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5 Diseases |  |
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- risperidone / Generic mfg., ketamine / Generic mfg.
[VIRTUAL] Molecular Mechanisms Involved in the Prevention and Reversal of Ketamine-Induced Schizophrenia-Like Behavior by Rutin: The Role of Glutamic Acid Decarboxylase isoform-67, cholinergic, Nox-2-Oxidative Stress Pathways in Mice () - Mar 1, 2021 - Abstract #SIRS2021SIRS_824;
Conversely, these were significantly reduced by rutin in both the prevention and reversal studies. The decreased glutathione levels due to ketamine were marked increased by rutin in both studies Discussion The study showed that rutin prevents and reverses KET-induced schizophrenia-like behavior via mechanisms linked to inhibition of Nox-2 expression, oxidative/nitrergic stress, down-regulation of acetylcholinesterase activity, and increased expression of GAD67 protein in the brains of rats.
- risperidone / Generic mfg.
[VIRTUAL] Real-World Effectiveness of Antipsychotic Treatments in Schizophrenia with Comorbid Substance Use Disorder () - Mar 1, 2021 - Abstract #SIRS2021SIRS_774;
Sensitivity analyses confirmed all results. Discussion Clozapine should be considered the treatment of choice in patients with schizophrenia at risk of developing SUDs or already suffering from one.
- risperidone / Generic mfg.
[VIRTUAL] The Impact of Combined CYP2D6, CYP2C19 and CYP1A2 Polymorphic Variants on Suicidal Behavior in Schizophrenia Spectrum Disorders () - Mar 1, 2021 - Abstract #SIRS2021SIRS_734;
- PM and IM phenotypes of CYP2C19 were significantly associated with non-specific suicidal ideation( Wald Chi-Square = 4.636, df 1, p=0.031)and wishes of being dead when current age, age at onset and patient gender were also considered ( Wald Chi-Square = 8.160,df, p=0.004 ) Discussion Results support the utility of genotyping in the treatment of schizophrenia spectrum disorders and we propose to use combined CYP2D6, CYP2C19 and CYP1A2 polymorphic variants as possible biological predictors of suicidal behavior. More work is also needed to better understand the underlying mechanisms tied to suicidal ideation among individuals with schizophrenia
- risperidone / Generic mfg.
[VIRTUAL] Pharmacokinetics, Safety, and Tolerability of Ultra-Long Acting Sustained-Release Oral Risperidone in Patients with Schizophrenia or Schizoaffective Disorder () - Mar 1, 2021 - Abstract #SIRS2021SIRS_716;
P1, P1b
Both high and low doses of LYN-005 were well tolerated. Once weekly delivery of risperidone with this novel formulation has the potential to improve treatment adherence and quality of life of patients with schizophrenia or schizoaffective disorder.
- risperidone / Generic mfg., ketamine / Generic mfg.
[VIRTUAL] Molecular Mechanisms Involved in the Prevention and Reversal of Ketamine-Induced Schizophrenia-Like Behavior by Rutin: The Role of Glutamic Acid Decarboxylase isoform-67, cholinergic, Nox-2-Oxidative Stress Pathways in Mice () - Mar 1, 2021 - Abstract #SIRS2021SIRS_698;
Conversely, these were significantly reduced by rutin in both the prevention and reversal studies. The decreased glutathione levels due to ketamine were marked increased by rutin in both studies Discussion The study showed that rutin prevents and reverses KET-induced schizophrenia-like behavior via mechanisms linked to inhibition of Nox-2 expression, oxidative/nitrergic stress, down-regulation of acetylcholinesterase activity, and increased expression of GAD67 protein in the brains of rats.
- risperidone / Generic mfg.
[VIRTUAL] Real-World Effectiveness of Antipsychotic Treatments in Schizophrenia with Comorbid Substance Use Disorder () - Mar 1, 2021 - Abstract #SIRS2021SIRS_648;
Sensitivity analyses confirmed all results. Discussion Clozapine should be considered the treatment of choice in patients with schizophrenia at risk of developing SUDs or already suffering from one.
- risperidone / Generic mfg.
[VIRTUAL] The Impact of Combined CYP2D6, CYP2C19 and CYP1A2 Polymorphic Variants on Suicidal Behavior in Schizophrenia Spectrum Disorders () - Mar 1, 2021 - Abstract #SIRS2021SIRS_608;
- PM and IM phenotypes of CYP2C19 were significantly associated with non-specific suicidal ideation( Wald Chi-Square = 4.636, df 1, p=0.031)and wishes of being dead when current age, age at onset and patient gender were also considered ( Wald Chi-Square = 8.160,df, p=0.004 ) Discussion Results support the utility of genotyping in the treatment of schizophrenia spectrum disorders and we propose to use combined CYP2D6, CYP2C19 and CYP1A2 polymorphic variants as possible biological predictors of suicidal behavior. More work is also needed to better understand the underlying mechanisms tied to suicidal ideation among individuals with schizophrenia
- Invega Sustenna (paliperidone palmitate extended-release 1-month injection) / J&J
[VIRTUAL] Effectiveness of Injectable Paliperidone Palmitate on Treatment Adherence and Relapse in the Adult Schizophrenia Population of Colombia: A Mirror-Image Single Center Study () - Mar 1, 2021 - Abstract #SIRS2021SIRS_572;
PP1M initiation was also associated with an increase in the management of relapse symptoms in the outpatient setting, which could be explained by a decrease in relapse severity after PP1M initiation. Generalizability of results is limited to the population treated at this facility.
- risperidone / Generic mfg.
[VIRTUAL] Weight Gain and Metabolic Adverse Effects of Off-Label Second-Generation Antipsychotic Use in the Adult Population: A Systematic Review and Meta-Analysis () - Mar 1, 2021 - Abstract #SIRS2021SIRS_519;
A meta-regression analysis revealed a positive dose response association between average dose of olanzapine and weight gain (regression coefficient: 0.39 [0.17, 0.60], p-value = 0.04, I2 = 62.8%), as well as between average dose of quetiapine and weight gain (regression coefficient: 0.0053 [0.00034, 0.0103], p= 0.038, I2 = 90.40%)...SGA use in on-label patients irrefutably contributes to their significantly higher risks of type 2 diabetes, metabolic syndrome, and cardiovascular disease; therefore, similar attention should be given to these risks in off-label populations as well. Further studies are required to better understand the effects of off-label SGA use on other metabolic parameters.
- risperidone / Generic mfg.
[VIRTUAL] Pharmacokinetics, Safety, and Tolerability of Ultra-Long Acting Sustained-Release Oral Risperidone in Patients with Schizophrenia or Schizoaffective Disorder () - Mar 1, 2021 - Abstract #SIRS2021SIRS_477;
Both high and low doses of LYN-005 were well tolerated. Once weekly delivery of risperidone with this novel formulation has the potential to improve treatment adherence and quality of life of patients with schizophrenia or schizoaffective disorder.
- Invega Sustenna (paliperidone palmitate extended-release 1-month injection) / J&J
[VIRTUAL] Effectiveness of Injectable Paliperidone Palmitate on Treatment Adherence and Relapse in the Adult Schizophrenia Population of Colombia: A Mirror-Image Single Center Study () - Mar 1, 2021 - Abstract #SIRS2021SIRS_434;
PP1M initiation was also associated with an increase in the management of relapse symptoms in the outpatient setting, which could be explained by a decrease in relapse severity after PP1M initiation. Generalizability of results is limited to the population treated at this facility.
- risperidone / Generic mfg.
[VIRTUAL] Weight Gain and Metabolic Adverse Effects of Off-Label Second-Generation Antipsychotic Use in the Adult Population: A Systematic Review and Meta-Analysis () - Mar 1, 2021 - Abstract #SIRS2021SIRS_381;
A meta-regression analysis revealed a positive dose response association between average dose of olanzapine and weight gain (regression coefficient: 0.39 [0.17, 0.60], p-value = 0.04, I2 = 62.8%), as well as between average dose of quetiapine and weight gain (regression coefficient: 0.0053 [0.00034, 0.0103], p= 0.038, I2 = 90.40%)...SGA use in on-label patients irrefutably contributes to their significantly higher risks of type 2 diabetes, metabolic syndrome, and cardiovascular disease; therefore, similar attention should be given to these risks in off-label populations as well. Further studies are required to better understand the effects of off-label SGA use on other metabolic parameters.
- risperidone / Generic mfg.
[VIRTUAL] Baseline Falff Derived from Resting-State fMRI Predicts Acute Treatment Response in First Episode Psychosis () - Mar 1, 2021 - Abstract #SIRS2021SIRS_256;
Discussion Baseline resting state measures, obtained relatively easily even in impaired, early-phase patients with schizophrenia show promise as prognostic biomarkers. Combined with prior literature, results suggest that prefrontal deficits may be a critical target for antipsychotic treatment, whereas temporal abnormalities may be associated with lingering positive symptoms.
- risperidone / Generic mfg.
[VIRTUAL] The Role of ABCB1 and CYP3A Gene Variations in Clinical Response to Antipsychotic Treatment in Patients with Chronic Schizophrenia () - Mar 1, 2021 - Abstract #SIRS2021SIRS_193;
This association seems to be particularly strong in the subgroup of individuals with an illness of multi-episodic, chronic course. Further studies about the role of CYP polymorphisms and treatment efficacy will help to clear up whether pharmacogenetic studies of candidate genes can be used as reliable clinical markers.
- risperidone / Generic mfg.
[VIRTUAL] Baseline Falff Derived from Resting-State fMRI Predicts Acute Treatment Response in First Episode Psychosis () - Mar 1, 2021 - Abstract #SIRS2021SIRS_84;
Discussion Baseline resting state measures, obtained relatively easily even in impaired, early-phase patients with schizophrenia show promise as prognostic biomarkers. Combined with prior literature, results suggest that prefrontal deficits may be a critical target for antipsychotic treatment, whereas temporal abnormalities may be associated with lingering positive symptoms.
- risperidone / Generic mfg.
[VIRTUAL] The Role of ABCB1 and CYP3A Gene Variations in Clinical Response to Antipsychotic Treatment in Patients with Chronic Schizophrenia () - Mar 1, 2021 - Abstract #SIRS2021SIRS_21;
This association seems to be particularly strong in the subgroup of individuals with an illness of multi-episodic, chronic course. Further studies about the role of CYP polymorphisms and treatment efficacy will help to clear up whether pharmacogenetic studies of candidate genes can be used as reliable clinical markers.
- | risperidone / Generic mfg., ziprasidone / Generic mfg.
Journal: A simple and rapid LC-MS/MS method for the simultaneous determination of eight antipsychotics in human serum, and its application to therapeutic drug monitoring. (Pubmed Central) - Feb 27, 2021
Coefficients of variation ranged from 1.82 - 13.5% for intra-day precision, 5.69-14.7% for inter-day precision, and the relative error for accuracy did not exceed ± 13.5% for any analyte. The method was successfully applied to routine clinical therapeutic drug monitoring for 2,173 samples.
- || risperidone / Generic mfg., ziprasidone / Generic mfg.
Biomarker, Clinical, Journal: Comparative Study of the Effects of Atypical Antipsychotic Drugs on Plasma and Urine Biomarkers of Oxidative Stress in Schizophrenic Patients. (Pubmed Central) - Feb 26, 2021
A 4-week treatment with ADs caused the improvement of psychopathology symptoms estimated by Positive and Negative Syndrome Scale (PANSS) that was accompanied by decreased lipid peroxidation (F2-isoprostanes, TBARS; p=2.9x10, p=7.6x10, respectively) and an increase in total antioxidative capacity (FRAP) (p=5.16x10). Atypical antipsychotics especially clozapine, olanzapine and quetiapine demonstrate the effective outcome of antipsychotic treatment, beneficial antioxidative action by reducing lipid peroxidation and increased total plasma antioxidant activity.
- || risperidone / Generic mfg.
Clinical, Review, Journal: Drug interactions for elderly people with mental and behavioral disorders: a systematic scoping review. (Pubmed Central) - Feb 23, 2021
Atypical antipsychotics especially clozapine, olanzapine and quetiapine demonstrate the effective outcome of antipsychotic treatment, beneficial antioxidative action by reducing lipid peroxidation and increased total plasma antioxidant activity. Knowing the clinical conditions or risk morbidities associated with the use of potentially inappropriate medications and management of these medications for safer therapeutic equivalents or non-pharmacotherapeutic alternatives are relevant for patient safety.
- | risperidone / Generic mfg.
Journal: The Effect of PLGA Molecular Weight Differences on Risperidone Release from Microspheres. (Pubmed Central) - Feb 20, 2021
Instead, the drug release appeared to be dependent on the glass transition temperature of the polymers as well as the porosity of the prepared formulations. The catalytic effect of risperidone (an amine drug) on PLGA during manufacturing and release testing, minimized the differences in the molecular weights of the four formulations, explaining the independence of the release profiles on PLGA molecular weight.
- || risperidone / Generic mfg., atomoxetine / Generic mfg.
Clinical, Review, Journal: Polypharmacy in the Management of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents: A Review and Update. (Pubmed Central) - Feb 20, 2021
Limited support exists for the effectiveness of other medication combinations, including no trials studying three or more medications concurrently. Combinations frequently yielded more side effects, leaving monotherapy preferable if a sufficient treatment response can be achieved.
- || Abilify MyCite (aripiprazole tablets embedded with sensor) / Otsuka
Clinical: Hummingbird Study: Results from an Exploratory Trial Assessing the Performance and Acceptance of a Digital Medicine System in Adults with Schizophrenia, Schizoaffective Disorder, or First-Episode Psychosis. (Pubmed Central) - Feb 20, 2021
P4
Medical device skin irritations were the only TEAEs reported. The DMS had sufficient performance in, and acceptance from, subjects with psychotic disorders and was generally well tolerated.
- | risperidone / Generic mfg.
Journal: Risk Genes in Schizophrenia and Their Importance in Choosing the Appropriate Antipsychotic Treatment. (Pubmed Central) - Feb 17, 2021
In the future, after examining these SNPs, it might be possible to choose the most appropriate antipsychotic drug. Thus, schizophrenic patients with a good response to a determined antipsychotic treatment and patients with resistance to this treatment could be well differentiated.
- || risperidone / Generic mfg., lurasidone oral / Generic mfg.
Clinical, Journal: The Effectiveness of Lurasidone Add-On for Residual Aggressive Behavior and Obsessive Symptoms in Antipsychotic-Treated Children and Adolescents with Tourette Syndrome: Preliminary Evidence from a Case Series. (Pubmed Central) - Feb 13, 2021
No significant neuromotor or metabolic side effects were reported in all cases in a follow-up period ranging from 4 months to 6 months, supporting the stability of the observed clinical improvement. While still investigational, the preliminary evidence presented here gives reason to hope that lurasidone could possibly be an effective option in Tourette syndrome, warranting further investigation of its potential benefits in neurodevelopmental conditions.
- || risperidone / Generic mfg.
Clinical, Journal: De Clérambault's syndrome revisited: a case report of Erotomania in a male. (Pubmed Central) - Feb 11, 2021
The diagnosis of Erotomania has implications in case management, treatment and prognosis, and missing it, especially in men, may culminate in violent situations that can have legal implications. The developed diagnostic criteria and classifications seem to retain use and should be kept in mind, in the sense that they facilitate making an important diagnosis.
- || risperidone / Generic mfg.
Clinical, Journal: Links between the amount of antipsychotic medication prescribed per population at general practice level, local demographic factors and medication selection. (Pubmed Central) - Feb 11, 2021
We found a link between depot prescriptions with higher antipsychotic DDD and risperidone prescriptions with lower antipsychotic DDD. It is important that all prescribers are aware of these drivers / links.
- | risperidone / Generic mfg.
Journal: Comparative Analysis of Prescription Drug Prices in South Asian Association for Regional Cooperation Countries. (Pubmed Central) - Feb 10, 2021
After adjusting for GDP, drug prices became more polarized across countries, with Nepal featuring the highest prices. In determining drug prices, the country's GDP and the population's purchasing power need to be taken into account.
- || risperidone / Generic mfg.
Clinical, Journal: Standardized Observation Analogue Procedure in the Treatment of Severe Childhood Aggression Study. (Pubmed Central) - Feb 10, 2021
During a 9-week acute trial, children with severe physical aggression and attention-deficit/hyperactivity disorder received parent training + titrated psychostimulant for 3 weeks, and those who failed to show an optimal response during Week 4 through Week 6 received in addition either randomly assigned placebo (Basic treatment) or titrated risperidone (Augmented treatment)...The SOAP demonstrated sensitivity to behavior changes between short-term treatments for a few (but not most) measures. The acute treatment differences for Child Compliance and Child Negative Behavior are generally consistent with the moderate superiority of Augmented over Basic treatment previously reported for the primary study outcome.
- | risperidone / Generic mfg.
Journal: Severe hypothermia, bradycardia and cardiac arrest in association with risperidone. (Pubmed Central) - Feb 9, 2021
We present two patients who developed hypothermia, bradycardia and cardiac arrest in association with risperidone. We briefly review previously similarly reported cases.
- | Saphris (asenapine) / Lundbeck, Meiji Seika, AbbVie
Journal: A Low Dose of Aripiprazole Has the Strongest Sensitization Effect Among 19 Repositioned Bipolar Drugs in P-gp-overexpressing Drug-resistant Cancer Cells. (Pubmed Central) - Feb 9, 2021
We briefly review previously similarly reported cases. Co-treatment of anti-mitotic drug-resistant cancer cells with a low dose of aripiprazole had the strongest sensitization effect and is highly dependent on P-gp-inhibitory activity.
- || Lonasen (blonanserin) / Sumitomo Dainippon
Clinical, Journal: Model-based analysis of therapeutic efficacy of blonanserin and risperidone in schizophrenia patients and effects on prolactin: A randomized double-blind study. (Pubmed Central) - Feb 7, 2021
Prolactin elevations in female patients were 2.95-fold of the value in male patients administered the same drug. The model demonstrated Blonanserin has similar antischizophrenic efficacy and less serum prolactin rising compared to risperidone in Chinese patients.
- | risperidone / Generic mfg., lurasidone oral / Generic mfg.
Journal: Rapid and Sustained Resolution of Risperidone Associated Hyperprolactinemia and Galactorrhea With Low-Dose Lurasidone. (Pubmed Central) - Feb 7, 2021
The model demonstrated Blonanserin has similar antischizophrenic efficacy and less serum prolactin rising compared to risperidone in Chinese patients. No abstract available
- | risperidone / Generic mfg.
Preclinical, Journal: Irreversible Primary Visual Cortex Impairment in a Mouse Model of High-Risk Schizophrenia. (Pubmed Central) - Feb 7, 2021
This study aimed to investigate the pathological changes of the primary visual cortex in a prenatal mouse model of MK801-induced high-risk schizophrenia...One HRMMS group received the antipsychotic agent risperidone beginning at postnatal week 4 and another group did not receive any treatment...Visual cortex impairment might be a prominent feature of individuals at high risk of schizophrenia that cannot be normalized by early treatment with antipsychotic medication, indicating the presence of independent regulatory pathways for visual perception disturbance in schizophrenia. Thus, visual system impairment in schizophrenic patients must be further studied.
- || risperidone / Generic mfg.
Clinical, Journal: Assessment of potential drug interactions among psychiatric inpatients receiving antipsychotic therapy of a secondary care hospital, United Arab Emirates. (Pubmed Central) - Feb 4, 2021
Knowing the severity of different pDDIs will help clinicians and prescribers monitor patient safety through regular monitoring for interactions and adverse drug effects in future. The number of medications and polypharmacy was found to be the most significant predictor of pDDIs.
- risperidone / Generic mfg.
[VIRTUAL] COVID-19 Induced Myxedema Madness (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1933;
For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
- risperidone / Generic mfg.
[VIRTUAL] Hemichorea Associated With Nonketotic Hyperglycemia : Rare Presentation of Uncontrolled Diabetes Mellitus (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1137;
For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
- risperidone / Generic mfg.
[VIRTUAL] Hemi Chorea and Hemi Balllismus: A Rare Presentation of Prolonged Uncontrolled Hyperglycemia (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1122;
For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
- || risperidone / Generic mfg., amisulpride / Generic mfg.
Clinical, Journal: A different insight in hair analysis: Simultaneous measurement of antipsychotic drugs and metabolites in the protein and melanin fraction of hair from criminal justice patients. (Pubmed Central) - Feb 2, 2021
The results show that hair melanin would have a much higher affinity for the antipsychotic medications than do hair proteins, being influenced mainly by biochemical individuality effects and less by hair colour. Future studies would be of interest using the proposed extraction method applied to hair of different colours.
- || Saphris (asenapine) / Lundbeck, Meiji Seika, AbbVie
Clinical, Journal: Risk of Mortality Associated With Atypical Antipsychotic use: A National Cohort Study of Older Adults With Depression and Parkinson's Disease. (Pubmed Central) - Jan 30, 2021
Inappropriate AAP use is associated with a higher risk of all-cause-mortality in older patients with PD which is mainly mediated by pneumonia. Therefore, inappropriate AAP use should be avoided to improve quality of care in PD.
- || risperidone / Generic mfg.
Clinical, Journal: Predictors of 1-year rehospitalization in inpatients with bipolar I disorder treated with atypical antipsychotics. (Pubmed Central) - Jan 30, 2021
Therefore, inappropriate AAP use should be avoided to improve quality of care in PD. Our findings can be conducive to understanding prognosis, and predicting rehospitalization risk in patients with BPD on AAP.
- || Actemra IV (tocilizumab) / Roche, JW Pharma
Review, Journal: Drug-drug interactions between COVID-19 treatments and antipsychotics drugs: integrated evidence from 4 databases and a systematic review. (Pubmed Central) - Jan 30, 2021
Our findings can be conducive to understanding prognosis, and predicting rehospitalization risk in patients with BPD on AAP. Clinicians prescribing antipsychotics should be aware of the likely risk of drug-drug interaction with COVID-19 medication and may benefit from taking into account present recommendations of use to preserve patient safety.
- | risperidone / Generic mfg.
@NICEComms @FDArecalls @FDA_Drug_Info deriving from Risperdal I was told (Twitter) - Jan 29, 2021
- || risperidone / Generic mfg.
Clinical, Journal: Risperidone-Induced Acute Laryngeal Dystonia: A Case Report. (Pubmed Central) - Jan 29, 2021
Our case highlights the association of ALD with an atypical antipsychotic agent, risperidone. Prompt recognition of this entity is necessary to prevent complications and guide definitive management.
- ||| risperidone / Generic mfg., lurasidone oral / Generic mfg., ziprasidone / Generic mfg.
Journal, Adverse events: Schizophrenia Treatment with Second-Generation Antipsychotics: A Multi-Country Comparison of the Costs of Cardiovascular and Metabolic Adverse Events and Weight Gain. (Pubmed Central) - Jan 29, 2021
Lurasidone is predicted to have the lowest rates of these adverse events, and so the lowest costs amongst patients initiating acute treatment in seven European countries compared to nine other antipsychotics. Future research should investigate the individual costs of relapse management, including differences in the costs and proportions of hospitalizations.
- || risperidone / Generic mfg.
Observational data, Retrospective data, Review, Journal: Current antipsychotic agent use and risk of venous thromboembolism and pulmonary embolism: a systematic review and meta-analysis of observational studies. (Pubmed Central) - Jan 29, 2021
Subgroup analyses suggest that new users are more likely to develop VTE. However, due to significant heterogeneity among studies, conclusions should be considered with caution.
- | risperidone / Generic mfg.
Journal: The effects of concurrent oral paliperidone or risperidone use with paliperidone long-acting injection. (Pubmed Central) - Jan 29, 2021
Patients who receive OAP overlap while receiving PP receive more benztropine and have more psychiatric emergency visits and hospitalizations than those treated without OAP. Larger studies with better control for confounding variables are needed to confirm these results.
- || aripiprazole / Generic mfg., risperidone / Generic mfg.
Clinical, Journal: Comparison of aripiprazole and risperidone effectiveness in first episode non-affective psychosis: rationale and design of a prospective, randomized, 3-phase, investigator-initiated study (PAFIP-3). (Pubmed Central) - Jan 29, 2021
Larger studies with better control for confounding variables are needed to confirm these results. No abstract available
- || risperidone / Generic mfg., haloperidol / Generic mfg.
Clinical, Journal: Effect of Haloperidol and Risperidone on Serum Melatonin and GAP-43 in Patients with Schizophrenia: A Prospective Cohort Study. (Pubmed Central) - Jan 29, 2021
PANSS decreased significantly in both the groups and there was a significant negative correlation between serum melatonin at 2:00 hours and PANSS (r = -0.5) at baseline. Monotherapy with haloperidol and risperidone can achieve symptomatic improvement but cannot improve sleep and circadian rhythm disturbances in schizophrenia.
- | risperidone / Generic mfg., olanzapine / Generic mfg.
Trial initiation date: "Extended" (Alternate Day) Antipsychotic Dosing (clinicaltrials.gov) - Jan 28, 2021
P4, N=120, Not yet recruiting, Sponsor: Centre for Addiction and Mental Health
Monotherapy with haloperidol and risperidone can achieve symptomatic improvement but cannot improve sleep and circadian rhythm disturbances in schizophrenia. Initiation date: Aug 2020 --> Aug 2021
- || risperidone / Generic mfg.
Clinical, Review, Journal: Clinical picture and treatment of bipolar affective disorder in children and adolescents. (Pubmed Central) - Jan 28, 2021
Pharmacotherapy of BD in the pediatric population includes 1st and 2nd generation mood stabilizers, while their efficacy and safety profiles are different than in adults. The American Food and Drug Administration recommends treating manic episodes in young persons with lithium, aripiprazole, quetiapine, risperidone, olanzapine and depressive episodes with a combination therapy of olanzapine and fluoxetine.