LY294002 / Eli Lilly 
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  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  Piceatannol Suppresses the Proliferation and Induced Apoptosis of Osteosarcoma Cells Through PI3K/AKT/mTOR Pathway. (Pubmed Central) -  May 6, 2020   
    Human osteosarcoma cells in this study were, respectively, treated with PIC at various concentrations (0, 20, 40, 80 μmol/L), PI3K/AKT/mTOR pathway inhibitor (LY294002), or pathway activator (740Y-P) plus PIC...The PI3K/AKT/mTOR pathway was prominently inhibited in PIC-treated osteosarcoma cells and tumor tissues. PIC suppresses the proliferation and induces apoptosis of osteosarcoma cells through regulating PI3K/AKT/mTOR pathway, which is expected to be the therapeutic of osteosarcoma.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    CLAUDIN-1 ENHANCES LIPID DROPLET ACCUMULATION TO PROMOTE DYSPLASIA BY AKT/SREBP-1C SIGNALING () -  May 4, 2020 - Abstract #DDW2020DDW_4233;    
    Moreover, claudin-1 mediated increase in LD through SREBP-1c was accompanied by a significant increase in mTOR/AKT activation as LY294002 significantly repressed the TNF-α mediated increase in PLIN-1 expression...Colon crypts from Cldn-1Tg mice demonstrated increased PLIN-1 expression (LD coat protein) relative to the WT crypts. Overall, these findings unravel a novel role of Claudin-1 protein in regulating lipogenesis to regulate intestinal homeostasis and role in promoting IBD and progression to cancer
  • ||||||||||  AiTan (rivoceranib) / HLB Bio Group
    Journal, IO Biomarker:  Apatinib suppresses the Proliferation and Apoptosis of Gastric Cancer Cells via the PI3K/Akt Signaling Pathway. (Pubmed Central) -  May 2, 2020   
    Overall, these findings unravel a novel role of Claudin-1 protein in regulating lipogenesis to regulate intestinal homeostasis and role in promoting IBD and progression to cancer The experiment proves that Apatinib can effectively suppress the proliferation and induce the apoptosis of human gastric cancer HGC-27 cells, the mechanism of which is related to the inhibition on phosphorylation of the PI3K/Akt signaling pathway.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  The role of secreted Hsp90α in HDM-induced asthmatic airway epithelial barrier dysfunction. (Pubmed Central) -  Apr 30, 2020   
    Therefore, we have shown that GLP-1 exerts its cardioprotective effects by alleviating ER stress-induced apoptosis due to H/R injury and that these effects are most likely associated with the activation of GLP-1R/PI3K/Akt signaling pathway. Secreted Hsp90α medicates HDM-induced asthmatic airway epithelial barrier dysfunction via PI3K/AKT pathway, indicating that anti-secreted Hsp90α therapy might be a potential treatment to asthma in future.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  Trans-10-hydroxy-2-decenoic acid alleviates LPS-induced blood-brain barrier dysfunction by activating the AMPK/PI3K/AKT pathway. (Pubmed Central) -  Apr 23, 2020   
    Compound C (an AMPK inhibitor) and LY294002 (a PI3K inhibitor) markedly reversed the alleviating effect of 10-HDA on the expression of tight junction proteins, indicating that 10-HDA inhibited LPS-induced BBB dysfunction by triggering the activation of the AMPK/PI3K/AKT pathway. Collectively, these data reveal that 10-HDA may be an interesting candidate for clinical evaluation in the treatment of diseases related to BBB damage.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Preclinical, Journal:  Protectin DX increases alveolar fluid clearance in rats with lipopolysaccharide-induced acute lung injury. (Pubmed Central) -  Apr 22, 2020   
    Furthermore, BOC-2, Rp-cAMP, and LY294002 blocked the increased alveolar fluid clearance in response to protectin DX. Protectin DX stimulates alveolar fluid clearance through a mechanism partly dependent on alveolar epithelial sodium channel and Na, K-ATPase activation via the ALX/PI3K/Nedd4-2 signaling pathway.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  PI3K inhibition highlights new molecular interactions involved in the skeletogenesis of Paracentrotus lividus embryos. (Pubmed Central) -  Apr 22, 2020   
    The effects of LY294002 (LY), a PI3K-specific inhibitor, were evaluated at morphological and molecular levels...Based on the present results and in silico analyses, we propose an "interactomic" model simulating PI3K connections in P. lividus embryos. Our findings define a novel regulatory step in the embryonic skeletogenesis, and provide valuable molecular data for further studies on the role of PI3K signaling in invertebrate biomineralization.
  • ||||||||||  sirolimus / Generic mfg., University of Cincinnati
    Journal:  Extracellular transglutaminase 2 induces myotube hypertrophy through G protein-coupled receptor 56. (Pubmed Central) -  Apr 22, 2020   
    Knockdown of G protein-coupled receptor 56 (GPR56) inhibited the effects of TG2 on mTOR signaling, protein synthesis, and hypertrophy. These results indicated that TG2 expression was upregulated through ATRA-mediated RARγ and that extracellular TG2 induced myotube hypertrophy by activating mTOR signaling-mediated protein synthesis through GPR56, independent of transglutaminase activity.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  Sanbai Melon Seed Oil Exerts Its Protective Effects in a Diabetes Mellitus Model via the Akt/GSK-3β/Nrf2 Pathway. (Pubmed Central) -  Apr 14, 2020   
    Further studies showed that LY294002, aPI3K inhibitor, abolished the effects of SMSO on GSK-3β phosphorylation and Nrf2 nuclear translocation as well as the protective effects on pancreatic β cells. Together, these results suggest that SMSO regulates the Akt/GSK-3β/Nrf2 pathway and induces the expression of antioxidant proteins to impede oxidative stress in rats with T2DM.
  • ||||||||||  dexamethasone / Generic mfg., Decadron (dexamethasone) / Merck (MSD)
    Journal:  Dexamethasone Interferes with Autophagy and Affects Cell Survival in Irradiated Malignant Glioma Cells. (Pubmed Central) -  Apr 11, 2020   
    Dexamethasone increased cell survival in p53 mutated malignant glioma cells and increased autophagy in PTEN-mutant malignant glioma cell but not in PTEN-wildtype cell. The difference of autophagy response could be mediated though the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin signaling pathway.
  • ||||||||||  TriptoSar (triptolide) / Pierre Fabre
    Journal:  Triptolide inhibits angiogenesis in microvascular endothelial cells through regulation of miR-92a. (Pubmed Central) -  Apr 10, 2020   
    Meanwhile, ITGA5 overexpression increased phosphorylation of ERK, PI3K and AKT while ITGA5 silence reversed the trend. TPL (as an anti-angiogenesis agent) suppressed angiogenesis by upregulating miR-92a, and miR-92a-mediated down-regulation of ITGA5 blocked the signaling transduction of ERK and PI3K/AKT pathways.
  • ||||||||||  quercetin (LY294002) / Eli Lilly, silmitasertib (CX-4945) / Senhwa Biosciences, University of California
    Journal:  Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells. (Pubmed Central) -  Apr 10, 2020   
    However, we found that the PI3K inhibitor LY294002 reduced GSK3β pS9, and concomitantly decreased Snail1 levels (a GSK3β target and Epithelial-to-Mesenchymal transition marker). The effects of LY294002 were observed also in CK2β-downregulated cells, suggesting that reducing GSK3β pS9 could be a strategy to control Snail1 levels in any situation where CK2β is defective, as possibly occurring in cancer cells.
  • ||||||||||  quercetin (LY294002) / Eli Lilly, U0126 / Promega
    Journal, IO Biomarker:  SULF2 promotes tumorigenesis and inhibits apoptosis of cervical cancer cells through the ERK/AKT signaling pathway. (Pubmed Central) -  Apr 9, 2020   
    The results in the SULF2 group were quite the opposite in which SULF2 facilitated the growth of cervical cancer cells, which was reversed by LY294002 or U0126. SULF2 is highly expressed in cervical cancer, and thus, downregulation of SULF2 can inhibit the ERK1/2 and AKT signaling pathways to suppress the proliferation, invasion, and migration of cervical cancer cells while facilitating apoptosis.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  Fisetin Prevents HT22 Cells From High Glucose-Induced Neurotoxicity via PI3K/Akt/CREB Signaling Pathway. (Pubmed Central) -  Apr 9, 2020   
    More importantly, the decreased phosphorylation of phosphoinositide 3 kinase (PI3K), Akt, and cAMP-response element binding protein (CREB) was rescued by fisetin treatment and that neuroprotective effect of fisetin was partially blocked by PI3K inhibitor, LY294002. These findings indicate that fisetin has potent neuroprotective effect and prevents HG-induced neurotoxicity by activation of PI3K/Akt/CREB pathway.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  Critical roles of PI3K/Akt/NF‑κB survival axis in angiotensin II‑induced podocyte injury. (Pubmed Central) -  Mar 31, 2020   
    Cells were treated with 10‑6 mol/l of Ang II and/or LY294002 (inhibitor of Akt) or 740Y‑P (activator of PI3K) for 48 h to detect Akt, phosphorylated (phospho)‑Akt, p65 NF‑κB, and phospho‑p65 NF‑κB, nephrin, podocin and caspase‑9 expression, and podocyte apoptosis...The data suggested that Ang II could regulate the expression of nephrin, podocin and caspase‑9. Collectively, our findings suggested that the PI3K/Akt/NF‑κB survival axis may serve a pivotal role in podocyte injury.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Preclinical, Journal:  The Effects of Progranulin in a Rat Model of Acute Myocardial Ischemia/Reperfusion are Mediated by Activation of the P13K/Akt Signaling Pathway. (Pubmed Central) -  Mar 31, 2020   
    Before modeling, one group was treated with progranulin (0.03 µg/kg), and one group was treated with the P13K/Akt inhibitor, LY294002 (3 mg/kg)...CONCLUSIONS In the rat model of acute MI/R injury, progranulin had a protective effect on cardiac function and morphology, associated with activation of the P13K/Akt signaling pathway. The mechanisms of the anti-apoptotic, anti-inflammatory, and inotropic effects of progranulin in the setting of acute MI/R injury require further in vivo studies.