LY294002 / Eli Lilly 
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  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway. (Pubmed Central) -  Oct 24, 2020   
    Furthermore, the Akt agonist, insulin-like growth factor-1 (IGF-1), prevented I/R injury in TSLPR-/- mice and an Akt inhibitor, LY294002, blocked the protective effects of TSLP in WT mice subjected to I/R...Through this pathway, TSLP induces autophagy in hepatocytes. Thus, TSLP is a potent inhibitor of stress-induced hepatocyte necrosis.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Preclinical, Journal, IO Biomarker:  Herbal complex 'Buyang Huanwu Tang' improves motor endplate function of denervated-dependent skeletal muscle atrophy in rat. (Pubmed Central) -  Oct 24, 2020   
    Moreover, PI3K specific blocker, LY294002, significantly inhibited the effects of Buyang Huanwu Tang on the above molecule expression (P < 0.05). In conclusion, Buyang Huanwu Tang improved motor endplate functions of denervated-dependent skeletal muscle atrophy rat model through suppressing mitochondria-mediated apoptosis and activating PI3K/PKB/FOXO1 signaling pathway.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  BuShen HuoXue Decoction Promotes Decidual Stromal Cell Proliferation via the PI3K/AKT Pathway in Unexplained Recurrent Spontaneous Abortion. (Pubmed Central) -  Oct 23, 2020   
    RhIL-17 A, LY294002 (a PI3K pathway inhibitor), and BSHXD were individually or simultaneously administered in NEP DSCs, suggesting that BSHXD restored cell proliferation without excessive stimulation and IL-17A promotes proliferation via the PI3K/AKT pathway...We demonstrated that BSHXD affected IL-17A/IL-17R via PI3K/AKT pathway to promote the proliferative activity of DSCs in URSA. These results provide a new insight to further clarify the relationship between inflammation and apoptosis and the mechanism of imbalance in the dynamic equilibrium between Th17/Treg immune cells at the maternal-fetal interface.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  CLEC5A promotes the proliferation of gastric cancer cells by activating the PI3K/AKT/mTOR pathway. (Pubmed Central) -  Oct 21, 2020   
    CLEC5A-mediated GC proliferation and anti-apoptosis were impaired by blocking the PI3K/AKT/mTOR pathway with LY294002. We hypothesize that CLEC5A is of vital importance to GC initiation and progression via the PI3K/AKT/mTOR pathway, and that our results might represent promising therapeutic strategies for GC patients.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Preclinical, Journal:  Trilobatin ameliorates insulin resistance through IRS-AKT-GLUT4 signaling pathway in C2C12 myotubes and ob/ob mice. (Pubmed Central) -  Oct 20, 2020   
    Furthermore, administration with trilobatin for 4 weeks significantly improved insulin resistance by decreasing fasting blood glucose and insulin in serum, enhancing the phosphorylation of IRS1 and AKT, and recovering the expression and translocation of GLUT4 in ob/ob mice. IRS-AKT-GLUT4 signaling pathway might be involved in trilobatin ameliorating insulin resistance in skeletal muscle of obese animal models.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  Saponins of Momordica charantia increase insulin secretion in INS-1 pancreatic β-cells via the PI3K/Akt/FoxO1 signaling pathway. (Pubmed Central) -  Oct 20, 2020   
    Moreover, saponins increased the phosphorylation of Akt protein and decreased the protein level of FoxO1, which were both reversed by the PI3K inhibitor ly294002...The immunofluorescence results also confirmed this tendency. In conclusion, our findings improve our understanding of the function of saponins in INS-1 pancreatic β-cells and suggest that saponins may increase insulin secretion via the PI3K/Akt/FoxO1 signaling pathway.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Preclinical, Journal:  Inhibition of TRPA1 Promotes Cardiac Repair in Mice after Myocardial Infarction. (Pubmed Central) -  Oct 8, 2020   
    However, treatment of HUVECs with a PI3K inhibitor, LY294002 before HC administration almost completely abolished HC-induced migration in HUVECs. In conclusion, we demonstrate that inhibition of TRPA1 promotes angiogenesis after MI thereby alleviating myocardial ischemia injury via mechanisms involving inhibition of PTEN expression, and subsequent activation of the PI3K/Akt signaling.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51-AKT1 signaling. (Pubmed Central) -  Oct 8, 2020   
    Stable cell lines were produced by transducing with USP53 overexpression vector or short hairpin RNA targeting USP53 in the presence and absence of AKT pathway inhibitor LY294002...Mechanistically, USP53 deubiquitinates FKBP51, which in turn dephosphorylates AKT1, and ultimately inhibits tumor growth in lung adenocarcinoma. Taken together, our study establishes USP53 as a novel regulator of AKT1 pathway with an important role in tumorigenesis in lung adenocarcinoma.
  • ||||||||||  benzesulfonate (PF-562271) / Pfizer, quercetin (LY294002) / Eli Lilly
    Journal:  Antiangiogenic effects of AG36, a triterpenoid saponin from Ardisia gigantifolia stapf. (Pubmed Central) -  Oct 8, 2020   
    Molecular docking simulation indicated that AG36 formed hydrogen bonds and hydrophobic interactions within the ATP binding pocket of VEGFR2 kinase domain. The present study firstly revealed the high antiangiogenic potency and related underlying molecular of AG36, demonstrating that AG36 maybe a potential antiangiogenic cancer therapy agent or lead candidate.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    [VIRTUAL] LY294002 Improves the Collagen-induced Arthritis by Inducing Neutrophil Apoptosis () -  Oct 8, 2020 - Abstract #ACRARHP2020ACR_ARHP_1411;    
    The present study firstly revealed the high antiangiogenic potency and related underlying molecular of AG36, demonstrating that AG36 maybe a potential antiangiogenic cancer therapy agent or lead candidate. This data suggested that delayed apoptosis of neutrophils played an important role in the development of RA, therefore, inhibition of PI3K pathway to facilitate neutrophil apoptosis are possible approaches to reduce inflammatory arthritis which might open new doors to future clinical treatment of RA.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  Estradiol-Induced MMP-9 Expression via PELP1-Mediated Membrane-Initiated Signaling in ERα-Positive Breast Cancer Cells. (Pubmed Central) -  Oct 2, 2020   
    E-bovine serum albumin (BSA), a large molecular membrane-impenetrable conjugate of E, can also upregulate MMP-9 protein expression in MCF-7, and the action of E-BSA can be abolished by PI3K inhibitor LY294002; treating MCF-7 simultaneously with PELP1-shRNA and LY294002 did not show synergetic inhibitory effect on E-BSA-induced MMP-9 expression. Our results indicated that estrogen-induced MMP-9 expression in ER-positive breast cancer cells may be through PELP1-mediated PI3K/Akt signaling pathway.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Preclinical, Journal:  GPR174 suppression attenuates retinopathy in angiotensin II (Ang II)-treated mice by reducing inflammation via PI3K/AKT signaling. (Pubmed Central) -  Oct 1, 2020   
    The in vitro data showed that pre-treatment of PI3 K/AKT specific inhibitor LY294002 remarkably abrogated GPR174 over-expression-accelerated expression levels of Iba-1, tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in lipopolysaccharide (LPS)-incubated retinal microglial cells.Furthermore, in LPS-exposed retinal microglial cells, PI3 K/AKT and NF-κB pathways were further promoted by GPR174 over-expression, which were significantlyabolished by LY294002. Thus, GPR174 might be a positive meditator of inflammation, contributing to Ang II-induced retinopathy by activating PI3 K/AKT signaling, and could be considered as a novel therapeutic target for the treatment of hypertensive retinopathy.
  • ||||||||||  quercetin (LY294002) / Eli Lilly, CEP-33779 / Teva
    Journal:  EPO promotes axonal sprouting via upregulating GDF10. (Pubmed Central) -  Sep 30, 2020   
    Impeding JAK2 signaling with CEP-33779 can suppress the phosphorylation of PI3K, and this confirms that the upstream of PI3K signaling is JAK2. These present results provide a novel insight into the role of EPO and the molecular mechanism of axonal sprouting, which is beneficial for the development of novel approaches for neurological recovery after brain injury, including stroke.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  miR-365 inhibits duck myoblast proliferation by targeting IGF-Ⅰ via PI3K/Akt pathway. (Pubmed Central) -  Sep 26, 2020   
    Importantly, the enhanced PI3K, Akt, mTOR and S6K expression by miR-365 inhibitor (anti-miR-365) was abrogated by treatment with LY294002, a PI3K inhibitor. Together, our results indicated that miR-365 may target IGF-Ⅰ to inhibit duck myoblast proliferation via PI3K/Akt pathway.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  Zinc induces iron egress from intestinal Caco-2 cells via induction of Hephaestin: A role for PI3K in intestinal iron absorption. (Pubmed Central) -  Sep 25, 2020   
    LY294002, an inhibitor of PI3K, inhibited the zinc-induced iron transport, DMT1, HEPH mRNA and protein expression...These results suggest that intestinal cell zinc status is a critical determinant of iron absorption and effects are mediated via activation of PI3K. Further, PI3K pathway appears to selectively modulate the expression of iron transporters and iron absorption, therefore this might serve as a therapeutic target in iron overload disorders.
  • ||||||||||  low molecular weight dextran sulfate (ILB) / TikoMed, quercetin (LY294002) / Eli Lilly
    Preclinical, Journal:  Glutamine relieves oxidative stress through PI3K/Akt signaling pathway in DSS-induced ulcerative colitis mice. (Pubmed Central) -  Sep 25, 2020   
    The mice in the experimental group drank 4% dextran sulfate sodium salt (DSS) for 7 consecutive days...Administration of Gln to the DSS-induced colitis mice led to a clearly reduction in oxidative stress-induced injury. The Gln is confirmed as inhibiting the PI3K/Akt signaling pathway activity.
  • ||||||||||  sirolimus / Generic mfg.
    Preclinical, Journal:  Suppression of Akt-mTOR pathway rescued the social behavior in Cntnap2-deficient mice. (Pubmed Central) -  Sep 23, 2020   
    We further showed that the effect of LY294002 and rapamycin on social behaviors is reversible. Our results thus identified hyperactive Akt-mTOR signaling pathway as a therapeutic target for abnormal social behavior in patients with dysfunction of CNTNAP2.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  Low-intensity pulsed ultrasound promotes the proliferation of human bone mesenchymal stem cells by activating PI3K/AKt signaling pathways. (Pubmed Central) -  Sep 21, 2020   
    However, these effects were inhibited when cells were treated with PI3K inhibitor (LY294002), which in turn reduced LIPUS-mediated proliferation of hBMSCs. These results suggest that LIPUS exposure may be involved in the proliferation of hBMSCs via activation of the PI3K/AKt signaling pathway and high expression of cyclin D1, and the intensity of 50 or 60 mW/cm and exposure time of 5 minutes were determined to be the optimal parameters for LIPUS exposure.