal:  Acute presentation of dementia with Lewy bodies. (Pubmed Central) -  Sep 2, 2020   
    A positive dopamine transporter scan was done confirming a diagnosis of an acute presentation of DLB. She has been commenced on a cholinesterase inhibitor (rivastigmine) and is presently settled in care.
  • ||||||||||  rivastigmine / Generic mfg.
    Journal:  2-Hydroxy-N-phenylbenzamides and Their Esters Inhibit Acetylcholinesterase and Butyrylcholinesterase. (Pubmed Central) -  Sep 1, 2020   
    The majority of derivatives inhibit AChE more efficiently than BuChE and are comparable or superior to rivastigmine-an established cholinesterases inhibitor used in the treatment of Alzheimer's disease...Several structure-activity relationships were identified, e.g., favouring esters and benzamides obtained from 5-halogenosalicylic acids and polyhalogenated anilines. Both 2-hydroxy-N-phenylbenzamides and esters share convenient physicochemical properties for blood-brain-barrier penetration and thus central nervous system delivery.
  • ||||||||||  memantine / Generic mfg., rivastigmine / Generic mfg.
    Clinical, Journal:  Patterns of antidemential drug use in a group of patients from Colombia (Pubmed Central) -  Aug 23, 2020   
    Both 2-hydroxy-N-phenylbenzamides and esters share convenient physicochemical properties for blood-brain-barrier penetration and thus central nervous system delivery. Patients with anti-dementia drugs are using them at doses lower than those defined and they present an important frequency of comorbidities and comedications.
  • ||||||||||  rivastigmine / Generic mfg.
    [VIRTUAL] Development of potent isoflavone carbamate derviatives to target Alzheimer's disease (On Demand Poster) -  Aug 20, 2020 - Abstract #ACSFall2020ACS-Fall_3367;    
    For example, the carbamate moiety is present in rivastigmine, a pharmaceutical currently used to treat AD, and this is a key structural motif in many other FDA-approved drugs...Both experimentally and computationally, we will then assess the library’s abilities to inhibit AChE to further suppress, halt, and/or reverse the symptoms of AD. Inhibitor design, synthetic efforts, and computational docking studies will all be presented.
  • ||||||||||  rivastigmine / Generic mfg., duloxetine / Generic mfg.
    Trial completion date, Trial primary completion date:  Quality Improvement and Practice Based Research in Neurology Using the EMR (clinicaltrials.gov) -  Aug 14, 2020   
    P4,  N=3300, Enrolling by invitation, 
    Inhibitor design, synthetic efforts, and computational docking studies will all be presented. Trial completion date: Apr 2020 --> Dec 2020 | Trial primary completion date: Apr 2020 --> Oct 2020
  • ||||||||||  [VIRTUAL] Neuroenhacement: facts and artifacts (Poster Area) -  Aug 5, 2020 - Abstract #ECNP2020ECNP_816;    
    Thirdly, they tend to investigate the effect of a substance after a single dose, while information about a repeated use is lacking. In conclusion, the problem appears quite complex and requires to be analyzed with no prejudice and possibly also within an ethical conceptual frame.
  • ||||||||||  donepezil / Generic mfg., rivastigmine / Generic mfg.
    Clinical, Journal:  Effects of rivastigmine hydrogen tartrate and donepezil hydrochloride on the cognitive function and mental behavior of patients with Alzheimer's disease. (Pubmed Central) -  Aug 4, 2020   
    Following treatment, the bradykinin level in both groups was significantly decreased (P<0.05), although the decrease in the combination group was more significant than that in the monotherapy group (P<0.05). On the whole, the findings of the present study indicate that rivastigmine hydrogen tartrate used in combination with donepezil hydrochloride relieves the symptoms and improves the quality of life of patients with AD more effectively, which may be related to the reduction of the bradykinin level in these patients.
  • ||||||||||  donepezil / Generic mfg., galantamine hydrobromide / Generic mfg., rivastigmine / Generic mfg.
    [VIRTUAL] Frequency of comedication in patients with dementia () -  Aug 2, 2020 - Abstract #AAIC2020AAIC_3777;    
    Since available data overwhelmingly suggests that patients with dementia suffer from more comorbidities than those without, this data can be interpreted as evidence for undertreatment of somatic comorbidities in this patient group. with dementia and controls.
  • ||||||||||  rivastigmine / Generic mfg., quetiapine / Generic mfg.
    [VIRTUAL] Prolonged Therapy of Dementia with Lewy Bodies with Quaternary Ammonium Anti-Muscarinic/High-Dose Cholinesterase Inhibitor (QAAM/HDCI) () -  Aug 2, 2020 - Abstract #AAIC2020AAIC_3342;    
    The results show that prolonged symptomatic, cognitive and functional improvement of dementia with Lewy Bodies is possible with the high-level inhibition of central nervous system cholinesterase achievable when rivastigmine is combined with glycopyrrolate. The discussion correlates these observations with current experimental, clinical and epidemiological evidence regarding the mechanism and treatment of this, and other, neurodegenerative diseases.
  • ||||||||||  Trintellix (vortioxetine) / Lundbeck, Takeda, rivastigmine / Generic mfg.
    [VIRTUAL] Vortioxetine use in demented patients () -  Aug 2, 2020 - Abstract #AAIC2020AAIC_3068;    
    Available evidence indicates that target receptors for vortioxetine play an important role in brain networks, and this could explain its efficacy regardless the antidepressive effect. No safety concerns were found in this group of patients with doses from 10 to 20 mg/day according with tolerability profile already described .