- |||||||||| risperidone / Generic mfg., Egis, thyroxine / Generic mfg., lithium / Generic mfg.
[VIRTUAL] An A-Tip-ical Side Effect of Lithium () - Oct 27, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_3937; Medications included levothyroxine, Risperdal, and lithium...Lithium was discontinued, and the patient underwent diuresis with Lasix/albumin infusions...Variable visceral cell hyperplasia. (Hematoxylin and eosin, 400X)
- |||||||||| risperidone / Generic mfg., Egis
Clinical, Review, Journal: CYP2D6 and Antipsychotic Treatment Outcomes in Children and Youth: A Systematic Review. (Pubmed Central) - Oct 23, 2020 The included studies were of fair to moderate quality and included mostly males, individuals of European ancestry, and those treated with risperidone...However, several limitations with the current literature (e.g., sample sizes, study design, sample heterogeneity) should be addressed in future studies. Assuming that future studies support the link between CYP2D6 genetic variation and antipsychotic outcomes, we would anticipate an increase in the implementation of CYP2D6-guided antipsychotic drug selection and dose optimization in child and adolescent psychiatric services.
- |||||||||| risperidone / Generic mfg., Egis
[VIRTUAL] Pleiotropic Analysis of Genotype and Phenotype of Schizophrenia Supporting the Key Role of WNT Signaling in the Response of Risperidone Treatment () - Oct 13, 2020 - Abstract #WCPG2020WCPG_657; The DMRs were significantly enriched (p<0.05) in Chr 6, 5, 1, 8 and 10 and annotated in the regions of genes as ZFP57 , VTRNA2-1 , FMOD and PDGFRL respectively. Enrichment analyses showed that the DNAm changes were significantly associated with obesity, nervous system disease and SCZ in disease, the functional effects of DNAm changes were enriched in cellular process, regulation of response to the stimulus, and binding process (ion and protein), the Wnt signaling (e.g.
- |||||||||| [VIRTUAL] Prediction of Abnormal Metabolic Parameters Change Induced by Antipsychotics () - Oct 13, 2020 - Abstract #WCPG2020WCPG_643;
In the association analysis of LDL change, rs142100580 in KCNQ1 (p=4.1010-8) is significantly associated with the LDL change after treatment with olanzapine, and rs75684025 in ZFPM2 (p=3.8810-8) is associated with the treatment with ziprasidone. In the ROC analyses of all the developed model, the prediction accuracy of the genetic risk score was area under the curve 70%.
- |||||||||| risperidone / Generic mfg., Egis
[VIRTUAL] Pleiotropic Analysis of Genotype and Phenotype of Schizophrenia Supporting the Key Role of WNT Signaling in the Response of Risperidone Treatment () - Oct 13, 2020 - Abstract #WCPG2020WCPG_489; The DMRs were significantly enriched (p<0.05) in Chr 6, 5, 1, 8 and 10 and annotated in the regions of genes as ZFP57 , VTRNA2-1 , FMOD and PDGFRL respectively. Enrichment analyses showed that the DNAm changes were significantly associated with obesity, nervous system disease and SCZ in disease, the functional effects of DNAm changes were enriched in cellular process, regulation of response to the stimulus, and binding process (ion and protein), the Wnt signaling (e.g.
- |||||||||| [VIRTUAL] Prediction of Abnormal Metabolic Parameters Change Induced by Antipsychotics () - Oct 13, 2020 - Abstract #WCPG2020WCPG_475;
In the association analysis of LDL change, rs142100580 in KCNQ1 (p=4.1010-8) is significantly associated with the LDL change after treatment with olanzapine, and rs75684025 in ZFPM2 (p=3.8810-8) is associated with the treatment with ziprasidone. In the ROC analyses of all the developed model, the prediction accuracy of the genetic risk score was area under the curve 70%.
- |||||||||| risperidone / Generic mfg., Egis, olanzapine / Generic mfg., clozapine / Generic mfg.
[VIRTUAL] PALIPERIDONE-INDUCED EOSINOPHILIC PLEURAL EFFUSION () - Oct 12, 2020 - Abstract #CHEST2020CHEST_1784; Drug-induced EPE is a rarely reported complication of certain medications and should be taken into consideration as part of the differential with pleural effusions. Paliperidone should be considered as a potential drug that may cause EPE and eosinophilia.
- |||||||||| Journal: Occurrence of pharmaceuticals, hazard assessment and ecotoxicological evaluation of wastewater treatment plants in Costa Rica. (Pubmed Central) - Oct 8, 2020
Thirty-three PhACs were found, with 1,7-dimethylxanthine, caffeine, acetaminophen, ibuprofen, naproxen, ketoprofen and gemfibrozil being the most frequently detected (influents/effluents)...The top HQ values were obtained for risperidone, lovastatin, diphenhydramine and fluoxetine (influent/effluent samples), plus caffeine (influent) and trimethoprim (effluent)...Likewise, ecotoxicological results and ∑HQ values showed a rather poor correlation; instead, better correlations were obtained between ecotoxicological parameters and HQ values for some individual pharmaceuticals such as cephalexin and diphenhydramine. Findings from this study provide novel information on the occurrence of pharmaceuticals and the performance of WWTPs in the tropical region of Central America.
- |||||||||| risperidone / Generic mfg., Egis
Clinical, Journal: A case of cerebral infarction after deep burn tangential excision and skin grafting (Pubmed Central) - Oct 7, 2020 After the case was discussed, we think that postoperative decreased blood volume and blood concentration resulting from tangential excision bleeding of deep burn and wound exudate as well as inadequate fluid infusion are the main causes of hemodynamic change, the patient had the basis of multiple cerebral artery stenosis, and superposition of multiple factors led to the occurrence of postoperative acute cerebral infarction. Appropriate increase in the fluid infusion volume during and after surgery and transfusion if necessary to increase blood and oxygen supply to the brain can reduce the occurrence of cerebral infarction.
- |||||||||| Abilify Maintena (aripiprazole extended release) / Otsuka, Lundbeck
Trial completion date: Study of the Impact of Aripiprazole (Abilify (clinicaltrials.gov) - Oct 6, 2020 P4, N=47, Completed, Appropriate increase in the fluid infusion volume during and after surgery and transfusion if necessary to increase blood and oxygen supply to the brain can reduce the occurrence of cerebral infarction. Trial completion date: Dec 2019 --> Jul 2020
- |||||||||| risperidone / Generic mfg., Egis
Preclinical, Journal: Risperidone accelerates bone loss in rats with autistic-like deficits induced by maternal lipopolysaccharides exposure. (Pubmed Central) - Oct 2, 2020 The AI method support a better Real World Evidence understanding of antipsychotic treatment sequences in schizophrenic patients. The results of our preclinical study, consistent with previous studies in animals, explore that autistic-like deficits induced by prenatal exposure to LPS, can reduce bone stability and bone mass similar to those observed in neurodevelopmental disorders, and, for the first time, reveal that this condition worsened when these animals were treated with RIS.
- |||||||||| Clinical, Journal: Little Agreement on Treating Residual Bipolar Disorder Symptoms in a Child. (Pubmed Central) - Oct 1, 2020
Of the child MDs, 75% suggested increasing the 1-mg dose of risperidone, while few adult MDs suggested this...There was little consensus on how to manage ADHD symptoms unresponsive to methylphenidate 36 mg/d...There was wide variation in suggestions on to how to treat persistent symptoms of anxiety, ADHD, and oppositional behavior in a child whose mania and depression had been brought under good control. We surmise that this great diversity in recommendations among experts in child and adult bipolar disorder stems at least partially from inadequate literature on treatment and that a new emphasis on funding and conducting studies on efficacy and effectiveness is needed.
- |||||||||| [VIRTUAL] Dysphagia from Long-Term Olanzapine Use- A Rare Adverse Effect () - Sep 30, 2020 - Abstract #ANA2020ANA_709;
Dysphagia can occur with any antipsychotic therapy and prompt diagnosis and treatment are essential to avoid fatal complications like aspiration pneumonia and airway obstruction. Unfortunately, our patient denied any change in the medication or it’s dose as it helped him with his mood.
- |||||||||| risperidone / Generic mfg., Egis
[VIRTUAL] Coincidental POLG Mutation Found in a Case of Drug-Induced Parkinsonism () - Sep 30, 2020 - Abstract #ANA2020ANA_634; POLG1 mutation spectrum- Parkinsonism, PEO/ptosis, myopathy, polyneuropathy, ataxia, encephalopathy, epilepsy, cognitive impairment, psychiatric disorders, sensorineural hearing loss, dysarthria/dysphagia, hepatopathy, hypogonadism, cataracts, premature ovarian failure, and so forth. 2.
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