- |||||||||| Review, Journal: Menopause and Sleep Disorders. (Pubmed Central) - Jun 22, 2022
Hormone replacement therapy presently lacks concrete evidence to be used in menopausal women for sleep disorder. Sleep hygiene practices, self-hypnosis, meditation, and exercise play a very important role.
- |||||||||| eszopiclone / Generic mfg., trazodone ER / Generic mfg.
Trial completion date, Trial primary completion date: NAP: National Adaptive Trial for PTSD Related Insomnia (clinicaltrials.gov) - Jun 13, 2022
P3, N=1224, Recruiting,
Therefore, FDFs' technology could increase the therapeutic effect of Eszopiclone. Trial completion date: Jun 2024 --> Oct 2025 | Trial primary completion date: Jun 2024 --> Oct 2025
- |||||||||| Dayvigo (lemborexant) / Eisai, Belsomra (suvorexant) / Merck (MSD)
A UNIQUE CASE OF SEVERE SLEEP ONSET AND MAINTENANCE INSOMNIA FOLLOWING COVID-19 VACCINATION () - Jun 6, 2022 - Abstract #SLEEP2022SLEEP_1295;
As vaccination efforts continue worldwide, awareness of side effects from vaccines is paramount for clinicians facing the challenges in patient care.This case demonstrates that chronic insomnia can be a side effect of the COVID-19 vaccines. Therefore, further surveillance of patients and side effects from COVID-19 vaccination is warranted as insomnia can have significant clinical and psychosocial consequences.
- |||||||||| eszopiclone / Generic mfg.
EFFECTIVENESS OF A DIGITAL THERAPEUTIC COMPARED TO MEDICATIONS AND COGNITIVE BEHAVIORAL THERAPY FOR TREATING CHRONIC INSOMNIA IN ADULTS () - Jun 6, 2022 - Abstract #SLEEP2022SLEEP_1006;
Of 184 articles identified in a systematic literature review, 13 studies reported ISI mean change from baseline data: 1 using the digital therapeutic (DT) SHUTi (now known as the prescription digital therapeutic Somryst), 1 on the medication eszopiclone, and 11 on traditional CBT... The DT in this study was projected to be the most effective therapy on both mean change in ISI and ISI remission within 6-12 weeks of treatment start vs. either traditional CBT-I or medications.
- |||||||||| eszopiclone / Generic mfg., trazodone ER / Generic mfg., zaleplon / Generic mfg.
FIRST-LINE TREATMENT PATTERNS IN PATIENTS WITH INSOMNIA: A LARGE-SCALE, REAL-WORLD COHORT STUDY () - Jun 6, 2022 - Abstract #SLEEP2022SLEEP_995;
Additionally, more insomnia patients are discontinued from medical treatment than are switched to a different medicine. Further study is needed to determine what proportion of treatment discontinuation is due to successful treatment, versus being due to adverse events or lack of efficacy.
- |||||||||| eszopiclone / Generic mfg., zaleplon / Generic mfg.
POPULATION WAKEFULNESS AND NOCTURNAL SUICIDE RISK () - Jun 6, 2022 - Abstract #SLEEP2022SLEEP_638;
Fifteen years of data from suicides across the United States show a significantly increased risk for suicide during the circadian night that peaks at 3AM. Nocturnal wakefulness remains a significant risk factor for suicide, and suicide prevention efforts may benefit from interventions to reduce nocturnal wakefulness and/or an increase in prevention resources at this time.
- |||||||||| imatinib / Generic mfg.
Imatinib Promotes Reverse Cholesterol Transport And Elevates Sr-bi (Grand Ballroom ABC) - Jun 1, 2022 - Abstract #ATVBPVDGPM2022ATVB_PVD_GPM_457;
Furthermore, in wildtype C57Bl/6 mice on a high fat, high cholesterol diet, imatinib treatment (50mg/kg) was sufficient to decrease plasma total cholesterol, HDL-C and triglyceride levels and elevate hepatic SR-BI expression. In summary, our data supports the exploration of imatinib-mediated SR-BI regulation, HDL metabolism, and RCT pathway to identify new therapeutic targets for dyslipidemia.
- |||||||||| zolpidem ER / Generic mfg., eszopiclone / Generic mfg.
SLEEP ASSESSED BY ACTIGRAPHY DURING DISCONTINUATION OF CHRONIC HYPNOTIC USE (Richardson Ballroom B) - May 20, 2022 - Abstract #SLEEP2022SLEEP_480;
Most participants successfully discontinued hypnotic use when instructed to do so. While some degree of sleep disturbance returned, it never exceeded the baseline levels.
- |||||||||| zolpidem ER / Generic mfg., eszopiclone / Generic mfg.
BASELINE SLEEP DISTURBANCE AND INABILITY TO DISCONTINUE CHRONIC HYPNOTIC USE (Richardson Ballroom B) - May 20, 2022 - Abstract #SLEEP2022SLEEP_479;
The majority (85%) of the participants discontinued 6-month nightly hypnotic use (i.e. took < 6 total capsules over the 14 discontinuation nights) and among those taking capsules the rate declined from week 1 to 2. Baseline SE <81% may help identify those with difficulty discontinuing.
- |||||||||| Compulsive Cleaning, Bizarre Behavior, and Persecutory Delusions in a 63-Year-Old Woman With Schizoaffective Disorder Using Z-Drug Hypnotics () - May 5, 2022 - Abstract #APA2022APA_416;
Use of the z-drug hypnotic eszopiclone has shown some promise in this population for reducing insomnia severity [1]...R was a 63 year old with schizoaffective disorder, bipolar type, maintained in partial remission with no psychiatric hospitalizations for 11 years prior to presentation on haloperidol 10 mg BID, valproic acid 500 mg BID, and benztropine 1 mg BID, who was brought in by EMS after exhibiting bizarre threatening behavior, defecating on her neighbor’s lawn...R’s case, there were no changes to her psychotropic medication regimen before or after her admission to the hospital, aside from discontinuing zolpidem and starting hydroxyzine...The present report can be added to a growing list of reports describing adverse psychotic effects with zolpidem use. Moreover, it illustrates the importance in exploring all potential causes of psychosis in a patient with a primary psychotic disorder.
- |||||||||| eszopiclone / Generic mfg.
Enrollment open: ExPRESSION: Do Endotypes Predict Response and Sequelae in OSA Patients (clinicaltrials.gov) - Feb 24, 2022
P2, N=200, Recruiting,
Sedative-hypnotic use is common among persons who use opioids, which is concerning given the elevated mortality risk with concurrent use of these substances. Not yet recruiting --> Recruiting
- |||||||||| eszopiclone / Generic mfg.
Journal: Eszopiclone and Zolpidem Produce Opposite Effects on Hippocampal Ripple Density. (Pubmed Central) - Jan 29, 2022
In addition, eszopiclone led to a drastic decrease in spike firing, both in putative pyramidal cells and interneurons, while zolpidem did not substantially alter spiking. These results provide an explanation of the different effects of eszopiclone and zolpidem on memory in human studies and suggest that sleep medications can be used to regulate hippocampal ripple oscillations, which are causally linked to sleep-dependent memory consolidation.
- |||||||||| Dayvigo (lemborexant) / Eisai
Journal: Lemborexant for the Treatment of Insomnia: Direct and Indirect Comparisons With Other Hypnotics Using Number Needed to Treat, Number Needed to Harm, and Likelihood to Be Helped or Harmed. (Pubmed Central) - Dec 22, 2021
P3
Due to the addiction and tolerance, Z drugs should also be prescribed with great caution in middle-aged and elderly patients. Direct comparisons were made with zolpidem extended release (ER), and indirect comparisons were made with other hypnotic agents, including suvorexant, doxepin, ramelteon, zolpidem immediate release, eszopiclone, zaleplon, and selected benzodiazepines, using data from published reports and regulatory documents...Trial Registration:ClinicalTrials.gov identifiers: NCT02783729, NCT02952820.
- |||||||||| Belsomra (suvorexant) / Merck (MSD)
Journal, HEOR: Standardization of Hypnotic Agents for Prevention of Falls: A Pharmacoeconomic Study (Pubmed Central) - Dec 16, 2021
These results suggest that in order to prevent the incidence of falls by 1 case, it is necessary to increase costs by 12,086 yen which is the subthreshold cost for switching to the recommended medicine as standardization. The selection of recommended medicines may be a cost-effectiveness option compared with non-recommended medicines.
- |||||||||| gabapentin / Generic mfg.
Retrospective data, Review, Journal: Pharmacologic and hormonal treatments for menopausal sleep disturbances: A network meta-analysis of 43 randomized controlled trials and 32,271 menopausal women. (Pubmed Central) - Nov 24, 2021
Despite benefits of raloxifene-only [SMD = -1.86 (95% CI:-3.09-0.63)] and raloxifene-oral estrogen [SMD = -2.64 (95% CI:-4.64-0.63)], patient selection may be a confounder...Eszopiclone [RR = 3.84 (95% CI: 1.14-12.87)] and oral combined hormone therapy [RR = 2.51 (95% CI: 1.04-6.07)] were associated with higher rates of adverse event-related discontinuation. The results support combined estrogen-progesterone therapy for menopausal sleep disturbances associated with vasomotor symptoms but showed no significant effects of hypnotics in this clinical setting.
- |||||||||| zaleplon / Generic mfg.
Clinical, Review, Journal, Adverse events: Zolpidem: Efficacy and Side Effects for Insomnia. (Pubmed Central) - Nov 10, 2021
Even so, zolpidem could be a suitable pharmacological treatment for insomnia. Decisions for whether or not to prescribe it and the dosage should be made on a case-by-case basis, considering both the psychical and psychiatric risks posed to the patient with insomnia versus if the patient were to take zolpidem to treat their condition.
- |||||||||| eszopiclone / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date: ExPRESSION: Do Endotypes Predict Response and Sequelae in OSA Patients (clinicaltrials.gov) - Oct 13, 2021
P2, N=200, Not yet recruiting,
The effect of zolpidem and zaleplon on CPAP adherence requires further investigation by larger scale, randomized, controlled trials. Trial completion date: Jun 2026 --> Jan 2027 | Initiation date: Jun 2021 --> Jan 2022 | Trial primary completion date: Jun 2026 --> Jan 2027
- |||||||||| pravastatin / Generic mfg., zaleplon / Generic mfg., clopidogrel / Generic mfg.
Journal: Evaluation of serious bleeding signals during concomitant use of clopidogrel and hypnotic drugs. (Pubmed Central) - Jul 28, 2021
Trial completion date: Jun 2026 --> Jan 2027 | Initiation date: Jun 2021 --> Jan 2022 | Trial primary completion date: Jun 2026 --> Jan 2027 While we could not confirm or refute previously identified DDI signals, numerically elevated RRRs for serious bleeding with several clopidogrel + hypnotic pairs warrant further examination.
- |||||||||| eszopiclone / Generic mfg., trazodone ER / Generic mfg.
Clinical, Journal: Case report of acute liver injury caused by the eszopiclone in a patient with chronic liver disease. (Pubmed Central) - Jul 3, 2021
Patients with chronic hepatitis B or C may have a threefold risk of liver dysfunction after receiving antituberculosis treatment.[1,2] A proinflammatory environment induced by actively replicating the hepatitis virus may alter the detoxication process and increase drug toxicity.[3] At this time, the safety of other drugs should be reevaluated. Although hepatitis and liver injury are listed as rare adverse reactions of eszopiclone, this case is the first to report the eszopiclone-involved acute liver injury.
- |||||||||| trazodone ER / Generic mfg., zaleplon / Generic mfg.
Journal: Prescription medications for insomnia are associated with suicidal thoughts and behaviors in two nationally representative samples. (Pubmed Central) - Jul 1, 2021
Z-drugs (eszopiclone, zolpidem, and zaleplon) are commonly used for insomnia but are also associated with suicide risk...Associations of Z-drugs, trazodone, and sedative benzodiazepines (temazepam, triazolam, flurazepam) with suicidal ideation, planning, and attempts were estimated using binomial logistic regression...In the NHANES, Z-drugs were associated with suicidal ideation (OR 2.44 [1.41-4.22], as was trazodone(OR 2.33 [1.45-3.75]), after adjusting for age, sex, race/ethnicity, and exposure to various psychotropic medications. Multiple classes of prescription insomnia medications are associated with suicidal thinking and behaviors, even after adjusting for measures of mental health.
- |||||||||| Silenor (doxepin) / Currax
Retrospective data, Review, Journal: Comparative Efficacy and Safety of Hypnotics for Insomnia in Older Adults: A Systematic Review and Network Metaanalysis. (Pubmed Central) - May 22, 2021
Considering study quality and the potential adverse effects of benzodiazepines and nonbenzodiazepines, low-dose doxepin seems to be the optimal pharmacotherapy for the improvements of total sleep time and sleep efficiency. Future randomized controlled trials investigating the treatment effects of hypnotics, particularly low-dose doxepin, on insomnia in older adults are warranted.
- |||||||||| eszopiclone / Generic mfg.
Preclinical, Journal: The dual orexin receptor antagonist DORA-22 improves mild stress-induced sleep disruption during the natural sleep phase of nocturnal rats. (Pubmed Central) - May 20, 2021
Rats were administered DORA-22 or the GABA receptor-targeting hypnotic eszopiclone early in the light period, then exposed to six hourly clean cage changes with measurements of NREM sleep onset latency...The lowest dose (1mg/kg) did not decrease sleep onset latency at the six-hour timepoint, suggesting no residual hypersomnolence. We described here DORA-22 hypnotic efficacy during the normal sleep period of nocturnal rats, and demonstrate that well-chosen (low) hypnotic doses of DORA-22 may be hypnotically effective yet have minimal lingering effects.
- |||||||||| eszopiclone / Generic mfg.
[VIRTUAL] A Ghost from the Past: Unmasked Insomnia Affecting Hypoglossal Nerve Stimulation Therapy Adherence () - May 17, 2021 - Abstract #SLEEP2021SLEEP_1075;
He was diagnosed with recurrent chronic insomnia, for which eszopiclone was initiated without significant improvement...Our center is now routinely screening for a history of insomnia to identify patients who may benefit from treatment prior to HNS implantation. Larger studies are needed to explore a possible relationship between insomnia and HNS adherence.
- |||||||||| zaleplon / Generic mfg.
[VIRTUAL] Opioid Use and Abuse are Associated with Use of Sedative Hypnotic Medications () - May 17, 2021 - Abstract #SLEEP2021SLEEP_597;
Conclusion Individuals who use or abuse opioids are significantly more likely to receive a sedative-hypnotic medication, a finding that is of concern and one that also suggests that sleep disturbance is common in this population. Further research is needed to determine the underlying nature and prevalence of sleep continuity disturbances in this population.
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