risperidone / Generic mfg. 
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  • ||||||||||  risperidone / Generic mfg., olanzapine / Generic mfg., quetiapine / Generic mfg.
    Journal:  Patterns and predictors of oral antipsychotic prescribing in adult patients with schizophrenia. (Pubmed Central) -  Jun 28, 2022   
    Multiple factors were associated with prescribing an SGA or FGA versus no antipsychotic, but no factors were associated with prescribing an SGA versus FGA. Future studies are needed to determine the reasoning behind differences in antipsychotic prescribing.
  • ||||||||||  aripiprazole / Generic mfg., risperidone / Generic mfg., olanzapine / Generic mfg.
    Journal:  Mechanisms Underlying Antipsychotic-Induced NAFLD and Iron Dysregulation: A Multi-Omic Approach. (Pubmed Central) -  Jun 25, 2022   
    We identified numerous differentially expressed traits affecting these pathways conserved across study systems and AA medications. We used these findings to propose mechanisms for AA-associated development of NAFLD and dysregulated iron homeostasis.
  • ||||||||||  Trintellix (vortioxetine) / Lundbeck, Takeda
    Journal:  Inhibitory Effectiveness in Delayed-Rectifier Potassium Current Caused by Vortioxetine, Known to Be a Novel Antidepressant. (Pubmed Central) -  Jun 25, 2022   
    In continued presence of VOR, neither further addition of propranolol nor risperidone reversed VOR-mediated inhibition of I. Increasing VOR concentration not only depressed I conductance but also shifted toward the hyperpolarized potential...The inhibition of I by a train pulse was enhanced during exposure to VOR. In Neuro-2a cells, this drug decreased I. Overall, inhibitory effects of VOR on ionic currents might constitute another underlying mechanism of its actions.
  • ||||||||||  Zyprexa Relprevv (olanzapine pamoate long-acting injection) / Eli Lilly
    Journal:  Optimal Doses of Specific Antipsychotics for Relapse Prevention in a Nationwide Cohort of Patients with Schizophrenia. (Pubmed Central) -  Jun 24, 2022   
    Our results suggest that olanzapine LAI is highly effective in dose ranges >0.9 DDD/day, and especially at 1.4-<1.6 DDDs/day (405 mg/4 weeks) associated with substantially lower risk of rehospitalization than any dose of any other antipsychotic. The current WHO standard dose definitions appear to be clearly too high for perphenazine and somewhat too high for risperidone.
  • ||||||||||  Rexulti (brexpiprazole) / Lundbeck, Otsuka, Nuplazid (pimavanserin) / Acadia Pharma
    Journal:  Comparative Safety Signal Assessment of Hospitalization Associated With the Use of Atypical Antipsychotics. (Pubmed Central) -  Jun 24, 2022   
    This cross-sectional assessment of data from FAERs (2004-2021) suggested that users of clozapine, olanzapine, quetiapine, risperidone, aripiprazole, and ziprasidone were more likely to report being hospitalized than users of other AAPs. Given that the FAERs database only contains spontaneous reports of AEs experienced by persons exposed to a drug but without information on exposed persons who did not have an event, a cohort study comparing hospitalizations among new users of individual AAPs against each other is needed to delineate these safety signals further.
  • ||||||||||  Invega Sustenna (paliperidone palmitate extended-release 1-month injection) / J&J
    Journal:  Letter to the Editor: Rethinking The Cost Of Antipsychotic Treatment: The Average Cost Of The Drugs Used In Turkey In 2020. (Pubmed Central) -  Jun 23, 2022   
    For example, there was a 3 to 4-fold increase in the prices of haloperidol, chlorpromazine, fluphenazine, trifluperazine and zuclopenthixol, while a less than two-fold increase in pimozide, flupenthixol, sulpiride, amisulpride and quetiapine and a decrease in the prices of clozapine, olanzapine, ziprasidone and risperidone in the tablet form...Consta 25, 37.5, 50 LAI 37.5/1 444.17 11.840 1/15* 29.61 10,807 5,402 16 Paliperidone Invega 3, 6, 9 tb 6/28 213.15 1.268 6 7.61 2,777 - Xeplion 50, 75, 100, 150 LAI 100/1 1161.56 11.615 1/30* 38.72 14,132 - Trevicta 175, 263, 350, 525 LAI 350/1 3426.95 9.788 1/90* 38.08 13,899 - 17 Aripiprazole Abilify 5, 10, 15, 20 tb; 1 sol 20/28 113.25 0.404 20 8.08 2,949 - Abilify Main...Table 2. Comparison of the Annual Costs of Antipsychotic Drugs Calculated By The Daily Standard Average Dose Use, at Certain Price Ranges, for the Years 2005 and 2020 Price bracket (TRY) 2005 2020 500 ↓ Haloperidol tb, amp, Trifluoperazine drj, Chlorpromazine tb, Pimozid tb, Fluphenazine LAI Haloperidol tb, amp, depo, Trifluoperazine drj, Pimozid tb 500-1,000 Flupenthixol drj, LAI, Zuklopenthixol tb, acu, LAI, Sulpirid tb Chlorpromazine tb, Fluphenazine LAI, Flupenthixol drj, LAI, Clozapine tb, Risperidone tb 1,000-2,000 Clozapine tb, Risperidone tb Olanzapine tb, Sulpirid tb 2,000-3,000 Amisulpirid tb, Olanzapine tb, Quetiapine tb Zuklopenthixol tb, acu, LAI, Amisulpirid tb, Ziprasidone tb, Paliperidone tb, Aripiprazole tb 3,000-5,000 Ziprasidone tb Quetiapine tb 5,000-10,000 Risperidone consta Sertindole tb 10,000 ↑ Risperidone consta, Paliperidone monthly, Paliperidone 3 monthly, Aripiprazole maintana tb: Tablet, drj: Dragee, amp: Ampoule, LAI: Long-acting injectable, acu: Acuphase.
  • ||||||||||  risperidone / Generic mfg., olanzapine / Generic mfg.
    Prescribing antipsychotics in dermatology: a national survey of clinical experience, physician confidenceand training needs (M1) -  Jun 23, 2022 - Abstract #BAD2022BAD_420;    
    Overall, 78% (n = 61/78), including all 20 registrars surveyed, expressed a wish to participate in a training course for prescribing antipsychotics. Our national survey demonstrates that there is a need to improve both exposure to psychocutaneous conditions; confidence in the prescription of antipsychotic medications across all grades, including consultants,; that there is a clear demand from trainees for participation in such courses, which would satisfy this training need, in addition to ensuring that consultants of the future are well equipped to provide care for patients with psychocutaneous conditions.
  • ||||||||||  risperidone / Generic mfg.
    Journal:  Commentary on "Idiopathic granulomatous mastitis with normal prolactin level caused by risperidone". (Pubmed Central) -  Jun 22, 2022   
    Our national survey demonstrates that there is a need to improve both exposure to psychocutaneous conditions; confidence in the prescription of antipsychotic medications across all grades, including consultants,; that there is a clear demand from trainees for participation in such courses, which would satisfy this training need, in addition to ensuring that consultants of the future are well equipped to provide care for patients with psychocutaneous conditions. No abstract available
  • ||||||||||  risperidone / Generic mfg., quetiapine / Generic mfg.
    Journal:  Antipsychotic Use and Risk of Stroke Among Community-Dwelling People With Alzheimer's Disease. (Pubmed Central) -  Jun 9, 2022   
    Stroke risk is increased shortly after antipsychotic initiation in people with AD, suggesting that even short-term use of antipsychotics should be avoided if possible. If antipsychotics are prescribed, effectiveness and safety should be assessed soon after initiation and treatment limited to the shortest possible duration.
  • ||||||||||  risperidone / Generic mfg., naproxen / Generic mfg.
    Preclinical, Journal:  Novel adapter method for in vitro release testing of in situ forming implants. (Pubmed Central) -  Jun 8, 2022   
    In addition, the adapter-based method could discriminate formulation and dissolution apparatus changes and could be utilized to develop accelerated release testing methods. This adapter-based method has the promise of wide use in release testing of in situ forming implant formulations and has the potential to be used in the development of in vivo-predictive in vitro release methods.
  • ||||||||||  risperidone extended release (LYN-005) / Lyndra
    Lyndra Therapeutics (Theater 1) -  Jun 4, 2022 - Abstract #BIO2022BIO_140;    
    In its first six years, Lyndra has achieved rapid progress, formulating 19 therapies in the lab and advancing four therapeutic products to the clinic, validating the feasibility of its platform with multiple APIs. Thanks to more than $240 million raised to date from investors and partners, Lyndra has advanced the LYNX™ drug delivery platform, prepared oral weekly risperidone (LYN-005) for pivotal trials and opened a custom-built GMP manufacturing facility in Lexington, MA.
  • ||||||||||  FT03 - Racial/Ethnic Differences in Pharmacogenetics () -  May 27, 2022 - Abstract #CINP2022CINP_222;    
    There was no difference in remoxipride, olanzapine, paliperidone and lurasidone...Frye’s group compared lithium and mood stabilizing anticonvulsants (MSA) treatment patterns in more contemporary cohorts including the Mayo Clinic Bipolar Disorder Biobank, University of Mississippi Medical Center (UMMC), and the NIH funded All of Us (AoU) Research Program. While study designs differed, the AA vs EA lithium utilization was less (Mayo: OR=0.30, p=0.06; UMMC: RR=0.56 (0.43-0.72)
  • ||||||||||  aripiprazole / Generic mfg., risperidone / Generic mfg.
    Journal:  Millennium Nutrient N,N-Dimethylglycine (DMG) and its Effectiveness in Autism Spectrum Disorders. (Pubmed Central) -  May 25, 2022   
    The current review discusses ASD, the prevalence of ASD, CAM approach and efficacy of CAM treatment in children with ASD. Moreover, it highlights the chemistry, pharmacological effect, and clinical studies of DMG, highlighting its potential for improving the lifestyle of children with ASD.
  • ||||||||||  Journal:  Psychopharmacology of agitation in acute psychotic and manic episodes. (Pubmed Central) -  May 25, 2022   
    Tier 3 includes asenapine and quetiapine. For intramuscular treatment, the first-tier includes haloperidol plus promethazine, and olanzapine alone, and the second-tier includes haloperidol with lorazepam, and lorazepam alone.
  • ||||||||||  risperidone / Generic mfg.
    Review, Journal:  Risperidone Induced Hyperprolactinemia: From Basic to Clinical Studies. (Pubmed Central) -  May 25, 2022   
    However, the mechanism of Risperidone-induced HPL is complicated and still far from fully understood. Most of the preclinical and clinical studies described in this study show that hyperprolactinemia is one of the most common if not the leading side effect of Risperidone therefore to improve the quality of life of these patients, clinicians must recognize and treat HPL associated with the use of these drugs.
  • ||||||||||  risperidone / Generic mfg.
    Journal:  Long-Acting Injectable Antipsychotics in a Prescription Claims Data Source: A Validation Study. (Pubmed Central) -  May 18, 2022   
    Quantity dispensed and days supplied provide valid estimates of dose and dosing interval for second-generation LAIAs, but underestimated these parameters for first-generation LAIAs. However, a large proportion of medical record-confirmed doses were missing from claims data, and dose and dosing interval are underestimated in claims data.