Ongoing

4

315

Europe

Methotrexate, Sulfasalazine, Leflunomide, Humira, N/A, Tablet, Injection, Methotrexate, Salazopyrin EN, Arava, Humira

University of Oxford, NIHR

Physical Inactivity , Poor dietary behaviour , Obesity , Overweight

 

 

Completed

4

320

 

leflunomide 10mg,orally taken once daily for 24 weeks ;leflunomide 50mg, orally taken weekly for 24 weeks

People's Hospital, Peking University; Ministry of Science and Technology of China, National Key Technologies R&D Program

Rheumatoid arthritis

 

 

Completed

4

280

 

TGP capsules (TGP) + methotrexate (MTX) + leflunom ;methotrexate(MTX) + leflunomide (LEF)

Anhui Provincial Hospital Department of Rheumatism; Ningbo Lihua Pharmaceutical Company Limited, Ningbo Lihua Pharmaceutical Company Limited

Rheumatoid Arthritis

 

 

Completed

4

60

 

CTX 10-15mg/kg, 2, 4, 6, 9, 12, 18, 24month ;MMF1.5-2.0g/d, reduced by 500mg every 3 months from ;Leflunomide 20mg/d, reduced by 10mg every 3 months

Shanghai Jiaotong University Affiliated Ruijin Hospital; Level of the institution：, Shanghai Jiaotong University Affiliated Ruijin Hospital

ANCA Associated Systemic Vasculitis with renal involvement in remission

 

 

Ongoing

4

15

Europe

Mabthera, Arava, Solu-Medrone 2mg, Rituximab, Leflunomide, Methylprednisolone, Mabthera, Arava, Solu-Medrone 2 Gram, Mabthera, Arava, Solu-Medrone 2 Gram

University of Leeds

Active Rheumatoid Arthritis

 

 

Ongoing

4

100

Europe

Arava 20 mg filmdragerade tabletter, Arava 20 mg filmdragerade tabletter

Karolinska Universitetssjukhuset

BK Virusinfektion vid Njurtransplantation

 

 

Completed

4

60

 

LEF combined with prednisone ;yclophosphamide (CTX) combined with prednisone

Department of Nephrology, The First Affiliated Hospital of Bengbu Medical College; The First Affiliated Hospital of Bengbu Medical College, Bengbu Medical College Natural Science Project

f PLA2R-associated primary membranous nephropathy

 

 

Recruiting

4

315

Europe

Methotrexate, Sulfasalazine, Leflunomide, Adalimumab

University of Oxford

Psoriatic Arthritis

08/24

02/25

Not yet recruiting

4

1000

 

None ;Adalimumab tapering combined with methotrexate therapy. The recommended dosage of adalimumab is as follows: Adalimumab, 40 mg/2 weeks, subcutaneous injection, reduce the dose after full dose treatment after reaching low disease activity. The dose reduction is carried out as follows: to extend the duration of administration and limiting the maximum duration of administration interval to 6 weeks (it is recommended to extend the duration of administration interval to 3, 4 or 6 weeks). The recommended dose of methotrexate is as follows: Methotrexate, taken orally, 10-30 mg once a week. ;triple therapy is applied. According to the patient's condition and willingness of patients, three traditional synthetic anti-rheumatic drug combination treatment could be applied, including but not limited to: methotrexate, leflunomide, sulfasalazine, hydroxychloroquine, etc. Recommended usage and dosage are as follows: Methotrexate, oral, 10-30 mg each time, once a week; Leflunomide, 10-20 mg once daily; Sulfasalazine, orally, 500 mg-1,000 mg each time, 3-4 times a day; Hydroxychloroquine, orally, 0.2 g to 0.4 g, once a day.

The First Affiliated Hospital of Chengdu Medical College; The First Affiliated Hospital of Chengdu Medical College, Self-funded

rheumatoid arthritis

 

 

Recruiting

4

400

RoW

Iguratimod, IGU, T-614, Methotrexate, MTX, Adalimumab Injection, adalimu, Leflunomide, LEF, Hydroxychloroquine, HCQ

Qilu Hospital of Shandong University

Arthritis, Rheumatoid

06/25

12/26

Ongoing

3

30

Europe

Leflunomide mylan, Plaquenil, Capsule, Leflunomide Mylan, Plaquenil

UMC Utrecht, ZonMw

Sjogren's Syndrome Syndroom van Sjogren, Sjogren's Syndrome Syndroom van Sjogren, Diseases [C] - Immune System Diseases [C20]

 

 

Not yet recruiting

3

200

 

Oral leflunomide ;Oral placebo

Renmin Hospital of Wuhan University; Renmin Hospital of Wuhan University, Science and technology department of Hubei province

Novel Coronavirus Pneumonia (COVID-19)

 

 

Completed

3

178

Europe

leflunomide

Ashford and St. Peter's Hospitals NHS Trust

COVID-19

07/22

07/22

Recruiting

3

60

 

Oral leflunomide + Symptomatic treatment ;Symptomatic treatment

Renmin Hospital of Wuhan University; Renmin Hospital of Wuhan University, self-raised

Novel Coronavirus Infected (COVID-19)

 

 

Recruiting

3

270

Europe

Prednisolone, Prednisolone generic drugs, Sulfasalazine, Azulfidine, Leflunomide, Arava, Methotrexate, Lantarel, Metex, Tofacitinib, Xeljanz, Apremilast, Otezla, Etanercept, Enbrel, Erelzi, Benepali, Adalimumab, Humira, Amgevita, Imraldi, Hyrimoz, Infliximab, Remicade, Zessly, Inflectra, Certolizumab pegol, Cimzia, Golimumab, Simponi, Abatacept, Orencia, Secukinumab, Cosentyx, Ixekizumab, Taltz, Ustekinumab, Stelara

University of Erlangen-Nürnberg Medical School

Psoriatic Arthritis, Withdrawal, Reduction

10/24

10/25

Recruiting

3

400

US

Methotrexate, Methotrexate (MTX), Abatacept, Orencia, Adalimumab, Humira, Azathioprine, Imuran, Baricitinib, Olimuant, Certolizumab, Cimzia, Etanercept, Enbrel, Golimumab, Simponi, Hydroxychloroquine, Plaquenil, Infliximab, Remicade, Leflunomide, Arava, Minocycline, Minocin, Rituximab, Rituxin, Sarilumab, Kevzara, Sulfasalazine, Azulfidine, Tofacitinib, Xeljanz

University of Nebraska

Rheumatoid Arthritis

03/27

03/28

Active, not recruiting

2/3

70

RoW

Cilostazol 100 MG, conventional synthetic antirheumatic drugs

Ain Shams University, Misr International University, Al-Azhar University

Rheumatoid Arthritis

10/24

10/24

Completed

2

240

 

Tu Fu Ling Tablets, 200mg Bid. Other: Placebo ;Tu Fu Ling Tablets, 100mg Tid. Other: Placebo. ;Leflunomide Tablets, 20mg Qd. Other: Placebo

The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine; Jingxiutang Pharmaceutical Company Ltd., Guangzhou, China., Jingxiutang Pharmaceutical Company Ltd., Guangzhou, China.

Rheumatoid Arthritis

 

 

Ongoing

2

52

Europe

Leflunomide, Hydroxychloroquine, Film-coated tablet, Tablet, Leflunomide, Plaquenil

University Medical Center Utrecht, ZonMw

Primary Sjogren Syndrome, Primary Sjogren Syndrome, Diseases [C] - Immune System Diseases [C20]

 

 

Completed

2

92

RoW

Montelukast, Placebo, Conventional DMARDs

Noha Mansour

Rheumatoid Arthritis

12/22

12/22

Completed

2

1

US

Leflunomide, Arava, SU101

City of Hope Medical Center, National Cancer Institute (NCI)

Recurrent Lymphoproliferative Disorder, Refractory Lymphoproliferative Disorder

07/21

07/21

Recruiting

2

70

RoW

Nicotinamide Tablet, conventional synthetic antirheumatic drugs

Ain Shams University

Rheumatoid Arthritis

06/25

06/25

Recruiting

2

29

US

Dexamethasone, Aacidexam, Adexone, Aknichthol Dexa, Alba-Dex, Alin, Alin Depot, Alin Oftalmico, Amplidermis, Anemul mono, Auricularum, Auxiloson, Baycadron, Baycuten, Baycuten N, Cortidexason, Cortisumman, Decacort, Decadrol, Decadron, Decadron DP, Decalix, Decameth, Decasone R.p., Dectancyl, Dekacort, Deltafluorene, Deronil, Desamethasone, Desameton, Dexa-Mamallet, Dexa-Rhinosan, Dexa-Scheroson, Dexa-sine, Dexacortal, Dexacortin, Dexafarma, Dexafluorene, Dexalocal, Dexamecortin, Dexameth, Dexamethasone Intensol, Dexamethasonum, Dexamonozon, Dexapos, Dexinoral, Dexone, Dinormon, Fluorodelta, Fortecortin, Gammacorten, Hexadecadrol, Hexadrol, Lokalison-F, Loverine, Methylfluorprednisolone, Millicorten, Mymethasone, Orgadrone, Spersadex, TaperDex, Visumetazone, ZoDex, Leflunomide, Arava, SU101, Pomalidomide, 4-Aminothalidomide, Actimid, CC-4047, Imnovid, Pomalyst

City of Hope Medical Center, National Cancer Institute (NCI)

Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma

02/27

02/27

Recruiting

2

60

RoW

Carnitine, Disease-modifying anti-rheumatic drugs

German University in Cairo

Rheumatoid Arthritis (RA)

06/25

06/25

Completed

1/2

12

US

Laboratory Biomarker Analysis, Leflunomide, Arava, SU101, Pharmacological Study

City of Hope Medical Center, National Cancer Institute (NCI)

Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma

09/18

06/22

Recruiting

1/2

54

US

Leflunomide, Arava

Joseph Sparano

Breast Neoplasms, Breast Diseases, Metastatic Triple Negative Breast Cancer

10/25

10/26

Completed

1

120

 

observation group: Leflunomide Tablets, from the first day to the third day, 50mg, qd, po, then 20mg, qd, po. Ligustrazine Powder-Needle, 0.12g, solubling in 5% GS/NS 100ml, qd, iv, in 30 to 60 minutes. ;control group: Leflunomide Tablets, from the first day to the third day, 50mg, qd, po, then 20mg, qd, po.

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences; Level of the institution：, Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences

Rheumatoid Arthritis

 

 

Completed

1

92

RoW

Telitacicept, RC18, standard therapy

RemeGen Co., Ltd.

Systemic Lupus Erythematosus

10/23

11/23

Completed

1

60

 

Local fumigation with traditional Chinese medicine prescription; Methotrexate tablets combined with leflunomide tablets for oral treatment

Jiangxi Provincial People's Hospital; Jiangxi Provincial People's Hospital, Science and Technology Plan of Jiangxi Provincial Administration of Traditional Chinese Medicine

(rheumatoid arthritis)

 

 

Recruiting

1

19

US

Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Cholestyramine, Cholybar, Colestyramine, Duolite AP143 Resin, Questran, Questran Light, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Diagnostic Imaging, Medical Imaging, Gemcitabine, dFdC, dFdCyd, Difluorodeoxycytidine, Leflunomide, Arava, SU101, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI

City of Hope Medical Center, National Cancer Institute (NCI)

Advanced Pancreatic Adenocarcinoma, Stage III Pancreatic Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8, Unresectable Pancreatic Ductal Adenocarcinoma

11/26

11/26

Recruiting

1

18

US

Cholestyramine, Cholybar, Colestyramine, Duolite AP143 Resin, Questran, Questran Light, Leflunomide, Arava, SU101, Steroid Therapy

City of Hope Medical Center, National Cancer Institute (NCI)

Acute Graft Versus Host Disease, Hematopoietic and Lymphoid System Neoplasm

07/25

07/25

Recruiting

N/A

30

 

Tofacitinib 5mg twice a day and Methotrexate 10mg once a week ;Leflunomide 20mg once a day and Methotrexate 10mg once a week

Yuyao People's Hospital; Yuyao People's Hospital, salf-paying

psoriatic arthritis

 

 

Completed

N/A

120

 

Methotrexate 10mg qw PO + Leflunomide 10mg qd PO ;M+L+SEA+ZJSM

Institute of Acupuncture-Moxibustion and Meridian, Shanghai University of Traditional Chinese Medicine; Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Development of Chinese medicine in Shanghai three-year action plan

rheumatoid arthritis

 

 

Recruiting

N/A

90

 

The level of SELSNA-SLEDAI was evaluated at week 4, week 12 and week 24, the BILAG table, the SLE lesion index, and the SLE damage index were measured at 4 weeks, 12 weeks and 24 weeks. The levels of Th17, Treg and Th17 / Treg were measured. ;Leflunomide tablets 10m, 1 times / day, orally. The SELSNA-SLEDAI score table, BILAG worksheet, SLE damage index score were assessed at week 4, week 12 and week 24, and serum Th17, Treg and Th17 / Treg ratios were measured. ;0 weeks to give prednisone acetate tablets 0.5-1mg / kg.d (or patients can choose to take the same dose of methylprednisolone tablets), 4 weeks after the beginning of the dose by 2 weeks to reduce the regular dose of 10% Reduction to prednisone acetate tablets 10mg / day to maintain. ;All patients without contraindications plus hydroxychloroquine tablets 0.2,2 / day, orally; and according to the condition plus calcium (800-1200mg / day), vitamin D (200-800IU / day) and other treatment.

The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology; The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Self-raised

Primary mild to moderate systemic systemic lupus erythematosus

 

 

Not yet recruiting

N/A

80

 

Leflunomide ;Chinese herbalshentongzhuyudecoction

The First Affiliated Hospital of Heilongjiang Chinese Medicine Colledge; The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Self sponsored and department sponsored

Ankylosing spondylitis

 

 

Recruiting

N/A

72

 

Yiyisise ointment, Methotrexate, Leflunomide tablets and Folic acid tablets ;Yiyisise ointment simulant, Methotrexate, Leflunomide tablets and Folic acid tablets

Yunnan Hospital of Traditional Chinese Medicine; Yunnan Provincial Hospital of Traditional Chinese Medicine/The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Science and Technology Department of Yunnan Province

Rheumatoid arthritis

 

 

Recruiting

N/A

72

 

Rebi ointment, Methotrexate tablets, Leflunomide tablets, and Folic acid tablets ;Rebi cream simulant, Methotrexate tablets, Leflunomide tablets, and Folic acid tablets

Yunnan Provincial Hospital of Traditional Chinese Medicine/The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine; Yunnan Provincial Hospital of Traditional Chinese Medicine/The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Science and Technology Department of Yunnan Province

Rheumatoid Arthritis

 

 

Recruiting

N/A

93

 

Juanbi granule, Prednisone Acetate Tablets, Methotrexate and Leflunomide ;Prednisone Acetate Tablets, Methotrexate and Leflunomide

Yunnan Hospital of Traditional Chinese Medicine /The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine; Medical Ethics Committee of Yunnan Traditional Chinese Medicine Hospital, Science and Technology Department of Yunnan Province

rheumatoid arthritis

 

 

Completed

N/A

100

 

All patients were routinely treated with methotrexate (MTX), leflunomide, and nonsteroidal anti-inflammatory drugs.; Methotrexate (MTX), leflunomide, and non-steroidal anti-inflammatory drugs were routinely given. The anti-HP group was additionally given anti-HP treatment. The drugs used were: amoxicillin 1.0g, twice a day, clarithromycin 0.5 g,2 times a day, omeprazole 20 mg,2 times a day,2 weeks of treatment.; The control group did not use antibiotics or bismuth during the study period.

Qingdao Traditional Chinese Medicine Hospital; Qingdao Traditional Chinese Medicine Hospital, unit matching

Rheumatoid Arthritis

 

 

Recruiting

N/A

60

RoW

Prednisone and Mycophenolate Mofetil, Mycophenolate Mofetil, Leflunomide

Peking Union Medical College Hospital

Autoimmune Diseases

12/24

12/24

Recruiting

N/A

60

 

Prednisone acetate, Methotrexate, Leflunomide, Yupingfeng cassia branch granules ;Prednisone acetate, Leflunomide, Methotrexate

The First Affiliated Hospital of Yunnan University of Chinese Medicine; Yunnan Hospital of Traditional Chinese Medicine, Research fund

Rheumatoid arthritis

 

 

Not yet recruiting

N/A

70

 

Follow up every 12 weeks to evaluate the Treatment to Target. If not reach the target, first increase the TNFi dose to the standard dose, and then adjust the csDMARDs (including methotrexate, Tripterygium wilfordii, Iguratimod, leflunomide, hydroxychloroquine, and sulfasalazine); If reach the target, the TNFi was reduced and maintained until the maintenance dose was achieved. The order of reduction was YSP/ETA 50mg QW, 25mg QW, 25mg Q2W (maintenance dose), ADA 40mg Q2W, Q3W, Q4W (maintenance dose), and csDMARDs remained unchanged.; Follow up every 12 weeks to evaluate the Treatment to Target. If not reach the target, first increase the TNFi dose to the standard dose, and then adjust the csDMARDs (including methotrexate, Tripterygium wilfordii, Iguratimod, leflunomide, hydroxychloroquine, and sulfasalazine); If reach the target, the TNFi was reduced and maintained until the maintenance dose was achieved. The order of reduction was YSP/ETA 50mg QW, 25mg QW, 25mg Q2W (maintenance dose), ADA 40mg Q2W, Q3W, Q4W (maintenance dose), and csDMARDs remained unchanged.

Beijing Hospital; Beijing Hospital, National High Level Hospital Clinical Research Funding

rheumatoid arthritis

 

 

Not yet recruiting

N/A

3500

Europe

Leflunomide, ARAVA®

Sanofi

Rheumatoid Arthritis, Psoriatic Arthritis

07/25

07/25

Recruiting

N/A

50

RoW

Everolimus, reduced dose tacrolimus

King Chulalongkorn Memorial Hospital

Kidney Transplant Infection, BK Virus Infection

09/25

Not yet recruiting

N/A

188

 

Tripterygium glycoside tablets alone; Tripterygium glycoside tablets + methotrexate tablets; Tripterygium glycoside tablets + leflunomide tablets; Tripterygium glycoside tablets + hydroxychloroquine sulfate tablets

Dongzhimen Hospital, Beijing University of Chinese Medicine; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing Tongzhou district science and technology plan project

Rheumatoid arthritis

 

 

Recruiting

N/A

36

RoW

Leflunomide

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Henoch-Schonlein Purpura

06/27

06/27

Recruiting

N/A

500

RoW

YISAIPU® ( An etanercept biosimilar), a recombinant tumor necrosis factor receptor-Fc fusion protein, rhTNFR:Fc, csDMARDs

The First Affiliated Hospital of Xiamen University

Rheumatoid Arthritis

06/25

12/25