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5 Diseases |  |
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- risperidone / Generic mfg.
[VIRTUAL] Role of selective serotonin reuptake inhibitors in the management of motor tics in Tourette's Syndrome () - Sep 29, 2021 - Abstract #MDSCongress2021MDS_Congress_553;
Previous studies have shown the ineffectiveness of SSRIs in the management of motor manifestations in ST [5,6]. However, a relationship between 5HT2 receptors and dopaminergic pathways in basal ganglia has been established, explaining the possible relationship between SSRIs and movement control [3].
- risperidone / Generic mfg.
[VIRTUAL] Atypical gait in a patient with Huntington's Disease (HD): Functional movement disorders in the spectrum of motor phenotypes in HD () - Sep 29, 2021 - Abstract #MDSCongress2021MDS_Congress_504;
It reflects the complex interaction between neuropsychiatric and motor symptoms in HD and highlights the importance of treating all the different manifestations of the disease. Early diagnosis and treatment of FMD can positively influence the patient's quality of life.
- risperidone / Generic mfg.
[VIRTUAL] Excessive directional antisaccade errors in Tourette Syndrome with Attention-deficit Hyperactivity Disorder: a case report () - Sep 29, 2021 - Abstract #MDSCongress2021MDS_Congress_473;
This leads to a suboptimal diagnosis and treatment of these patients who present typical symptoms of TS, but also show oculomotor pathway impairments (uncontrolled saccadic involuntary movements) as the main clinical affection (4,5,6). Thus, it is essential to see TS as a multidimensional disease, where other comorbidities could not only be associated but may even mark the clinical course of the disease.
- | aripiprazole / Generic mfg., risperidone / Generic mfg., atomoxetine / Generic mfg.
New P2 trial: The neuropsychological features of aggressive behaviour in children and adolescents with diagnosis of Conduct Disorder or Oppositional Defiant Disorder (CD/ODD) Caratteristiche neuropsicologiche del comportamento aggressivo in bambini e adolescenti con diagnosi di Disturbo della Condotta o Disturbo Oppositivo Provocatorio (EUDRACT) - Sep 29, 2021
P2, N=160, , Sponsor: RADBOUD UNIVERSITY MEDICAL CENTER
- || risperidone / Generic mfg., sertraline / Generic mfg.
Clinical, Journal: A case of trichotillomania with binge eating disorder: combined with N-acetylcysteine synergistic therapy. (Pubmed Central) - Sep 28, 2021
To our knowledge, this may be the first case report of using NAC as a synergist to treat TTM comorbid BED successfully, which suggest that these two disorders may have a common pathophysiological mechanism. Moreover, NAC can be one choice as a synergistic treatment for OCRDs.
- | risperidone / Generic mfg.
Journal: Improvement of Drug Delivery Properties of Risperidone via Preparation of Fast Dissolution Tablet Containing Nanostructured Microparticles. (Pubmed Central) - Sep 28, 2021
The formulations of FDT containing 9.5% of sodium starch glycolate and 83.2% microcrystalline cellulose were selected with a disintegration time of less than 30 s and a dissolution time of 10 min. This investigation shows that the preparation of FDT containing nanoparticles using SFD is an easy and feasible method for improving the dissolution profile of many drugs with low solubility.
- [VIRTUAL] Increased Mental Health Needs in Pediatric Admissions During COVID-19: The Epidemic Within the Pandemic () - Sep 25, 2021 - Abstract #AAPNCE2021AAP_NCE_1312;
Additionally, these patients were of higher psychiatric acuity, based on increased use of as-needed medications and restraints. These findings highlight the dramatic changes experienced by individual patients and their healthcare teams during the pandemic.
- || risperidone / Generic mfg.
PK/PD data, Journal: Lack of Smoking Effects on Pharmacokinetics of Oral Paliperidone-analysis of a Naturalistic Therapeutic Drug Monitoring Sample. (Pubmed Central) - Sep 23, 2021
Paliperidone is not affected by smoking, and paliperidone dose-adjustments in smokers may not be necessary. This may be seen as an essential difference to risperidone, whose cytochrome-mediated metabolism might be affected by smoking.
- || risperidone / Generic mfg.
Clinical, Journal: Prevalence of metabolic syndrome and its correlation with sexual dysfunction in adult psychiatric patients treated with psychotropics in a tertiary care hospital. (Pubmed Central) - Sep 23, 2021
Hence, the metabolic function of psychiatric patients must be regularly assessed for early detection and management of any metabolic abnormalities. The study did not find a significant correlation between SD and MetS in psychiatric patients.
- | risperidone / Generic mfg.
Journal: Simulating the Effects of Common Comedications and Genotypes on Alzheimer's Cognitive Trajectory Using a Quantitative Systems Pharmacology Approach. (Pubmed Central) - Sep 22, 2021
The study did not find a significant correlation between SD and MetS in psychiatric patients. Once these simulations are validated, the platform can in principle provide optimal treatment guidance in clinical practice at an individual patient level, identify negative pharmacodynamic interactions with novel targets and address protocol amendments in clinical trials.
- || risperidone / Generic mfg.
Clinical, Journal: Risperidone-induced bruise-like rash in a child. (Pubmed Central) - Sep 19, 2021
This is especially important for pediatric cases where physical abuse may be suspected. SIMILAR CASES PUBLISHED: None.
- | risperidone / Generic mfg.
Journal: Discovery of a new class of multi-target heterocycle piperidine derivatives as potential antipsychotics with pro-cognitive effect. (Pubmed Central) - Sep 17, 2021
Results from the conditioned avoidance response test and novel object recognition task demonstrated that 4w had pro-cognitive effects. Thus, the antipsychotic drug-like activities of 4w indicate that it may be a potential polypharmacological antipsychotic candidate drug.
- || risperidone / Generic mfg.
Clinical, Journal: Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia. (Pubmed Central) - Sep 16, 2021
Patients taking typical antipsychotics have better memory than those taking clozapine or risperidone. Patients taking clozapine have better language function than those taking risperidone.
- | risperidone / Generic mfg.
Journal: Interaction of graphene with antipsychotic drugs: Is there any charge transfer process? (Pubmed Central) - Sep 16, 2021
The charge transfer is more significant with risperidone than with dopamine, and this could be related to the mechanism of action. This is in agreement with the working hypotheses that establish that it is possible to distinguish between agonists and antagonists since they have different capacity to transfer charge.
- || risperidone / Generic mfg.
Clinical, Journal: Evaluation of the CYP2D6 haplotype activity scores based on metabolic ratios of 4,700 patients treated with three different CYP2D6 substrates. (Pubmed Central) - Sep 16, 2021
Compared to the CYP2D6Norm alleles, the activity scores of CYP2D6*41 and CYP2D6*9-10 alleles were estimated to be one sixth and one third, respectively. The results of this highly powered study provide a solid basis for the translation of the CYP2D6 genotype into a drug metabolic phenotype.
- || Rexulti (brexpiprazole) / Lundbeck, Otsuka
Retrospective data, Review, Journal: Antipsychotics for negative and positive symptoms of schizophrenia: dose-response meta-analysis of randomized controlled acute phase trials. (Pubmed Central) - Sep 15, 2021
Most dose-response curves suggested that the near-maximum effective doses could be in the lower-to-medium range of the licensed dose. Additional RCTs are necessary to establish the optimal dose.
- || risperidone / Generic mfg.
Clinical, Observational data, Journal: Frailty and potentially inappropriate medications using the 2019 Beers Criteria: findings from the Australian Longitudinal Study on Women's Health (ALSWH). (Pubmed Central) - Sep 15, 2021
Additional RCTs are necessary to establish the optimal dose. Given that the majority of frail women were using medications that may have been potentially inappropriate, it is important to consider both frailty and PIMs as indicators of health outcomes, and to review the need for PIMs for women aged 77-96 years who are frail.
- || risperidone / Generic mfg.
Clinical, Journal: Atypical Antipsychotics Augmentation in Patients with Depressive Disorder and Risk of Subsequent Dementia: A Nationwide Population-Based Cohort Study. (Pubmed Central) - Sep 15, 2021
Healthcare professionals should be aware of this potential long-term risk. A limitation that should be mentioned is that we could not exclude patients with bipolar depression.
- || risperidone / Generic mfg.
Clinical, Clinical protocol, Journal: Antipsychotics withdrawal in adults with intellectual disability and challenging behaviour: study protocol for a multicentre double-blind placebo-controlled randomised trial. (Pubmed Central) - Sep 15, 2021
In order to develop AP withdrawal guidelines for people with ID, we need to understand why withdrawal of AP is not successful in the majority of people with ID and challenging behaviour. With this study, we will bridge the gap between the lack of available evidence on AP use and withdrawal on the one hand and the international policy drive to reduce prescription of AP in people with ID and challenging behaviour on the other hand.
- | risperidone / Generic mfg.
Journal: Cotard Syndrome in an Adolescent With a First Episode of Psychosis. (Pubmed Central) - Sep 12, 2021
The patient's rapid response to risperidone is unique, as most existing evidence suggests that electroconvulsive therapy is the most effective treatment for Cotard syndrome. This response indicates an opportunity for the implementation of a second-generation antipsychotic medication in patients with Cotard syndrome in areas where electroconvulsive therapy is not available.
- | risperidone / Generic mfg.
Preclinical, Journal, PD(L)-1 Biomarker, IO biomarker: Paliperidone Inhibits Glioblastoma Growth in Mouse Brain Tumor Model and Reduces PD-L1 Expression. (Pubmed Central) - Sep 11, 2021
The enhancement of PD-L1 in GBM was antagonized by paliperidone and risperidone as well as DRD2 selective inhibitor L741426...The present study suggests that DRD2 may be involved in regulating the PD-L1 expression in GBM and the microenvironment of GBM. Our results provide a valuable therapeutic strategy and indicate that treatments combining DRD2 antagonist paliperidone with standard immunotherapy may be beneficial for GBM treatment.
- || risperidone / Generic mfg.
Clinical, Journal, Real-world evidence: Validation of Random Forest Machine Learning Models to Predict Dementia-Related Neuropsychiatric Symptoms in Real-World Data. (Pubmed Central) - Sep 11, 2021
Our results provide a valuable therapeutic strategy and indicate that treatments combining DRD2 antagonist paliperidone with standard immunotherapy may be beneficial for GBM treatment. Given their relatively good performance, the predictive models can be used to estimate prevalence of NPS in population databases.
- | risperidone / Generic mfg.
Journal: The Role of Butyric Acid in Treatment Response in Drug-Naïve First Episode Schizophrenia. (Pubmed Central) - Sep 10, 2021
Increased serum levels of butyric acid might be associated with a favorable treatment response in drug-naïve, first episode schizophrenia. The clinical implications of our findings were discussed.
- | Trial completion: Correlation Between Cognitive Function and Relapse of Schizophrenia Regarding Dose Reduction (clinicaltrials.gov) - Sep 9, 2021
P=N/A, N=139, Completed, Sponsor: Juntendo University
The clinical implications of our findings were discussed. Active, not recruiting --> Completed
- | risperidone / Generic mfg.
Journal: Finding Early Improvement Threshold to Predict Response After 8 Weeks of Treatment Using Risperidone in First-Episode Psychosis. (Pubmed Central) - Sep 9, 2021
However, the more accurate prediction was possible with week 4 response (area under the curve = 88.7%, P < 0.001). Our study suggests that patients with an early response at week 2 are likely to achieve positive response after 8 weeks.
- || aripiprazole / Generic mfg., risperidone / Generic mfg., amisulpride / Generic mfg.
Clinical, Review, Journal: Covert Dyskinesia With Aripiprazole: Tip of the Iceberg? A Case Report and Literature Review. (Pubmed Central) - Sep 9, 2021
A possible risk might be APZ's unique mechanism of action and its association with akathisia. Following up patients with serial Abnormal Involuntary Movement Scale after antipsychotic discontinuation is recommended.
- ||| risperidone / Generic mfg.
Preclinical, Journal, Adverse events: A comparison of the metabolic side-effects of the second-generation antipsychotic drugs risperidone and paliperidone in animal models. (Pubmed Central) - Sep 8, 2021
In preclinical models, both risperidone and paliperidone exhibited notable metabolic side-effects that were dose-dependent. Differences between the two were modest, and most notable as effects on fasting glucose.
- || risperidone / Generic mfg.
Clinical, Journal: A study to understand the pattern of hyponatremia in patients using selective serotonin reuptake inhibitors and serotonin dopamine antagonists. (Pubmed Central) - Sep 7, 2021
Among SDAs, risperidone had maximum percentage, whereas quetiapine had minimum percentage of hyponatremia. Patients who were taking both fluoxetine + olanzapine or fluoxetine + risperidone had higher percentage of hyponatremia.
- | risperidone / Generic mfg., lurasidone / Generic mfg.
Journal: Contrasting Typical and Atypical Antipsychotic Drugs. (Pubmed Central) - Sep 7, 2021
These advantages of the atypical APDs in efficacy and safety are due, in part, to initiation of synaptic plasticity via direct and indirect effects of the atypical APDs on a variety of proteins, especially G proteins, and release of neurotrophins (e.g., brain-derived neurotrophic factor). The typical APDs beneficial effects on psychosis are mainly the result of D receptor blockade, which can be associated with serious side effects and lack of tolerability.
- | risperidone / Generic mfg.
Journal: Identification of EP300 as a Key Gene Involved in Antipsychotic-Induced Metabolic Dysregulation Based on Integrative Bioinformatics Analysis of Multi-Tissue Gene Expression Data. (Pubmed Central) - Sep 7, 2021
Taken together, our analysis identified EP300 as a key gene in AP-induced metabolic abnormalities, indicating that the dysregulation of EP300 function could be important in the development of these side effects. However, more studies are needed to disentangle the role of this gene in the mechanism of action of APs.
- || risperidone / Generic mfg.
Clinical, Journal: Psychopharmacology in the Pediatric Oncology and Bone Marrow Transplant Units: Antipsychotic Medications Palliate Symptoms in Children with Cancer. (Pubmed Central) - Sep 5, 2021
Olanzapine and risperidone can be well tolerated and ameliorate severe psychiatric-medical symptoms in children and adolescents with cancer. The potential palliative benefits of these second-generation antipsychotics (e.g., rapid onset of action, antiemesis, sedation, and appetite stimulation) increase the utility of their use in children treated in oncology and bone marrow transplant units.
- || risperidone / Generic mfg.
Clinical, Journal: Use of Tic-Suppressing Medication and Other Psychotropic Drugs in Children and Adolescents with Newly Diagnosed Tic Disorders in Denmark. (Pubmed Central) - Sep 5, 2021
The use of aripiprazole superseded risperidone, however risperidone remains the most common first-choice treatment. Treatment was mainly handled by specialists, which is reassuring given the lack of national guidelines, however, regional variations merit further attention as do the variation in treatment between young girls and boys.
- | risperidone / Generic mfg.
Journal: CD200 Change Is Involved in Neuronal Death in Gerbil Hippocampal CA1 Field Following Transient Forebrain Ischemia and Postischemic Treatment with Risperidone Displays Neuroprotection without CD200 Change. (Pubmed Central) - Sep 5, 2021
In addition, treatment of 10 mg/kg risperidone (an atypical antipsychotic drug) after the ischemia hardly changed CD200 immunoreactivity in the CA1 field, showing that CA1 pyramidal neurons were protected from the ischemic injury. These results indicate that the transient ischemia-induced change in CD200 expression may be associated with specific and selective neuronal death in the hippocampal CA1 field following transient forebrain ischemia.
- |||| risperidone / Generic mfg.
Clinical: @amazon @Tesla @Walmart. @VersaillesMiami @GovRonDeSantis @HealthyFla @FLHospitalAssn ⬇thats the end for bug pharma when I get it sent2every biz. Astaxanthin Berberine Liposomes daily will block multiple viruses,+boot up IQ&metabolism. Look up both 4mental health then risperdal (Twitter) - Sep 4, 2021
- || risperidone / Generic mfg.
Clinical, Journal: Frequency and Correlates of Acute Dystonic Reactions After Antipsychotic Initiation in 441 Children and Adolescents. (Pubmed Central) - Sep 4, 2021
SGAs and low-potency FGA monotherapy in children and adolescents were associated with a relatively low ADR risk, whereas high- and mid-potency FGAs were associated with a high risk. Independent predictors of ADRs were antipsychotic polypharmacy, inpatient treatment, FGAs, and schizophrenia or bipolar disorder diagnoses, which may be related to more aggressive antipsychotic dosing.
- || risperidone / Generic mfg., olanzapine / Generic mfg.
Clinical, Journal: Association study between HTR2A rs6313 polymorphism and early response to risperidone and olanzapine in schizophrenia patients. (Pubmed Central) - Sep 3, 2021
Moreover, the repeated measures analysis indicated an association of rs6313 with the disorganized thought dimension for risperidone, and with the depressive and anxiety dimensions for olanzapine. These data add support to the hypothesis that the HTR2A gene is involved in antipsychotic treatment outcome.
- || risperidone / Generic mfg.
Clinical, Journal: Window to His World: Using a Patient's YouTube Channel to Help Diagnose Chronic Mania. (Pubmed Central) - Sep 3, 2021
To our knowledge, this is the first case in the literature in which an online video-sharing service was used longitudinally to facilitate diagnosis of a mental illness. We suggest that technology has great potential to improve our diagnostic tools, especially for disorders such as chronic mania the diagnosis of which relies primarily on self-report and collateral information.
- || risperidone / Generic mfg.
Clinical, Journal: Commentary on "Window to His World: Using a Patient's YouTube Channel to Help Diagnose Chronic Mania". (Pubmed Central) - Sep 3, 2021
To our knowledge, this is the first case in the literature in which an online video-sharing service was used longitudinally to facilitate diagnosis of a mental illness. We suggest that technology has great potential to improve our diagnostic tools, especially for disorders such as chronic mania the diagnosis of which relies primarily on self-report and collateral information.
- | risperidone / Generic mfg.
Journal: Zebrafish Larvae Carrying a Splice Variant Mutation in cacna1d: A New Model for Schizophrenia-Like Behaviours? (Pubmed Central) - Sep 3, 2021
Together, these findings demonstrate that cacna1da haploinsufficiency induces behaviours in larval zebrafish analogous to those observed in rodent models of psychosis. Future studies on homozygous mutants will determine how cacna1d GOF alters behaviour in this context.
- | risperidone / Generic mfg.
Journal: Idiopathic granulomatous mastitis with normal prolactin level caused by risperidone. (Pubmed Central) - Sep 2, 2021
Future studies on homozygous mutants will determine how cacna1d GOF alters behaviour in this context. No abstract available
- | aripiprazole / Generic mfg., risperidone / Generic mfg.
Enrollment open, Phase classification: Pragmatic Trial Comparing Weight Gain in Children With Autism Taking Risperidone Versus Aripiprazole (clinicaltrials.gov) - Sep 2, 2021
P4, N=350, Recruiting, Sponsor: Vanderbilt University Medical Center
No abstract available Not yet recruiting --> Recruiting | Phase classification: PN/A --> P4
- || aripiprazole / Generic mfg., risperidone / Generic mfg.
Enrollment closed, Trial completion date, Trial primary completion date: LAP01: Long-term Antipsychotic Pediatric Safety Trial (clinicaltrials.gov) - Sep 1, 2021
P=N/A, N=509, Active, not recruiting, Sponsor: Duke University
Not yet recruiting --> Recruiting | Phase classification: PN/A --> P4 Recruiting --> Active, not recruiting | Trial completion date: Jul 2021 --> Sep 2024 | Trial primary completion date: Jul 2021 --> Sep 2024
- || risperidone / Generic mfg.
PK/PD data, Journal: Field-amplified sample injection in capillary zone electrophoresis for the pharmacokinetic research of trace risperidone and its major metabolite 9-hydroxyrisperidone in beagle dogs. (Pubmed Central) - Sep 1, 2021
All validation data were within the required limits. In conclusion, the method developed was successfully applied to pharmacokinetic studies of risperidone and 9-hydroxyrisperidone in beagle dogs.
- || risperidone / Generic mfg.
Clinical, Observational data, Journal: BDNF serum levels and cognitive improvement in drug-naive first episode patients with schizophrenia: A prospective 12-week longitudinal study. (Pubmed Central) - Sep 1, 2021
In addition, baseline BDNF levels were associated with improvement of delayed memory and were a prognostic factor for the improvement of the delayed memory and RBANS total score in patients with high-BDNF. Our result suggests risperidone treatment can partially improve certain domains of the cognitive impairment and baseline BDNF levels are related to cognitive response to risperidone in DNFE patients with schizophrenia.
- || risperidone / Generic mfg.
Clinical, Journal: Antipsychotic-placebo separation on the PANSS-6 subscale as compared to the PANSS-30: a pooled participant-level analysis. (Pubmed Central) - Aug 29, 2021
Here, we assessed the drug-placebo sensitivity of the six-item subscale (PANSS-6) of the 30-item Positive and Negative Syndrome Scale (PANSS-30) using a large collection of patient-level data (n = 6685) from randomized controlled trials of risperidone and paliperidone...Similarly, early improvement (≥20% improvement at week 1) on the PANSS-6 predicted subsequent response (≥40% improvement at endpoint) as well as the analog prediction using PANSS-30. Finally, cross-sectional symptom remission assessed via the PANSS-6 showed very good agreement (sensitivity = 100%, specificity = 98%) with cross-sectional symptom remission defined by the Remission in Schizophrenia Working Group.
- | risperidone / Generic mfg., amphetamine / Generic mfg.
Journal: Chronic risperidone administration leads to greater amphetamine-induced conditioned place preference. (Pubmed Central) - Aug 29, 2021
The density of forebrain dopamine transporters, a primary target of amphetamine, was also quantified in rats administered risperidone early in life and found to be reduced in the medial anterior, posterior, and ventral caudate nucleus. These results suggest that chronic risperidone treatment modifies later locomotor activity and sensitivity to the reinforcing effects of amphetamine, perhaps via a mechanism related to decreased forebrain dopamine transporter density.
- | risperidone / Generic mfg.
Biomarker, Journal: CYP2D6 pharmacogenetics and risperidone: reflections after 25 years of research. (Pubmed Central) - Aug 28, 2021
These results suggest that chronic risperidone treatment modifies later locomotor activity and sensitivity to the reinforcing effects of amphetamine, perhaps via a mechanism related to decreased forebrain dopamine transporter density. No abstract available
- || risperidone / Generic mfg.
Clinical, Journal: Cannabidiol versus risperidone for treatment of recent-onset psychosis with comorbid cannabis use: study protocol for a randomized controlled clinical trial. (Pubmed Central) - Aug 28, 2021
P2
No abstract available The results of this trial can potentially contribute with a new treatment paradigm for patients suffering from dual diagnosis.
- || risperidone / Generic mfg.
Right? Why not try Risperdal? Hemlock? Arsenic? (Twitter) - Aug 28, 2021
- | risperidone / Generic mfg.
Journal: Risperidone stimulates food intake and induces body weight gain via the hypothalamic arcuate nucleus 5-HT2c receptor-NPY pathway. (Pubmed Central) - Aug 27, 2021
The results of this trial can potentially contribute with a new treatment paradigm for patients suffering from dual diagnosis. Our findings provide critical insight into the mechanisms underlying antipsychotic-induced obesity, which may assist the development of therapeutic strategies to address metabolic side effects of risperidone.