- |||||||||| Review, Journal: Pharmacotherapy in autism spectrum disorders, including promising older drugs warranting trials. (Pubmed Central) - Jun 29, 2023
Methylphenidate (MPH) studies showed lower efficacy and tolerability for attention deficit hyperactivity disorder (ADHD) than in the typically developing (TD) population; atomoxetine demonstrated lower efficacy but comparable tolerability to TD outcomes...Controlled trials of the selective serotonin reuptake inhibitors citalopram and fluoxetine demonstrated poor tolerability and lack of efficacy for repetitive behaviors...Amitriptyline at approximately 1 mg/ kg/day used cautiously, shows efficacy for sleep, anxiety, impulsivity and ADHD, repetitive behaviors, and enuresis. Both drugs have promising neurotrophic properties.
- |||||||||| aripiprazole / Generic mfg., risperidone / Generic mfg., olanzapine / Generic mfg.
Journal: Incidence of Venous Thromboembolism Among Commonly Prescribed Second-Generation Antipsychotics. (Pubmed Central) - Jun 22, 2023
There was no difference in the incidence of VTE between risperidone, olanzapine, or aripiprazole. Given multiple limitations with this study, higher-powered studies should be conducted to investigate the possibility of differences in the incidence of VTE between the SGAs.
- |||||||||| olanzapine / Generic mfg.
Preclinical, Journal: Thermoneutral housing does not rescue olanzapine-induced trabecular bone loss in C57BL/6J female mice. (Pubmed Central) - Jun 20, 2023
Overall, olanzapine causes trabecular bone loss and inhibits the positive effect of thermoneutral housing on bone. Understanding how housing temperature modulates the impact of AA drugs on bone is important for future pre-clinical studies, as well as for the prescription of AA drugs, particularly to older adults and adolescents who are most vulnerable to the effects on bone.
- |||||||||| Lodopin (zotepine) / Astellas, Serlect (sertindole) / Lundbeck, Abbott
Retrospective data, Review, Journal: Antipsychotic-induced akathisia in adults with acute schizophrenia: A systematic review and dose-response meta-analysis. (Pubmed Central) - Jun 19, 2023
We obtained data on all antipsychotics except clozapine and zotepine. In patients with acute exacerbations of chronic schizophrenia, from moderate to high certainty of evidence, our analysis showed that sertindole and quetiapine carried negligible risks for akathisia across examined doses (flat curves), while most of the other antipsychotics had their risks increase initially with increasing doses and then either plateaued (hyperbolic curves) or continued to rise (monotonic curves), with maximum ORs ranging from 1.76 with 95% Confidence Intervals [1.24, 2.52] for risperidone at 5.4
- |||||||||| risperidone / Generic mfg.
Journal: Guiding safer risperidone prescribing in Alzheimer's disease with therapeutic drug monitoring. (Pubmed Central) - Jun 19, 2023
The model predicted that 26.2% (95% CI 18.6 - 32.6%) had C/D ratios above 14ng/ml per mg/day. These findings confirm the importance of age-related risperidone dose adjustments and argue strongly for therapeutic drug monitoring in the initial stages of treatment, to identify those at greatest risk of toxicity.
- |||||||||| risperidone / Generic mfg., galantamine hydrobromide / Generic mfg., rivastigmine / Generic mfg.
Review, Journal: Acetylcholinesterase inhibitors for autistic spectrum disorders. (Pubmed Central) - Jun 6, 2023
There is a need for more evidence of improvement in outcomes of relevance to clinical care, autistic people, and their families. There are a number of ongoing studies involving acetylcholinesterase inhibitors, and future updates of this review may add to the current evidence.
- |||||||||| acetazolamide / Generic mfg.
Journal: An open-label study of oral acetazolamide for the prevention of antipsychotic associated weight gain. (Pubmed Central) - Jun 5, 2023
Similarly, the BPRS and CGI scores were significantly reduced in both arms, with satisfaction rates better among the cases compared to controls. There was a non-significant reduction in the weight, body mass index, abdominal circumference, and brief psychiatric rating scale scores in patients treated with acetazolamide.Ethics committee protocol number: - 2018/244CTRI India registration number: CTRI/2019/05/018884.
- |||||||||| risperidone / Generic mfg.
Three child with CTNNB1-associated neurodevelopmental disorder improved with levodopa treatment (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_878;
In these three girls, identification of deleterious variants in CTNNB1 led to changes in care, including personalized treatment with levodopa. In CTNNB1-associated neurodevelopmental disorder, levodopa may be considered as it can impact motor, cognitive and social function, maximizing acquisitions in critical periods of development.
- |||||||||| Treatment of chorea in NXK2-1-related disorders: A Systematic Review (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_626;
The percentage of patients treated with methylphenidate who experience improvement in chorea is greater than that of patients treated with other medications. However, due to poor methodological quality, additional treatment studies may be required to recommend therapeutic options.
- |||||||||| risperidone / Generic mfg.
Is it all about lupus? Neuropsychiatric manifestations as systemic lupus erythematosus opening diagnosis with fatal outcome (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_551;
In the present case, the participation of SLE, previously undiagnosed, in the child's psychiatric symptoms - chronic mood disorder - is questioned. Furthermore, a possible decompensation of the disease is observed through the acute manifestation of psychosis with a subsequent decrease in the level of consciousness, in addition to alterations in renal and hematological laboratory exams.
- |||||||||| risperidone / Generic mfg.
Features of tissue energy metabolism in children with autism (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_107;
impaired mitochondrial activity is an important link in the pathogenesis of (A). The addition of ETT to the ongoing treatment with psychotropic drugs increases the effectiveness of therapy and improves the prognosis of the course of the disease.
- |||||||||| Review, Journal: Mood Stabilizers of First and Second Generation. (Pubmed Central) - May 27, 2023
The article presents clinical experiences with mood stabilizers of the first and second generations and with "insufficient" ones. Further, current suggestions for their use in preventing recurrences of bipolar mood disorder are provided.
- |||||||||| Preclinical, Journal: Developing In Vitro Models to Define the Role of Direct Mitochondrial Toxicity in Frequently Reported Drug-Induced Rhabdomyolysis. (Pubmed Central) - May 27, 2023
To confirm the human relevance of the findings, fenofibrate and risperidone were evaluated in primary human skeletal muscle-derived cells (HSKMDC), using the acute metabolic switch assay and real-time respirometry, which confirmed this designation, although the toxic effects on the mitochondria were more pronounced in HSKMDC. Overall, these studies demonstrate that the L6 model of acute modification may find utility as an initial, cost-effective screen for identifying potential myotoxicants with relevance to humans and, importantly, that drug-induced mitochondrial dysfunction may be a common mechanism shared by some drugs that induce myotoxicity.
- |||||||||| risperidone / Generic mfg.
Journal: Acute Mania in a Patient With Primary Adrenal Insufficiency Due to Autoimmune Adrenalitis: A Case Report. (Pubmed Central) - May 22, 2023
The decision was made to restart corticosteroid treatment for the patient's primary adrenal insufficiency (formerly known as Addison disease), coupled with administration of both risperidone and valproate for mania and psychosis...His final diagnosis was acute mania secondary to autoimmune adrenalitis. Although acute mania in adrenal insufficiency is quite rare, clinicians should be aware of the range of psychiatric manifestations associated with Addison disease so that they can pursue the optimal course of both medical and psychiatric treatment for these patients.
- |||||||||| Journal, Adverse events: Antipsychotics and obsessive-compulsive disorder/obsessive-compulsive symptoms: A pharmacovigilance study of the FDA adverse event reporting system. (Pubmed Central) - May 17, 2023
In contrast to prior reports noting clozapine as the antipsychotic most commonly associated with de novo or exacerbated OCD/OCS, this pharmacovigilance study found aripiprazole was most frequently reported for this adverse effect. While these findings from FAERS offer a unique perspective on OCD/OCS with different antipsychotic agents, due to the inherent limitations of pharmacovigilance studies they should ideally be validated through alternative prospective research studies involving direct comparisons of antipsychotic agents.
- |||||||||| Antipsychotic-Induced Hypothermia in Jail Patients: A Rare Adverse Effect Meets Structural Vulnerability (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_1220;
As it stands, consultant psychiatrists should know that correctional settings may increase AIH risk through structural vulnerabilities such as poor temperature control, limited clothing, and high rates of AP use.4,5,6 Additionally, care should be taken to distinguish hypothermic symptoms (e.g. confusion, apathy) from psychiatric illness.7 Finally, the authors aim to motivate advocacy of awareness of AIH as a potential contributor to hypothermia in incarcerated populations. Collaborating with jail medical staff regarding environmental exposure and psychiatric treatment may prevent patient harm from phenomena such as AIH.
- |||||||||| olanzapine / Generic mfg.
Agranulocytosis After Re-Initiation of Olanzapine (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_1216;
He was trialed on fluphenazine in 1998 but was started on olanzapine in 2002, which he had been taking until hospitalization...During his hospitalization, due to recurrent psychosis while off olanzapine, the patient was transitioned and up-titrated to risperidone 3 mg twice daily as his new antipsychotic treatment...Although clozapine is the most well-known antipsychotic associated with the development of agranulocytosis, other antipsychotics, such as olanzapine, are also associated with this phenomenon (Mijovic 2020; Woon 2018)...Finally, we review the current literature regarding cases of olanzapine-induced agranulocytosis. Ultimately, this information is intended to make clinicians more aware of a rare but serious side effect of a commonly used psychiatric medication.
- |||||||||| Trintellix (vortioxetine) / Lundbeck, Takeda, Viibryd (vilazodone) / AbbVie
An Evidence-Based Approach to Psychopharmacology for Generalized Anxiety Disorder (GAD)-2022 Update, With Emphasis on Older Adults (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_1167;
For a third medication trial, additional alternatives now include pregabalin/gabapentin, lavender oil, or agomelatine (not available in the United States)...One could consider venlafaxine, quetiapine, risperidone, or aripiprazole. We decided to recommend not using the following in this population: benzodiazepines, hydroxyzine, olanzapine, vortioxetine, or, vilazodone.
- |||||||||| risperidone / Generic mfg., diazepam / Generic mfg.
Psychotropic Prescribing Practices in Adults With Intellectual Disability and Autism Spectrum Disorder (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_1094;
Conclusions Prescribing of psychotropic medication is common in this group of people and there was clear evidence that prescriptions were regularly reviewed, in keeping with STOMP guidance. However, we found that input from behaviour analysis and PBS plans were not always in place for some cases where their input would have been helpful.
- |||||||||| Austedo (deutetrabenazine) / Teva
Hypomania Following Low-Dose Deutetrabenazine in a Geriatric Patient With Bipolar Disorder: A Case Report (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_1072;
The patient was previously taking a combination of valproic acid and risperidone for bipolar disorder, but risperidone was later discontinued due to adverse effects...She was initially treated with benztropine 1mg twice daily for these movements but experienced minimal benefit and had an adverse effect of dry mouth...Valproic acid was increased and quetiapine was added to target hypomania...Deutetrabenazine is an important novel treatment for TD, but providers should be aware of its possible risks. TD remains a challenging clinical concern and future research is needed to both prevent and treat this debilitating condition.
- |||||||||| risperidone / Generic mfg.
Grandiosity in Behavioral Variant Frontotemporal Dementia: A Case of Misfortunate Misdiagnosis (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_1069;
Given the above history and exam findings, BvFTD was found to be the most appropriate diagnosis. This case highlights the difficulties associated with delayed diagnosis, behavioral management, and interdisciplinary care coordination for general hospital patients diagnosed with BvFTD.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Challenges in Management of Catatonia in Patients With Chronic Use of Antipsychotics: Case Report (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_1049;
A management dilemma arouses given her chronic use of antipsychotics and the possibility that these drugs may be causing or worsening her symptoms and deteriorating her convulsive and motor disorder. In this poster we discuss the challenge in the approach and management of patients with catatonia who need an antipsychotic as part of the treatment for the underlying condition of a catatonic presentation.
- |||||||||| risperidone / Generic mfg., prednisone / Generic mfg.
Primary Versus Secondary Psychosis in a Patient With Covid-19 Induced Cytotoxic Lesion of the Corpus Callosum (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_1008;
The patient Collateral was obtained and revealed that he was discharged stable 12 days ago after a psychiatric hospitalization totaling 9 days for which he was admitted for altered mental status, auditory hallucinations, and disorganized behavior five days after taking 1 dose of prednisone for an asthma exacerbation that was found to be secondary to a COVID-19 infection...He was started on risperidone and over the next week, his affect improved, his hallucinations resolved, his concentration and cognition improved, but his grandiosity strengthened into delusions of him being
- |||||||||| risperidone / Generic mfg., sodium valproate / Generic mfg.
Overshadowed and Under-Connected: A Case of Agenesis of the Corpus Callosum Eclipsed by Autistic Symptomatology (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_1003;
With an increase to his home risperidone, he was no longer distressed by his hallucinations nor his delusions...There is further evidence linking structural and genetic abnormalities of the corpus callosum in psychosis; the disrupted-in-schizophrenia 1 (DISC1) gene is associated with AgCC and psychosis, and decreased corpus callosum size and volume have been correlated with positive psychotic symptoms (1,8,9,10,5). Implications: - Autistic symptomatology may overshadow the presence of AgCC - Increased severity of psychosis should raise concern for comorbid AgCC - Relatively few patients with AgCC carry a true diagnosis of ASD
- |||||||||| risperidone / Generic mfg., haloperidol / Generic mfg.
Neurosyphilis or Schizophrenic Disorder? A Subtle, Yet Crucial Clinical Distinction (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_1001;
Implications: - Autistic symptomatology may overshadow the presence of AgCC - Increased severity of psychosis should raise concern for comorbid AgCC - Relatively few patients with AgCC carry a true diagnosis of ASD She was placed on depakote for mood stabilization, risperdal for psychosis, and given a one-time benzathine penicillin injection for possible syphilis...On the contrary, the patient
- |||||||||| risperidone / Generic mfg.
Mania in Autoimmune Adrenalitis: Steroids as the Cause or the Cure? (Hall B Foyer, Exhibition Level Moscone South) - May 17, 2023 - Abstract #APA2023APA_996;
She was placed on depakote for mood stabilization, risperdal for psychosis, and given a one-time benzathine penicillin injection for possible syphilis...On the contrary, the patient The decision was made to restart corticosteroid treatment for Addison
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