- |||||||||| risperidone / Generic mfg., Egis, iloperidone / Generic mfg.
Journal: Determination of Specific Absorbance (A¦) for Six Psychoactive Drugs Encountered in Forensic Toxicology. (Pubmed Central) - Sep 25, 2020
This work focused on determining the quantitative value of the specific absorbance of six psychoactive drugs using ultraviolet-visible spectroscopy, as well as comparing A¦ values of drugs purchased in 2017 to A¦ of their counterparts purchased in 2019. The drugs analyzed included Iloperidone, Risperidone, Aripiprazole, Vilazodone, Vortioxetine, and Suvorexant.
- |||||||||| Clinical, Journal: Anticholinergic medicines use among older adults before and after initiating dementia medicines. (Pubmed Central) - Sep 23, 2020
Use of anticholinergic medicines is common among persons initiating dementia medicines and this occurs against a backdrop of widespread campaigns to reduce irrational medicine combinations in this vulnerable population. Decisions about deprescribing medicines with questionable benefit among persons with dementia may be complicated by conflicting recommendations in prescribing guidelines.
- |||||||||| Journal: Transdermal Delivery of Antipsychotics: Rationale and Current Status. (Pubmed Central) - Sep 23, 2020
Despite the current availability of a large number of antipsychotics, only a few of these drugs (e.g. aripiprazole, asenapine, blonanserin, chlorpromazine, haloperidol, olanzapine, prochlorperazine, quetiapine, and risperidone) have been developed as transdermal delivery systems...However, few clinical trials on transdermal delivery of antipsychotic drugs are available and only delivery systems containing asenapine and blonanserin have shown interesting clinical results in terms of pharmacokinetic data, efficacy, and tolerability. Recently, the transdermal patch formulation of blonanserin was approved in Japan for the treatment of schizophrenia.
- |||||||||| risperidone / Generic mfg., Egis, Ingrezza (valbenazine) / Neurocrine, Mitsubishi Tanabe, olanzapine / Generic mfg.
[VIRTUAL] Treatment of hemichorea-hemiballism with valbenazine () - Sep 20, 2020 - Abstract #MDSCongress2020MDS Congress_367;
The available data suggest possible nonketotic hyperglycemia as the etiology for HCHB though an ischemic infarct could not be definitely ruled out. Regardless of etiology, this case of HCHB suggests that valbenazine is an effective and well-tolerated treatment.
- |||||||||| risperidone / Generic mfg., Egis
[VIRTUAL] Novel GNO1 mutation in monozygotic twins responsive to DBS () - Sep 20, 2020 - Abstract #MDSCongress2020MDS Congress_162;
Various medications including benzodiazepines, benztropine, risperidone, tetrabenazine, topiramate and levetiracetam were used in order to abolish hyperkinetic movements without significant benefit. Neurodevelopmental disorders with involuntary movements are becoming increasingly recognized as GNAO1 mutation-associated neurological disorders and DBS should perhaps be considered earlier in the course to prevent prolonged hospitalizations and other potential complications.
- |||||||||| risperidone / Generic mfg., Egis, quetiapine / Generic mfg.
[VIRTUAL] Tardive Dystonia Successfully treated with DBS () - Sep 20, 2020 - Abstract #MDSCongress2020MDS Congress_136;
In 2017 was prescribed Haloperidol and Lithium... Tardive Dystonia can be a limiting condition and, similarly to idiopathic dystonia, can be successfully treated with GPi-DBS.
- |||||||||| Review, Journal: Lumateperone (Caplyta) for schizophrenia. (Pubmed Central) - Sep 20, 2020
Tardive Dystonia can be a limiting condition and, similarly to idiopathic dystonia, can be successfully treated with GPi-DBS. No abstract available
- |||||||||| risperidone / Generic mfg., Egis
Journal: Some current trends in the use of prolonged injectable antipsychotics in the conditions of modernization of the psychiatric service (Pubmed Central) - Sep 20, 2020
There is a significant increase in public spending on the purchase and use of these drugs for the treatment of privileged categories of patients, most of this applies to injectable forms of paliperidone, the cost of using these drugs has increased more than 20 times over a five-year period. These trends indicate a shift in emphasis towards outpatient psychiatric care and improvement of approaches to treatment of patients with schizophrenia, which indicate a new stage in the development of out-of-hospital treatment and rehabilitation systems based on the latest achievements of psychopharmacology and the development of social support systems for patients with schizophrenia spectrum disorders.
- |||||||||| risperidone / Generic mfg., Egis, olanzapine / Generic mfg., quetiapine / Generic mfg.
Clinical, Journal: Psychotropic Treatment During Pregnancy: Research Synthesis and Clinical Care Principles. (Pubmed Central) - Sep 19, 2020
Antipsychotics, other than risperidone and potentially paliperidone, have not been associated with an increase in birth defects; olanzapine and quetiapine have been linked with an elevated risk of gestational diabetes...The goal of perinatal mental health treatment is to optimally provide pharmacotherapy to mitigate the somatic and psychosocial burdens of maternal psychiatric disorders. Regular symptom monitoring during pregnancy and postpartum and medication dose adjustments to sustain efficacy constitutes good practice.
- |||||||||| risperidone / Generic mfg.
Enrollment open, Trial completion date, Trial primary completion date: Risperidone for the Treatment of Huntington's Disease Involuntary Movements (clinicaltrials.gov) - Sep 17, 2020
P2, N=12, Recruiting,
Regular symptom monitoring during pregnancy and postpartum and medication dose adjustments to sustain efficacy constitutes good practice. Not yet recruiting --> Recruiting | Trial completion date: Feb 2022 --> Aug 2022 | Trial primary completion date: Feb 2022 --> Aug 2022
- |||||||||| risperidone / Generic mfg., Egis, olanzapine / Generic mfg.
[VIRTUAL] Relationship between type of antipsychotic treatment and psychopathology in acute schizophrenia and schizoaffective patients (Poster Area) - Sep 17, 2020 - Abstract #ECNP2020ECNP_1227;
The aim of this study is to evaluate the effectiveness and safety of paliperidone palmitate compared with risperidone, olanzapine and aripiprazole...The equivalent doses of chlorpromazine with respect to treatment also have significant differences (p = 0.012)...The type of antipsychotic treatment and the doses used influence in the time to achieve the clinic stabilization, being in our study more favorable for risperidone, although there not differences respect to the treatment in the psychopathology improvement finally. Our results support the hypothesis that paliperidone can be a good antipsychotic to the adherence compliance and to obtain the clinic remission.
- |||||||||| risperidone / Generic mfg., Egis, olanzapine / Generic mfg.
Clinical, Journal: Circadian patterns of hallucinatory experiences in patients with schizophrenia: Potentials for chrono-pharmacology. (Pubmed Central) - Sep 17, 2020
Since the dopamine D receptor blockade by antipsychotics was stable, the nocturnal circadian pattern found in this study may reflect intrinsic dopaminergic fluctuation or generally quieter environments at night. These circadian patterns may be considered to devise individualized treatment approach in the context of "chrono-pharmacology" for patients with schizophrenia.
- |||||||||| risperidone / Generic mfg., Egis
Clinical, Journal: Case report: manic episode with psychotic symptoms induced by hyponatremia. (Pubmed Central) - Sep 16, 2020
Antipsychotic treatment with risperidone was initiated...We therefore assume a causal relationship between hyponatremia and manic-psychotic symptoms in our patient. Hyponatremia was most likely induced by excessive water intake during a period of fasting in the context of a wellness practice.
- |||||||||| risperidone / Generic mfg., Egis
[VIRTUAL] First Case of Risperidone-Associated Secondary Sclerosing Cholangitis () - Sep 15, 2020 - Abstract #ACG2020ACG_713;
The fibrotic changes of biliary duct, as well as the temporal relationship between risperidone intake and elevation of hepatic enzymes, are suggestive of this diagnosis. The findings of multiple ductal stones and ductal dilation likely represent the chronic inflammatory process.
- |||||||||| risperidone / Generic mfg., Egis, paliperidone extended release / Generic mfg.
Clinical, Retrospective data: Delayed-Onset Toxicity in an Adolescent Case Following Attempted Suicide with an Overdose of Paliperidone Intake. (Pubmed Central) - Sep 13, 2020
The drug was generated by combining the active metabolite of risperidone, 9-hydroxyrisperidone, with osmotic controlled-release oral administration system (OROS) technology...This might in turn, prompt us to switch our usual evaluation and intervention practices. With this case report, we have aimed to discuss delayed onset toxicity with paliperidone overdose in an adolescent case, due to a suicide attempt with excessive intake of the medication.
- |||||||||| methylphenidate tablet / Generic mfg., risperidone / Generic mfg., Egis
Clinical, Journal: Dopaminergic drugs alter beta coherence during motor imagery and motor execution in healthy adults. (Pubmed Central) - Sep 10, 2020
The administration of methylphenidate and risperidone was able to produce electrocortical changes of the cortical central regions, even when featuring antagonistic effects on the dopaminergic pathways. Moreover, the execution task allowed beta-band modulation increase.
- |||||||||| nitroprusside / Generic mfg., risperidone / Generic mfg., Egis
Preclinical, Journal: Enhancement of the antipsychotic effect of risperidone by sodium nitroprusside in rats. (Pubmed Central) - Sep 8, 2020
The increased prefrontal dopamine release induced by the drug combination may also improve cognition as indicated by previous preclinical and clinical studies and, furthermore, via enhanced synaptic spine function and morphology in mPFC generate a both rapid and prolonged antipsychotic and pro-cognitive effect. Our results delineate SNP as a promising new treatment option for schizophrenia, including TRS, when added to currently available antipsychotic medication in order to improve efficacy at maintained or even reduced dosage.
- |||||||||| Preclinical, Journal: In vitro effects of antipsychotics on mitochondrial respiration. (Pubmed Central) - Sep 2, 2020
Mitochondrial respiratory rate was significantly inhibited by all tested APs, except for olanzapine...Due to the complicated processes associated with mitochondrial activity, it is necessary to measure not only the effect of the drug on individual mitochondrial enzymes but also the respiration rate of the mitochondria or a similar complex process. The experimental approach used in the study can be applied to mitochondrial toxicity testing of newly developed drugs.
- |||||||||| risperidone / Generic mfg., Egis, rivastigmine / Generic mfg.
Review, Journal: Acute presentation of dementia with Lewy bodies. (Pubmed Central) - Sep 2, 2020
A positive dopamine transporter scan was done confirming a diagnosis of an acute presentation of DLB. She has been commenced on a cholinesterase inhibitor (rivastigmine) and is presently settled in care.
- |||||||||| risperidone / Generic mfg., Egis, amisulpride / Generic mfg.
Journal, Adverse events: Whole transcriptome in silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side effects. (Pubmed Central) - Sep 1, 2020
Pathways enriched in antipsychotic signatures were linked to the cardiovascular and immune systems (eg, brain derived neurotrophic factor [BDNF], platelet derived growth factor receptor [PDGFR]-beta, tumor necrosis factor [TNF], transforming growth factor [TGF]-beta, selenoamino acid metabolism, and influenza infection). These findings for the first time mechanistically link antipsychotics to specific cardiovascular and infectious diseases which are known side effects of their use in dementia, providing new information to explain related adverse events.
- |||||||||| risperidone / Generic mfg., Egis, olanzapine / Generic mfg.
Review, Journal: Long-Acting Injectable Second-Generation/Atypical Antipsychotics for the Management of Bipolar Disorder: A Systematic Review. (Pubmed Central) - Aug 30, 2020
These findings for the first time mechanistically link antipsychotics to specific cardiovascular and infectious diseases which are known side effects of their use in dementia, providing new information to explain related adverse events. Second-generation LAI antipsychotics, particularly risperidone and aripiprazole LAI, may be a safe and effective alternative to oral medications in the management of bipolar disorder.
- |||||||||| risperidone / Generic mfg., Egis
Journal: CYP2D6 Genotype-Based Dose Recommendations for Risperidone in Asian People. (Pubmed Central) - Aug 28, 2020
For ultrarapid metabolizers, risperidone dose should be increased by about 33% for white people and 30% for Asians. This was a first attempt to apply pharmacogenetics to suggest dose-regimens for Asian people; further research to replicate and extend these findings is recommended.
- |||||||||| risperidone / Generic mfg., Egis
Journal: Esperienze di switch a cariprazina in pazienti schizofrenici con comparsa di effetti collaterali/comorbilità mediche. (Pubmed Central) - Aug 27, 2020
La strategia terapeutica utilizzata è stata lo switch a un antipsicotico di terza generazione, cariprazina, con risoluzione delle collateralità e una migliore gestione dei sintomi negativi riportati. In conclusione, il modello di trattamento personalizzato sulla base delle condizioni cliniche e delle esigenze del paziente rappresenta l'approccio maggiormente adeguato nella gestione di ogni singolo caso.
- |||||||||| risperidone / Generic mfg., Egis
Journal: Antipsychotic-induced immune dysfunction: A consideration for COVID-19 risk. (Pubmed Central) - Aug 26, 2020
Furthermore, RIS also prevented treated animals from mounting an antibody response following vaccination with Pneumovax23®. These data indicate that short-to intermediate-term exposure to clinically relevant levels of RIS dysregulate innate and adaptive immune responses, which may affect susceptibility to respiratory infections, including COVID-19.
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