LY294002 / Eli Lilly 
Welcome,         Profile    Billing    Logout  
 0 Diseases   1 Trial   1 Trial   4393 News 


«12...2425262728293031323334...4950»
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  IRS-2/Akt/GSK-3β/Nrf2 Pathway Contributes to the Protective Effects of Chikusetsu Saponin IVa against Lipotoxicity. (Pubmed Central) -  May 29, 2021   
    Furthermore, siRNA-targeted Nrf2, PI3K/Akt inhibitor (LY294002), or GSK-3β inhibitor (LiCl) was used to investigate the crosstalk relationships between proteins...In addition, inhibition of PI3K/Akt or GSK-3β with specific inhibitors dramatically abrogated the protective effects of CHS, revealing that the IRS-2/Akt/GSK-3β signaling axis was involved in the protective effects of CHS. These results demonstrate that CHS protected βTC3 cells against PA-induced oxidative stress and cell dysfunction through Nrf2 by the IRS-2/Akt/GSK-3β-mediated pathway.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal, IO biomarker:  Kirenol Inhibits B[a]P-Induced Oxidative Stress and Apoptosis in Endothelial Cells via Modulation of the Nrf2 Signaling Pathway. (Pubmed Central) -  May 29, 2021   
    Activation of suppressed nuclear Nrf2 and reduced antioxidant genes across cells interacting with an LY294002 confirmed this phenomenon...Finally, the expression of apoptotic proteins also supported the hypothesis that KRL may inhibit endothelial dysfunction. This study showed that KRL potentially prevents B[a]P-induced redox imbalance in the vascular endothelium by inducing the Nrf2 signaling via the PI3K/AKT pathway.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  Knockdown of NOLC1 Inhibits PI3K-AKT Pathway to Improve the Poor Prognosis of Esophageal Carcinoma. (Pubmed Central) -  May 29, 2021   
    A recombined lentiviral vector containing NOLC1 was applied for transfecting ESCA cells (Eca109 and TE-13) and established a stable cell line with low NOLC1 expression or high NOLC1 expression, in the absence or presence of PI3K inhibitor (LY294002) treatment...NOLC1 may be a marker for poor prognosis. It can participate in the occurrence and development of ESCA via the PI3K/AKT pathway.
  • ||||||||||  erastin - Whitehead Institute for Biomedical Research, Dana / Farber Cancer Institute, Columbia University, Prolexys
    Journal:  Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway. (Pubmed Central) -  May 29, 2021   
    In conclusion, this work demonstrated that LXA4 exerted a neuroprotective effect in Erastin-induced ferroptosis of primary spinal cord neurons by activating Akt/Nrf2/HO-1 signaling pathway. Thus, this work provides novel insights into the mechanisms of action of LXA4 in ferroptosis of primary spinal cord neurons, and indicates that LXA4 may be a potential therapeutic agent for SCI.
  • ||||||||||  Venclexta (venetoclax) / Roche, AbbVie, quercetin (LY294002) / Eli Lilly
    Journal, IO biomarker:  Bcl-2 Is Involved in Cardiac Hypertrophy through PI3K-Akt Pathway. (Pubmed Central) -  May 27, 2021   
    Furthermore, no matter LY294002, an inhibitor of the PI3K/AKT signaling pathway, or Venetoclax, a selective Bcl-2 inhibitor, protected against cardiac hypertrophy. In conclusion, these data indicate that Bcl-2 is involved in cardiac hypertrophy as a key downstream effector of PI3K-Akt signaling pathway, suggesting a potential therapeutic target for the clinical management of cardiac hypertrophy.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Preclinical, Journal:  Myricitrin pretreatment ameliorates mouse liver ischemia reperfusion injury. (Pubmed Central) -  May 26, 2021   
    Thus, our results suggest that targeting of FoxO3a can be considered as a novel strategy for the treatment of LN. These results demonstrate that myricitrin alleviates liver I/R injury by suppressing oxidative stress, the inflammatory response, and apoptosis, improving liver proliferation and upregulating p-eNOS expression.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  Nobiletin alleviates ischemia/reperfusion injury in the kidney by activating PI3K/AKT pathway. (Pubmed Central) -  May 26, 2021   
    Additionally, the PI3K/AKT inhibitor LY294002 was also used in mechanistic experiments...The inhibition of PI3K/AKT signaling with pharmacological inhibitors could reverse the beneficial effects of NOB during renal I/R insult. In conclusion, NOB pre‑treatment may alleviate I/R injury in the kidney by inhibiting reactive oxygen species production and ERS‑induced apoptosis, partly through the PI3K/AKT signaling pathway.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  Dieckol Ameliorates Aβ Production via PI3K/Akt/GSK-3β Regulated APP Processing in SweAPP N2a Cell. (Pubmed Central) -  May 22, 2021   
    The specific phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 triggered GSK-3β activation and Aβ expression. In addition, co-treatment with LY294002 noticeably blocked the effect of dieckol on Aβ production, demonstrating that dieckol promoted the PI3K/Akt signaling pathway, which in turn inactivated GSK-3β, resulting in the reduction in Aβ levels.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  The effects and mechanisms of GM-CSF on endometrial regeneration. (Pubmed Central) -  May 21, 2021   
    NOX4-mediated ROS production alters TGF-β-induced cell differentiation and collagen I protein synthesis in HBSMCs in part through the p38MAPK/Akt signaling pathway in a Smad-dependent manner. We found that GM-CSF could improve endometrial regeneration, possibly through activating PI3K/Akt signaling pathway.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Preclinical, Journal, IO biomarker:  Activation of the Melanocortin-1 Receptor by NDP-MSH Attenuates Oxidative Stress and Neuronal Apoptosis through PI3K/Akt/Nrf2 Pathway after Intracerebral Hemorrhage in Mice. (Pubmed Central) -  May 21, 2021   
    Mc1r siRNA and PI3K inhibitor LY294002 were administrated to inhibit the expression of Mc1r and phosphorylation of PI3K, respectively...Conversely, downregulating the expression of Mc1r and phosphorylation of PI3K aggravated the neurological deficits and brain edema at 24 hours after ICH, meanwhile, the effect of NDP-MSH on the expression of Mc1r, p-PI3K, p-Akt, p-Nrf2, Bcl-2, and cleaved caspase 3 was also abolished. In conclusion, our data suggest that the activation of Mc1r by NDP-MSH ameliorates oxidative stress and neuronal apoptosis through the PI3K/Akt/Nrf2 signaling pathway after ICH in mice.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  PI3K/AKT/mTOR signaling participates in insulin-mediated regulation of pathological myopia-related factors in retinal pigment epithelial cells. (Pubmed Central) -  May 20, 2021   
    In summary, SPostC prevented myocardial ischemia/reperfusion injury possibly through TOPK-mediated PTEN/PI3K/Akt activation and impaired activation of this signaling pathway may be responsible for the loss of SPostC cardioprotection by SPostC in diabetes. Our results indicated that insulin regulated the secretion of PM-related factors via the PI3K/AKT/mTOR signaling pathway in retinal pigment epithelial cells, and thus probably promoted the development of PM through transducing regulation signals from retina to choroid and sclera.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Preclinical, Journal:  Dahuang Zhechong pill attenuates CCl4-induced rat liver fibrosis via the PI3K-Akt signaling pathway. (Pubmed Central) -  May 15, 2021   
    In vitro experiments further demonstrated that DHZCP markedly suppressed HSCs proliferation by downregulating PI3K/Akt, which exerted a synergistic effect with the PI3K inhibitor LY294002. To sum up, our results confirmed that DHZCP exerted an antifibrotic effect in the animal model through inactivating the PI3K/Akt pathway, thus protecting rats from liver injury.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Preclinical, Journal:  Tolerance induced by DHPG postconditioning is mediated by the PI3K/Akt/GSK3β signalling pathway in an in vitro model of cerebral ischemia. (Pubmed Central) -  May 15, 2021   
    DHPG PostC also induces a transient increased in GSK3β phosphorylation and inactivation that is followed by nuclear accumulation of β-catenin, that probably lead to the up-regulation of neuroprotective genes. Our results propose GSK3β as new target for neuroprotection, therefore, we verified that the two GSK3β inhibitors N-(3-Chloro-4-methylphenyl)-5-(4-ni​trophenyl)-1,3,4-oxadiazol-2-amine (TC-G 24) and LiCl are neuroprotective agents in OGD and also can be used as PostC agents.
  • ||||||||||  Nexavar (sorafenib) / Bayer, Amgen
    Journal, Cancer stem cells:  Secretory clusterin promotes hepatocellular carcinoma progression by facilitating cancer stem cell properties via AKT/GSK-3β/β-catenin axis. (Pubmed Central) -  May 15, 2021   
    Our results propose GSK3β as new target for neuroprotection, therefore, we verified that the two GSK3β inhibitors N-(3-Chloro-4-methylphenyl)-5-(4-ni​trophenyl)-1,3,4-oxadiazol-2-amine (TC-G 24) and LiCl are neuroprotective agents in OGD and also can be used as PostC agents. Taken together, the oncogenic sCLU might promote CSC phenotype via activating AKT/GSK3β/β-catenin axis, suggesting that sCLU was a potential molecular-target for HCC therapy.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal, IO biomarker:  Tribulus terrestris Ameliorates Oxidative Stress-Induced ARPE-19 Cell Injury through the PI3K/Akt-Nrf2 Signaling Pathway. (Pubmed Central) -  May 15, 2021   
    Pretreatment with the inhibitor of PI3K/Akt signaling (LY294002) completely blocked these EE-TT-upregulated mRNA expressions and abolished the improvement of cell viability in HO-treated ARPE-19 cells. These findings all suggest that Tribulus terrestris has significant antioxidant effects on oxidative stressed ARPE-19 cells through regulating PI3K/Akt-Nrf2 signaling pathway.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  Hesperidin ameliorates liver ischemia/reperfusion injury via activation of the Akt pathway. (Pubmed Central) -  May 14, 2021   
    In summary, the results of the present study suggested that HDN may protect against liver I/R injury through activating the Akt pathway by ameliorating liver oxidative stress, suppressing inflammation and preventing hepatocyte apoptosis. HDN may be a useful factor for liver injury protection and a potential therapeutic treatment for liver I/R injury in the future.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Preclinical, Journal:  Astaxanthin alleviates spinal cord ischemia-reperfusion injury via activation of PI3K/Akt/GSK-3β pathway in rats. (Pubmed Central) -  May 12, 2021   
    Overall, these results suggest that AST pretreatment not only mitigates pathological tissue damage but also effectively improves neural functional recovery following SCII, primarily by alleviating oxidative stress but not inhibiting inflammation. A possible underlying molecular mechanism of AST may be mainly attributed to the activation of PI3K/Akt/GSK-3β pathway.
  • ||||||||||  quercetin (LY294002) / Eli Lilly
    Journal:  Mangiferin inhibits cell migration and angiogenesis via PI3K/AKT/mTOR signaling in high glucose‑ and hypoxia‑induced RRCECs. (Pubmed Central) -  May 11, 2021   
    Additionally, further activation of the PI3K/AKT signaling pathway by IGF‑1 inhibited the beneficial effects of mangiferin on RRCECs, whereas deactivation of the PI3K/AKT signaling pathway by LY294002 displayed the opposite results. Collectively, the results of the present study suggested that mangiferin suppressed RRCEC angiogenesis via modulating the PI3K/AKT/mTOR signaling pathway, which could serve as an effective treatment strategy for DR.
  • ||||||||||  sirolimus / Generic mfg.
    Journal:  AIM2 inhibits colorectal cancer cell proliferation and migration through suppression of Gli1. (Pubmed Central) -  May 8, 2021   
    Moreover, AIM2 could modulate Protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway and the increased Gli1 expression and EMT progress induced by AIM2 depletion was reversed after incubation with AKT inhibitor Ly294002 in CRC cells. In conclusion, our results define AIM2 as a novel regulator of Gli1 in CRC cell growth and metastasis, and suggest that the AIM2/AKT/mTOR/Gli1 signaling axis may serve as a potential target for treatment of CRC.