- |||||||||| risperidone / Generic mfg., olanzapine / Generic mfg., lorazepam / Generic mfg.
Psychiatric Comorbidities in Infectious Diseases () - May 5, 2022 - Abstract #APA2022APA_607;
Thus both the literature and the aforementioned case indicate that physicians must maintain a high degree of suspicion for an infectious process as a potential underlying cause of novel or re-emergent psychosis. However, this remains an open hypothesis and should be explored further.
- |||||||||| risperidone / Generic mfg., olanzapine / Generic mfg., escitalopram / Generic mfg.
Nihilism, Neurocognition, and COVID: A Case of Acute Onset Cotard’s Syndrome () - May 5, 2022 - Abstract #APA2022APA_572;
Escitalopram was added to treat depressed mood...Olanzapine was transitioned to risperidone to further address the delusions...As the pandemic continues, it is likely more instances of post-COVID psychiatric complications will manifest. In this poster, we discuss the presentation and treatment course for a case of post-COVID psychotic symptoms in a geriatric patient with minimal psychiatric history and highlight the importance of additional research to further determine possible neuropsychiatric sequelae of infection.
- |||||||||| aripiprazole / Generic mfg., risperidone / Generic mfg., sertraline / Generic mfg.
New Onset of Depression, Psychosis and Cognitive Impairment After COVID-19 Infection: The Need for Longer Treatment () - May 5, 2022 - Abstract #APA2022APA_569;
Treatment consisted of sertraline for depression and risperidone for psychosis...Two weeks later, she was noted to have recurrent symptoms of depression and psychosis after self-discontinuing risperidone; aripiprazole was then started instead...The severity of COVID-19 infection and medical comorbidities may serve as prognostic value for illness. We discuss our pharmacological approaches to the treatment of psychiatric symptoms to contribute to the growing body of literature as we learn more about the psychiatric effects and treatment of the post-COVID-19 syndrome.
- |||||||||| risperidone / Generic mfg., tetrabenazine / Generic mfg.
Management of Neuro- Psychiatric Disturbances in Huntington’s Disease () - May 5, 2022 - Abstract #APA2022APA_540;
Further research is required to reach an evidence-based consensus as well as develop specific guidelines for managing Psychiatric conditions related to HD. Additional developments to navigate the insurance barriers as well as create more defined clinical pathways would be the next steps to ensure adequate long-term care in a timely manner
- |||||||||| risperidone / Generic mfg., lorazepam / Generic mfg.
Long Post-Covid Psychosis: A Case Report () - May 5, 2022 - Abstract #APA2022APA_536;
In our case, such a presentation may have been a combination of a family history of autoimmunity, psychosocial stressors, and COVID-19 infection. We review the connections between pathogens and psychosis and review the major proposed etiologies of post viral psychosis including the mechanism of post-viral autoimmunity, which may have played a role in our case.
- |||||||||| Yervoy (ipilimumab) / Ono Pharma, BMS
Ipilimumab Induced-Hypophysitis With Subsequent Encephalitis in a Patient With Cholangiocarcinomna: A Case Report () - May 5, 2022 - Abstract #APA2022APA_513;
The patient had been initially treated for cholangiocarcinoma with gemcitabine, cisplastin and paclitaxel but due to high tumor burden he was started on palliative immunotherapy with intravenous Ipilimumab/Nivolumab...Nivolumab was discontinued and patient was started on risperidone...Ipilimumab, nivolumab) that are used to enhance the immune system have been associated with multiple side effects, including hypophysitis and encephalitis. In this poster, we discuss the challenges of treating the psychiatric complications of treating a patient who developed delirium and manic symptoms after treatment of hypophysitis with high dose steroids
- |||||||||| risperidone / Generic mfg.
Delusional Disorder in the Context of Adverse Childhood Experiences (Aces) and Sexual Abuse () - May 5, 2022 - Abstract #APA2022APA_434;
After initiation of risperidone 1 mg, AS endorsed improved mood and sleep...Clinicians should be aware of the psychiatric ramifications of ACEs, especially sexual abuse and other insidious experiences, so that further morbidity may be prevented. In conclusion, helping children cope with ACEs such as sexual abuse is a worthy target for effective mental illness prevention and should be a public health priority [6].
- |||||||||| lithium carbonate ER / Generic mfg.
COVID-19 Creating a “Long-Haul” Hospitalization for Bipolar Disorder () - May 5, 2022 - Abstract #APA2022APA_422;
Additionally, this patient was treated with antipsychotic medication that is not known to have a significant anti-inflammatory effect. This may represent further support for reported success with psychiatric medications that also have anti-inflammatory properties through the sigma receptor such as: Fluvoxamine and Haloperidol.
- |||||||||| Vyvanse (lisdexamfetamine) / Shionogi, Takeda
Challenges in Treating Disinhibited Social Engagement Disorder in a Patient Adopted Post-Infancy () - May 5, 2022 - Abstract #APA2022APA_397;
Additionally, given the refractory nature of S’s case and similar cases reported in the literature, we urge the exploration of alternative frameworks for understanding DSED outside the classical attachment perspective. We hope that this will lead to more effective interventions for patients past infancy and those whose symptoms persist even after secure family placement.
- |||||||||| risperidone / Generic mfg., quetiapine / Generic mfg.
Atypical Neuroleptic Malignant Syndrome With Rash After Loading Dose of Paliperidone Palmitate: A Case Report () - May 5, 2022 - Abstract #APA2022APA_374;
He improved on a combination of Depakote and Quetiapine without complications. To our knowledge, this is the first documented case of atypical NMS occurring in association with a morbiliform skin eruption and provides insight on the challenges of recognizing and treating a patient with atypical NMS occurring with the use of second-generation LAIs along with lithium and Depakote.
- |||||||||| Antipsychotic Induced Hypothermia () - May 5, 2022 - Abstract #APA2022APA_360;
Clinicians should be aware of APD induced hypothermia and monitor body temperature particularly during initiation of APD use. Mild hypothermia can be easily missed leading to severe hypothermia.
- |||||||||| aripiprazole / Generic mfg., risperidone / Generic mfg.
Adverse Consequences of Continuing Antipsychotics for Childhood Behavioral Dysregulation Into Adulthood () - May 5, 2022 - Abstract #APA2022APA_351;
Additionally, this case highlights the importance of screening for side effects, specifically obtaining a menstrual history as this patient had been hospitalized several times before amenorrhea was discovered and before hyperprolactinemia and gynecological workup were pursued. More research needs to be done to guide treatment of patients with a history of behavioral dysregulation and intellectual disability as they transition from childhood into adulthood.
- |||||||||| lithium carbonate ER / Generic mfg.
A Difficult Pediatric Case of Treatment-Resistant Bipolar Disorder: A Case Report () - May 5, 2022 - Abstract #APA2022APA_332;
The patient showed a good response to this regimen and was discharged with no recurrence of symptoms for 3 months of outpatient follow-up. In this poster we discuss the challenges of treating pediatric bipolar disorder and summarize recent guidelines that provide a stepwise approach for its management.
- |||||||||| risperidone / Generic mfg., quetiapine / Generic mfg.
“The Russians and Chinese Hacked My Phone!”: The Case of THC Induced Psychosis in an Older Adult () - May 5, 2022 - Abstract #APA2022APA_315;
The patient was subsequently switched to risperidone and titrated to 4 mg nightly...However, very few studies have investigated the role of THC in new onset psychosis in older adults. In this poster we will discuss a case report of THC induced psychosis in an older adult and summarize existing research findings about THC use and the risk of psychosis in older populations.
- |||||||||| “It’s Not a Question of Whether It’ll Happen, but One of When?” Coping With Patient and Resident Suicide as a Trainee () - May 5, 2022 - Abstract #APA2022APA_311;
He had occasional suicidal ideation although stated that he felt responsible for family and would not hurt himself; and was started on Lexapro, Vistaril and Buspar...He presented anxious, tense and tearful, and later endorsed suicidal thoughts so he was placed on constant observation and started on Abilify, Risperdal and Trazodone...He continued weekly outpatient visits where he continued to present with increased anxiety and clonazepam was started...Nevertheless, studies suggest that operationalized postvention programs that addresses medico-legal concerns, normalizes emotional responses and offers psychotherapy, process groups and connection with peers/faculty that had a similar experience, can strengthen suicide prevention, destigmatize the tragedy, and promote caregiver recovery in a more impactful way for residents than other less structured forms of support. Some guiding principles for these programs are: to decrease the feelings of isolation among resident physicians; to help trainees understand that bad patient outcomes do not equal personal failures; and to respond to this professional tragedy with kindness and support even if that takes more work and attention.
- |||||||||| risperidone / Generic mfg.
“I’m Giving Birth!” The Neuropsychiatric Presentation of a Patient With Bartonella Infection. () - May 5, 2022 - Abstract #APA2022APA_310;
The patient’s neuropsychiatric symptoms greatly improved after two weeks of appropriate antibiotics for Bartonella endocarditis and risperidone...Clinicians should inquire about housing status and cat exposure in patients with new-onset psychosis of difficult to determine etiology. Given the frequent concurrence of homelessness in patients with psychotic illness, consideration of Bartonella infection is an important etiologic consideration for psychiatrists to be aware of.
- |||||||||| risperidone / Generic mfg.
Journal: Psychosis Associated with Chronic Subdural Hematoma. (Pubmed Central) - May 5, 2022
A thorough history and physical are vital to ascertain this diagnosis and noncontrast head imaging is confirmatory. Management varies based on the etiology of the CSDH.
- |||||||||| Journal: Major Bleeding Risk in Atrial Fibrillation Patients Co-Medicated With Non-Vitamin K Oral Anticoagulants and Antipsychotics. (Pubmed Central) - May 3, 2022
The concomitant use of a NOAC with chlorpromazine (AIRD: 103.87, 95% CI: 51.22-156.52), haloperidol (AIRD: 149.52, 95% CI: 125.03-174.00), prochlorperazine (AIRD: 90.43, 95% CI: 78.55-102.32), quetiapine (AIRD: 44.6, 95% CI: 37.11-52.09), or risperidone (AIRD: 41.55, 95% CI: 22.86-60.24) (All p < 0.01) showed a higher adjusted incidence rate of major bleeding than using NOACs alone. The concomitant use of typical (chlorpromazine, haloperidol, or prochlorperazine) or atypical (quetiapine or risperidone) antipsychotic with NOACs was associated with a significantly increased risk of major bleeding.
- |||||||||| Retrospective data, Review, Journal: Pharmacological Treatments for Psychotic Symptoms in Dementia: A Systematic Review with Pairwise and Network Meta-Analysis. (Pubmed Central) - Apr 30, 2022
Besides, donepezil, memantine and mirtazapine were more efficacious than sertraline (SMDs ranged from -0.47 to -0.36)...Donepezil, memantine and aripiprazole are probably the appropriate options to consider when a pharmacological treatment is indicated. Given the limitations of the meta-analytic approach and the low methodological quality of the majority of studies, our results should be cautiously interpreted.
- |||||||||| Clopixol (zuclopenthixol) / Lundbeck
Pharmacogenetics: Clinical Applications and Cases Across the Lifespan (Rooms 283-285 , Ernest N. Morial Convention Center) - Apr 26, 2022 - Abstract #APA2022APA_286;
Helen Lavretsky will focus on late-life mental health. She will present a published case highlighting the potential utility of pharmacogenetic testing in late-life depression and will also share results of a recent survey that assessed the perspectives on pharmacogenetic testing among members of the American Association of Geriatric Psychiatry.
- |||||||||| risperidone / Generic mfg., quetiapine / Generic mfg., dexmedetomidine / Generic mfg.
Review, Journal: Delirium in the Neonate. (Pubmed Central) - Apr 26, 2022
When identified, initial steps in management should include resolving underlying causes and implementation of standard nonpharmacologic measures. Mounting pediatric evidence suggests that the atypical antipsychotics, as well as the α-2 agonists, may be additionally beneficial in treating delirium as well as improving the ability to wean off other neurosedative medications.
- |||||||||| risperidone / Generic mfg.
Journal: The polymorphic nuclear factor NFIB regulates hepatic CYP2D6 expression and influences risperidone metabolism in psychiatric patients. (Pubmed Central) - Apr 22, 2022
Based on 604 risperidone treated patients genotyped for CYP2D6 and NFIB, we found that the rate of risperidone hydroxylation was elevated in NFIB rs28379954 T>C carriers among CYP2D6 normal metabolisers, resulting in similar rate of drug metabolism to what is observed in CYP2D6 ultrarapid metabolisers, with no such effect observed in CYP2D6 poor metabolisers lacking functional enzyme. The results indicate that NFIB constitutes a novel nuclear factor in the regulation of cytochrome P450 genes, and that its polymorphism is a predictor for the rate of CYP2D6 dependent drug metabolism in vivo.
- |||||||||| risperidone / Generic mfg.
Journal: Association of Risperidone With Gastric Cancer: Triangulation Method From Cell Study, Animal Study, and Cohort Study. (Pubmed Central) - Apr 22, 2022
In addition, the population-based cohort study found that risperidone users had reduced risks of gastric cancer compared with non-users, with lowered adjusted hazard ratios (HRs) for two induction periods (HR = 0.75; 95% confidence interval [CI] 0.68-0.83 for the one-year induction period, and HR = 0.68; 95% CI 0.61-0.75 for the two-year induction period). The findings are consistent with anticancer effects associated with risperidone, but further research and evaluations are warranted.
- |||||||||| risperidone / Generic mfg.
Journal: Low-Dose Risperidone for an Autistic Child with Comorbid ARFID and Misophonia. (Pubmed Central) - Apr 21, 2022
Here, authors report on a challenging case of low-functioning ASD child with comorbid ARFID and misophonia that responded favorably to a low-dose risperidone. This is followed by a brief discussion of purported pharmacodynamic mechanisms and relevant literature.
- |||||||||| risperidone / Generic mfg., olanzapine / Generic mfg.
Preclinical, Journal: Efficacy of VMAT2 inhibition and synergy with antipsychotics in animal models of schizophrenia. (Pubmed Central) - Apr 20, 2022
This study shows that combining these postsynaptic dopaminergic modulators with a presynaptic dopamine modulator (VMAT2 inhibitor) potentiates efficacy synergistically in animal models of schizophrenia without potentiating weight gain. Our data suggest that adding a VMAT2 inhibitor may be a viable therapeutic strategy for reducing antipsychotic side effects by lowering antipsychotic dose while maintaining therapeutic efficacy.
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