risperidone / Generic mfg. 
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  • ||||||||||  risperidone / Generic mfg.
    Journal:  Towards safer risperidone prescribing in Alzheimer's disease. (Pubmed Central) -  Mar 12, 2022   
    P=N/A
    Our findings argue for age- and MMSE-related dose adjustments and suggest that a single measure of the concentration-to-dose ratio could be used to identify those with slower drug clearance.
  • ||||||||||  risperidone / Generic mfg.
    Journal:  A joint method for the screening of pharmacological chaperones for phenylalanine hydroxylase. (Pubmed Central) -  Mar 11, 2022   
    In conclusion, we established a joint method that is highly reliable, cost-effective, labor-saving, and time-saving. And we also found a specific agonist for D101N-mutated PAH by this joint method which may assist the development of clinical treatment for PAHD patients with different enzyme deficiencies.
  • ||||||||||  risperidone / Generic mfg.
    Clinical, Journal:  A case report of late-onset schizophrenia differentiated from a dementing disorder. (Pubmed Central) -  Mar 11, 2022   
    However, the results of cerebrospinal fluid biomarkers indicated that neurofibrillary tangles and neuronal death, which are characteristic of Alzheimer 's disease, may also have been present. Late-onset schizophrenia should be treated based on an appropriate differential diagnosis, including neuropathological consideration of dementing disorders.
  • ||||||||||  lithium carbonate ER / Generic mfg., risperidone / Generic mfg.
    Review, Journal:  Therapeutic Interventions to Mitigate Mitochondrial Dysfunction and Oxidative Stress-Induced Damage in Patients with Bipolar Disorder. (Pubmed Central) -  Mar 11, 2022   
    Furthermore, it reviews the efficacy of the most used therapies for BD, such as cognitive-behavioral therapy, bright light therapy, imagery-focused cognitive therapy, and electroconvulsive therapy. A better understanding of the roles of OS, mitochondrial dysfunction, and inflammation in the pathogenesis of bipolar disorder, along with a stronger elucidation of the therapeutic functions of antioxidants, antipsychotics, anti-inflammatory agents, lithium therapy, and light therapies, may lead to improved strategies for the treatment and prevention of bipolar disorder.
  • ||||||||||  risperidone / Generic mfg.
    Synergy between VMAT2 Inhibitors and Antipsychotics in Animal Models of Schizophrenia () -  Mar 11, 2022 - Abstract #SIRS2022SIRS_917;    
    CAR suppression increased when subthreshold doses of [+]-α-HTBZ and risperidone were combined (range, 6.5-7.1 escapes), and the results were comparable to the effects at threshold doses for [+]-α-HTBZ alone (4.8-11.4 escapes [0.3 mg/kg]) and risperidone alone (7.2-8.0 escapes [0.3 mg/kg]). This synergistic effect was not due to a drug-drug interaction, as the combination of drugs did not significantly affect the plasma concentration of either agent.
  • ||||||||||  Caplyta (lumateperone) - Intra / Cellular Therapies
    Efficacy and Tolerability of Lumateperone in Schizophrenia Spectrum Disorders () -  Mar 11, 2022 - Abstract #SIRS2022SIRS_878;    
    Lumateperone improves symptoms of schizophrenia and it is comparable to risperidone as efficacy, although it may be better tolerated. Mild and transient elevations of ALT were detected in controlled trials, but the mechanism underlying this adverse event is not known.
  • ||||||||||  risperidone / Generic mfg.
    Modulation of Striatal Adenosinergic Function by HTL0041178, a Selective GPR52 Agonist (Spadolini Pavilion Upper Floor) -  Mar 11, 2022 - Abstract #SIRS2022SIRS_578;    
    Risperidone also significantly reduced (p<0.05) caffeine- and istradefylline-induced hyperlocomotion. The presence of HTL0041178 had no effect on the affinity of caffeine or istradefylline for A2AR as measured in the in vitro assay.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    Could T Regulatory Cells Help to Uncover Novel Neuroimmune Mechanisms and Therapeutic Targets in psychosis? (Spadolini Pavilion Upper Floor) -  Mar 11, 2022 - Abstract #SIRS2022SIRS_358;    
    However, three studies identified lower percentages of blood Tregs in subgroups (around a third) of patients with schizophrenia, one including treatment-resistant patients. One study included a pooled sample of psychiatric patients (the largest proportion schizophrenia spectrum) and found a subgroup with lower but higher Treg percentages in the blood and cerebrospinal fluid, respectively.
  • ||||||||||  risperidone / Generic mfg.
    Optimal Doses of Antipsychotics for Relapse Prevention in a Nation-Wide Cohort of Patients with Schizophrenia (Spadolini Pavilion Upper Floor) -  Mar 11, 2022 - Abstract #SIRS2022SIRS_310;    
    Among the 15 most widely used antipsychotics, 13 had a U- or J-shaped dose-response curve, showing the lowest risks of relapse for doses of 0.6–<1.1 DDDs/day versus non-use of antipsychotics. The exceptions were oral perphenazine (aHR=0.72, 95% CI=0.68–0.76, <0.6 DDDs/day), and olanzapine-long-acting injectable (LAI) (aHR=0.17, 95%CI=0.11–0.25, 1.4–<1.6 DDDs/day), the latter of which had the lowest aHR of any antipsychotic.
  • ||||||||||  aripiprazole / Generic mfg., risperidone / Generic mfg.
    Agitation in Autism: Rising Concerns within Major Markets (In-person & Virtual) -  Mar 8, 2022 - Abstract #ISPOR2022ISPOR_404;    
    Agitation in autism is a cardinal concern and there is a need for research to identify the epidemiological patterns of the disease, primarily since children in their prime are most affected and is associated with a significant burden. Additionally, there is a need for more therapeutic guidelines and alternatives for this segment of patients to improve their quality of life.
  • ||||||||||  risperidone / Generic mfg.
    Journal:  Antipsychotic Drug-Induced Increases in Peripheral Catecholamines are Associated With Glucose Intolerance. (Pubmed Central) -  Mar 5, 2022   
    Importantly, there were strong and statistically significant associations between norepinephrine/epinephrine levels and glucose intolerance for all drugs. These findings confirm that increases in peripheral catecholamines co-occur in animals that exhibit antipsychotic-induced glucose intolerance, and these effects are strongly associated with each other, providing further evidence for elevated catecholamines as a substrate for antipsychotic metabolic side-effects.
  • ||||||||||  risperidone / Generic mfg.
    Retrospective data, Journal:  Time to Rehospitalization for Different Oral Risperidone Dosing Frequencies in Patients With Schizophrenia: A 17-Year Retrospective Cohort Study. (Pubmed Central) -  Mar 4, 2022   
    These findings confirm that increases in peripheral catecholamines co-occur in animals that exhibit antipsychotic-induced glucose intolerance, and these effects are strongly associated with each other, providing further evidence for elevated catecholamines as a substrate for antipsychotic metabolic side-effects. Patients receiving more doses of risperidone per day are more likely to be readmitted within 1 year following last discharge, indicating poorer treatment outcomes for patients who receive more frequent doses.
  • ||||||||||  lurasidone / Generic mfg.
    Trial completion date, Trial primary completion date:  Observational Study on the Effect of Switch to Lurasidone in Subjects With Schizophrenia" (clinicaltrials.gov) -  Mar 4, 2022   
    P=N/A,  N=300, Recruiting, 
    The overall paucity of trials and of adequate controls indicates that more well-designed randomized controlled trials are required for adequate assessment of antipsychotic drug treatment for juveniles. Trial completion date: Nov 2021 --> Apr 2022 | Trial primary completion date: Nov 2021 --> Apr 2022