leflunomide / Generic mfg. 
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 88 Diseases   68 Trials   68 Trials   2888 News 


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  • ||||||||||  sirolimus / generics, leflunomide / generics
    Autophagy inhibition enhances leflunomide-induced cytotoxicity in human bladder cancer cells (Poster Area (Hall 4)) -  Sep 11, 2019 - Abstract #ESMO2019ESMO_1398;    
    In addition, cell autophagy was demonstrated to be involved, combination leflunomide with autophagy modifier exerted enhanced antitumor effects in bladder cancer, which offered novel ideas for bladder cancer treatment. Legal entity responsible for the study: The author.
  • ||||||||||  leflunomide / Generic mfg.
    Trial completion date, Trial primary completion date:  Leflunomide in Treating Patients With Relapsed or Refractory Multiple Myeloma (clinicaltrials.gov) -  Sep 6, 2019   
    P1/2,  N=39, Active, not recruiting, 
    It can be proposed that γCD-MOF can be considered as novel strategy for delivery of leflunomide. Trial completion date: Jun 2019 --> May 2022 | Trial primary completion date: Jun 2019 --> Sep 2018
  • ||||||||||  Rituxan (rituximab) / Roche, Biogen
    Retrospective analysis of chronic relapsing inflammatory optic neuropathy (Poster Exhibition) -  Aug 28, 2019 - Abstract #ECTRIMS2019ECTRIMS_1331;    
    Variation in presentation, clinical course, and treatment response is apparent in our cohort. Vigilance is needed to identify CRION patients and treat them appropriately.
  • ||||||||||  teriflunomide / Generic Mfg.
    Effect of teriflunomide in serum urate and phosphate in RMS patients (Poster Exhibition) -  Aug 28, 2019 - Abstract #ECTRIMS2019ECTRIMS_1126;    
    After discontinuing treatment SUA levels increase in the first 2 months. Also, teriflunomide decrease phosphate plasma levels, without changing calcium levels, in 100% of patients in the first 12-24 weeks.
  • ||||||||||  Journal:  Drug-associated pulmonary arterial hypertension. (Pubmed Central) -  Aug 28, 2019   
    Despite several agents being implicated in the development of PAH, the supportive evidence is typically limited, based on case series and observational data. Furthermore, even in the drugs with relatively strong associations, factors that predispose an individual to PAH have yet to be elucidated.
  • ||||||||||  Kevzara (sarilumab) / Asahi Kasei, Regeneron, Sanofi
    Trial completion, Enrollment change, Patient reported outcomes:  SariPRO: Effect of Sarilumab on Patient-reported Outcomes in Patients With Active Rheumatoid Arthritis (clinicaltrials.gov) -  Aug 28, 2019   
    P4,  N=84, Completed, 
    Furthermore, even in the drugs with relatively strong associations, factors that predispose an individual to PAH have yet to be elucidated. Active, not recruiting --> Completed | N=140 --> 84
  • ||||||||||  hydroxychloroquine / Generic Mfg., hydroxychloroquine / VG Lifesciences
    Journal:  Determinants of non-nociceptive pain in Rheumatoid Arthritis. (Pubmed Central) -  Aug 23, 2019   
    Greater structural damage, increased disease duration and ACPA positivity did not seem to increase the odds of NP. Possible association of NP and underlying csDMARD treatment was uncovered.
  • ||||||||||  prednisone / generics, methotrexate / generics, leflunomide / generics
    Journal:  Rheumatoid arthritis seems to have DMARD treatment decision influenced by fibromyalgia. (Pubmed Central) -  Aug 23, 2019   
    RA patients with FM used more leflunomide and prednisone, and RA mistreatment was more frequent in FM patients. Certainly, RA patients with FM will benefit from a personalized T2T strategy, including ultrasound (when suitable) and proper FM treatment.
  • ||||||||||  hydroxychloroquine / Generic Mfg., hydroxychloroquine / VG Lifesciences
    Review, Journal:  Optimizing conventional DMARD therapy for Sjögren's syndrome. (Pubmed Central) -  Aug 23, 2019   
    Certainly, RA patients with FM will benefit from a personalized T2T strategy, including ultrasound (when suitable) and proper FM treatment. No abstract available
  • ||||||||||  leflunomide / generics
    Journal:  Phylogeography and Molecular Species Delimitation of Pratylenchus capsici n. sp., a New Root-Lesion Nematode in Israel on Pepper (Capsicum annuum). (Pubmed Central) -  Aug 21, 2019   
    ...Here, we report on a new species, Pratylenchus capsici n. sp., from the Arava rift, Israel, which was characterized by integrative methods, including detailed morphology, molecular phylogeny, population genetics, and phylogeography...We found high cytochrome oxidase subunit I haplotype diversity, and phylogeography analysis suggests that contemporary gene flow is prevented among different agricultural farms, while population dispersal from weeds (Chenopodium album and Sonchus oleraceus) to pepper occurs on a relatively small scale. Our results suggest that weeds are important reservoir for the dispersal of P. capsici n. sp., either as the original nematode source or at least in maintaining the population between growing seasons.
  • ||||||||||  prednisolone / generics, methotrexate / generics, leflunomide / generics
    Journal:  Hepatic manifestation of a macrophage activation syndrome (MAS) (Pubmed Central) -  Aug 17, 2019   
    Under therapy with prednisolone, the fever disappeared and transaminases and ferritin rapidly normalized. Conclusion Aside from the frequent causes of elevated liver values in younger patients, such as nutritive toxic, drug induced liver injury, viral or autoimmune hepatitis, especially in case of massive hyperferritinemia, a MAS should be considered as a rare cause of acute liver disease.
  • ||||||||||  leflunomide / generics
    Preclinical, Journal:  Control of hyperglycemia in male mice by leflunomide: mechanisms of action. (Pubmed Central) -  Aug 17, 2019   
    Leflunomide treatment increased AKTphosphorylation in the fat and muscle ofmice but not in normal mice. Our results suggest that leflunomide sensitizes the insulin receptor by inhibiting S6K1 activity, and that leflunomide could be potentially useful for treating patients with both RA and diabetes.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    A Case of CMV Colitis Seen in DRESS (Exhibit Halls 3 and 4 (Street Level)) -  Aug 8, 2019 - Abstract #ACG2019ACG_1557;    
    Owl’s eye inclusion bodies on staining are highly specific for infection with CMV. The gastrointestinal tract is thought to contain latent CMV after a primary infection This case highlights the importance of recognizing the risks of long term medical treatment with immunomodulatory drugs such as leflunomide or corticosteroids, including local reactivation of a latent virus as in our patient.
  • ||||||||||  leflunomide / generics
    Journal:  Microbial Diversity in an Arid, Naturally Saline Environment. (Pubmed Central) -  Jul 19, 2019   
    The Arava Valley in is a rock desert within the Great African Rift valley...Even if taxonomic resolution of the 16S rRNA gene V4 region for Archaea is limited, this study indicates the need of further and more detailed studies of Archaea. By using culture-dependent analysis, bacteria of the order Bacillales as well as archaea from all three halobacterial orders Halobacteriales, Haloferacales, and Natrialbales including potentially novel species from the genera Halorubrum and Haloparvum were isolated.
  • ||||||||||  Tai'ai (telitacicept) / Rongchang Pharma
    Enrollment closed, Enrollment change:  Study of RC18 Administered Subcutaneously to Subjects With Systemic Lupus Erythematosus(SLE) (clinicaltrials.gov) -  Jul 18, 2019   
    P2b,  N=249, Active, not recruiting, 
    By using culture-dependent analysis, bacteria of the order Bacillales as well as archaea from all three halobacterial orders Halobacteriales, Haloferacales, and Natrialbales including potentially novel species from the genera Halorubrum and Haloparvum were isolated. Recruiting --> Active, not recruiting | N=160 --> 249
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, Allergan
    Preclinical, Journal:  Xinfeng capsule improves pulmonary function of rats with rheumatoid arthritis by inhibiting PKC/NF-κB pathway (Pubmed Central) -  Jul 17, 2019   
    ...Methods Rats were divided into normal control(NC) group, model control(MC) group, XFC group, and leflunomide group (LEF)...Ras-associated C3 botoxin substrate 1 (Rac-1), PKC, NF-κBp65 mRNA were detected by real-time quantitative PCR...Compared with the MC group, the expression of PKC, NF-κBp65 and Rac-1 decreased in the XFC group. Conclusion XFC improves the lung function by inhibiting the PKC/NF-κB pathway and balancing the cytokine network.
  • ||||||||||  leflunomide / generics
    Journal:  Spatiotemporal variations in soil cultivable mycobiota at the Arava desert (Israel) along latitudinal and elevational gradients. (Pubmed Central) -  Jul 12, 2019   
    The mycobiota characteristics such as species composition, contribution of major groupings to mycobiota structure, diversity level, and isolate density showed significant correlations with measured edaphic parameters-organic matter content, water content, pH, and especially, with electrical conductivity. Among the environmental aspects, locality position along altitudinal and latitudinal gradients accompanied by locality type (open sun-exposed or under shrubs), strongly influenced the community's characteristics, thus demonstrating the effect of the unique altitudinal position of the northern part of the Arava Valley as well as the ability of microfungal communities to be sensitive to the microscale environmental variability.
  • ||||||||||  cisplatin / generics, rifampicin / generics
    Journal:  The Involvement of Pregnane X Receptor-regulated Pathways in the Antitumor Activity of Cisplatin. (Pubmed Central) -  Jul 11, 2019   
    These results suggest that PXR can modify the antitumor activity of CDDP, presumably through regulating the expression of transporters, which control intracellular CDDP concentration. Thus, PXR antagonists can be further investigated as potential drugs capable of overcoming CDDP resistance.