- |||||||||| risperidone / Generic Mfg., Egis
Clinical, Journal: A framework for 2-stage global sensitivity analysis of GastroPlus™ compartmental models. (Pubmed Central) - Oct 4, 2019
Both methods detected nonlinearities and parameter interactions that would have otherwise been missed by local approaches. Future work includes further exploration of how the input domain influences the calculated global sensitivity measures as well as extending the framework to consider a whole-body PBPK model.
- |||||||||| risperidone / Generic Mfg., Egis
Biomarker, Review, Journal: Immunological Dysfunction in Autism Spectrum Disorder: A Potential Target for Therapy. (Pubmed Central) - Oct 4, 2019
These studies used various data acquisition methodologies. Questions arose such the need for randomized and placebo-controlled studies with greater numbers of participants as well as the use of biomarkers to refine the treatment of autistic subjects.
- |||||||||| risperidone / Generic Mfg., Egis, olanzapine / Generic Mfg., quetiapine / Generic Mfg.
Biomarker, Retrospective data, Journal, Adverse drug reaction: An opportunity for clinical pharmacology trained physicians to improve patient drug safety: A retrospective analysis of adverse drug reactions in teenagers. (Pubmed Central) - Oct 4, 2019
Despite any data limitations, physicians prescribing risperidone in males should be aware of the high rates of adverse drug events and an alternative psychotropic should be considered in male patients. Further, patients with a history of pneumothorax or genetically predisposed to pneumothorax should be considered for an alternative antiemetic to ondansetron hydrochloride, due to increased odds associated with the drug and adverse event.
- |||||||||| risperidone / Generic Mfg., Egis
Journal: Classics in Chemical Neuroscience: Risperidone. (Pubmed Central) - Oct 2, 2019
It is on the World Health Organization's List of Essential Medicines for its balance of efficacy, safety, tolerability, and cost-effectiveness. In this review, we highlight the history and importance of risperidone as an atypical antipsychotic, in addition to its chemical synthesis, manufacturing, drug metabolism and pharmacokinetics, pharmacology, structure-activity relationship, indications, and adverse effects.
- |||||||||| Phase classification, Enrollment change: Glulipid: Glucose and Lipid Metabolism on Antipsychotic Medication (clinicaltrials.gov) - Oct 2, 2019
P=N/A, N=96, Completed,
In this review, we highlight the history and importance of risperidone as an atypical antipsychotic, in addition to its chemical synthesis, manufacturing, drug metabolism and pharmacokinetics, pharmacology, structure-activity relationship, indications, and adverse effects. Phase classification: P4 --> P=N/A | N=216 --> 96
- |||||||||| risperidone / Generic Mfg., Egis
Preclinical, Journal, IO Biomarker: The effects of donepezil on phencyclidine-induced cognitive deficits in a mouse model of schizophrenia. (Pubmed Central) - Oct 2, 2019
Moreover, donepezil can also improve PCP-induced schizophrenia-like cognitive deficits by inhibiting neuronal apoptosis and regulating synaptic plasticity, which was possible through the up-regulation of p-Akt, p-GSK-3β, Bcl-2 and the down-regulation of Bax, Caspase-3. The results indicated that donepezil might exhibit a beneficial effect on the treatment of cognitive dysfunction in schizophrenia.
- |||||||||| risperidone / Generic Mfg., Egis
Clinical, Journal: Extrapyramidal symptoms resulting from risperidone use in a four year old child: A case report. (Pubmed Central) - Oct 2, 2019
The patient became symptom free after management and risperidone was discontinued. Although risperidone has been approved to treat different indications in adolescents and children, scarce scientific evidence and our case report, are suggestive of further studies to establish safety of risperidone use in preschool children.
- |||||||||| risperidone / Generic Mfg., Egis, sertraline / Generic Mfg.
Journal: The characteristics of temper outbursts in Prader-Willi syndrome. (Pubmed Central) - Sep 28, 2019
Distracting the person or giving them space to calm down were the only management strategies judged effective. Risperidone, sertraline, and fluoxetine were the most common medications prescribed for outbursts, though parents reported only minor effects.
- |||||||||| risperidone / Generic Mfg., Egis
Biomarker, Clinical, Journal: Evaluation of Correlation Between the Pharmacogenetic Profiles of Risperidone Treated Psychiatry Patients with Plasma and Urine Concentration of Risperidone and its Active Moiety 9-OH Risperidone Determined with Optimized Bioanalytical LC Method. (Pubmed Central) - Sep 28, 2019
All the patients were previously genotyped for CYP2D6 (EM=30, EM/IM=14, IM=4 IM/PM=1 and PM=3) and ABCB1 using Real-Time PCR methods with TaqMan SNP genotyping suitable assays according to the guidelines of the manufacturer (Life Technologies, USA).The influence of CYP2D6 phenotype on metabolic ratio MR (Ris/9-OHRis) in plasma (p=0.012) and in urine (p=0.048) was confirmed. Statistically significant correlation (R2=55.53%, Rho=0.844, p<0,0001) for MR in both plasma and urine indicates that urine may be utilized as appropriate media for initial CYP2D6 phenotype identification and selection of patients on risperidone treatment with high risk for ADR.
- |||||||||| risperidone / Generic Mfg., Egis
Clinical, Review, Journal: Molecular targets of atypical antipsychotics: From mechanism of action to clinical differences. (Pubmed Central) - Sep 26, 2019
We also introduce relatively new concepts like biased agonism, receptor dimerization and neurogenesis to identify better the old and new hallmarks of "atypia". Finally, a detailed confrontation of clinical differences among the AAPs is presented, especially in relation to their molecular targets, and new means like therapeutic drug monitoring are also proposed to improve the effectiveness of AAPs in clinical practice.
- |||||||||| risperidone / Generic Mfg., Egis
Drug-induced dystonia (Les Muses Terrace, Level 3) - Sep 24, 2019 - Abstract #MDSCongress2019MDS_2164;
Clinical distribution is mainly cranial, but can be generalized. Benzodiazepines and anticholinergics are an effective treatment
- |||||||||| risperidone / Generic Mfg., Egis, Gablofen (baclofen) / Mallinckrodt
Improvement of lower extremity Holmes tremor with intrathecal baclofen: First Report (Les Muses Terrace, Level 3) - Sep 24, 2019 - Abstract #MDSCongress2019MDS_2008;
Weiss N et al described incidental improvement of upper extremity cerebellar intentional tremor after baclofen pump was implanted for spasticity [6].Our case is the first to demonstrate responsiveness of atypical Holmes tremor to ITB. ITB pump may be a promising neuromodulation option for medically-refractory atypical Holmes tremor of the lower extremity.
- |||||||||| risperidone / Generic Mfg., Egis, olanzapine / Generic Mfg., quetiapine / Generic Mfg.
Patterns of Lewy body dementia diagnosis and treatment in Florida (Les Muses, Level 3) - Sep 24, 2019 - Abstract #MDSCongress2019MDS_1678;
African-Americans account for a lower percent of LBD cases than the proportion of African-Americans (17%) in Florida suggesting LBD may be underdiagnosed in this population [1]. Opportunities to improve care include diagnosis amongst racial/ethnic minorities and decreased use of inappropriate antipsychotics.
- |||||||||| risperidone / Generic Mfg., Egis, quetiapine / Generic Mfg.
Antipsychotics Use in Parkinson’s Disease and Mortality Risks (Les Muses, Level 3) - Sep 24, 2019 - Abstract #MDSCongress2019MDS_1379;
Antipsychotic medication, particularly quetiapine, is commonly prescribed for PD in Taiwan, despite the black-box warning. The cause of higher mortality risks among antipsychotics users in PD warrants further investigation.
- |||||||||| aripiprazole / Generic Mfg., risperidone / Generic Mfg., Egis, quetiapine / Generic Mfg.
Drug-Induced Parkinsonism May Persist Beyond Two Years After Discontinuation of Dopamine Transmission Blocking Agents (Agora 2 West, Level 2) - Sep 24, 2019 - Abstract #MDSCongress2019MDS_1143;
Parkinsonism persisted at our last visit but improved during longitudinal follow-up, going against a progressive degenerative disorders such as Parkinson’s disease. DaT scans showing normal dopamine transporters at 8 and 16 months since discontinuation of causative agents persuade us that the patients did not evolve or concurrently suffer from neurodegenerative causes of parkinsonism.
- |||||||||| risperidone / Generic Mfg., Egis
Re-emerging Neuroleptic Malignant Syndrome (NMS) without Re-introduced Neuroleptic in a Schizophrenia Patient: a Case Report (Agora 2 West, Level 2) - Sep 24, 2019 - Abstract #MDSCongress2019MDS_830;
The patient was diagnosed with NMS and treated with bromocriptine...This case report shows that re-emerging NMS without any re-introduced neuroleptic drugs may be possible due to long-acting properties of neuroleptics injection. It is important for clinicians to be aware that the long-acting typical neuroleptic injection could cause prolonged effect to have an early identification and intervention
- |||||||||| Use of Inappropriate Antipsychotics Among US Long-Term Care Residents with Parkinson’s Disease Psychosis (Agora 3 West, Level 3) - Sep 24, 2019 - Abstract #MDSCongress2019MDS_421;
Currently, pimavanserin is the only therapy approved for hallucinations and delusions in PDP, but second-generation AP therapies are frequently used, off label, for the treatment of PDP, including quetiapine and clozapine, the latter of which is associated with burdensome monitoring (3)...The relative rates in AP use was similar in the other database: quetiapine (57.0%), risperidone (24.6%), olanzapine (17.2%), aripiprazole (9.1%), and haloperidol (20%)...A high percentage of non-indicated APs are prescribed in LTC to treat PDP despite equivocal efficacy and questionable safety, especially, haloperidol, a first-generation AP (4). These data highlight the need for increased awareness of appropriate AP selection to support optimal treatment of LTC PDP residents.
- |||||||||| risperidone / Generic Mfg., Egis, olanzapine / Generic Mfg.
Journal, HEOR: Cost analysis study of neuropsychiatric drugs: Role of National List of Essential Medicines, India. (Pubmed Central) - Sep 22, 2019
Antipsychotic medications and drugs for OCD in the NLEM group have a wider range than in the NNLEM group. The NLEM group has economical drugs in some disease categories; there is a need to consider the cost effectiveness of all drug categories while revising the NLEM next time and attention should focus on drug price regulation policies to accomplish the goal of rational use of medicines.
- |||||||||| risperidone / Generic Mfg., Egis
Journal: Risperidone induced rabbit syndrome. (Pubmed Central) - Sep 20, 2019
The NLEM group has economical drugs in some disease categories; there is a need to consider the cost effectiveness of all drug categories while revising the NLEM next time and attention should focus on drug price regulation policies to accomplish the goal of rational use of medicines. No abstract available
- |||||||||| risperidone / Generic Mfg., Egis
Clinical, Journal: Dopamine (DRD2) and Serotonin (HTR2A, 2C) Receptor Gene Polymorphisms do not influence early response to Risperidone in South Indian Patients with Schizophrenia. (Pubmed Central) - Sep 18, 2019
DRD2 -141 C Ins/Del (n=310, Ins/Ins=177, Ins/Del+ Del/Del=133, OR 0.70, 95% CI 0.4-1.2 p 0.2), Taq1A (n=320, AA=35, AG=132, GG=153, p 0.2), HTR2A -1438 G/A (n=320, AA=39, AG=164, GG=117, p 0.2), HTR2A 102T/C (n=320, CC=115, CT=165, TT=40, p 0.1) HTR2C -759 C/T (females n=132, CC=65, CT+TT=67, OR 1.3, 95% CI 0.6-2.8, p 0.5; males n=186, C=120, T=66, OR 1.2, 95% CI 0.6-2.4, p 0.4) genetic polymorphisms did not show any association with antipsychotic response to risperidone. DRD2 -141 C Ins/Del, Taq1A, HTR2A -1438 G/A, 102T/C and HTR2C -759 C/T genetic variants are not associated with antipsychotic response to risperidone.
- |||||||||| risperidone / Generic Mfg., Egis
Clinical, Journal: Do Long-Acting Injectable Antipsychotics Prevent or Delay Hospital Readmission? (Pubmed Central) - Sep 14, 2019
Those who received a LAI with administration frequency of a month or longer had a significantly longer survival time without readmission (mean 307.9 days) when compared to those with a shorter administration frequency (mean 245.0 days). This study revealed the use of LAI antipsychotics in those with a history of medication non-adherence, particularly those with longer administration frequency, have potentially promising outcomes.
- |||||||||| risperidone / Generic Mfg., Egis
Clinical, Journal: A Case of Hyper Sexuality Probably Associated with Clozapine. (Pubmed Central) - Sep 14, 2019
Due to non-compliance and relapse of symptoms, she was started on clozapine 450 mg which was further increased to 650 mg along with an injectable antipsychotic zuclopenthixol 400 mg...Poor understanding of the condition by the patient could lead to marital discord and suffering. WHO scale indicates clozapine as the probable cause of sexual dysfunction in our patient.
- |||||||||| risperidone / Generic Mfg., Egis, olanzapine / Generic Mfg.
Journal, IO Biomarker: Atypical antipsychotics induce human osteoblasts apoptosis via Wnt/β-catenin signaling. (Pubmed Central) - Sep 11, 2019
APs cause OB cells apoptosis relating to Wnt/β-catenin signaling while resevratrol could reverse this phenomenon. Our study could lay the foundation for overcoming the APs-induced osteal side effects to improve the life quality of schizophrenia patients.
- |||||||||| risperidone / Generic Mfg., Egis, olanzapine / Generic Mfg., carbamazepine / Generic Mfg.
Review, Journal: Lithium for acute mania. (Pubmed Central) - Sep 10, 2019
However, when compared to other drugs, too few studies provided data on adverse effects to provide high-certainty evidence. More, rigorously designed, large-scale studies are needed to definitively conclude if lithium is superior to other interventions in treating acute mania.
- |||||||||| risperidone / Generic Mfg., Egis, olanzapine / Generic Mfg.
Seizures beyond epileptic seizures. () - Sep 10, 2019 - Abstract #EUSEM2019EUSEM_1509;
In this case, the vascular and neoplastic causes were ruled out, with the CT scan of the skull; like the infectious and toxic cause was ruled out. The most successful possibility was the metabolic cause.
- |||||||||| risperidone / Generic Mfg., Egis, olanzapine / Generic Mfg.
All excess is harmful, including water intake. () - Sep 10, 2019 - Abstract #EUSEM2019EUSEM_1269;
The clinician may partially decrease these electrolyte disturbances and theirconsequences. It is necessary to strictly monitor the ions in patients with psychiatric disorders, provided that certain drugs are associated with their treatment.
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