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68 Trials |
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- || hydroxychloroquine / Generic mfg., methotrexate / Generic mfg., celecoxib oral / Generic mfg.
Clinical, Observational data, Journal, Interview: Relationship between different anti-rheumatic drug therapies and complementary and alternative medicine in patients with rheumatoid arthritis: an interview based cross-sectional study. (Pubmed Central) - Jun 22, 2021
Other factors related to CAM were meloxicam use (AOR 2.342 [95% CI: 1.341, 4.089]; p = 0.003) and traditional therapy (AOR 2.989 [95% CI: 1.647, 5.425]; p = 0.000)...CAM use is prevalent in patients with RA. Understanding patients and disease related factors associated with higher use of CAM is warranted to improve RA management and provide more rational use of these remedies.
- | leflunomide / Generic mfg.
New P2 trial: Leflunomide for Musculoskeletal GVHD After Allogeneic Stem Cell Transplant (clinicaltrials.gov) - Jun 21, 2021
P2, N=10, Recruiting, Sponsor: Tata Memorial Centre
- Cubicin (daptomycin) / Merck (MSD)
[VIRTUAL] DAPTOMYCIN INDUCED RHABDOMYOLYSIS. WHEN DRUG-DRUG INTERACTIONS PLAY A CRUCIAL RULE () - Jun 14, 2021 - Abstract #CSCTRMWAFMR2021CSCTR-MWAFMR_59;
The patient was admitted one month before the current presentation for acute osteomyelitis of the left foot and underwent left partial foot amputation, pathological margin was negative for osteomyelitis, and she was discharged on oral sulfamethoxazole-trimethoprim for soft tissue infection...Tissue culture grew methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE)...The patient was at high risk of developing muscle injury as she was taking a high dose of daptomycin (> 8 mg/kg) and several other medications that are also known to be prone to muscle injuries, including atorvastatin and leflunomide...Oritavancin was approved for skin infections in 2014 and is said to be clinically effective against gram-positive osteomyelitis, although further studies are needed. Doctors should be vigilant when prescribing daptomycin, especially when patients are taking other medications by holding some medications and carrying out more frequent CK checks.
- | hydroxychloroquine / Generic mfg., leflunomide / Generic mfg.
New P2 trial, Combination therapy: Leflunomide and Hydroxychloroquine combination therapy for primary Sj (EUDRACT) - Jun 10, 2021
P2, N=52, Ongoing, Sponsor: University Medical Center Utrecht
- | sulfasalazine / Generic mfg., leflunomide / Generic mfg.
Trial termination, Monotherapy: Comparison of Disease Modifying Antirheumatic Drugs Therapy in Patients With RA Failing Methotrexate Monotherapy (clinicaltrials.gov) - Jun 10, 2021
P3, N=136, Terminated, Sponsor: Jawaharlal Institute of Postgraduate Medical Education & Research
Doctors should be vigilant when prescribing daptomycin, especially when patients are taking other medications by holding some medications and carrying out more frequent CK checks. Completed --> Terminated; Due to time constraints, the study was halted prematurely
- ||| Lumakras (sotorasib) / Amgen
Clinical, FDA event: Patients like Steve Castellaw, with a KRAS G12C gene mutation, are benefitting from sotorasib. MD Anderson researchers and patients played a pivotal role in the trials that led to its historic FDA approval. https://t.co/88L3OI92vV @FSkoulidis @DavidHongMD @AraVaporciyan #ASCO21 (Twitter) - Jun 4, 2021
- | leflunomide / Generic mfg.
Journal: Leflunomide Loaded Chitosan Nanoparticles for the Preparation of Aliphatic Polyester Based Skin Patches. (Pubmed Central) - Jun 3, 2021
Analysis of the prepared films showed that the incorporation of the drug-loaded CS NPs resulted in a significant increase in the drug's release rate and extent as compared to neat LFD-loaded polyester patches (i.e., prepared without the use of CS NPs). In-depth analysis of the prepared formulations showed that the amorphization of the drug within the matrix and the increased wetting properties of the prepared CS NPs were responsible for the improved thin-film patch characteristics.
- || leflunomide / Generic mfg.
Clinical, Journal: Interleukin-18 in Brazilian Rheumatoid Arthritis Patients: Can Leflunomide Reduce It? (Pubmed Central) - Jun 1, 2021
IL-16, IL-18, IL-31, and IL-32 are increased in the serum of RA patients. IL-18 is at lower levels in those AR who are taking leflunomide as treatment.
- |||| leflunomide / Generic mfg.
Clinical: A great opportunity to thank my mentor @MattGalsky (who epitomizes #heforshe ), scientific mentor @Ramon_Parsons, advocate @ivybelkins, and collaborators @MDAndersonNews. This award will fund our study of leflunomide for pts with PTEN null solid tumors opening soon @TischCancer! (Twitter) - May 29, 2021
- | leflunomide / Generic mfg.
Journal: Leflunomide ameliorates experimental autoimmune myasthenia gravis by regulating humoral and cellular immune responses. (Pubmed Central) - May 29, 2021
In addition, leflunomide rebuilt the balance of Th1/Th2/Th17/Treg subsets. These results suggested that leflunomide ameliorated EAMG severity by regulating humoral immune responses and Th cell profiles thereby providing a novel effective treatment strategy for MG.
- |||| Orencia (abatacept) / BMS, Xeljanz (tofacitinib) / Pfizer
Clinical: Vaccinated patients on certain meds (#methotrexate #prednisone #tofacitinib #abatacept, #cyclosporine, #leflunomide) should continue #masking #distancing when they are in contact with people who are not vaccinated against COVID-19 or whose vaccination status is not verifiable. (Twitter) - May 28, 2021
- || Humira (adalimumab) / Eisai, AbbVie
Clinical, Observational data, Journal: Evaluation of prescription practices in rheumatoid arthritis at the rheumatology clinic in a tertiary care teaching hospital in Uttarakhand: A cross-sectional study. (Pubmed Central) - May 28, 2021
Overall, 4 DMARDs were prescribed in all the studied patients: Methotrexate (n = 150), hydroxychloroquine (n = 35), leflunomide (n = 5), and adalimumab (n = 1)...Adjuvant therapy drugs included: Prednisolone (n = 150), folic acid (n = 150), naproxen (n = 150), calcium (n = 150), vitamin D (n = 150) and indomethacin (n = 40)...A total of five adjuvant medications were commonly prescribed to all patients. There was a high prevalence of self-medicated CAM therapy in the majority of these patients.
- || Cytovene (ganciclovir) / Roche
Regimen ended up leflunomide + cytogam. Ganciclovir took time to peel off. (Twitter) - May 27, 2021
- || leflunomide / Generic mfg.
Clinical, Journal: Chemo-Geographic Variations in Wild Population of Asteriscus graveolens in Israel Based on Volatile Composition Analyses. (Pubmed Central) - May 26, 2021
Geographically, A. graveolens populations growing in Israel were found to be chemically diverse with unique varieties in the Dead Sea basin and the Arava region. This work demonstrates that chemo-geographic variation of volatile composition exists within A. graveolens population growing in Israel, so future research evaluating the medicinal potential of that plant should take this into consideration.
- || leflunomide / Generic mfg.
Clinical, Journal: Efficacy of leflunomide in the treatment of vasculitis. (Pubmed Central) - May 25, 2021
Leflunomide can be an effective therapeutic option for various vasculitides, especially for non-severe refractory or relapsing ANCA-associated vasculitis or large-vessel vasculitis. No new safety signals for LEF were identified in this population.
- [VIRTUAL] CERTOLIZUMAB PEGOL RELOADING SUCCESSFULLY CONTROLS INFLAMMATORY ARTHRITIS FLARES DURING PREGNANCY – A CASE REPORT () - May 21, 2021 - Abstract #EULAR2021EULAR_3872;
Reloading CZP to control increased IA disease activity during pregnancy may be a viable treatment option. To our knowledge, this is the first report of dose optimization in IA and in pregnancy in a patient treated with CZP.
- [VIRTUAL] THE FIRST CASE OF AN AUTOLOGOUS STEM CELL TRANSPLANTATION FOR AN EXTREMELY REFRACTORY PROGRESSIVE SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS PATIENT IN BRASÍLIA, BRAZIL () - May 21, 2021 - Abstract #EULAR2021EULAR_3661;
ASCT has been used in some refractory children with sJIA as well as hematologic malignancy and some progressive autoimmune diseases. However it is associated with significant morbidity and mortality, due to prolonged and severe depression of T cell immunity.
- [VIRTUAL] SHORT-TERM OUTCOMES OF COVID-19 IN PATIENTS WITH RHEUMATIC DISEASES WHO ARE TREATED BY BIOLOGICAL AND TARGETED SYNTHETIC DMARDS: OBSERVATIONAL SINGLE-CENTER STUDY () - May 21, 2021 - Abstract #EULAR2021EULAR_3493;
In this observational study, we found no association between biologic and targeted therapy for rheumatic diseases and severe course of new coronavirus infection, as well as with the need for hospitalization for COVID-19. The outcome of COVID-19 was favorable in all patients receiving treatment with biological and targeted synthetic drugs for rheumatic diseases.
- Actemra IV (tocilizumab) / Roche, JW Pharma
[VIRTUAL] CORONAVIRUS 19 DISEASE VACCINE: PERCEPTIONS AND INTENTIONS OF TUNISIAN PATIENTS WITH RHEUMATOID ARTHRITIS () - May 21, 2021 - Abstract #EULAR2021EULAR_3487;
Most of RA patients expressed their unwillingness to get vaccinated against covid-19. Doubts about the vaccine’s efficiency and security and religious beliefs were the main reasons for this choice.
- Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, Actemra IV (tocilizumab) / Roche, JW Pharma, Humira (adalimumab) / Eisai, AbbVie
[VIRTUAL] COVID-19 İNFECTION IN PATIENTS WITH RHEUMATIC DISEASES: TWO CENTERS EXPERIENCE () - May 21, 2021 - Abstract #EULAR2021EULAR_3483;
Meta-analysis has shown that the frequency of COVID-19 is increased in autoimmune diseases. However, this increase was mostly associated with the use of> 10mg/day prednisolone.
- Humira (adalimumab) / Eisai, AbbVie, Cimzia (certolizumab pegol) / Astellas, UCB
[VIRTUAL] INCIDENCE AND SEVERITY OF COVID-19 IN PATIENTS WITH SPONDYLOARTHRITIS IN ARGENTINA: EXPERIENCE IN A COUNTRY WITH STRICT ISOLATION () - May 21, 2021 - Abstract #EULAR2021EULAR_3477;
Regarding the treatments: 4 (28.6%) were in treatment with anti TNF (3 with Adalimumab, 1 with certolizumab pegol), 4 (28.6%) with Anti IL17 (3 with Secukinumab, 1 with Ixekizumab), 8 (57%) with methotrexate and 2 (14%) with Leflunomide. An incidence of 4.4% of COVID-19 was found in this population with SpA and most of the patiend had mild symptoms and no deaths were reported.
- Xeljanz (tofacitinib) / Pfizer, Rinvoq (upadacitinib) / AbbVie
[VIRTUAL] REAL LIFE SEVERE INFECTIONS IN PATIENTS WITH RHEUMATOID ARTHRITIS ON TREATMENT WITH BIOLOGICAL THERAPY AND JAKI () - May 21, 2021 - Abstract #EULAR2021EULAR_3036;
In our study, 10.9% of patients with RA treated with BT or JAKi developed severe infection during 5 years of follow-up. Concomitant GCC therapy and comorbidity increased the risk of presenting this complication.
- [VIRTUAL] RHEUMATOID ARTHRITIS ASSOCIATED LUNG DISEASE: EXPERIENCE IN A BIOLOGICAL THERAPY UNIT () - May 21, 2021 - Abstract #EULAR2021EULAR_3032;
Lung involvement is asymptomatic and chest X-ray is normal in most RA patients. High resolution CT is the gold standard for diagnosis.
- [VIRTUAL] LIVER INVOLVEMENT IN RHEUMATOID ARTHRITIS () - May 21, 2021 - Abstract #EULAR2021EULAR_3025;
A careful monitoring of liver enzymes tests is crucial to detect hepatic disease and prevent its evolution to a chronic liver disease and cirrhosis. On the other hand, screening for viral hepatitis B and C is necessary to prevent an aggravation of a chronic infection and a reactivation of a latent one [2].
- sulfasalazine / Generic mfg., leflunomide / Generic mfg.
[VIRTUAL] PREVALENCE, RISK FACTORS, AND TREATMENT MODALITIES OF ATLANTOAXIAL DISLOCATION IN RHEUMATOID ARTHRITIS () - May 21, 2021 - Abstract #EULAR2021EULAR_3023;
Immunopositive patients seem to have more frequently ADD, as well as those with high disease activity and severe structural joint damage. The treatment modalities do not appear to be affected by AAD; however, patients with ADD seem to have higher cumulative doses of corticosteroids and methotrexate.
- sulfasalazine / Generic mfg., leflunomide / Generic mfg.
[VIRTUAL] SCREENING FOR DEPRESSION IN A GROUP OF TUNISIAN PATIENTS WITH RHEUMATOID ARTHRITIS () - May 21, 2021 - Abstract #EULAR2021EULAR_3020;
Depression was frequent among RA patients. Our study suggests that better control of the disease may reduce the incidence of depression within this group of patients.
- Orencia (abatacept) / BMS
[VIRTUAL] CLINICAL AND RADIOLOGICAL CHARACTERISTICS AND TREATMENTS OF A COHORT OF PATIENTS WITH RHEUMATOID ARTHRITIS AND DIFFUSE INTERSTICIAL PULMONARY DISEASE FOLLOWED AT THE VIRGEN MACARENA UNIVERSITY HOSPITAL () - May 21, 2021 - Abstract #EULAR2021EULAR_2921;
Half of the patients used to smoke. At the diagnosis of ILD (at ILD diagnosis), dyspnea was the most relevant clinical symptom, with a slight deterioration in the?
- leflunomide / Generic mfg.
[VIRTUAL] B- AND T- LYMPHOCYTE SUBSETS IN PATIENTS WITH EARLY AND PROGRESSED RHEUMATOID ARTHRITIS () - May 21, 2021 - Abstract #EULAR2021EULAR_2913;
As disease activity was high in both groups, therefore therapy was ineffective, and results could be interpreted as natural progression of RA, resulting mainly in dynamics of switched B-memory cells, transitioning B-cells and plasmoblasts. These subsets might be indicating disease development patterns but further research is required.
- leflunomide / Generic mfg.
[VIRTUAL] DISCONTINUATION OF ANTI-TNFα IN PATIENTS WITH PSORIATIC ARTHRITIS: A SINGLE-CENTER EXPERIENCE () - May 21, 2021 - Abstract #EULAR2021EULAR_2463;
However the disease-free interval was not short. Retreatment with the same anti-TNF was effective and safe.
- leflunomide / Generic mfg.
[VIRTUAL] COMBINATION OF METHOTREXATE AND LEFLUNOMIDE IS SAFE AND HAS GOOD DRUG RETENTION AMONG PATIENTS WITH PSORIATIC ARTHRITIS () - May 21, 2021 - Abstract #EULAR2021EULAR_2433;
Combination of MTX and LEF was well tolerated and had good drug retention time, with 84% of patients having ongoing treatment to date. Our data provides initial evidence that MTX and LEF combination therapy could be an effective treatment option for PsA
- sulfasalazine / Generic mfg., leflunomide / Generic mfg.
[VIRTUAL] THERAPIES FOR PERIPHERAL JOINT INVOLVEMENT IN PSORIATIC ARTHRITIS: A SYSTEMATIC LITERATURE REVIEW () - May 21, 2021 - Abstract #EULAR2021EULAR_2431;
Further work seeking agreement from a broader group of stakeholders is in progress. Certainty of evidence (GRADE) and Recommendation for peripheral arthritis of PsA NS: not statistically significant; *included data from abstract; ¥ not making recommendation due to not approved and not available in market; † reserve for no alternatives.
- Xeljanz (tofacitinib) / Pfizer
[VIRTUAL] A VERY EARLY CLINICAL RESPONSE TO TOFACITINIB IS ASSOCIATED WITH LOW RHEUMATOID ARTHRITIS ACTIVITY AFTER 3 AND 6 MONTHS () - May 21, 2021 - Abstract #EULAR2021EULAR_2288;
An early clinical response to tofacitinib (pain relief) predicts a decrease in RA activity after 3 and 6 months of the therapy. Limitation: Open-label observatory study.
- Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, Enbrel (etanercept) / Pfizer, Amgen, Humira (adalimumab) / Eisai, AbbVie
[VIRTUAL] DISCORDANCE OF RAPID3 AND CDAI IN RHEUMATOID ARTHRITIS () - May 21, 2021 - Abstract #EULAR2021EULAR_2254;
Treatment escalation based on RAPID3 in discordant patients may be inappropriate. When making treatment decisions, a measure that includes objective physical examination and provider judgment is desirable.
- hydroxychloroquine / Generic mfg.
[VIRTUAL] IMPACT OF CONVENTIONAL ANTIRHEUMATIC TREATMENT ON CARDIOVASCULAR RISK IN PATIENTS WITH RHEUMATOID ARTHRITIS () - May 21, 2021 - Abstract #EULAR2021EULAR_2087;
GCs significantly increase CVD risk. To clarify the impact of hydroxychloroquine and leflunomid on CVD risk, a study on a larger number of pts is required.
- Cimzia (certolizumab pegol) / Astellas, UCB
[VIRTUAL] CERTOLIZUMAB IN MONOTHERAPY AS EFFECTIVE THAN IN COMBINATION IN RHEUMATOID ARTHRITIS PATIENTS () - May 21, 2021 - Abstract #EULAR2021EULAR_2017;
Although results are not statistically different, it seems that certolizumab in monotherapy could be as least as effective as combination therapy. Prospective studies with larger sample size and with a structured follow-up are needed to confirm these findings.
- Orencia (abatacept) / BMS
[VIRTUAL] ANTI-CITRULLINATED PROTEIN ANTIBODY (ACPA) POSITIVITY IS ASSOCIATED WITH REDUCED WITHDRAWAL RATES OF ABATACEPT IN RHEUMATOID ARTHRITIS BUT ONLY IN PATIENTS WHO ARE ANTI-NUCLEAR ANTIBODY (ANA) NEGATIVE () - May 21, 2021 - Abstract #EULAR2021EULAR_1995;
Our data suggests patients who are ACPA positive and ANA negative are more likely to remain on abatacept therapy. Concomitant csDMARD use also acts as a positive predictor of abatacept treatment retention.
- sulfasalazine / Generic mfg., leflunomide / Generic mfg.
[VIRTUAL] THE EFFECTS OF COMMON THERAPEUTICS ON AIRE METHYLATION STATUS AND THE LEVELS OF IL-16, IL-1Β, AND IFN-Γ IN LPS-INDUCED MACROPHAGE CELLS CAN SULPHASALAZINE’S INFLUENCE ON METHYLATION STATUS OF AIRE EXPLAIN ITS AUTOIMMUNE SIDE EFFECTS? () - May 21, 2021 - Abstract #EULAR2021EULAR_1908;
Relative increase in methylation of AIRE promoter by SLZ usage can be responsible for its autoimmune side effects, like drug induced lupus or hypersensitivity reactions, which are not common in MTX and LEF usage. IL16 is a key regulator of biological properties of CD4+T cells, it also regulates migration of CD4+CD25+Treg cells.[3] MTX treatment was shown to increase Treg cells in early rheumatoid arthritis patients.
- Orencia (abatacept) / BMS, Actemra IV (tocilizumab) / Roche, JW Pharma
[VIRTUAL] RHEUMATOID ARTHRITIS AND INTERSTITIAL LUNG DISEASE: PREVALENCE AND DRUG PRESCRIPTIONS IN GERMAN CLAIMS DATA (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_3799;
Specialist care is necessary to provide disease-specific therapies. While methotrexate is the most commonly used DMARD, the bDMARD prescription is heterogeneous.
- Actemra IV (tocilizumab) / Roche, JW Pharma
[VIRTUAL] ADULT-ONSET STILL’S DISEASE: A SINGLE-CENTER EXPERIENCE (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_3772;
In the differential diagnosis of fever of unknown origin especially with rash, AOSD should be considered. Corticosteroid was the main treatment modality.
- leflunomide / Generic mfg.
[VIRTUAL] THE REMITTING SERONEGATIVE SYMMETRICAL SYNOVITIS WITH PITTING EDEMA SYNDROME (RS3PE): REVIEW OF TEN YEARS AT A REFERENCE HOSPITAL (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_3758;
No specific biomarkers have been described, but inflammatory reaction is often found in the absence of rheumatoid arthritis biomarkers. Rapid response to corticosteroids is prevalent.
- hydroxychloroquine / Generic mfg., rifampicin / Generic mfg.
[VIRTUAL] CHEMOPROPHYLAXIS IN LATENT TUBERCULOSIS ASSOCIATED WITH RHEUMATIC IMMUNE-MEDIATED DISEASES. STUDY OF 240 PATIENTS FROM A SINGLE UNIVERSITY HOSPITAL (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_3746;
RIF was mainly used as second-line therapy if an adverse event with INH was observed. Treatment was generally well tolerated and most adverse events did not require the withdrawal of the treatment.
- [VIRTUAL] MULTICENTER STUDY OF 71 PATIENTS WITH REFRACTORY UVEITIS RELATED TO IMMUNE-MEDIATED INFLAMMATORY DISEASES ON CERTOLIZUMAB PEGOL TREATMENT (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_3744;
Previous BT was administered in 48 (67.6%) patients, with a mean of 1.4±1.3 drugs per patient as follows: ADA (n=56), IFX (27), golimumab (14), tocilizumab (5) and etanercept (3)... CZP seems to be effective and safe in patients with refractory uveitis due to IMID.
- Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
[VIRTUAL] COMORBID INFECTIONS IN PATIENTS WITH SPONDYLOARTHRITIS. (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_3425;
The data obtained indicate the important of the problem of CI in SpA. Further studies are needed on large samples of patients in order to find significant risk factors for CI, study their relationship with clinical characteristics and influence on the course of SpA.
- Simponi (golimumab) / Merck (MSD), Mitsubishi Tanabe, J&J, Enbrel (etanercept) / Pfizer, Amgen, Humira (adalimumab) / Eisai, AbbVie
[VIRTUAL] IMMUNOGENICITY AND SAFETY OF 23-VALENT PNEUMOCOCCAL POLYSACCHARIDE VACCINE IN PATIENTS WITH SPONDYLOARTHRITIS. (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_3424;
The obtained data indicate satisfactory immunogenicity and good tolerability of PPV-23 in patients with SpA. Further studies are needed to better assess the immunogenicity and safety of vaccine, as well as to study of the influence of anti-rheumatic therapy on the effectiveness of immunization.
- sulfasalazine / Generic mfg., leflunomide / Generic mfg.
[VIRTUAL] PREDICTING CARDIOVASCULAR EVENTS IN PATIENTS WITH SPONDYLOARTHRITIS: 3 RISK ALGORITHMS (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_3286;
The adaptation of CV risk algorithms according EULAR recommendations did not provide an improvement in discriminative ability. Overall, the algorithms studied presented a low sensibility or specificity.
- sulfasalazine / Generic mfg., leflunomide / Generic mfg.
[VIRTUAL] SCORES OF CARDIOVASCULAR RISK CALCULATORS AS PREDICTORS OF EARLY ATHEROSCLEROSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_3106;
The optimal ratio of specificity and sensitivity is shown for the mSCORE scale. Stratification of CVR in RA patients should include assessment of the carotid intima-media thickness.
- [VIRTUAL] EFFECT OF RHEUMATOID ARTHRITIS TREATMENTS ON THE INTIMA-MEDIA THICKNESS OF SUPRA-AORTIC TRUNKS AND ON CARDIOVASCULAR RISK (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_3059;
SLZ was associated with an increase in IMT. NSAIDs did not affect IMT in our study.
- Actemra SC (tocilizumab SC) / Roche, Halozyme
[VIRTUAL] ANTI-IL-6 THERAPY EFFECT FOR REFRACTORY JOINT AND SKIN INVOLVEMENT IN SYSTEMIC SCLEROSIS: A REAL-WORLD, SINGLE CENTER EXPERIENCE (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_2776;
Long-term retention rates and disease stabilization for most real-world patients suggest that tocilizumab might be a valuable choice for difficult-to-treat SSc. Clinical and laboratory parameters and measures (mean ± SD) at baseline and after one year of treatment with tocilizumab in 20 patients with Systemic Sclerosis mRSS: modified Rodnan skin score; DAS28: disease activity score 28; FVC: forced vital capacity; DLCO: diffusing lung capacity for carbon monoxide; ESR: erythrocyte sedimentation rate; CRP: c-reactive protein; SHAQ: scleroderma health assessment questionnaire; VAS: visual analogue scale
- hydroxychloroquine / Generic mfg.
[VIRTUAL] CLINICAL FEATURES AND OUTCOME OF 1054 PATIENTS WITH SYSTEMIC SCLEROSIS: AN ANALYSIS OF THE PORTUGUESE REUMA.PT REGISTRY FOR SCLERODERMA (REUMA.PT/SSC) (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_2761;
Clinical features of Portuguese SSc patients are similar to what has been described in other populations although the overall 5-year survival in recently diagnosed patients appears to be higher than previously reported. Cumulative clinical and immunologic characteristics of Portuguese SSc patients PDE-5 (phosdiasterase-5); PPIs (proton pump inhibitors); PAH-Pulmonary arterial hypertension confirmed by right heart catheterization.
- Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
[VIRTUAL] DIFFERENTIAL CLINICAL PRESENTATION BETWEEN SLE RUPHUS PATIENTS AND SLE NON-RHUPUS PATIENTS: A CASE-CONTROL STUDY (Posters Viewing) - May 21, 2021 - Abstract #EULAR2021EULAR_2596;
Patients with rhupus were older and had lower SLEDAI-2K scores compared with those non-rhupus. Furthermore, renal, neurological, and hematological manifestations were more common in non-rhupus patients than in rhupus patients.