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- || leflunomide / Generic mfg.
Seasoned surgeons & educators: Early career surgeons would benefit from your advice and guidance on this #CTCareers chat tonight. Please join us! @AraVaporciyan @jdoningtonmd @DouglasEWood1 @roberthiggins32 @Jasosamd @leahbackhusmd @ShandaBlackmon @BadhwarVinay @DavidCookeMD (Twitter) - Feb 26, 2020
- Rituxan (rituximab) / Roche, Biogen, Zenyaku Kogyo
Safety and efficacy of combining biological therapies together or with small molecules in patients with Inflammatory Bowel Disease: a retrospective multicenter national observational case series study. (Room TEUN) - Feb 24, 2020 - Abstract #BWG2020BWG_85;
Conclusions In our experience, combination of biologics in patients with IBD +/- another IMID was associated with short term increased efficacy in almost half of patients but also with a risk of infections in one third. No new safety signals was observed in this difficult to treat patients but extensive data are urgently needed.
- | Journal: Serum free amino acid levels in rheumatoid arthritis according to therapy and physical disability. (Pubmed Central) - Feb 24, 2020
The obtained results are not accidental (p value less than 0.05), and all of the selected amino acids play an important role in inflammation and immune response. It is suggested that studied amino acids can be considered as a markers for diagnosis of RA and monitoring pharmacotherapy of the disease.
- | leflunomide / Generic mfg.
Journal: Targeting the CRP-HIF1α axis in RA improves response to leflunomide. (Pubmed Central) - Feb 24, 2020
It is suggested that studied amino acids can be considered as a markers for diagnosis of RA and monitoring pharmacotherapy of the disease. No abstract available
- | leflunomide / Generic mfg.
Journal: HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis. (Pubmed Central) - Feb 21, 2020
Hepatocyte-specific HIF1α deletion or a HIF1α inhibitor Acriflavine re-activates Leflunomide-AHR-CRP signaling to inhibit bone erosion. This study presents a precision medicine-based therapeutic strategy for RA.
- | Journal: Long-term breastfeeding influences disease activity in a low-income juvenile idiopathic arthritis cohort. (Pubmed Central) - Feb 20, 2020
Breastfeeding over 6 months was associated with less disease activity. Key Point • Long-term breastfeeding benefits juvenile idiopathic arthritis.
- | benazepril / Generic mfg., leflunomide / Generic mfg.
Preclinical, Journal: Combination of leflunomide and benazepril reduces renal injury of diabetic nephropathy rats and inhibits high-glucose induced cell apoptosis through regulation of NF-κB, TGF-β and TRPC6. (Pubmed Central) - Feb 20, 2020
It was also observed leflunomide and benazepril reduced high-glucose induced cell apoptosis of RMCs. The combination use of leflunomide and benazepril could improve the renal function and reduce the renal injury of DN rats and could reduce the levels of NF-κb, TGF-β and TRPC6 in both DN rats and high-glucose induced RMCs.
- methotrexate / Generic mfg., leflunomide / Generic mfg.
Earlier Biologic Initiation Over Two Decades of Real World Observational Data From the RAPPORT Biologics Registry of Northern Alberta, Canada () - Feb 19, 2020 - Abstract #CRAAHPA2020CRA-AHPA_386;
Possible reasons include the rapid increase in availability of bDMARDs between and across classes and increased uptake and confidence in bDMARD use by prescribing rheumatologists over time. Further work to evaluate the impact of bDMARD prescription patterns on patients and society is planned.
- | leflunomide / Generic mfg.
Enrollment open: Leflunomide Plus Low Dose Corticosteroid in Immunoglobulin A (IgA) Nephropathy With Renal Insufficiency (clinicaltrials.gov) - Feb 18, 2020
P4, N=70, Recruiting, Sponsor: Shenzhen Second People's Hospital
Further work to evaluate the impact of bDMARD prescription patterns on patients and society is planned. Not yet recruiting --> Recruiting
- | Review, Journal: Drugs for psoriatic arthritis. (Pubmed Central) - Feb 15, 2020
Not yet recruiting --> Recruiting No abstract available
- | leflunomide / Generic mfg.
Journal: Leflunomide plus glucocorticoids for IgG4-RD. (Pubmed Central) - Feb 15, 2020
No abstract available No abstract available
- || Actemra IV (tocilizumab) / Roche, JW Pharma
Clinical, Journal: Effectiveness of intravenous tocilizumab in routine clinical practice in a cohort of Costa Rican patients with rheumatoid arthritis. (Pubmed Central) - Feb 15, 2020
No abstract available IV TCZ (4mg/kg) is an effective and safe treatment for RA patients in a clinical setting in Costa Rica.
- || Remicade (infliximab) / Mitsubishi Tanabe, J&J, Enbrel (etanercept) / Pfizer, Amgen
Clinical, Journal: Spectrum of glomerulonephritis in Egyptian patients with rheumatoid arthritis: A University Hospital experience. (Pubmed Central) - Feb 14, 2020
Hydroxychloroquine and leflunomide are accused in membranous nephropathy. Infliximab is associated with focal segmental sclerosis and amyloidosis of tubulointerstial type, and etanercept appear to be safe as regards kidney affection.
- Vistide (cidofovir) / Gilead, cyclophosphamide intravenous / Generic mfg.
[VIRTUAL] USE OF INTRAVESICAL HYALURONIC ACID TO TREAT HEMORRHAGIC CYSTITIS AFTER HEMATOPOIETIC CELL TRANSPLANTATION (ePoster Area) - Feb 8, 2020 - Abstract #EBMT2020EBMT_1727;
Patients who do not respond to support treatment have poorer outcomes and limited treatment options. Our experience suggests that HA bladder instillation is an effective and safe procedure in patients who had failed conservative treatment, leading to marked overall and complete response rates, especially when introduced promptly after diagnosis.
- tacrolimus / Generic mfg., Vistide (cidofovir) / Gilead, leflunomide / Generic mfg.
[VIRTUAL] LEFLUNOMIDE, SUCCESSFUL PRE-EMPTIVE THERAPY IN RESISTANT CYTOMEGALOVIRUS REACTIVATION IN A HEMATOPOIETIC CELL TRANSPLANTATION RECIPIENT (ePoster Area) - Feb 8, 2020 - Abstract #EBMT2020EBMT_1526;
Given the limited number of drugs available for the treatment of resistant CMV infection, leflunomide can be considered for adjuvant therapy. Further prospective research is recommended.
- Vistide (cidofovir) / Gilead, cyclophosphamide intravenous / Generic mfg.
[VIRTUAL] BK VIRUS EFFECT ON DEVELOPING LATE HEMORRHAGIC CYSTITIS IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION RECIPIENTS: SINGLE CENTER EXPERIENCE (ePoster Area) - Feb 8, 2020 - Abstract #EBMT2020EBMT_1503;
Non - infectious cystitis causes cytotoxic affects of antineoplastic therapy especially cyclophosphamide...Alternative medical thearpy includes hyperbaric oxygen treatment, leflunomide and flouroquinolones... In light of our findings, we concluded that low dose weekly used cidofovir therapy is a safely treatment option for BK virus associated HC.
- | methotrexate / Generic mfg., leflunomide / Generic mfg.
Retrospective data, Review, Journal: Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis: a meta-analysis. (Pubmed Central) - Feb 8, 2020
It is advisable to apply TGP as an adjuvant given its hepatoprotective and possible lipid-regulating effect. However, further large-scale and high-quality clinical trials are warranted, and the efficacy of TGP in terms of its effect on lipid profiles should be further confirmed.
- || prednisone / Generic mfg., leflunomide / Generic mfg.
Clinical, Journal: Obstructive uropathy associated with rheumatoid arthritis successfully treated with steroids and immunosuppressive therapy: A case report. (Pubmed Central) - Feb 1, 2020
However, further large-scale and high-quality clinical trials are warranted, and the efficacy of TGP in terms of its effect on lipid profiles should be further confirmed. Our case showed that RA might cause local inflammation involving the urinary tract which leads to obstruction and AKI.
- || tacrolimus / Generic mfg., methotrexate / Generic mfg., leflunomide / Generic mfg.
Clinical, Journal: Efficacy and safety of add-on tacrolimus versus leflunomide in rheumatoid arthritis patients with inadequate response to methotrexate. (Pubmed Central) - Jan 30, 2020
The efficacy of TAC combined with MTX was non-inferior to LEF + MTX. It had a reasonable safety profile in RA patients with moderate to severe disease activity (http://cris.nih.go.kr; KCT0000781).
- | leflunomide / Generic mfg.
Retrospective data, Journal: Efficacy and safety of leflunomide in psoriatic arthritis treatment: A single-arm meta-analysis. (Pubmed Central) - Jan 30, 2020
It had a reasonable safety profile in RA patients with moderate to severe disease activity (http://cris.nih.go.kr; KCT0000781). Leflunomide is an effective and well-tolerated treatment for PsA, and would be a safe and convenient option.
- || methotrexate / Generic mfg., leflunomide / Generic mfg.
Clinical, Journal: Onset of Hypertension in Leflunamide Treated Low Socioeconomic Rheumatoid Arthritis Patients: An unseen iceberg. (Pubmed Central) - Jan 29, 2020
Leflunomide is an effective and well-tolerated treatment for PsA, and would be a safe and convenient option. Risk of developing hypertension in patient receiving Leflunomide is much higher in Asian population like Pakistan as compared to western population.
- || methotrexate / Generic mfg., leflunomide / Generic mfg.
Clinical, Journal: Anti-interleukin 17 is a new possible treatment of patients with psoriatic arthritis (Pubmed Central) - Jan 29, 2020
However, many patients lose efficacy or have an insufficient response to TNF-inhibitors. Biologic agents targeting interleukin-17A have shown encouraging clinical results.
- | Zortress (everolimus) / Novartis, tacrolimus / Generic mfg.
Retrospective data, Journal: Viremia Negativization After BK Virus Infection in Kidney Transplantation: A National Bicentric Study. (Pubmed Central) - Jan 28, 2020
Early BKV diagnosis and stepwise minimization of immunosuppression remain the first-line approach in patients with BK viremia. In the presence of BKV nephropathy, a combination of antiviral drugs like leflunomide and fluoroquinolones/everolimus should favor viremia clearance.
- ||| leflunomide / Generic mfg.
Clinical: I’m counting on #heforshe support at the @WomenInThoracic #STS2020 event from @TomVargheseJr @biniamkidaneMD @DouglasEWood1 @roberthiggins32 @AraVaporciyan @DavidCookeMD @tomcnguyen @Cerf_MD @DavidDOdell @GloorLoor @JeffJacobs215 @BrianMitzman @rweisel12 @STS_CTsurgery (Twitter) - Jan 26, 2020
- |||| leflunomide / Generic mfg.
Clinical: Dr. @maraantonoff from @MDAndersonNews presenting now at the #STS2020 residents Symposium at the Rivergate room on achieving a successful work/life balance @WomenInThoracic @STS_CTsurgery @AraVaporciyan @DavidCookeMD @TomVargheseJr (Twitter) - Jan 26, 2020
- || leflunomide / Generic mfg.
We’re very proud of this! @TSRA_official Lots of useful information for residents and students interested in CT surgery! Thanks to our mentors for their wonderful column @tomcnguyen @AraVaporciyan @EHStephensCHD @cmpmd (Twitter) - Jan 22, 2020
- ||| leflunomide / Generic mfg.
Check out our inaugural TSRA Newsletter, which includes a full list of resident events at #STS2020 & tons of content, featuring @AraVaporciyan @EHStephensCHD @cmpmd @tomcnguyen @elkrebs7 @JasonHanMD @JordanBloomMD @CoyanGarrett & many others! Click here: https://t.co/vk09seIF4V~~ (Twitter) - Jan 22, 2020
- | leflunomide / Generic mfg.
Trial initiation date, IO biomarker: Leflunomide in Treating Patients with Steroid Dependent Chronic Graft Versus Host Disease (clinicaltrials.gov) - Jan 22, 2020
P1, N=24, Not yet recruiting, Sponsor: City of Hope Medical Center
In the presence of BKV nephropathy, a combination of antiviral drugs like leflunomide and fluoroquinolones/everolimus should favor viremia clearance. Initiation date: Jan 2020 --> Apr 2020
- || tacrolimus / Generic mfg., leflunomide / Generic mfg.
Clinical, Journal: Leflunomide-induced colitis in association with enterocutaneous fistula in an immunosuppressed patient with renal transplant and rheumatoid arthritis. (Pubmed Central) - Jan 21, 2020
Following dose reduction of leflunomide, there was a significant improvement in the frequency and severity of the patient's diarrhoea. He continues to be managed non-operatively for his fistula as he is at high risk of peri-operative morbidity and mortality.
- || Remicade (infliximab) / Mitsubishi Tanabe, J&J, Stelara (ustekinumab) / J&J, Humira (adalimumab) / Eisai, AbbVie
Retrospective data, Review, Journal: Efficacy and safety of systemic treatments in psoriatic arthritis. A systematic review, meta-analysis and GRADE evaluation. (Pubmed Central) - Jan 17, 2020
Besides the established treatment of anti TNF antibodies und ustekinumab for psoriatic arthritis, the newer treatment options of IL17 antibodies and apremilast are also effective for the treatment of psoriatic arthritis. Based on just one comparative trial and one drug each, the new class of anti IL 17 antibodies appears to be equally effective as the group of anti TNF antibodies, for apremilast this is yet unclear.
- | teriflunomide / Generic mfg., leflunomide / Generic mfg.
Journal: Dihydroorotate dehydrogenase inhibitors in anti-infective drug research. (Pubmed Central) - Jan 16, 2020
Dihydroorotate dehydrogenase (DHODH), which is involved in the de novo biosynthesis of pyrimidines, is a validated target for anti-infective drug research. Recent advances in the DHODH microorganism field are discussed herein, as is the potential for the development of DHODH-targeted therapeutics.
- || Remicade (infliximab) / Mitsubishi Tanabe, J&J
Biomarker, Clinical, Journal: Proteomic analysis of biomarkers predicting the response to triple therapy in patients with rheumatoid arthritis. (Pubmed Central) - Jan 15, 2020
Recent advances in the DHODH microorganism field are discussed herein, as is the potential for the development of DHODH-targeted therapeutics. This study demonstrated the feasibility of exploring biomarkers by applying iTRAQ and PRM mass spectrometry techniques, and a panel of biomarkers were identified to predict clinical response of IFX + MTX + LEF treatment in active RA patients.
- ||| leflunomide / Generic mfg.
Clinical: I find that using 2 tabs of leflunomide 10 mg instead of 20 mg can limit the diarrhea in some patients. (Twitter) - Jan 14, 2020
- |||| leflunomide / Generic mfg.
Clinical: Great point to look out for diarrhea in leflunomide. I have used it in enteropathic arthritis w/ success (esp MTX contraindicated/failure). This open label cohort suggested reduced joint disease and efficacy in CD, and steroid-sparing: https://t.co/XXHlJpsGxn #MondayNightIBD (Twitter) - Jan 14, 2020
- |||| leflunomide / Generic mfg.
Clinical: I have seen multiple people with active synovitis & enthesitis on US which wasn't clear from H&P and which resolved clinically after maximizing MTX or adding leflunomide (Twitter) - Jan 13, 2020
- |||| leflunomide / Generic mfg.
A reference slide I've used about my treatment approach to extra-intestinal manifestations of IBD for tonight's discussion. Don't forget leflunomide! #MondayNightIBD (Twitter) - Jan 13, 2020
- || leflunomide / Generic mfg.
I think of all the drugs mentioned , #GI are the least familiar w leflunomide ! When and how do you use it #Rheum colleagues ? @EBRheum @psufka @anisha_dua ? (Twitter) - Jan 13, 2020
- ||| teriflunomide / Generic mfg., leflunomide / Generic mfg.
Veliki broj pacijenat mi postavlja pitanja o off-label terapiji u #MultipleSclerosis. Pogledajte moje jučerašnje odgovore, posebno predstavljanje leka #leflunomide #Aubagio i pročitajte @GavinGiovannoni #offlabel ⏩ https://t.co/JlUdYDJroo (Twitter) - Jan 12, 2020
- ||| teriflunomide / Generic mfg., leflunomide / Generic mfg.
Kako je postovana @DraganaObrado20 objasnila, kod nas dostupan lek za reumatski artiritis, Arava (Leflunomid) je ekvivalent Aubagio (sa mnogo manjom cenom). Kako je @AaronBosterMD u videu objasnio, po efikasnosti dodje na nekoj sredini. Izmedju boc-boc i najmodernijih lekova. (Twitter) - Jan 12, 2020
- || torasemide / Generic mfg., leflunomide / Generic mfg.
@sasa_stojsin @MS_Platforma 20mg je adekvatna doza jer je leflunomid pro-lek, tj teriflunomid nastaje razgradnjom od njega u organizmu. Uračunat je i procenat apsorpcije u crevima. Pročitajte ⏬ prof @GavinGiovannoni #OffLabel: #leflunomide https://t.co/Vh5bt4tw5o (Twitter) - Jan 11, 2020
- || leflunomide / Generic mfg.
I ovako vec imam dosta lekova za gutanje, jos jedan nece praviti neku razliku 🙃@DraganaObrado20 Da li znate, da li je bilo slucajeva u Srbiji da se ovaj lek (vidim kod nas da se zove Arava) upotrebljavan za MS? (Twitter) - Jan 11, 2020
- ||| teriflunomide / Generic mfg., leflunomide / Generic mfg.
efikasniji je od injekcionih lekova, 1x dnevno tableta, nema subkutanih injekcija 3x nedeljno. Kontrolišu se enzimi jetre i broj leukocita, prolazno opadanje kose - mogući neželjeni efekti, zabranjen u trudnoći #Aubagio #Leflunomide #Teriflunomide #MultipleSclerosis (Twitter) - Jan 11, 2020
- |||| teriflunomide / Generic mfg., leflunomide / Generic mfg.
Znači da su Leflunomide i Tetiflunomide #Aubagio isti lek, istog dejstva. Ogromna razlika u ceni, 22X skuplje Off-label terapija se preporučuje zemljama koje nemaju novca da finansiraju zvaničnu terapiju za #MultipleSclerosis pogledajte ⏩ @GavinGiovannoni https://t.co/JlUdYDJroo (Twitter) - Jan 11, 2020
- || methotrexate / Generic mfg., leflunomide / Generic mfg.
Retrospective data, Review, Journal: Systematic review and meta-analysis of the efficacy and safety of leflunomide and methotrexate in the treatment of rheumatoid arthritis. (Pubmed Central) - Jan 11, 2020
Leflunomide used as the first DMARD in RA seemed to be as efficacious as methotrexate; only the reduction of swollen joint count was more marked for methotrexate. Leflunomide was linked to a greater increase in liver enzymes, but there were fewer GI complaints.
- | cyclophosphamide intravenous / Generic mfg.
Retrospective data, Journal: Primary immune-mediated haemolytic anaemia: a retrospective long-term study in 61 dogs. (Pubmed Central) - Jan 10, 2020
However, a relapse can occur after many years. Relapse was the most common cause of death in dogs with pIMHA that survive more than 90 days.
- || teriflunomide / Generic mfg.
Clinical, PK/PD data, Journal: A population pharmacokinetic study to accelerate early phase clinical development for a novel drug, teriflunomide sodium, to treat systemic lupus erythematosus. (Pubmed Central) - Jan 8, 2020
Body weight, sex, and ABCG2 34G>A genotype were identified to significantly affect PK characteristics. The developed EHC Pop PK model exhibited the ability to predict PK profiles of teriflunomide in patients after long-term dosing and could be utilized to support phase II trial design.
- || PK/PD data, Preclinical, Journal: Pharmacodynamic assessment of ex-vivo canine T-lymphocyte proliferation: Responses to dexamethasone, cyclosporine, mycophenolic acid, and the active metabolite of leflunomide. (Pubmed Central) - Jan 8, 2020
These results support the use of this assay for detecting the efficacy of individual immunosuppressants used to diminish T-lymphocyte proliferation. In future, the assay may be applied to pet dogs with spontaneous immune-mediated disease to help tailor individual treatment.
- || leflunomide / Generic mfg.
@roberthiggins32 @tomcnguyen @PhilipCarrott @DrRosengart @DavidOdell @AraVaporciyan @jmills1955 @ErinGillaspie @KatieSNason1 @EADavidMD @SteligaMD @LisaBrownMD @WTSpres @sgworrell (Twitter) - Jan 6, 2020
- | tacrolimus / Generic mfg., cyclophosphamide intravenous / Generic mfg., Rituxan (rituximab) / Roche, Biogen
Retrospective data, Journal: Effectiveness and safety of common therapeutic drugs for refractory lupus nephritis: A network meta-analysis. (Pubmed Central) - Jan 5, 2020
There were no statistically significant differences in adverse reactions, including gastrointestinal reactions and leukopenia between any two treatment regimens. In conclusion, the regimen of CTX + TAC + GC exhibited a trend in superiority regarding clinical efficacy among common therapeutic drug treatments for RLN, while the regimen of CTX + GC had a higher probability to cause adverse effects among the nine interventions compared.
- | leflunomide / Generic mfg.
Journal: Protective effects of vitamin D and losartan in complete Freund's adjuvant-induced arthritis in rats. (Pubmed Central) - Jan 4, 2020
The remaining three groups (III, IV, V) were given CFA followed by treatment with leflunomide, vitamin D or losartan, respectively for two weeks...It could be concluded that vitamin D and losartan are able to repress the alterations associated with adjuvant-induced arthritis (AIA). This preserving effect might be partially attributed to antiarithritic, hypolipidemic and antianemic properties.