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- | LY294002 / Eli Lilly
Journal: Trimethylamine N-Oxide Induces Renal Fibrosis Through the PI3K/AKT/SREBP1 Pathway (Pubmed Central) - Jan 6, 2024
Besides, the high expression of SREBP1 caused by TMAO was inhibited after HK2 cells were incubated with LY294002, a PI3K-AKT pathway inhibitor (P<0.05). TMAO may induce renal fibrosis by promoting the PI3K/AKT/SREBP1 pathway.
- | LY294002 / Eli Lilly
Journal: 27-Hydroxycholesterol inhibits trophoblast fusion during placenta development by activating PI3K/AKT/mTOR signaling pathway. (Pubmed Central) - Jan 5, 2024
Moreover, the PI3K inhibitor LY294002 rescued the inhibitory effect of 27-OHC...This study was the first to prove that 27-OHC inhibits trophoblast cell fusion by Activating PI3K/AKT/mTOR signaling pathway. This study reveals a novel mechanism by which dyslipidemia during pregnancy results in adverse pregnancy outcomes.
- | LY294002 / Eli Lilly
Preclinical, Journal: ADORA2B, transcriptionally suppressing by MYC, promotes ferroptosis of chondrocytes via inhibition of the PI3K/Akt pathway in mice with osteoarthritis. (Pubmed Central) - Jan 4, 2024
Overexpression of ADORA2B promoted ferroptosis, while the PI3K/Akt pathway inhibitor LY294002 reversed the promotion of ADORA2B on ferroptosis...In summary, ADORA2B, transcriptionally suppressing by MYC, promotes ferroptosis of chondrocytes via inhibition of the PI3K/Akt pathway. Thus, ADORA2B can be used as a potential treatment target for ferroptosis-related diseases.
- | LY294002 / Eli Lilly
Journal: MiR-22-3p facilitates bone marrow mesenchymal stem cell osteogenesis and fracture healing through the SOSTDC1-PI3K/AKT pathway. (Pubmed Central) - Dec 28, 2023
Thus MiR-22-3p facilitated the femoral fracture healing in rats. MiR-22-3p overexpression promoted fracture healing via the activation of PI3K/AKT pathway by targeting SOSTDC1.
- | LY294002 / Eli Lilly
Preclinical, Journal: Impacts of delta 9-tetrahydrocannabinol against myocardial ischemia/reperfusion injury in diabetic rats: Role of PTEN/PI3K/Akt signaling pathway. (Pubmed Central) - Dec 27, 2023
LY294002 pretreatment abolished the cardioprotective action of THC. This study revealed the cardioprotective effects of THC against IR-induced myocardial injury in diabetic rats and also suggested that the mechanism may be associated with enhanced activity of the PI3K/Akt signaling pathway through the reduction of PTEN phosphorylation.
- | LY294002 / Eli Lilly, MG132 / Jilin University, Dorothy M. Davis Heart and Lung Research Institute
Journal: Ursolic acid inhibits the metastasis of colon cancer by downregulating ARL4C expression. (Pubmed Central) - Dec 26, 2023
Collectively, it was revealed in the present study that UA served as a novel solution to relieve colon cancer metastasis by inducing the ubiquitination?mediated degradation of ARL4C by modulating the AKT signalling pathway. Thus, UA may be a promising treatment option to prolong the survival of patients with colon cancer metastasis.
- | LY294002 / Eli Lilly
Journal, IO biomarker: TIM-3 regulates the proliferation by BDNF-mediated PI3K/AKT axis in the process of endometriosis. (Pubmed Central) - Dec 24, 2023
Thus, UA may be a promising treatment option to prolong the survival of patients with colon cancer metastasis. TIM-3 can promote the proliferation of endometriosis by BDNF-mediated PI3K/AKT axis in vivo and in vitro, which may provide a new therapeutic target for the treatment of endometriosis.
- | LY294002 / Eli Lilly
Journal, IO biomarker: Bilobalide attenuates lipopolysaccharide?induced HepG2 cell injury by inhibiting TLR4?NF??B signaling via the PI3K/Akt pathway. (Pubmed Central) - Dec 21, 2023
Furthermore, it was observed that LY294002 diminished the cytoprotective effects of BB on cell injury, TLR4 expression and NF-?B activation. These findings indicated that BB could attenuate LPS-induced inflammatory injury to HepG2 cells by regulating TLR4-NF-?B signaling.
- | LY294002 / Eli Lilly
Preclinical, Journal, IO biomarker: Intranasal administration of recombinant prosaposin attenuates neuronal apoptosis through GPR37/PI3K/Akt/ASK1 pathway in MCAO rats. (Pubmed Central) - Dec 20, 2023
These findings indicated that BB could attenuate LPS-induced inflammatory injury to HepG2 cells by regulating TLR4-NF-?B signaling. PSAP small interfering ribonucleic acid (siRNA), GPR37 siRNA, and PI3K specific inhibitor LY294002 were administered intracerebroventricularly 48
- | LY294002 / Eli Lilly
Journal: miR-30a-5p targets ITGA6 to inhibit oral squamous cell carcinoma progression. (Pubmed Central) - Dec 17, 2023
PSAP small interfering ribonucleic acid (siRNA), GPR37 siRNA, and PI3K specific inhibitor LY294002 were administered intracerebroventricularly 48 Taken together, miR-30a-5p prevents OSCC progression by inhibiting PI3K/AKT pathway through inhibition of ITGA6 expression.
- | LY294002 / Eli Lilly
Journal: The CXCL10/CXCR3 axis regulates Th1 cell differentiation and migration in experimental autoimmune prostatitis through the PI3K/AKT pathway. (Pubmed Central) - Dec 14, 2023
Taken together, miR-30a-5p prevents OSCC progression by inhibiting PI3K/AKT pathway through inhibition of ITGA6 expression. Our investigations indicate that the CXCL10/CXCR3 axis regulates Th1 cell differentiation and migration in EAP through the PI3K/AKT pathway, which provides a new perspective on the immunological mechanisms of CP/CPPS.
- | LY294002 / Eli Lilly
Preclinical, Journal: Astragaloside IV promotes cerebral angiogenesis and neurological recovery after focal ischemic stroke in mice via activating PI3K/Akt/mTOR signaling pathway. (Pubmed Central) - Dec 13, 2023
Finally, AS-IV increased the expression of vascular endothelial growth factor (VEGF) through activating the PI3K/AKT/mTOR signaling pathway in the process of promoting angiogenesis. These results suggested that AS-IV may promote angiogenesis after ischemic stroke through increasing the expression of VEGF via PI3K/Akt/mTOR pathway, which unveils novel therapeutic effects of AS-IV and suggests promising application of AS-IV in ischemic stroke.
- | LY294002 / Eli Lilly
Journal: Ghrelin inhibits myocardial pyroptosis in diabetic cardiomyopathy by regulating ERS and NLRP3 inflammasome crosstalk through the PI3K/AKT pathway. (Pubmed Central) - Dec 13, 2023
In summary, we demonstrated that ghrelin inhibited myocardial pyroptosis in diabetic cardiomyopathy by regulating ERS and NLRP3 inflammasome crosstalk through the PI3K/AKT pathway. Our results provide new insights into the mechanism of diabetic myocardial injury induced by high glucose and high palmitic acid and ghrelin-mediated anti-inflammatory protection and provide potential therapeutic targets and strategies for diabetic cardiomyopathy.
- | LY294002 / Eli Lilly
Journal, IO biomarker: The Role of Bcl-2 and Beclin-1 Complex in "Switching" between Apoptosis and Autophagy in Human Glioma Cells upon LY294002 and Sorafenib Treatment. (Pubmed Central) - Dec 9, 2023
Our results provide new insights into the mechanism of diabetic myocardial injury induced by high glucose and high palmitic acid and ghrelin-mediated anti-inflammatory protection and provide potential therapeutic targets and strategies for diabetic cardiomyopathy. "Switching" between apoptosis and autophagy using PI3K and Raf inhibitors with Bcl-2:beclin-1 complex formation opens new therapeutic perspectives against gliomas.
- | LY294002 / Eli Lilly, dizocilpine (MK801) / Merck (MSD)
Preclinical, Journal: Inhibiting Caveolin-1-Related Akt/mTOR Signaling Pathway Protects Against N-methyl-D-Aspartate Receptor Activation-Mediated Dysfunction of Blood-Brain Barrier in vitro. (Pubmed Central) - Dec 9, 2023
"Switching" between apoptosis and autophagy using PI3K and Raf inhibitors with Bcl-2:beclin-1 complex formation opens new therapeutic perspectives against gliomas. Caveolin-1 (Cav-1) related Akt/mTOR signaling probably contributes to BBB dysfunction by activating NMDAR on human brain microvascular cells.
- | LY294002 / Eli Lilly
Journal: Emodin exhibits anti-acne potential by inhibiting cell growth, lipogenesis, and inflammation in human SZ95 sebocytes. (Pubmed Central) - Dec 7, 2023
In addition, emodin could decrease the secretion of pro-inflammatory cytokines IL-6 and IL-8, and suppress the expression of NLRP3, capase-1, IL-1?, and IL-18 in SZ95 sebocytes exposed to Cutibacterium acnes. Overall, our study provides preliminary evidence supporting the anti-growth, anti-lipogenic and anti-inflammatory properties of emodin, indicating the potential therapeutic application of emodin for acne treatment.
- | LY294002 / Eli Lilly
Preclinical, Journal: Tsantan Sumtang, a traditional Tibetan medicine, protects pulmonary vascular endothelial function of hypoxia-induced pulmonary hypertension rats through AKT/eNOS signaling pathway. (Pubmed Central) - Dec 6, 2023
TS restored pulmonary arterial endothelial function in HPH rats. The bioactive fraction 17 was screened, which protected hypoxia-injured PAECs via upregulating AKT/eNOS signaling.
- | LY294002 / Eli Lilly
New trial: Mechanism of PI3K / AKT Regulating COL2A1 Expression in Delaying Intervertebral Disc Degeneration (EUDRACT) - Dec 5, 2023
P=N/A, N=24, Recruiting, Sponsor: Orthopedics Department of Affiliated Hospital of Zunyi Medical University; Affiliated Hospital of Zunyi Medical University
The bioactive fraction 17 was screened, which protected hypoxia-injured PAECs via upregulating AKT/eNOS signaling. .
- | LY294002 / Eli Lilly
Journal: Intestinal uric acid excretion contributes to serum uric acid decrease during acute gout attack. (Pubmed Central) - Dec 4, 2023
Increased intestinal urate excretion resulted in spontaneous SUA downregulation during acute gout attacks. Inflammation-induced PI3K/Akt activation and ABCG2 expression in epithelial cells might contribute to the upregulation of intestinal uric acid excretion.
- | LY294002 / Eli Lilly, SP600125 / BMS
Journal: Disruption of CADM1-dependent cell-cell adhesion in human oral squamous cell carcinoma cells results in tumor progression, possibly through an increase of MMP-2 and MMP-9 expression. (Pubmed Central) - Nov 30, 2023
Inflammation-induced PI3K/Akt activation and ABCG2 expression in epithelial cells might contribute to the upregulation of intestinal uric acid excretion. The disruption of CADM1-dependent cell-cell adhesion in human oral squamous cell carcinoma cells resulted in tumor progression, possibly through an increase in MMP-2 expression in a MEK/PI3K-dependent manner and an increase in MMP-9 expression in a JNK/p38 MAPK/PI3K-dependent manner.
- | LY294002 / Eli Lilly
Journal: Xinshuaining preparation protects H9c2 cells from HO-induced oxidative damage through the PI3K/Akt/Nrf-2 signaling pathway. (Pubmed Central) - Nov 30, 2023
However, Xinshuaining preparation on the cell viability, apoptosis, and oxidative stress was notably antagonized by LY294002 pre-treatment. The medicated serum of Xinshuaining preparation increased the cell viability and suppressed apoptosis and oxidative stress via the PI3K/Akt/Nrf-2 signaling pathway.
- | LY294002 / Eli Lilly
Journal: PLEKHG2 Promotes NSCLC Cell Growth by Increasing Glycolysis via Activated PI3K/AKT Pathway. (Pubmed Central) - Nov 29, 2023
PLEKHG2 contributed to NSCLC development by promoting glycolysis via activation of the PI3K/AKT pathway. PLEKHG2 was a potential therapeutic target and biomarker for poor prognosis of NSCLC.
- | LY294002 / Eli Lilly
Preclinical, Journal: Se-(Methyl)-selenocysteine ameliorates blood-brain barrier disruption of focal cerebral ischemia mice via ferroptosis inhibition and tight junction upregulation in an Akt/GSK3?-dependent manner. (Pubmed Central) - Nov 29, 2023
These results suggested that SeMC exerted protection against ischemic stroke, which might be attributed to activating the Akt/GSK3? signaling pathway and increasing the nuclear translocation of Nrf2 and ?-catenin, subsequently maintaining the integrity of BBB.
- | progesterone / Generic mfg.
Journal: Attenuated AKT signaling by miR-146a-5p interferes with chicken granulosa cell proliferation, lipid deposition and progesterone biosynthesis. (Pubmed Central) - Nov 29, 2023
In summary, the findings revealed that miR-146a-5p suppressed cell growth, lipid deposition, and progesterone biosynthesis via the DEGS1/AKT pathway. These results may further enrich our understandings of how non-coding RNA regulates productive performance in chickens.
- | LY294002 / Eli Lilly
Preclinical, Journal: Establishment of pseudorabies virus latency and reactivation model in mice dorsal root ganglia culture. (Pubmed Central) - Nov 27, 2023
The efficiency of reactivation for LY294002, forskolin, etoposide, dexamethasone, and acetylcholine was found to be dependent on their concentration. In conclusion, we developed a valuable model of PRV latency and reactivation, which provides a basis for future mechanism research.
- | LY294002 / Eli Lilly
Journal: HOXD9/miR-451a/PSMB8 axis is implicated in the regulation of cell proliferation and metastasis via PI3K/AKT signaling pathway in human anaplastic thyroid carcinoma. (Pubmed Central) - Nov 27, 2023
Blocking or activation of PI3K by LY294002 or 740Y-P could attenuate the effect of HOXD9 interference or overexpression on ATC progression...Our research suggests that through PI3K/AKT signaling, the HOXD9/miR-451a/PSMB8 axis may have significance in the control of cell proliferation and metastasis in ATC. Thus, HOXD9 could serve as a potential target for the diagnosis of ATC.
- | LY294002 / Eli Lilly, erastin - Whitehead Institute for Biomedical Research, Dana / Farber Cancer Institute, Columbia University, Prolexys, MG132 / Jilin University, Dorothy M. Davis Heart and Lung Research Institute
Preclinical, Journal: Corilagin attenuates intestinal ischemia/reperfusion injury in mice by inhibiting ferritinophagy-mediated ferroptosis through disrupting NCOA4-ferritin interaction. (Pubmed Central) - Nov 27, 2023
Thus, HOXD9 could serve as a potential target for the diagnosis of ATC. Corilagin might be a potential therapeutic agent for II/R-induced tissue injury.
- | LY294002 / Eli Lilly
Journal: Resveratrol inhibits bFGF-induced M-CSF synthesis via the PI3-kinase/Akt pathway in osteoblasts. (Pubmed Central) - Nov 27, 2023
Deguelin, Akt inhibitor, and LY294002, phosphatidylinositol 3-kinase (PI3-kinase) inhibitor, reduced bFGF-induced M-CSF synthesis...Suppressive effect of resveratrol on bFGF-induced osteoprotegerin mRNA expression was confirmed in the identical samples using in experiment of M-CSF mRNA expression. Therefore, resveratrol reduces bFGF-induced M-CSF synthesis in addition to OPG synthesis by inhibiting PI3-kinase/Akt pathway and suppressive effects are mediated through SIRT1 activation in osteoblasts.
- | LY294002 / Eli Lilly
Journal: Grape Seed Proanthocyanidin Ameliorates LPS-induced Acute Lung Injury By Modulating M2a Macrophage Polarization Via the TREM2/PI3K/Akt Pathway. (Pubmed Central) - Nov 27, 2023
In addition, GSP-enhanced PI3K/Akt activity was prevented by TREM2 siRNA. In conclusion, this study demonstrated that GSP could ameliorate LPS-induced ALI by modulating macrophage polarization from M1 to M2a via the TREM2/PI3K/Akt pathway.
- | LY294002 / Eli Lilly
Preclinical, Journal: Cheng's Juanbi Decoction alleviates the inflammation in collagen-induced arthritis (CIA) rats via inhibiting activation of PI3K/AKT/mTOR pathway (Pubmed Central) - Nov 23, 2023
Beclin-1 mRNA and protein expression and LC3B protein level were significantly increased. Conclusion JBT may alleviate joint inflammation by inhibiting the activation of the PI3K/AKT/mTOR signaling pathway, and the therapeutic effect of high-dose JBT is comparable to that of MTX and LY294002.
- | LY294002 / Eli Lilly
Journal: Hyperoside Prevents A?42-Induced Neurotoxicity in PC12 Cells and Caenorhabditis elegans. (Pubmed Central) - Nov 21, 2023
The results of molecular docking further indicated that the PI3K/Akt pathways may be involved in the protection of A?42-induced PC12 cells by hyperoside treatment. The study provides theoretical information for research and development of hyperoside as an antioxidant dietary supplement.
- | LY294002 / Eli Lilly
Journal: Salvianolic acid B and tanshinone IIA synergistically improve early diabetic nephropathy through regulating PI3K/Akt/NF-?B signaling pathway. (Pubmed Central) - Nov 21, 2023
The study provides theoretical information for research and development of hyperoside as an antioxidant dietary supplement. Salvianolic acid B and tanshinone IIA can synergistically improve glucose and lipid disorders, liver and kidney damage, and resist kidney inflammation in early DN rats, and the mechanism may be related to regulating PI3K/Akt/NF-?B signaling pathway.
- | LY294002 / Eli Lilly
Preclinical, Journal: Trichosanthin-derived peptide Tk-PQ attenuates immune rejection in mouse tracheal allotransplant model by suppressing PI3K-Akt and inducing type II immune polarization. (Pubmed Central) - Nov 20, 2023
Indeed, the immune suppression phenotypes of Tk-PQ was recapitulated by a PI3K inhibitor LY294002. Taken together, Tk-PQ regulates post-transplantation immuno-rejection by modulating the balance of T cell response via the PI3K-Akt pathway, making it a promising peptide based immune rejection suppressant for patients receiving allotransplant.
- | LY294002 / Eli Lilly
Journal: Pectolinarigenin attenuates hepatic ischemia/reperfusion injury via activation of the PI3K/AKT/Nrf2 signaling pathway. (Pubmed Central) - Nov 20, 2023
Further studies found that LY294002 (PI3K inhibitor) suppressed the protective effect of Pec on hepatic I/R injury. In summary, our results show that Pec inhibits oxidative stress, inflammatory responses, and apoptosis, thereby attenuating I/R-induced liver injury and H/R-induced cell damage via activation of the PI3K/AKT/Nrf2 pathway.
- | LY294002 / Eli Lilly
Journal, IO biomarker: Songorine inhibits oxidative stress-related inflammation through PI3K/AKT/NRF2 signaling pathway to alleviate lipopolysaccharide-induced septic acute lung injury. (Pubmed Central) - Nov 18, 2023
Furthermore, LY294002 (a PI3K inhibitor) treatment reversed the protective effect of songorine on sepsis-induced ALI. Songorine inhibits oxidative stress-related inflammation in sepsis-induced ALI via the activation of the PI3K/AKT/NRF2 signaling pathway.
- | Inlyta (axitinib) / Pfizer, LY294002 / Eli Lilly
Journal: Study on the Protective Effect of Platelet-Rich Plasma Combined with Injection of Pain Points Around Knee Joint on Knee Osteoarthritis and its Molecular Mechanism. (Pubmed Central) - Nov 17, 2023
The effect of the LY294002 +PRP group was better than that of the above groups...PRP can promote chondrocytes proliferation and repair by activating the PI3K/AKT signaling pathway, thereby exerting anti-OA effects. It provides new targets and methods for the clinical treatment of OA.
- | LY294002 / Eli Lilly
Preclinical, Journal: Protective Effect of Illicium Verum Extract On Vascularization In Rats With Osteoporotic Fracture. (Pubmed Central) - Nov 17, 2023
It provides new targets and methods for the clinical treatment of OA. Then, Illicium verum extract
- | LY294002 / Eli Lilly
Journal: Role of senkyunolide I in the promotion of neural stem/progenitor cell proliferation via the Akt/?-catenin pathway. (Pubmed Central) - Nov 15, 2023
downregulated differentiated processes. Thus, SEI promoted the NS/PC proliferation and suppressed NS/PC differentiation into neurons and/or astrocytes, therefore SEI could be an interesting and promising candidate for stimulating NSCs.
- | LY294002 / Eli Lilly, Erivedge (vismodegib) / Roche
Journal: Inhibition of Hedgehog signaling ameliorates foam cell formation by promoting autophagy in early atherosclerosis. (Pubmed Central) - Nov 14, 2023
Therefore, our result demonstrated that inhibition of the Hh signaling pathway increases cholesterol efflux and ameliorates macrophage-derived foam cell formation by promoting autophagy in vitro. Our data thus suggested a novel therapeutic target of atherosclerosis and indicated the potential of vismodegib to treat atherosclerosis.
- | LY294002 / Eli Lilly, SB225002 / GSK
Journal: Chemokine receptor CXCR2 in primary sensory neurons of trigeminal ganglion mediates orofacial itch. (Pubmed Central) - Nov 13, 2023
Collectively, we report that CXCR2 in the primary sensory neurons of trigeminal ganglion contributes to orofacial itch through the PI3K/Akt signaling pathway. These observations highlight the potential of molecules involved in the regulation of CXCR2 as viable therapeutic targets for the treatment of itch.
- | Victoza (liraglutide) / Novo Nordisk
Journal: The Key Role of Liraglutide in Preventing Autophagy of Vascular Smooth Muscle Cells in High Glucose Conditions. (Pubmed Central) - Nov 13, 2023
This protective role of LIRA was augmented by LY294002, but inhibited by Exe9-39. LIRA plays a significant role in the improvement of the biological features of VSMCs in HG conditions.
- | LY294002 / Eli Lilly
Journal: POLR3G promotes EMT via PI3K/AKT signaling pathway in bladder cancer. (Pubmed Central) - Nov 7, 2023
Inhibition of this pathway with LY294002 reduced the enhanced migration and invasion of BLCA cells induced by POLR3G overexpression, whereas the activation of this pathway using 740Y-P restored the abilities that were inhibited by POLR3G knockdown. Taken together, our findings suggested that POLR3G is a prognostic predictor for BLCA and promotes EMT of BLCA through activation of the PI3K/AKT signaling pathway.
- | LY294002 / Eli Lilly
Preclinical, Journal: Veratramine Inhibits Porcine Epidemic Diarrhea Virus Entry through Macropinocytosis by Suppressing PI3K/Akt Pathway. (Pubmed Central) - Nov 6, 2023
Taken together, VAM possessed anti-PEDV properties against the entry stage of PEDV by inhibiting the macropinocytosis pathway by suppressing the PI3K/Akt pathway. VAM could be considered as a lead compound for the development of anti-PEDV drugs and may be used during the viral entry stage of PEDV infection.
- | CBT-1 (tetrandrine) / CBA Pharma
Journal: Tetrandrine (TET) inhibits African swine fever virus entry into cells by blocking the PI3K/Akt pathway. (Pubmed Central) - Nov 6, 2023
Furthermore, the inhibitory effect of TET against other viruses such as Lumpy Skin Disease Virus (LSDV) and Porcine Epidemic Diarrhea Virus (PEDV) was also identified. Our findings suggest that TET effectively inhibits ASFV and reveal the potential for broad-spectrum antiviral drugs targeting the PI3K/Akt pathway.
- | LY294002 / Eli Lilly
Journal: Berberine protects against neomycin-induced ototoxicity by reducing ROS generation and activating the PI3K/AKT pathway. (Pubmed Central) - Nov 6, 2023
The protective effect of BBR against ototoxicity was also evident in a neomycin-injured animal model, as evidenced by the preservation of HC and SGN in mice administered subcutaneous BBR for 7?days. In summary, all results suggest that BBR has potential as a new and effective otoprotective agent, operating via the PI3K/AKT signaling pathway.
- | LY294002 / Eli Lilly
Preclinical, Journal, IO biomarker: The Streptococcus virulence protein PepO triggers anti-tumor immune responses by reprograming tumor-associated macrophages in a mouse triple negative breast cancer model. (Pubmed Central) - Nov 5, 2023
In summary, all results suggest that BBR has potential as a new and effective otoprotective agent, operating via the PI3K/AKT signaling pathway. Our research identified a possible macrophage-based TNBC immunotherapeutic approach and suggested a novel anticancer immunoregulatory molecular called PepO.
- | LY294002 / Eli Lilly
Journal: MiR-150-5p contributes to unexplained recurrent spontaneous abortion by targeting VEGFA and downregulating the PI3K/AKT/mTOR signaling pathway. (Pubmed Central) - Nov 5, 2023
Our research identified a possible macrophage-based TNBC immunotherapeutic approach and suggested a novel anticancer immunoregulatory molecular called PepO. Overall, these findings imply that miR-150-5p is among the key factors that regulate the pathogenesis of URSA.
- | LY294002 / Eli Lilly
Journal: MEK/ERK and PI3K/AKT pathway inhibitors affect the transformation of myelodysplastic syndrome into acute myeloid leukemia via H3K27me3 methylases and de?methylases. (Pubmed Central) - Nov 5, 2023
Treatment with U0126/Ly294002 also resulted in a decreased H3K27me3 protein level and H3K27me3 level in the DLX5 promoter region, leading to an increased DLX5 expression. Overall, the findings of the present study suggest that U0126/Ly294002 participates in MDS?AML transformation by modulating the levels of H3K27me3 methylases and de?methylases, and regulating DLX5 transcription and expression.
- | LY294002 / Eli Lilly
Journal, Metastases: IL-8 is a novel prometastatic chemokine in intrahepatic cholangiocarcinoma that induces CXCR2-PI3K/AKT signaling upon CD97 activation. (Pubmed Central) - Nov 4, 2023
Finally, the induction of CD97 expression by the PI3K pathway was verified by treatment with the inhibitor LY294002...Collectively, the study presents a novel mechanism of the IL-8-CXCR2-PI3K/AKT axis in regulating CD97 expression, which leads to ICC metastasis mainly through EMT. The study may provide alternatives for targeting the tumor microenvironment in metastatic ICC.
- | LY294002 / Eli Lilly
Journal: KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway. (Pubmed Central) - Nov 4, 2023
KIRREL may mediate the proliferation and angiogenesis of gastric cancer cells through the PI3K/AKT/mTOR signalling pathway. These findings could help in the further development of potential anti-angiogenesis targets.