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- Xeljanz (tofacitinib) / Pfizer, Marche Polytechnic University
[VIRTUAL] COMORBIDITIES IN RHEUMATOID ARTHRITIS: UTILITY OF RACI SCORE (RHEUMATOID ARTHRITIS COMORBIDITY INDEX) () - May 22, 2020 - Abstract #EULAR2020EULAR_3462;
The prevalence of comorbidities in RA by RACI was elevated (90.3%) and 73.3% of the patients presented more than one comorbidity. The patients with the highest RACI score had higher disease activity and used glucocorticoids more frequently.
- prednisone / Generic mfg., methotrexate / Generic mfg., leflunomide / Generic mfg.
[VIRTUAL] SAFETY IN PATIENTS WITH RHEUMATOID ARTHRITIS IN BIOLOGICAL TREATMENT OVER 65 YEARS OF AGE (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_3337;
2) In our sample there is a link between incidence of infection and the introduction of biological therapy, which is maintained with the increasing age of our patients, and it is not so clear with neoplasms and CD. These data are consistent with the existing literature 1,2,3 .
- Rituxan (rituximab) / Roche, Biogen, Zenyaku Kogyo
[VIRTUAL] FRACTURE RISK ASSESSMENT BY FRAX IN A SYSTEMIC LUPUS ERYTHEMATOSUS PORTUGUESE COHORT (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_3208;
However, we found no statistically significant difference in the estimated fracture risk with and without DXA. This, together with the good level of agreement between FRAX with and without DXA, suggests that the fracture risk estimation, even without DXA, may be an appropriate approach.
- leflunomide / Generic mfg.
[VIRTUAL] PROTECTIVE EFFECT OF LEFLUNOMIDE ON THE SALIVARY SECRETION OF SUBMANDIBULAR GLAND IN THE NOD MOUSE (Poster Tour) - May 22, 2020 - Abstract #EULAR2020EULAR_3158;
This, together with the good level of agreement between FRAX with and without DXA, suggests that the fracture risk estimation, even without DXA, may be an appropriate approach. Leflunomide may prevent and improve salivary gland hypofunction and inhibit immune activation in NOD mice, providing a theoretical basis for evaluating leflunomide in the treatment of Sjogren’s syndrome.
- [VIRTUAL] THE FREQUENCY OF CONTRACEPTION DOCUMENTATION IN WOMEN ON AND OFF TERATOGENIC ANTI-RHEUMATIC MEDICATIONS IN THE RISE REGISTRY (Poster Tour) - May 22, 2020 - Abstract #EULAR2020EULAR_3116;
Increased uniformity in documentation and/or analysis of visit notes will be essential to use the RISE Registry to study the implementation of published contraceptive guidelines. While the documentation of contraception identified in this analysis of the RISE Registry likely under-estimates actual contraceptive use, it reveals important gaps in care.
- Xeljanz (tofacitinib) / Pfizer, Marche Polytechnic University
[VIRTUAL] INCIDENCE RATE OF HERPES ZOSTER IN RHEUMATOID ARTHRITIS PATIENTS UNDER TOFACITINIB: REAL-LIFE DATA FROM TURKEY – HURBIO REGISTRY (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_3109;
Figure 1. Reported herpes zoster incidence rates across different countries (numbers in paranthesis indicate reference number)
- Xeljanz (tofacitinib) / Pfizer, Marche Polytechnic University
[VIRTUAL] А VERY EARLY (7-28 DAYS) RESPONSE ON JAK INHIBITOR TOFACITINIB IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS: EFFECT ON PAIN AND CENTRAL SENSITIZATION. (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_2965;
The application of JAK inhibitor tofacitinib allows to reach a fast analgesic effect, also due to impact on CS and NCP. Source: National Registry patients with RA
- methotrexate / Generic mfg., sulfasalazine / Generic mfg.
[VIRTUAL] FIRST-LINE CSDMARD MONOTHERAPY RETENTION IN PSORIATIC ARTHRITIS: METHOTREXATE OUTPERFORMS SULFASALAZINE (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_2900;
The pooled median time to failure was 31.8 months (IQR 9.04-110). Drug retention was significantly higher in MTX (median 34.5 months; IQR 9.60-123) as compared to SSZ treated patients (median 12.0 months; IQR 4.80-55.7)(p=0.016, log-rank test) ( Figure 1 ).
- Orencia (abatacept) / BMS, Ilaris (canakinumab) / Novartis
[VIRTUAL] THE INTERLEUKIN-1B INHIBITOR CANAKINUMAB FOR REFRACTORY STILL’S DISEASE: LONG-TERM EXPERIENCE IN 50 CONSECUTIVE PATIENTS (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_2891;
We conducted a retrospective longitudinal outcome study of 50 consecutive patients aged 39 years (median, range 14-72), fulfilling the Yamaguchi disease classification criteria, with active disease despite treatment with corticosteroids (CS) (n=11) and/or methotrexate (n=9) and/or biologics (n=30) [tumor necrosis factor inhibitors (n=13), IL-6 blockade (n=7), abatacept (n=2), anakinra (n=24); ≥1 biologics (n=13)]...Concomitant treatment included CS (n=41), methotrexate (n=12) and leflunomide (n=3)... In this largest so far real-life patient cohort with refractory Still’s disease, high rates of sustained remission were induced by canakinumab both in adolescent and adult patients.
- [VIRTUAL] IMPACT OF TOLERABILITY ON RETENTION OF cDMARDs IN PSORIATIC ARTHRITIS - IS IT A CONCERN? () - May 22, 2020 - Abstract #EULAR2020EULAR_2681;
In the context of chronic disease, the median duration of treatment is short. Our analysis did not include patients who suffer from side effects but continue therapy thereby impacting treatment adherence and hence the true scale of the issue is likely higher.
- Krystexxa (pegloticase) / Horizon Therapeutics, leflunomide / Generic mfg.
[VIRTUAL] LEFLUNOMIDE CO-THERAPY WITH PEGLOTICASE IN UNCONTROLLED GOUT (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_2615;
No prior studies have examined the effect of leflunomide on pegloticase responder rates. The current study indicates that oral leflunomide may be a viable immunomodulator for patients with uncontrolled gout undergoing pegloticase therapy.
- Xeljanz (tofacitinib) / Pfizer, Marche Polytechnic University
[VIRTUAL] SAFETY OF JAK INHIBITORS IN PATIENTS WITH ARTHRITIS RHEUMATOID UNDER REAL-LIFE CONDITIONS () - May 22, 2020 - Abstract #EULAR2020EULAR_2486;
One pulmonary thromboembolism has been detected in a hypertensive 70 years old patient, supporting the recent recommendation of avoiding these drugs in patients over 65 or with cardiovascular risk factors. It is remarkable low survival results due to inefficacy, that could be related to clinical profile of refractory patients in our study, and/or to the small sample that we describe.
- methotrexate / Generic mfg.
[VIRTUAL] POOR ADHERENCE TO METHOTREXATE IS ASSOCIATED WITH PERSISTENT DISEASE ACTIVITY DURING FOLLOW-UP FOR RHEUMATOID ARTHRITIS (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_2398;
Adherence to MTX can affect disease activity during follow-up in Korean patients with RA. Our results provide a rationale for patient education to maintain good drug adherence in RA patients, to control disease activity.
- tacrolimus / Generic mfg., Rituxan (rituximab) / Roche, Biogen, Zenyaku Kogyo
[VIRTUAL] EFFECTIVENESS OF RITUXIMAB IN CSDMARDS-RESISTANT ACTIVE MIXED CONNECTIVE TISSUE DISEASE () - May 22, 2020 - Abstract #EULAR2020EULAR_2356;
Hydroxychloroquine was also associated in 8 of the patients... According to our preliminary results, RTX seems to be effective and relatively safe in patients with csDMARDs-resistant active MCTD.
- methotrexate / Generic mfg.
[VIRTUAL] LONG-TERM EFFECTIVENESS OF METHOTREXATE WITH STEP DOWN GLUCOCORTICOID BRIDGING (COBRA SLIM) VERSUS OTHER CONVENTIONAL DMARD REGIMENS AS INITIAL RA THERAPY: 5-YEAR OUTCOMES OF THE CARERA TRIAL. (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_2224;
Initial Cobra Slim therapy showed comparable 5-year effectiveness as Cobra Classic and Avant-Garde in high-risk early RA patients and better efficacy and safety than conservative step up treatment in low-risk patients. Figure 1.
- methotrexate / Generic mfg., sulfasalazine / Generic mfg., leflunomide / Generic mfg.
[VIRTUAL] DENDRITIC CELLS AS A PREDICTOR OF GOOD CLINICAL RESPONSE IN RHEUMATOID ARTHRITIS PATIENTS (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_2219;
The data obtained confirm the determining role of myeloid DC and B lymphocytes in maintaining systemic inflammation in rheumatoid arthritis. In addition, these cells are a target of DMARDs therapy and a predictor of a good clinical response.
- paroxetine / Generic mfg.
[VIRTUAL] RELATIONSHIP BETWEEN MELATONIN SERUM LEVELS AND THE EFFICACY OF SELECTIVE SEROTONIN REUPTAKE INHIBITOR PAROXETINE IN PATIENTS WITH RHEUMATOID ARTHRITIS (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_2127;
The proposed scheme of treatment with addition of paroxetine demonstrated high efficacy concerning the main manifestations of the disease in RA patients with high melatonin serum level. This study demonstrates the possible influence of serotoninergic interactions on the melatoninergic system and their contribution to the pathogenesis of RA.
- methotrexate / Generic mfg., sulfasalazine / Generic mfg., leflunomide / Generic mfg.
[VIRTUAL] LEVEL OF N-TERMINAL FRAGMENT OF BRAIN NATRIURETIC PEPTIDE PROGENITOR AND ATHEROSCLEROTIC DAMAGE OF BRACHIOCEPHALIC ARTERIES IN PATIENTS WITH EARLY AND LONG-STANDING ACTIVE RHEUMATOID ARTHRITIS (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_1975;
Early untreated RA pts had a higher NT-proBNP levels than pts with disease duration >12 months and resistance or intolerance of DMARDs. The increased concentration NT-pro-BNP (>125pg/ml) were found in half of pts with early untreated RA and every fourth pts with long-standing active RA.
- [VIRTUAL] FIRST LINE TREATMENT WITH CONVENTIONAL SYNTHETIC DISEASE MODIFYING ANTIRHEUMATIC DRUGS IN RHEUMATOID ARTHRITIS: A MULTINATIONAL POPULATION-BASED COHORT FROM 14 REAL WORLD HEALTHCARE DATABASES AND 9 COUNTRIES - REALITY VERSUS GUIDELINES (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_1956;
We report wide heterogeneity of first-line csDMARDs regimens internationally. Despite recommendations for MTX to be first line therapy, data suggest that a large proportion of patients receive alternative csDMARD.
- Rituxan (rituximab) / Roche, Biogen, Zenyaku Kogyo
[VIRTUAL] RITUXIMAB MAY DELAY THE MOVEMENT OF RHEUMATOID ARTHRITIS PATIENTS ON CARDIORENAL CONTINUUM: RESULTS FROM A PROSPECTIVE OBSERVATIONAL SINGLE-CENTRE COHORT STUDY () - May 22, 2020 - Abstract #EULAR2020EULAR_1930;
RTM may be effective in delay of the movement of RA patients on cardiorenal continuum. The clinical implications of RTM for cardiorenal correlations in RA patients need to be confirmed in large-scale clinical outcome trials.
- Simponi (golimumab) / Merck (MSD), Mitsubishi Tanabe, J&J
[VIRTUAL] FACTORS ASSOCIATED WITH PERSISTENCE OF GOLIMUMAB TREATMENT IN THE BIOBADASER REGISTRY, UP TO 7 YEARS OF FOLLOW-UP (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_1901;
A lower risk of treatment discontinuation was observed in patients who received golimumab as first biological agent and in PsA and SpA patients. Persistence was lower in patients needing corticosteroids, DMARDs different to methotrexate and in those with higher disease activity at golimumab onset Cox-regression analysis.HR for discontinuation of golimumab
- Actemra IV (tocilizumab) / Roche, JW Pharma, Rituxan (rituximab) / Roche, Biogen, Zenyaku Kogyo, Cimzia (certolizumab pegol) / Astellas, UCB, Eli Lilly
[VIRTUAL] SERIOUS INFECTION RATES WITH BIOLOGICAL DISEASE MODIFYING ANTI-RHEUMATIC AGENTS (bDMARDs) AND PREDISPOSING FACTORS: A 5-YEAR RETROSPECTIVE REVIEW (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_1755;
In this real-world NQ cohort of patients treated with a bDMARD for a rheumatic disease, we have identified a number of factors potentially contributing to the risk of the development of SIs. This study provides valuable data on SI rates in an Australian ‘real-world’ cohort that may assist clinicians’ choice of bDMARD in patients with a high baseline risk of infection and highlights the importance of minimising prednisone use in patients on bDMARDs.
- methotrexate / Generic mfg.
[VIRTUAL] REAL LIFE EXPERIENCE OF METHOTREXATE BASED DUAL COMBINATION DMARDS IN PSORIATIC ARTHRITIS- RESULTS FROM KARNATAKA PSORIATIC ARTHRITIS COHORT (KPsAC) () - May 22, 2020 - Abstract #EULAR2020EULAR_1705;
In this observational study, 3 groups of methotrexate plus csDMARD- leflunomide, sulphasalazine and apremilast fared similarly for articular domain of PsA. However, in cutaneous domain, PASI was significantly lower in apremilast + methotrexate group.
- [VIRTUAL] CONCOMITANT USE OF BIOLOGIC DMARDS WITH CSDMARDS INCREASES DRUG RETENTION RATE AND IMPROVES TREATMENT RESPONSE IN THE PSORIATIC ARTHRITIS. HUR-BIO REAL LIFE RESULTS (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_1661;
On the other hand, using bDMARD monotherapy is relatively higher than rheumatoid artritis (1). Figure.
- cyclosporine / Generic mfg., leflunomide / Generic mfg., azathioprine orodispersible / Generic mfg.
[VIRTUAL] MEDICATION USE IN SYSTEMIC LUPUS ERYTHEMATOSUS – DATA FROM A MULTICENTRE COHORT STUDY () - May 22, 2020 - Abstract #EULAR2020EULAR_1622;
AM treatment survival was high and associated with low disease activity, GC survival was high and associated with high disease activity, while IS survival was low. Patients with high disease activity received more medication combinations but had reduced IS survival.
- tacrolimus / Generic mfg.
[VIRTUAL] PREDICTORS OF BIOLOGIC DISEASE MODIFYING ANTI-RHEUMATIC DRUG INITIATION AMONG PATIENTS WITH RHEUMATOID ARTHRITIS IN KOREA (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_1614;
In this population-based nationwide study, we identified period-specific predictors of bDMARD initiation among RA patients in Korea. Overall, initial aggressive RA treatment after RA diagnosis were associated with less use of later bDMARD, while highly intensive therapy observed just before bDMARD initiation reflects refractory nature of RA during this period.
- [VIRTUAL] COMPARISON OF THE THERAPEUTIC TRAJECTORIES OF PATIENTS WITH OLIGO AND POLYARTICULAR PSORIATIC ARTHRITIS. A REPORT FROM THE RHUMADATA® CLINICAL DATABASE AND REGISTRY (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_1553;
Polyarticular PsA patients appear to be more aggressively treated than oligoarticular patients during the csDMARDs period. Although durations on bDMARDs are statistically similar, polyarticular patients change biotreatment more frequently.
- [VIRTUAL] TREATMENT OF A COHORT OF PATIENTS WITH INTERSTITIAL LUNG DISEASE AND RHEUMATOID ARTHRITIS (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_1541;
Our results, in general, agree with what is published in the literature. Prospective, multicentre and larger sample studies are necessary to better define which patients would benefit more from IS T or antifibrotic T (or if the antifibrotic should be added to the previous IS).
- leflunomide / Generic mfg.
[VIRTUAL] THE COMPARISON OF SYNDECAN-4 LEVEL IN SERA, SYNOVIAL FLUID AND SYNOVIUM OF RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS () - May 22, 2020 - Abstract #EULAR2020EULAR_1452;
The serum Syndecan-4 is higher in RA patients than in OA patients and healthy controls, and significantly higher in sero-positive RA patients than in sero-negative ones. Syndecan-4 may participate in the pathogenesis of RA.
- [VIRTUAL] RISK OF MALIGNANCIES ASSOCIATED WITH CS DMARDS IN RHEUMATOID ARTHRITIS: COMPARISON WITH GENERAL POPULATION AND BIOLOGIC TREATED PATIENTS (ANALYSIS OF A NATIONAL CLAIM DATABASE) (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_1437;
Using a large nationwide representative healthcare database, the overall risk of malignancies and the risk of organ-specific cancers and hematologic malignancies in biologic treated RA patients did not differ from that of patients treated with csDMARD. Compared to general population, patients treated with csDMARD had an increased risk of lung cancer and melanoma, but a decreased risk of pancreatic cancer.
- Remicade (infliximab) / Mitsubishi Tanabe, J&J, Humira (adalimumab) / Eisai, AbbVie, Cimzia (certolizumab pegol) / Astellas, UCB, Eli Lilly
[VIRTUAL] CERTOLIZUMAB THERAPY IN REFRACTORY UVEITIS DUE TO IMMUNE-MEDIATED INFLAMMATORY DISEASES (IMID). MULTICENTER STUDY OF 39 PATIENTS (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_1431;
CZP seems to be effective and safe in patients with refractory uveitis due to IMID. Table *p<0.05
- Taltz (ixekizumab) / Eli Lilly, Second Xiangya Hospital of Central South University
[VIRTUAL] EFFICACY AND SAFETY OF IXEKIZUMAB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS BASED ON CONCOMITANT CONVENTIONAL DISEASE-MODIFYING ANTIRHEUMATIC DRUGS (CDMARD) USE: RESULTS FROM SPIRIT-P1 AND SPIRIT-P2 (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_1411;
P3
While there are some numerical differences in ACR20/50/70 as well as PASI75/90/100, the overall responses with or without the addition of MTX or other cDMARDs were similar. In this post-hoc analysis, it appears that, for sustained responses over time, IXEQ4W does not require the addition of MTX or other cDMARDs.
- methotrexate / Generic mfg., leflunomide / Generic mfg.
[VIRTUAL] THE IMPACT OF DIABETES MELLITUS ON OUTCOMES OF RHEUMATOID ARTHRITIS AT 5-YEAR FOLLOW-UP: RESULTS FROM A MULTI-ETHNIC ASIAN COHORT IN SINGAPORE () - May 22, 2020 - Abstract #EULAR2020EULAR_1409;
There is a tendency that non diabetic RA patients use more methotrexate ( p = 0.052) and leflunomide ( p = 0.058). This is the first report on the impact of DM on RA outcomes in a long term follow-up RA registry in a multiethnic Asian society.
- [VIRTUAL] THE IMPACT OF TREATMENT WITH A BIOLOGICAL DISEASE-MODIFYING ANTIRHEUMATIC DRUG ON SPINAL MOBILITY AND ITS CORRELATION WITH DISEASE ACTIVITY IN PATIENTS WITH SPONDYLOARTHRITIS (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_1296;
As such, a TNFi may retard the progression of spinal mobility dysfunction in SpA patients. We cannot draw conclusions regarding differences between TNFi and interleukin 17 inhibitors and further work is needed to clarify possible differences in their impact in improving spine mobility.
- methotrexate / Generic mfg., sulfasalazine / Generic mfg., leflunomide / Generic mfg.
[VIRTUAL] IMPACT OF RAMADAN DIURNAL INTERMITTENT FASTING ON CHRONIC MEDICATIONS INTAKE IN PATIENTS WITH RHEUMATOID ARTHRITIS (Poster View) - May 22, 2020 - Abstract #EULAR2020EULAR_1240;
Even if the tolerability of chronic medications was not impaired by Ramadan fasting in the majority of patients, adherence to conventional DMARDs was reported to be reduced by more than a quarter of patients, mainly because of a lack of time between the two major meals. Physicians should be aware of the impact of Ramadan fasting on chronic drugs intake because they have a crucial role in helping patients with RA adjust medications safely.
- Orencia (abatacept) / BMS, Rituxan (rituximab) / Roche, Biogen, Zenyaku Kogyo
[VIRTUAL] ARE THERE DIFFERENCES IN CLINICAL PROFILE AND TREATMENT AMONG 2 DIFFERENT INTERCONTINENTAL COHORTS OF PATIENTS WITH RHEUMATOID ARTHRITIS-ASSOCIATED INTERSTITIAL LUNG DISEASE? () - May 22, 2020 - Abstract #EULAR2020EULAR_1211;
Globally pts with RA-associated ILD have similar clinical profile in both centers, however, we found some differences in radiological patterns and treatment strategies between both cohorts. Those differences could be explained in part by sociodemographic differences, diagnostic and therapeutic approach and/or access for health care among others.
- KZR-616 / Kezar, Amgen
[VIRTUAL] TREATMENT OF SLE WITH THE IMMUNOPROTEASOME INHIBITOR KZR-616: RESULTS FROM THE FIRST 4 COHORTS OF THE MISSION STUDY, AN OPEN-LABEL PHASE 1B DOSE ESCALATION TRIAL () - May 22, 2020 - Abstract #EULAR2020EULAR_1195;
P1b/2
Evidence of disease suppression at W13 in active SLE patients on stable background therapy was observed. In addition, one study participant with active proliferative nephritis was enrolled with significant reduction in proteinuria.
- || leflunomide / Generic mfg.
Ping @TomVargheseJr @tomcnguyen @LisaBrownMD @vlitlemd @jdoningtonmd @DrKathyHughes @drnikkistamp @Daniela_Molena @ShandaBlackmon @leahbackhusmd @EADavidMD @EHStephensCHD @FiedlerAmy @VanMorrisMD @DavidCookeMD @NahushMokadam @DavidDOdell @OPreventzaMD @OuzounianMD @AraVaporciyan (Twitter) - May 22, 2020
- | leflunomide / Generic mfg.
Enrollment open, IO biomarker: Leflunomide in Treating Patients with Steroid Dependent Chronic Graft Versus Host Disease (clinicaltrials.gov) - May 21, 2020
P1, N=24, Recruiting, Sponsor: City of Hope Medical Center
In addition, one study participant with active proliferative nephritis was enrolled with significant reduction in proteinuria. Not yet recruiting --> Recruiting
- ||| leflunomide / Generic mfg.
Preclinical: How worried should we be about leflunomide expsoure in pregnancy? Further post-marketing registry data (n=587) gives greater reassurance that things might not be so bad. Obviously best to avoid, but what's bad for rats may not be bad for humans? https://t.co/Nz4CSn1peW @RheumNow (Twitter) - May 18, 2020
- ||| leflunomide / Generic mfg.
Panelists Q/A period - @MDAndersonNews @UTH_CVSurgery debate journal club getting intense! #TSSMN @maraantonoff @tomcnguyen @AraVaporciyan @sgswisher (Twitter) - May 18, 2020
- ||| leflunomide / Generic mfg.
Background on the Debate Style Journal Club published in @annalsthorsurg and disseminated via @TECoG_ #TSSMN @maraantonoff @tomcnguyen @AraVaporciyan @MDAndersonNews @UTH_CVSurgery @STS_CTsurgery @AATSHQ @AASFoundation1 @UnivSurg @DavidDOdell (Twitter) - May 18, 2020
- || leflunomide / Generic mfg.
Make sure to join the @MDAndersonNews Virtual Debate-Style #CTSurgery Journal Club! Have been looking forward to this chance for years! @maraantonoff @AraVaporciyan @tomcnguyen Happening now! To participate, visit https://t.co/rU4S0c07cG. Spread the word! #TSSMN (Twitter) - May 18, 2020
- ||| leflunomide / Generic mfg.
Starting in just 10 minutes @MDAndersonNews-@UTH_CVSurgery #CTSurgery trainees debate on T2N0 esophageal cancer management. This debate-style journal club has gone virtual! Join NOW and spread the word! @tomcnguyen @AraVaporciyan @TSRA_official @ctsnetorg @AATSHQ @STS_CTsurgery (Twitter) - May 18, 2020
- |||| leflunomide / Generic mfg.
Tonight’s the night to see our @MDAndersonNews-@UTHealth #CTSurgery trainees debate on esophageal cancer management. This debate-style journal club has gone virtual! Join us and spread the word! @tomcnguyen @AraVaporciyan (Twitter) - May 18, 2020
- | leflunomide / Generic mfg.
Journal: Suppression of pyrimidine biosynthesis by targeting DHODH enzyme robustly inhibits rotavirus replication. (Pubmed Central) - May 17, 2020
In this study, we demonstrated that two specific DHODH enzyme inhibitors, brequinar (BQR) and leflunomide (LFM) robustly inhibited rotavirus replication in conventional human intestinal Caco2 cell line as well as in human primary intestinal organoids...Mechanistic study indicated that BQR and LFM exerted their anti-rotavirus effect through targeting DHODH to deplete pyrimidine nucleotide pool. Therefore, targeting pyrimidine biosynthesis represents a potential approach for developing antiviral strategies against rotavirus.
- || leflunomide / Generic mfg.
Make sure to join the @MDAndersonNews Virtual Debate-Style #CTSurgery Journal Club! Have been looking forward to this chance for years! @AraVaporciyan @tomcnguyen The session is on Mon May 18th, 6:30pm CT. To participate, visit https://t.co/rU4S0c07cG. Spread the word! #TSSMN (Twitter) - May 16, 2020
- Abraxane (albumin-bound paclitaxel) / Otsuka, BMS, gemcitabine / Generic mfg.
Mitochondrial fusion exerts KRAS-dependent therapeutic synergy with gemcitabine/nab-paclitaxel in preclinical models of pancreatic cancer (Virtual Meeting II: E-Posters) - May 16, 2020 - Abstract #AACRII2020AACR-II_1856;
Therefore, targeting pyrimidine biosynthesis represents a potential approach for developing antiviral strategies against rotavirus. Leflunomide exhibits therapeutic synergy with standard-of-care gemcitabine/nab-paclitaxel in patient-derived PDAC lines that harbor KRAS mutations, but are ineffective in KRAS WT lines, suggesting that this combination might be effective not only in PDAC, but in other cancer with mutant KRAS, such as cancers of colon, lung, or bile ducts.
- methotrexate / Generic mfg., leflunomide / Generic mfg., azathioprine orodispersible / Generic mfg.
[VIRTUAL] Catastrophic Antiphospholipid Syndrome, Kikuchi-Fujimoto Disease and Adult-Onset Still Disease: An Unusual Association (Virtual Meeting Room 6) - May 14, 2020 - Abstract #ISTH2020ISTH_1802;
The only autoantibodies detected were persistently triple positivity of aPL, always to high titers, without thrombosis. As with current therapies the patient has a poor prognosis we are evaluating to apply a biological treatment.
- || leflunomide / Generic mfg.
Review, Journal, Adverse drug reaction: The role of Chinese herbal medicine in the management of adverse drug reactions of leflunomide in treating rheumatoid arthritis. (Pubmed Central) - May 13, 2020
As with current therapies the patient has a poor prognosis we are evaluating to apply a biological treatment. This review introduced that the adoption of CHM is emerging as a novel strategy for the management of ADRs caused by LEF.