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72 Diseases |  |
13 Trials |
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13 Trials |  |
341 News |  |
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- | eszopiclone / generics
Journal: Z-drugs and risk for falls and fractures in older adults-a systematic review and meta-analysis. (Pubmed Central) - Sep 26, 2019
zolpidem, zopiclone, eszopiclone and zaleplon, also known as 'Z-drugs', are commonly used as alternatives to benzodiazepines (BZDs) to treat insomnia...However, studies included were observational and susceptible to confounding. Physicians should consider these potential risks before prescribing these medications in older adults.
- | eszopiclone / generics
Clinical, Journal: Sedative Hypnotics and the Risk of Falls and Fractures in the Elderly. (Pubmed Central) - Aug 30, 2019
Older age, poor sleep, and the use of the "Z" sedative hypnotic drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) commonly go together...Nonpharmacologic interventions for insomnia should therefore be considered as alternatives to the use of Z-drugs. Finally, patients prescribed Z-drugs and caregivers of these patients should be warned about the risk of falls and fractures and counseled about practical measures that can reduce the risk.
- | zolpidem ER / Generic mfg., eszopiclone / Generic mfg.
Trial completion date, Trial primary completion date: CIS2: Safety and Efficacy of Chronic Hypnotic Use 2 (clinicaltrials.gov) - Aug 15, 2019
P4, N=120, Recruiting, Sponsor: Henry Ford Health System
Finally, patients prescribed Z-drugs and caregivers of these patients should be warned about the risk of falls and fractures and counseled about practical measures that can reduce the risk. Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Jul 2020 --> Jul 2021
- | Stilnox (zolpidem) / Sanofi
Clinical, Journal: Patient Education and Pharmacist Consultation Influence on Nonbenzodiazepine Sedative Medication Deprescribing Success for Older Adults. (Pubmed Central) - Jun 15, 2019
Patients who received direct-to-patient education with or without a pharmacist consultation were significantly more likely to discontinue Z-drug use than patients receiving UC. Providing evidence-based information about Z-drug use is an effective and low-resource method to encourage drug discontinuation.
- | eszopiclone / generics
Journal: Bitterness-Masking Effects of Different Beverages on Zopiclone and Eszopiclone Tablets. (Pubmed Central) - Jun 14, 2019
H-NMR spectroscopic analysis of mixtures of citric acid with zopiclone suggested that the carboxyl groups of citric acid interact with the amine group on zopiclone. This study therefore showed that the bitterness intensities of zopiclone and eszopiclone can be suppressed by citric-acid-contained beverages and suggests that this bitterness suppression is due to a direct electrostatic interaction between citric acid and the two drugs.
- || eszopiclone / generics
Clinical: Those new @US_FDA warnings on the long-popular #sleepingpills Ambien, Sonata & Lunesta -- why now? @TJUHospital's Karl Doghramji has some thoughts: https://t.co/97yfJnFkEI @phillydotcom @PhillyInquirer (Twitter) - May 6, 2019
- | eszopiclone / Generic mfg.
New P4 trial: PRECEPT-D: Effectiveness of Combining Behavioral and Pharmacologic Therapy for Complex Insomnia in Veterans With PTSD (clinicaltrials.gov) - May 5, 2019
P4, N=52, Not yet recruiting, Sponsor: VA Office of Research and Development
- || Stilnox (zolpidem) / Sanofi
ICYMI: FDA recommends warning labels change for Lunesta, Sonata & Ambien (zolpidem). @UTSWIMchief @UTSWInternalMed @DinoKazi https://t.co/LP0N7G7ZtA (Twitter) - May 1, 2019
- || Edluar (zolpidem) / Mylan, Stilnox (zolpidem) / Sanofi
Eszopiclone (#Lunesta), #zaleplon (#Sonata) and #zolpidem (#Ambien, Ambien CR, #Edluar, Intermezzo and #Zolpimist) will require the new FDA boxed warnings about unsafe behavior like sleepwalking, sleep-driving and other complex behaviors while sleeping. https://t.co/CAplYeY3R4 (Twitter) - May 1, 2019
- | Stilnox (zolpidem) / Sanofi
Journal: Zolpidem and Eszopiclone Pre-medication for PSG: Effects on Staging, Titration, and Adherence. (Pubmed Central) - Apr 26, 2019
In a population with predominantly mild obstructive sleep apnea, NBSHs did not improve PSG or CPAP titration quality and did not increase CPAP adherence. There was no difference in effect between eszopiclone and zolpidem.
- | eszopiclone / Generic mfg.
Enrollment change: Insomnia and Osteoarthritis Study (clinicaltrials.gov) - Mar 14, 2019
P=N/A, N=30, Completed, Sponsor: Johns Hopkins University
There was no difference in effect between eszopiclone and zolpidem. N=105 --> 30
- | eszopiclone / Generic mfg., trazodone ER / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date: NAP: National Adaptive Trial for PTSD Related Insomnia (clinicaltrials.gov) - Mar 11, 2019
P3, N=1224, Not yet recruiting, Sponsor: VA Office of Research and Development
N=105 --> 30 Trial completion date: Jan 2023 --> Apr 2023 | Initiation date: Aug 2019 --> Nov 2019 | Trial primary completion date: Jan 2023 --> Apr 2023
- | eszopiclone / Generic mfg., trazodone ER / Generic mfg.
New P3 trial: NAP: National Adaptive Trial for PTSD Related Insomnia (clinicaltrials.gov) - Sep 12, 2018
P3, N=1224, Not yet recruiting, Sponsor: VA Office of Research and Development
- | eszopiclone / Generic mfg.
Trial completion date: Sleep Effectiveness and Insulin and Glucose Homeostasis (clinicaltrials.gov) - Aug 6, 2018
P1, N=48, Active, not recruiting, Sponsor: Beth Israel Deaconess Medical Center
Trial completion date: Jan 2023 --> Apr 2023 | Initiation date: Aug 2019 --> Nov 2019 | Trial primary completion date: Jan 2023 --> Apr 2023 Trial completion date: Dec 2018 --> Dec 2020
- |||| eszopiclone / Generic mfg., fluoxetine / Generic mfg.
Trial completion, Enrollment change: Improving Sleep and Psychological Functioning in People With Depression and Insomnia (clinicaltrials.gov) - Dec 19, 2017
P4, N=60, Completed, Sponsor: Wake Forest University Health Sciences
Trial completion date: Dec 2018 --> Dec 2020 Active, not recruiting --> Completed | N=96 --> 60
- | eszopiclone / Generic mfg.
Enrollment change: Insomnia and Osteoarthritis Study (clinicaltrials.gov) - Nov 9, 2017
P=N/A, N=105, Completed, Sponsor: Johns Hopkins University
Active, not recruiting --> Completed | N=96 --> 60 N=64 --> 105
- | eszopiclone / Generic mfg.
Trial completion, Enrollment change, Trial primary completion date: Effects of Eszopiclone on Sleep and Memory in Schizophrenia (clinicaltrials.gov) - Jun 14, 2017
P=N/A, N=59, Completed, Sponsor: Massachusetts General Hospital
N=64 --> 105 Recruiting --> Completed | N=80 --> 59 | Trial primary completion date: Jun 2015 --> Dec 2015
- || eszopiclone / Generic mfg.
Phase classification: The Effect of Eszopiclone on the Arousal Threshold in Sleep Apnea Syndrome (clinicaltrials.gov) - Apr 18, 2017
P, N=17, Completed, Sponsor: Brigham and Women's Hospital
Recruiting --> Completed | N=80 --> 59 | Trial primary completion date: Jun 2015 --> Dec 2015 Phase classification: P=N/A --> P
- | eszopiclone / Generic mfg.
Phase classification: Sleep Effectiveness and Insulin and Glucose Homeostasis (clinicaltrials.gov) - Apr 7, 2017
P1, N=48, Active, not recruiting, Sponsor: Beth Israel Deaconess Medical Center
Phase classification: P=N/A --> P Phase classification: P=N/A --> P1
- ||| eszopiclone / Generic mfg.
Trial completion: Investigation of the Safety and Efficacy of Long Term Administration of Eszopiclone in Insomnia Patients (clinicaltrials.gov) - Dec 30, 2016
P=N/A, N=438, Completed, Sponsor: Eisai Co., Ltd.
Phase classification: P=N/A --> P1 Active, not recruiting --> Completed
- ||| eszopiclone / Generic mfg.
Trial completion, Enrollment change: Investigation of the Safety and Efficacy of Eszopiclone in Insomnia Patients (clinicaltrials.gov) - Dec 30, 2016
P=N/A, N=4876, Completed, Sponsor: Eisai Co., Ltd.
Active, not recruiting --> Completed Active, not recruiting --> Completed | N=3300 --> 4876
- | eszopiclone / Generic mfg.
Trial completion: Eszopiclone for Sleep Disturbance and Nightmares in Post-Traumatic Stress Disorder (clinicaltrials.gov) - Apr 24, 2016
P4, N=27, Completed, Sponsor: Massachusetts General Hospital
Active, not recruiting --> Completed | N=3300 --> 4876 Recruiting --> Completed
- eszopiclone / Generic mfg.
Trial completion, Enrollment change, Trial primary completion date: Eszopiclone for the Treatment of Posttraumatic Stress Disorder (clinicaltrials.gov) - Apr 16, 2016
P4, N=81, Completed, Sponsor: Rush University Medical Center
Recruiting --> Completed Recruiting --> Completed | N=40 --> 81 | Trial primary completion date: Jun 2015 --> Dec 2015
- eszopiclone / Generic mfg.
Enrollment closed, Trial primary completion date: Sleep Effectiveness and Insulin and Glucose Homeostasis (clinicaltrials.gov) - Dec 18, 2015
P=N/A, N=48, Active, not recruiting, Sponsor: Beth Israel Deaconess Medical Center
Recruiting --> Completed | N=40 --> 81 | Trial primary completion date: Jun 2015 --> Dec 2015 Recruiting --> Active, not recruiting | Trial primary completion date: Aug 2014 --> Aug 2015
- eszopiclone / Generic mfg.
Trial termination: How do Sleeping Pills Affect Pain in the Brain? (clinicaltrials.gov) - Oct 27, 2015
P4, N=40, Terminated, Sponsor: University of California, San Diego
Recruiting --> Active, not recruiting | Trial primary completion date: Aug 2014 --> Aug 2015 Completed --> Terminated; Funding terminated by sponsor, insufficient data collection
- eszopiclone / Generic mfg.
Phase classification: Treatment of Insomnia and Glucose Metabolism (clinicaltrials.gov) - Oct 22, 2015
P4, N=20, Completed, Sponsor: University of Chicago
Completed --> Terminated; Funding terminated by sponsor, insufficient data collection Phase classification: P=N/A --> P4
- zolpidem ER / Generic mfg., eszopiclone / Generic mfg.
Enrollment open: CIS2: Safety and Efficacy of Chronic Hypnotic Use 2 (clinicaltrials.gov) - Sep 14, 2015
P4, N=120, Recruiting, Sponsor: Henry Ford Health System
Phase classification: P=N/A --> P4 Not yet recruiting --> Recruiting
- ||||||| eszopiclone / Generic mfg.
Trial completion, Trial initiation date, Trial primary completion date, Head-to-Head: A Non-inferiority Study With Two Treatment Arms Eszopiclone 3 mg Versus Zopiclone 7.5 mg - for the Treatment of Insomnia (clinicaltrials.gov) - Aug 13, 2015
P3, N=263, Completed, Sponsor: Eurofarma Laboratorios S.A.
Not yet recruiting --> Recruiting Not yet recruiting --> Completed | Initiation date: May 2010 --> Mar 2011 | Trial primary completion date: May 2010 --> Mar 2012
- eszopiclone / Generic mfg.
Trial completion, Enrollment change, Combination therapy: Combination Therapy to Treat Sleep Apnea (clinicaltrials.gov) - Jul 22, 2015
P=N/A, N=22, Completed, Sponsor: Brigham and Women's Hospital
Not yet recruiting --> Completed | Initiation date: May 2010 --> Mar 2011 | Trial primary completion date: May 2010 --> Mar 2012 Recruiting --> Completed | N=60 --> 22
- | zolpidem ER / Generic mfg., eszopiclone / Generic mfg.
New P4 trial: CIS2: Safety and Efficacy of Chronic Hypnotic Use 2 (clinicaltrials.gov) - May 28, 2015
P4, N=120, Not yet recruiting, Sponsor: Henry Ford Health System
- ||| eszopiclone / Generic mfg.
New trial: Investigation of the Safety and Efficacy of Long Term Administration of Eszopiclone in Insomnia Patients (clinicaltrials.gov) - May 27, 2015
P=N/A, N=400, Active, not recruiting, Sponsor: Eisai Co., Ltd.
- ||| eszopiclone / Generic mfg.
New trial: Investigation of the Safety and Efficacy of Eszopiclone in Insomnia Patients (clinicaltrials.gov) - May 26, 2015
P=N/A, N=3300, Active, not recruiting, Sponsor: Eisai Co., Ltd.
- eszopiclone / Generic mfg.
Enrollment open, Trial primary completion date: AAPI: Auricular Acupuncture for Primary Insomnia (clinicaltrials.gov) - Feb 6, 2015
P=N/A, N=288, Recruiting, Sponsor: Chengdu University of Traditional Chinese Medicine
Recruiting --> Completed | N=60 --> 22 Not yet recruiting --> Recruiting | Trial primary completion date: Jun 2015 --> Dec 2015
- | eszopiclone / Generic mfg.
New P1 trial: Bioequivalence Study of Eszopiclone Tablets, 3 mg Under Fasting Conditions (clinicaltrials.gov) - Dec 23, 2014
P1, N=46, Completed, Sponsor: Dr. Reddy's Laboratories Limited
- | eszopiclone / Generic mfg.
New P1 trial: Bioequivalence Study of Eszopiclone Tablets, 3 mg Under Fed Conditions (clinicaltrials.gov) - Dec 23, 2014
P1, N=46, Completed, Sponsor: Dr. Reddy's Laboratories Limited
- | eszopiclone / Generic mfg.
Enrollment change: Eszopiclone Treatment & Cortisol Responsivity (clinicaltrials.gov) - Nov 4, 2014
P4, N=12, Completed, Sponsor: Butler Hospital
Not yet recruiting --> Recruiting | Trial primary completion date: Jun 2015 --> Dec 2015 N=15 --> 12
- eszopiclone / Generic mfg.
Trial primary completion date: Eszopiclone for the Treatment of Posttraumatic Stress Disorder (clinicaltrials.gov) - Oct 22, 2014
P4, N=40, Recruiting, Sponsor: Rush University Medical Center
N=15 --> 12 Trial primary completion date: Jun 2014 --> Jun 2015
- eszopiclone / Generic mfg.
Enrollment change: Effects of Eszopiclone on Sleep-dependent Learning in Schizophrenia (clinicaltrials.gov) - Sep 9, 2014
P=N/A, N=25, Completed, Sponsor: Massachusetts General Hospital
Trial primary completion date: Jun 2014 --> Jun 2015 N=45 --> 25
- eszopiclone / Generic mfg.
Trial completion: How do Sleeping Pills Affect Pain in the Brain? (clinicaltrials.gov) - Aug 5, 2014
P4, N=0, Completed, Sponsor: University of California, San Diego
N=45 --> 25 Recruiting --> Completed
- ||| eszopiclone / Generic mfg.
Enrollment change, Trial initiation date: Efficacy & Safety of Eszopiclone (Lunesta) in Nursing Home Patients (clinicaltrials.gov) - Jul 15, 2014
P4, N=71, Completed, Sponsor: Emory University
Recruiting --> Completed N=30 --> 71 | Initiation date: Jun 2006 --> Jun 2005
- eszopiclone / Generic mfg.
Trial completion: Insomnia and Osteoarthritis Study (clinicaltrials.gov) - Mar 9, 2014
P=N/A, N=64, Completed, Sponsor: Johns Hopkins University
N=30 --> 71 | Initiation date: Jun 2006 --> Jun 2005 Active, not recruiting --> Completed
- ramelteon / Generic mfg., eszopiclone / Generic mfg.
Trial completion: The Effect of Marijuana and Prescription Medications in Mood, Performance and Sleep (clinicaltrials.gov) - Dec 2, 2013
P1, N=36, Completed, Sponsor: Johns Hopkins University
Active, not recruiting --> Completed Active, not recruiting --> Completed
- eszopiclone / Generic mfg.
Trial completion: Effects of Eszopiclone on Sleep-dependent Learning in Schizophrenia (clinicaltrials.gov) - Oct 24, 2013
P=N/A, N=45, Completed, Sponsor: Massachusetts General Hospital
Active, not recruiting --> Completed Active, not recruiting --> Completed
- eszopiclone / Generic mfg.
Enrollment open: Sleep Effectiveness and Insulin and Glucose Homeostasis (clinicaltrials.gov) - Jun 24, 2013
P=N/A, N=48, Recruiting, Sponsor: Beth Israel Deaconess Medical Center
Active, not recruiting --> Completed Not yet recruiting --> Recruiting
- eszopiclone / Generic mfg.
Enrollment open: Effects of Eszopiclone on Sleep and Memory in Schizophrenia (clinicaltrials.gov) - May 28, 2013
P=N/A, N=80, Recruiting, Sponsor: Massachusetts General Hospital
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- ||| eszopiclone / Generic mfg.
Enrollment change: Study of the Insomnia in Patients With Low Back Pain (clinicaltrials.gov) - Apr 30, 2013
P4, N=58, Completed, Sponsor: Duke University
Not yet recruiting --> Recruiting N=140 --> 58
- |||| eszopiclone / Generic mfg.
Trial completion: Study of the Insomnia in Patients With Low Back Pain (clinicaltrials.gov) - Apr 30, 2013
P4, N=58, Completed, Sponsor: Duke University
N=140 --> 58 Recruiting --> Completed
- | eszopiclone / Generic mfg.
Enrollment change: Eszopiclone in the Treatment of Insomnia and Fibromyalgia (clinicaltrials.gov) - Feb 27, 2013
P4, N=36, Completed, Sponsor: University of Medicine and Dentistry of New Jersey
Recruiting --> Completed N=95 --> 36
- eszopiclone / Generic mfg.
Enrollment change: MVP#1: Mindfulness Versus Pharmacotherapy for Chronic Insomnia: A Pilot Study (clinicaltrials.gov) - Feb 19, 2013
P2/3, N=30, Completed, Sponsor: University of Minnesota - Clinical and Translational Science Institute
N=95 --> 36 N=40 --> 30
- ||||| eszopiclone / Generic mfg.
Enrollment change: A Phase II/III Study of SEP-190 (Eszopiclone) in Patients With Primary Insomnia (Study 190-126) (clinicaltrials.gov) - Dec 27, 2012
P2/3, N=192, Completed, Sponsor: Eisai Co., Ltd.
N=40 --> 30 N=70 --> 192