risperidone / Generic mfg. 
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  • ||||||||||  risperidone / Generic mfg.
    Retrospective data, Journal:  Low continuation of antipsychotic therapy in Parkinson disease - intolerance, ineffectiveness, or inertia? (Pubmed Central) -  Jul 18, 2021   
    Over one-third of individuals with PD discontinued antipsychotic therapy, especially if the initial drug has greater dopamine-receptor blocking activity. Understanding the drivers of antipsychotic discontinuation, including ineffectiveness, potentially inappropriate use, clinician inertia, patient adherence and adverse effects, is needed to inform clinical management of psychosis in PD and appropriate antipsychotic use in this population.
  • ||||||||||  risperidone / Generic mfg.
    Clinical, Journal:  Superficial siderosis as a rare cause of visual and auditory pseudohallucinations: a case report. (Pubmed Central) -  Jul 18, 2021   
    The risk of missing this diagnosis can be reduced by applying a standardized diagnostic pathway for patients presenting with the first episode of psychiatric symptoms. Somatic and potentially treatable causes should not be missed because they might lead to unnecessary treatments, stigmatization, and legal restrictions of self-determination, especially for elderly people.
  • ||||||||||  risperidone / Generic mfg.
    Journal:  Risperidone-Associated Acute Eosinophilic Pneumonia. (Pubmed Central) -  Jul 16, 2021   
    Somatic and potentially treatable causes should not be missed because they might lead to unnecessary treatments, stigmatization, and legal restrictions of self-determination, especially for elderly people. No abstract available
  • ||||||||||  risperidone / Generic mfg.
    Review, Journal:  Toward personalized medicine in schizophrenia: Genetics and epigenetics of antipsychotic treatment. (Pubmed Central) -  Jul 14, 2021   
    Although pharmacoepigenetics is still in its infancy, consideration of both genetic and epigenetic factors contributing to antipsychotic response and side effects no doubt will be increasingly important in personalized medicine. We provide recommendations for next steps in research and clinical evaluation.
  • ||||||||||  risperidone / Generic mfg., lurasidone / Generic mfg.
    Review, Journal:  Modulation of Serotonin Receptors in Neurodevelopmental Disorders: Focus on 5-HT7 Receptor. (Pubmed Central) -  Jul 14, 2021   
    5-HTR modulators improved altered behaviors in animal models and also affected neuronal morphology via the 5-HTR/G signaling pathway. Through the investigation of recent studies, it is suggested that 5-HTR could be a potential therapeutic target for the treatment of NDDs.
  • ||||||||||  Abilify Maintena (aripiprazole depot formulation) / Otsuka, Lundbeck
    Journal:  One Plus One Sometimes Equals More Than Two: Long-acting Injectable Aripiprazole Adjunction in Clozapine-Resistant Schizophrenia. (Pubmed Central) -  Jul 10, 2021   
    One week after the third injection, a psychiatric examination revealed a significant improvement in the positive symptoms, and his caregivers confirmed an increase in the social interaction of the patient. Although we cannot postulate on a single exact mechanism for the increased efficacy of clozapine and aripiprazole combination, we may suggest that, at least for a subgroup of patients with schizophrenia who respond clinically to clozapine at a suboptimal level, combination with aripiprazole may be an effective therapeutic strategy.
  • ||||||||||  risperidone / Generic mfg., metoclopramide / Generic mfg.
    Clinical, Journal:  Childhood dystonic reactions in the middle Black Sea region. (Pubmed Central) -  Jul 10, 2021   
    Of the 9 patients, 5 were due to metoclopramide, 3 were due to risperidone, and 1 was due to aripiprazole...As a treatment, all of them were intramuscularly applied biperiden suitable for their weight and 30 minutes dramatic improvement was observed...No problem was observed in their follow-up.Drug-induced acute dystonic reaction can be diagnosed and has a clinical picture that completely resolves when effective treatment is applied. However, it should not be forgotten that it can reach life-threatening dimensions clinically.
  • ||||||||||  risperidone / Generic mfg., topiramate / Generic mfg.
    Retrospective data, Journal:  Revisiting the Efficacy and Tolerability of Topiramate for Tic Disorders: A Meta-Analysis. (Pubmed Central) -  Jul 9, 2021   
    Compared with haloperidol and tiapride, topiramate appears to be a promising medication with good efficacy and tolerability for children with TDs. In future studies, large-sample, double-blind, placebo-controlled trials are needed to confirm its efficacy and tolerability compared with atypical antipsychotic agents (such as risperidone or aripiprazole).
  • ||||||||||  risperidone / Generic mfg.
    [VIRTUAL] Baseline fALFF Predicts Acute Treatment Response in First Episode Psychosis () -  Jul 6, 2021 - Abstract #OHBM2021OHBM_1404;    
    Baseline resting state measures, obtained relatively easily even in impaired, early-phase patients with schizophrenia show promise as prognostic biomarkers. Combined with prior literature, results suggest that prefrontal deficits may be a critical target for antipsychotic treatment, whereas temporal abnormalities may be associated with lingering positive symptoms.
  • ||||||||||  Abilify Maintena (aripiprazole depot formulation) / Otsuka, Lundbeck
    Biomarker, PK/PD data, Review, Journal:  Review of Pharmacokinetics and Pharmacogenetics in Atypical Long-Acting Injectable Antipsychotics. (Pubmed Central) -  Jul 4, 2021   
    The combination of pharmacogenetics and pharmacokinetics (including popPK models) leads to a personalized antipsychotic therapy. In this sense, the optimization of these treatments improves the benefit-risk balance and, consequently, patients' quality of life.
  • ||||||||||  risperidone / Generic mfg.
    Journal:  Rhabdomyolysis induced by paliperidone palmitate (Pubmed Central) -  Jul 4, 2021   
    This report describes a case of rhabdomyolysis uncovered by chance after administration of paliperidonepalmitate as depot medication in a 45 years old schizophrenic male patient after having tolerated oral risperidone without any problems. Routine screening for clinical manifestations and serum-creatin kinase maybe essential in unravelling antipsychotic-induced rhabdomyolysis.
  • ||||||||||  risperidone / Generic mfg., amisulpride / Generic mfg.
    Clinical, Journal:  Sequential Multiple-Assignment Randomized Trials to Compare Antipsychotic Treatments (SMART-CAT) in first-episode schizophrenia patients: Rationale and trial design. (Pubmed Central) -  Jul 4, 2021   
    P4
    Phase 1 is a randomized controlled trial; patients will be randomly assigned to one of the treatments with oral olanzapine, risperidone, amisulpride, aripiprazole or perphenazine...Phase 2 is an equipoise-stratified randomization trial, and patients will be randomly assigned to oral olanzapine, amisulpride or clozapine for 8 weeks...As a result, we hope that this study can provide guidance for an optimal treatment algorithm in first-episode schizophrenia patients. Trial registration: ID NCT03510325 in ClinicalTrials.gov.
  • ||||||||||  risperidone / Generic mfg.
    Journal:  Sjögren syndrome associated with obsessive-compulsive disorder. (Pubmed Central) -  Jul 3, 2021   
    The data on BDNF protein and gene expression did not fully correspond with the behavioral outcomes, and thus it appears that other factors/mechanisms are involved in the observed antidepressant- and/or anxiolytic-like effects. This case illustrates a rare case of a patient with SS who evolved with OCD.
  • ||||||||||  risperidone / Generic mfg.
    Clinical, Journal:  A comprehensive entomological survey and evaluation of the efficacy of different therapies on a suspected delusional parasitosis case. (Pubmed Central) -  Jul 2, 2021   
    In Iran, the most important challenges these patients faced with are as follows: the absence of a specific referral center, patients resort to self-treatment or traditional methods, and lack of a certain duration and dosage of antipsychotic for these cases. Comprehensive clinical trials should be done on this rare syndrome at the national level for better understanding the epidemiological profile of DP and finding the best method of treatment for Persian community.
  • ||||||||||  risperidone / Generic mfg.
    Biomarker, Clinical, Journal:  Protocol for a pharmacogenomic study on individualised antipsychotic drug treatment for patients with schizophrenia. (Pubmed Central) -  Jun 30, 2021   
    Comprehensive clinical trials should be done on this rare syndrome at the national level for better understanding the epidemiological profile of DP and finding the best method of treatment for Persian community. This study aims to set up an individualized preferred treatment prediction model through the genetic analysis of patients using different kinds of antipsychotics.
  • ||||||||||  risperidone / Generic mfg.
    Clinical, Journal:  Differentiating the effect of antipsychotic medication and illness on brain volume reductions in first-episode psychosis: A Longitudinal, Randomised, Triple-blind, Placebo-controlled MRI Study. (Pubmed Central) -  Jun 30, 2021   
    However, a major unresolved question concerns whether these changes are driven by the underlying illness or represent iatrogenic effects of antipsychotic medication. In this study, 62 antipsychotic-naïve patients with first-episode psychosis (FEP) received either a second-generation antipsychotic (risperidone or paliperidone) or a placebo pill over a treatment period of 6 months...Our findings indicate that psychotic illness and antipsychotic exposure exert distinct and spatially distributed effects on brain volume. Our results align with prior work in suggesting that the therapeutic efficacy of antipsychotic medications may be primarily mediated through their effects on the basal ganglia.
  • ||||||||||  risperidone / Generic mfg.
    Journal:  One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia. (Pubmed Central) -  Jun 24, 2021   
    Their P50 ratios were all more than 0.5 and they took risperidone at 3-6 mg/day for at least a month before participating in the experiment...Furthermore, the improvement in RBANS total score was correlated with increased S1 latency (p < 0.05), and the increase in immediate memory score was correlated with decreased S2 amplitude. One day of treatment with tropisetron improved both cognitive and P50 inhibition deficits, suggesting that longer term treatment with α7 nAChR agonists for these deficits in SCZ may be promising.
  • ||||||||||  risperidone / Generic mfg., olanzapine / Generic mfg.
    Journal:  Lights and shadows of schizophrenia therapy research: Lessons from oral risperidone and olanzapine. (Pubmed Central) -  Jun 22, 2021   
    To date, greater involvement of independent research seems to be the only realistic chance to properly continue the investigation on the clinical properties of oral risperidone and olanzapine conventional tablets, as well as those of other off-patent antipsychotic drugs. However, the limits and potentialities of independent research in accomplishing such a demanding and enduring scientific effort should be addressed.
  • ||||||||||  risperidone / Generic mfg., ziprasidone / Generic mfg.
    Clinical, Journal:  Variants of GRM7 as risk factor and response to antipsychotic therapy in schizophrenia. (Pubmed Central) -  Jun 22, 2021   
    The rs1516569 variant (OR = 0.95, P < 3.47 × 10) was a significant risk factor, and a single-nucleotide polymorphism of GRM7 gene- rs9883258 (OR = 0.84, P = 2.18 × 10) has been determined as potential biomarkers for therapeutic responses of seven commonly used antipsychotic drugs (aripiprazole, haloperidol, olanzapine, perphenazine, quetiapine, risperidone and ziprasidone) in Chinese Han population; Significant associations with treatment response for several single-nucleotide polymorphisms in every antipsychotic drugs, such as rs779746 (OR = 1.39, P = 0.03), rs480409 (OR = 0.73, P = 0.04), rs78137319 (OR = 3.09, P = 0.04), rs1154370 (OR = 1.51, P = 0.006) have been identified in our study. Hence our research elucidates that GRM7 variants play the critical role of predicting the risk of schizophrenia and antipsychotic effect of seven common drugs.
  • ||||||||||  risperidone / Generic mfg.
    Clinical, Journal:  Characteristics of gray matter alterations in never-treated and treated chronic schizophrenia patients. (Pubmed Central) -  Jun 22, 2021   
    These findings provide new insights into the long-term effects of antipsychotic treatment on gray matter alterations in schizophrenia patients. Furthermore, the characteristic findings of reductions in the inferior parietal lobule might be specific for long-term antipsychotic treatment, which could be a possible target for medication development in the future.