 |
0 Diseases |  |
1 Trial |
|
1 Trial |  |
4393 News |  |
| 12345678910111213...4950» |
- | LY294002 / Eli Lilly
Journal, IO biomarker: Scutellarin Alleviates Neuronal Apoptosis in Ischemic Stroke via Activation of the PI3K/AKT Signaling Pathway. (Pubmed Central) - Mar 13, 2025
In a rat model of middle cerebral artery occlusion, scutellarin administration demonstrated comparable neuroprotective effects, maintaining neuronal survival and modulating apoptotic protein expression via PI3K/AKT pathway activation. Collectively, this study demonstrates the therapeutic potential of scutellarin in cerebral ischemia through PI3K/AKT pathway modulation, suggesting its possible application in treating ischemic disorders.
- | LY294002 / Eli Lilly
Journal: Wedelolactone activates the PI3K/AKT/NRF2 and SLC7A11/GPX4 signalling pathways to alleviate oxidative stress and ferroptosis and improve sepsis-induced liver injury. (Pubmed Central) - Mar 12, 2025
Ferroptosis and oxidative stress are pivotal in SILI. WEL mitigates SILI by inhibiting ferroptosis and oxidative stress, primarily through the PI3K/AKT/NRF2 and SLC7A11/GPX4 signalling pathways, thus suggesting a promising therapeutic strategy.
- | LY294002 / Eli Lilly, resatorvid (TAK-242) / Takeda, Akaza Bioscience
Journal: Mechanism of Qingjie Fuzheng Granules in inhibiting colitis associated colorectal cancer by regulating TLR4 and IL-4R mediated macrophage polarization. (Pubmed Central) - Mar 12, 2025
WEL mitigates SILI by inhibiting ferroptosis and oxidative stress, primarily through the PI3K/AKT/NRF2 and SLC7A11/GPX4 signalling pathways, thus suggesting a promising therapeutic strategy. Various monomer components within QFG can bind to MD2 or IL-4R, respectively, thereby inducing macrophages towards an M1-like phenotype through TLR4-mediated NF-?B, MAPK, and PI3K/Akt pathway activation, or inhibiting macrophages towards an M2-like phenotype via IL-4R-mediated JAKs pathway inhibition, ultimately exerting an inhibitory effect on the occurrence and development of CAC.
- | Nutlin-3 / EMD Serono, LY294002 / Eli Lilly
Journal: Regulatory dynamics of Nanog in chondrocyte dedifferentiation: role of KLF4/p53 and p38/AKT signaling. (Pubmed Central) - Mar 12, 2025
Various monomer components within QFG can bind to MD2 or IL-4R, respectively, thereby inducing macrophages towards an M1-like phenotype through TLR4-mediated NF-?B, MAPK, and PI3K/Akt pathway activation, or inhibiting macrophages towards an M2-like phenotype via IL-4R-mediated JAKs pathway inhibition, ultimately exerting an inhibitory effect on the occurrence and development of CAC. Moreover, the p53 activator Nutlin-3
- simvastatin / Generic mfg.
TITLE: TITLE: SIMVASTATIN AMELIORATED A?1-42-INDUCED NEURONAL INJURY BY REGULATING NRF2/KEAP1 ANTI-OXIDATIVE PATHWAY AND INDUCING AUTOPHAGY ACTIVATION () - Mar 10, 2025 - Abstract #ADPD2025ADPD_1026;
Moreover, the p53 activator Nutlin-3 Aims: In Alzheimer
- | LY294002 / Eli Lilly, sirolimus / Generic mfg.
Journal: IIS/TOR network plays an essential role in ovarian development in the pupal stage of the fall armyworm, Spodoptera frugiperda. (Pubmed Central) - Mar 10, 2025
In contrast, the injection of IIS/TOR pathway inhibitors, LY294002 and Rapamycin, reduced the phosphorylation of these proteins, inhibiting ovarian development during the pupal stage and leading to a significant shortening of the ovarioles, negatively impacting the reproductive performance of adult females. The current findings indicate that the IIS/TOR signaling network significantly regulates ovarian development during the pupal stage of Spodoptera frugiperda, providing new molecular insights for the development of pest management strategies.
- | LY294002 / Eli Lilly
Journal: PML Regulated HIF1AN Ubiquitination and Activated PI3K/AKT Pathway to Promote Bone Marrow Mesenchymal Stem Cells Osteogenic Differentiation. (Pubmed Central) - Mar 10, 2025
PML or SOD3 overexpression remarkably promoted the BMSCs osteoblast differentiation under osteogenic medium, which was reversed by LY294002. PML acts as a significant regulator in the BMSCs osteogenic differentiation by regulating the HIF1AN/HIF1?/SOD3 axis and phosphatidylinositol 3 kinase/ protein kinase B pathway.
- | LY294002 / Eli Lilly
Journal: SP1/ADAM10/DRP1 axis links intercellular communication between smooth muscle cells and endothelial cells under hypoxia pulmonary hypertension. (Pubmed Central) - Mar 9, 2025
SP1 increases the secretion and levels of ADAM10 in hypoxia ECs. ADAM10 released by ECs regulates the hypoxia-induced malignant phenotype of SMCs via the DRP1 and PI3K/AKT/mTOR signaling pathways.
- | LY294002 / Eli Lilly
Journal: Polydatin accelerates osteoporotic bone repair by inducing the osteogenesis-angiogenesis coupling of bone marrow mesenchymal stem cells via the PI3K/AKT/GSK-3?/?-catenin pathway. (Pubmed Central) - Mar 7, 2025
ADAM10 released by ECs regulates the hypoxia-induced malignant phenotype of SMCs via the DRP1 and PI3K/AKT/mTOR signaling pathways. The data above indicated that POL could accelerate osteoporotic bone repair by inducing the osteogenesis-angiogenesis coupling of BMSCs via the PI3K/AKT/GSK-3?/?-catenin pathway, which provided new insight and strategy for osteoporotic bone repair.
- | LY294002 / Eli Lilly
Journal: Knockdown of PLOD2 inhibits pulmonary artery smooth muscle cell glycolysis under chronic intermittent hypoxia via PI3K/AKT signal. (Pubmed Central) - Mar 2, 2025
The data above indicated that POL could accelerate osteoporotic bone repair by inducing the osteogenesis-angiogenesis coupling of BMSCs via the PI3K/AKT/GSK-3?/?-catenin pathway, which provided new insight and strategy for osteoporotic bone repair. Silencing of PLOD2 inhibits PI3K/AKT signaling to limit PASMC glycolysis which allows PASMC proliferation and migration in CIH-induced pulmonary arterial hypertension (PAH).
- | LY294002 / Eli Lilly
Journal: A novel and promising therapeutic approach for treating pancreatic cancer: Nectin?4?targeted antibody?drug conjugates alone or combined with autophagy inhibitors. (Pubmed Central) - Feb 28, 2025
When Nectin?4?MMAE was combined with autophagy inhibitors, the tumor burden of mice was decreased compared with treatment with either drug alone. The present study confirmed the potent therapeutic effects of Nectin?4?MMAE against pancreatic cancer, and its unique antitumor mechanism provides new approaches to treatment.
- | LY294002 / Eli Lilly
Preclinical, Journal: ANP Increases Zn2? Accumulation During Reperfusion in Ex Vivo and In Vivo Hearts. (Pubmed Central) - Feb 27, 2025
ANP modulates Zn2? homeostasis during reperfusion injury by downregulating ZnT8 through the PI3K signalling pathway, thereby reducing myocardial I/R injury.
- | LY294002 / Eli Lilly
Journal: Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling. (Pubmed Central) - Feb 27, 2025
homeostasis during reperfusion injury by downregulating ZnT8 through the PI3K signalling pathway, thereby reducing myocardial I/R injury. Co-treatment with the PI3K inhibitor LY294002 (5?
- | LY294002 / Eli Lilly
Preclinical, Journal: Enhanced Anti-Cancer Potential: Investigating the Combined Effects with Coriolus versicolor Extract and Phosphatidylinositol 3-Kinase Inhibitor (LY294002) In Vitro. (Pubmed Central) - Feb 26, 2025
This study highlights the potent cytotoxic enhancement between CV extract and LY294002 on cancer cells, primarily by inhibiting phospho-PI3K expression. These findings suggest promising avenues for developing novel combination therapies targeting cancer.
- | LY294002 / Eli Lilly, doxorubicin hydrochloride / Generic mfg.
Journal: Astragalus polyphenols attenuates doxorubicin-induced cardiotoxicity by activating the PI3K/AKT/NRF2 pathway. (Pubmed Central) - Feb 25, 2025
These findings suggest that ASP may serve as a potential therapeutic agent to alleviate DIC. Our results provide a novel strategy to protect the heart in patients undergoing DOX chemotherapy.
- | bleomycin / Generic mfg., LY294002 / Eli Lilly
Journal: A micro-lung chip with macrophages for targeted anti-fibrotic therapy. (Pubmed Central) - Feb 25, 2025
These findings suggest that macrophages play a pivotal role in the potential development at the tissue level. The micro-lung chip cocultured with macrophages holds significant potential for exploring the pathological progression of IPF and elucidating the mechanisms of anti-fibrotic drugs.
- | bleomycin / Generic mfg., LY294002 / Eli Lilly
Journal: Enhancement of Ndrg2 promotes hypertrophic scar fibrosis by regulating PI3K/AKT signaling pathway. (Pubmed Central) - Feb 24, 2025
In summary, our results demonstrated that Ndrg2 could promote HTS fibrosis by mediating PI3K/AKT signaling pathway. Our data suggest that Ndrg2 may be a promising therapeutic target for HTS.
- | LY294002 / Eli Lilly, cisplatin / Generic mfg., Amdray (valspodar) / Novartis
Journal, PARP Biomarker: Scutellarein enhances cisplatin?induced apoptotic effects by suppressing the PI3K/AKT?MDR1 pathway in human NPC/HK1 nasopharyngeal carcinoma cells. (Pubmed Central) - Feb 24, 2025
Moreover, treatment with the MDR1 inhibitor, PSC833, inhibited MDR1 expression and increased the cisplatin-induced viability inhibition and cytokeratin 18 fragment release. These findings indicated that scutellarein enhances the anticancer effects of cisplatin by inhibiting the PI3K/AKT-MDR1 signaling pathway in NPC/HK1 cells.
- | LY294002 / Eli Lilly
Preclinical, Journal: Inflammation induced PFKFB3-mediated glycolysis promoting myometrium contraction through the PI3K-Akt-mTOR pathway in preterm birth mice. (Pubmed Central) - Feb 24, 2025
Subsequently, the inhibition of glycolysis using the glycolysis inhibitor 2-deoxyglucose can reverse inflammation-induced cell contraction...The PI3K-Akt pathway inhibitor LY294002 and the mTOR pathway inhibitor rapamycin effectively inhibited the upregulation of PFKFB3 protein expression, lactate production, and the enhancement of cell contraction induced by lipopolysaccharide...The PI3K-Akt pathway inhibitor LY294002 and the mTOR pathway inhibitor Rapamycin effectively inhibited the upregulation of PFKFB3 protein expression, lactate production, and the enhancement of cell contraction induced by lipopolysaccharide. This study indicates that inflammation regulates PFKFB3 through the PI3K-Akt-mTOR pathway, which enhances the glycolytic process in pregnant mUSMCs, ultimately leading to myometrial contraction.
- | Tagrisso (osimertinib) / AstraZeneca
Journal: Downregulation of Rad51 expression and activity potentiates the cytotoxic effect of osimertinib in human non-small cell lung cancer cells. (Pubmed Central) - Feb 23, 2025
This study indicates that inflammation regulates PFKFB3 through the PI3K-Akt-mTOR pathway, which enhances the glycolytic process in pregnant mUSMCs, ultimately leading to myometrial contraction. Collectively, the downregulation of Rad51 expression and activity enhances the cytotoxic effect of osimertinib in human NSCLC cells.
- | LY294002 / Eli Lilly
Journal: Effect of calcitonin gene-related peptide on autophagy in hypoxic/reoxygenated cardiomyocytes through regulation of PI3K/Akt/mTOR signaling pathway (Pubmed Central) - Feb 19, 2025
CGRP pretreatment attenuated H/R-induced cardiomyocyte injury, increased cell survival rate, and reduced cellular LDH release. This effect may be achieved through inhibiting the activation of PI3K/Akt/mTOR signaling pathway.
- | LY294002 / Eli Lilly
Journal: Keratocan Improves Muscle Wasting in Sarcopenia by Promoting Skeletal Muscle Development and Fast-Twitch Fibre Synthesis. (Pubmed Central) - Feb 18, 2025
Keratocan ameliorates muscle atrophy by activating the PI3K/AKT/mTOR pathway, promoting muscle satellite cell proliferation and myogenic differentiation, and facilitating the conversion of slow-to-fast muscle fibres. Our findings demonstrate the potential of keratocan as a novel therapeutic target for osteosarcopenia.
- | LY294002 / Eli Lilly
Journal: Inhibition of Ultraviolet B-induced Apoptosis in Fibroblasts by Human Umbilical Cord Blood Mesenchymal Stem Cell Conditioned Media via the Phosphatidylinositol-3-Kinase/Akt Pathway. (Pubmed Central) - Feb 17, 2025
The CM-hUCB-MSC-induced phosphorylation of Akt was significantly inhibited by LY294002 (P<0.001, Tukey's HSD test). Taken together, it can be concluded that CM-hUCB-MSC inhibits UVB-induced NIH3T3 cell apoptosis via the activation of phosphatidylinositol-3-kinase (PI3K)/Akt signaling cascades.
- | LY294002 / Eli Lilly
Preclinical, Journal: Trideoxycytidine diphosphate promotes neural stem cell proliferation and neurogenesis in mice. (Pubmed Central) - Feb 16, 2025
Taken together, it can be concluded that CM-hUCB-MSC inhibits UVB-induced NIH3T3 cell apoptosis via the activation of phosphatidylinositol-3-kinase (PI3K)/Akt signaling cascades. A simple food-derived structural molecule CCC promotes NSC proliferation through eEF1A2/PI3K-Akt signaling pathway, thereby enhancing neurogenesis.
- | LY294002 / Eli Lilly
Journal: Chronic NaAsO2 exposure promotes migration and invasion of prostate cancer cells by Akt/GSK-3?/?-catenin/TCF4 axis-mediated epithelial-mesenchymal transition. (Pubmed Central) - Feb 15, 2025
inactivation in the "disruption complex" in chronic NaAsO2 exposed DU145 and PC-3 cells...These findings provide evidence that chronic arsenic exposure promotes migration and invasion of prostate cancer cells via an EMT mechanism driven by the AKT/GSK-3?/?-catenin/TCF4 signaling axis. Akt is expected to be a potential therapeutic target for chronic arsenic exposure-mediated prostate cancer metastasis.
- | LY294002 / Eli Lilly
Journal: Mitigation PFHxA-induced neurotoxicity in Carassius auratus brain cells by selenium-enriched Bacillus subtilis via the BDNF/PI3K/AKT/GSK-3? pathway. (Pubmed Central) - Feb 15, 2025
Furthermore, utilisation of LY294002 and LICl inhibitors provided additional confirmation of the pivotal function of this pathway in neuroprotection...Selenium-enriched Bacillus subtilis can be used as a novel microecological preparation. Implementing this approach could effectively counteract neurotoxic consequences of emerging contaminants, hence safeguarding and preserving aquatic ecosystems.
- | labetalol / Generic mfg.
Preclinical, Journal, IO biomarker: Lipid Emulsion Mitigates the Cardiotoxic Effects of Labetalol in Rat Cardiomyoblasts. (Pubmed Central) - Feb 12, 2025
Overall, lipid emulsion inhibited apoptotic cell death caused by labetalol toxicity via the inhibition of intrinsic apoptotic pathway and MPTP in rat cardiomyoblasts, which appears to involve PI3K, Akt, and GSK-3? signaling pathways.
- | Journal: Molecular mechanism underlying cardioprotective effect of dehydroepiandrosterone on endoplasmic reticulum stress induced apoptosis in human vascular smooth muscle cells and human umbilical vein endothelial cells. (Pubmed Central) - Feb 12, 2025
DHEA was utilized to inhibit the apoptotic effects of DTT, while estrogen receptor (ER) antagonists ICI 182,780 and G15, the androgen receptor (AR) antagonist flutamide and the aromatase inhibitor letrozole were used to identify the receptors activated during DHEA treatment in HVSMCs and HUVECs...Furthermore, the primary receptor signaling pathways were identified using signaling pathway blockers: LY294002 (PI3K blocker), SP600125 (JNK blocker), and U0126 (ERK1/2 blocker)...Our study has identified a novel mechanism underlying the cardioprotective effects of DHEA. Specifically, DHEA may mitigate ERS-induced cell apoptosis by activating estrogen receptors ER?, ER?, and GPER via the activated JNK pathway.
- | LY294002 / Eli Lilly, PD98059 / Wayne State University
Journal: Effect of basic fibroblast growth factor on hypoxia-inducible factor (HIF)-1? expression (Exp) and HIF-1 transcription in breast Cancer cell through PI-3 (Pubmed Central) - Feb 7, 2025
Specifically, DHEA may mitigate ERS-induced cell apoptosis by activating estrogen receptors ER?, ER?, and GPER via the activated JNK pathway. Both MEK1/ERK and PI-3
- | LY294002 / Eli Lilly
Preclinical, Journal, IO biomarker: Electroacupuncture improves cognitive impairment after subarachnoid hemorrhage in rats through the PI3K/AKT signaling pathway. (Pubmed Central) - Feb 6, 2025
In addition, the effects of EA were abolished by LY294002. EA appeared to improve CI in a rat model of SAH through the activation of the PI3K/AKT pathway.
- | LY294002 / Eli Lilly, Mustargen (mechlorethamine) / Recordati
Journal, Stroma: PI3K Signaling and Lysyl Oxidase is Critical to Corneal Stroma Fibrosis Following Mustard Gas Injury. (Pubmed Central) - Feb 5, 2025
On the contrary, LY294002 in NM hCSFs significantly reduced PI3K, AKT, COL I, COL III, and LOX protein expression. We concluded that PI3K signaling mediates stromal collagen synthesis and LOX production following SM injury.
- | LY294002 / Eli Lilly
Journal: Perfluorobutanoic acid: A short-chain perfluoroalkyl substance exhibiting estrogenic effects through the estrogen-related receptor ? pathways. (Pubmed Central) - Feb 4, 2025
Taken together, the results revealed that PFBA had estrogen effects at the human-related exposure concentration, and demonstrated a new estrogen effects mechanism of PFBA via ERR? pathway.
- | LY294002 / Eli Lilly
Preclinical, Journal: NEDD4's effect on osteoblastogenesis potential of bone mesenchymal stem cells in rats concerned with PI3K/Akt pathway. (Pubmed Central) - Feb 3, 2025
Silencing NEDD4 with siRNA elevated alkaline phosphatase (ALP), osteocalcin (OCN), Akt, and mTORC1 expression during induction, while subsequent treatment with LY294002 (a broad spectrum PI3K inhibitor) reduced Akt, mTORC1, ALP, and OCN levels. These findings suggest that NEDD4 may inhibit BMSCs differentiation by suppressing the PI3K/Akt pathway during osteogenesis.
- | LY294002 / Eli Lilly
Journal: Perfluorooctanoic Acid Induces Ferroptosis in Hepatocytes via Oxidative Stress and AKT/GSK3?/?-Catenin Pathway Disruption. (Pubmed Central) - Feb 3, 2025
Overall, our results suggest that PFOA can lead to liver cell injury by inducing oxidative stress and ferroptosis. The effects are conferred through the regulation of the AKT/GSK3?/?-catenin signaling cascades.
- | LY294002 / Eli Lilly
Preclinical, Journal: Sufentanil enhances the cortical neurogenesis of rats with traumatic brain injury via PI3K/AKT signal pathway. (Pubmed Central) - Feb 2, 2025
While the rats with TBI were treated with LY294002 and Sufentanil together, the abovementioned effects of Sufentanil on the TBI rats were partially reversed. Our results indicate Sufentanil enhances the cortical neurogenesis and inhibits mechanical allodynia of rats with TBI through suppressing the oxidative stress, inflammation response and increasing the melatonin and BDNF levels partly via PI3K/AKT signal pathway.
- | LY294002 / Eli Lilly
Preclinical, Journal: Roux-en-Y gastric bypass improves liver and glucose homeostasis in Zucker diabetic fatty rats by upregulating hepatic trefoil factor family 3 and activating the phosphatidylinositol 3-kinase/protein kinase B pathway. (Pubmed Central) - Feb 2, 2025
Our results indicate Sufentanil enhances the cortical neurogenesis and inhibits mechanical allodynia of rats with TBI through suppressing the oxidative stress, inflammation response and increasing the melatonin and BDNF levels partly via PI3K/AKT signal pathway. RYGB regulates the expression of TFF3 in the liver of ZDF rats, thereby activating the PI3K/Akt pathway and improving T2DM.
- | LY294002 / Eli Lilly, SB202190 / Amgen
Journal: The protective effect of irisin against hemorrhagic injury is mediated by PI3K and p38 pathways in hemorrhage/resuscitation. (Pubmed Central) - Feb 2, 2025
RYGB regulates the expression of TFF3 in the liver of ZDF rats, thereby activating the PI3K/Akt pathway and improving T2DM. Experimental groups were divided based on the different treatments during resuscitation as follows: (1)
- | LY294002 / Eli Lilly
Journal: Sodium selenite inhibits the growth of cervical cancer cells through the PI3K/AKT pathway. (Pubmed Central) - Jan 30, 2025
Experimental groups were divided based on the different treatments during resuscitation as follows: (1) SS exerted its anti-cervical cancer effects by inhibiting cell proliferation, promoting apoptosis, and inhibiting the PI3K/AKT signaling pathway.
- | LY294002 / Eli Lilly
Journal: Acteoside alleviates salsolinol-induced Parkinson's disease by inhibiting ferroptosis via activating Nrf2/SLC7A11/GPX4 pathway. (Pubmed Central) - Jan 30, 2025
SAL inducing ferroptosis through downregulating SLC7A11/GPX4 in SH-SY5Y cells, which neurotoxic effect was reversed by ferroptosis inhibitors deferoxamine (DFO) and ferrostatin-1 (Fer-1)...Meanwhile, the PI3K inhibitor LY294002 suppressed the acteoside-induced Nrf2 expression and ensued decreased expression of SLC7A11/GPX4 in SAL-treated SH-SY5Y cells...The present study revealed a novel molecular mechanisms underlining SAL-induced neurotoxicity via induction of ferroptosis in PD, and uncovered a new pharmacological effect against PD through inhibiting ferroptosis. This study highlights SAL-induced ferroptosis -dependent neurotoxicity as a potential therapeutic target in PD.
- | LY294002 / Eli Lilly
Journal, PARP Biomarker, IO biomarker: PD15, a steroidal saponin, induces apoptosis of HCT116 colorectal cancer cells via suppressing the Akt/GSK3? pathway. (Pubmed Central) - Jan 29, 2025
These findings indicate that PD15 could trigger apoptosis by suppressing the Akt/GSK3? signaling pathway in HCT116 cells.
- | Journal: Plinabulin exerts an anti-proliferative effect via the PI3K/AKT/mTOR signaling pathways in glioblastoma. (Pubmed Central) - Jan 29, 2025
Additionally, plinabulin combined with erlotinib showed greater cytotoxic efficacy than either drug alone in glioblastoma cells in vitro. Our study provides new insights into the efficacy of plinabulin against glioblastoma and highlights the potential clinical utility of combining plinabulin with EGFR inhibitors as a chemotherapy strategy.
- | LY294002 / Eli Lilly
Journal: Lysyl oxidase-like 2 promotes the survival, migration, and ferroptosis of endometrial cancer cells by activating the phosphoinositide 3-kinase/protein kinase B pathway. (Pubmed Central) - Jan 29, 2025
However, the LY294002 inhibitor restores SLC7A11 and FTH1 expression while decreasing GPX4 (P<0.001). Our research demonstrated that LOXL2 might protect EC via phosphorylation by activating the PI3K/AKT pathway.
- | LY294002 / Eli Lilly, PD98059 / Wayne State University
Journal: Triiodothyronine (T3) increases the expression of the amphiregulin (AREG) oncogene by activating extranuclear pathways in MCF-7 breast cancer cells. (Pubmed Central) - Jan 29, 2025
In addition, CHX completely abolished T3-induced AREG mRNA expression, indicating that this effect requires prior protein synthesis. The identification that T3 acts through this signaling pathway holds considerable potential for clinical application, as it could lead to the development of specific drugs to block it.
- | LY294002 / Eli Lilly
Journal: Alcohol intake exacerbates experimental autoimmune prostatitis through activating PI3K/AKT/mTOR pathway-mediated Th1 differentiation. (Pubmed Central) - Jan 28, 2025
Our study is the first to demonstrate that alcohol intake promotes Th1 cell differentiation and exacerbates EAP by activating the PI3K/AKT/mTOR pathway. Additionally, the role of LY294002 in inhibiting PI3K/AKT/mTOR pathway to relieve EAP suggests that it can serve as a promising therapeutic target for CP/CPPS.
- | ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
Journal: Remimazolam inhibits apoptosis of endothelial and epithelial cells by activating the PI3K/AKT pathway in acute lung injury. (Pubmed Central) - Jan 28, 2025
Additionally, REM targeted TSPO to regulate this pathway in endothelial cells. These results suggested a potential protective role for REM in ALI/ARDS management.
- | LY294002 / Eli Lilly
Journal: AKT activation participates in Fascin-1-induced EMT in hepatoma cells. (Pubmed Central) - Jan 27, 2025
Fastin-1 protein levels and p-Akt1/Akt1 rate were increased by Akt activator SC79 and were decreased by Akt inhibitor LY294002...In conclusion, silencing Fascin-1 reduced the malignant growth of HCC, and this process was closely related to AKT inactivation. The online version contains supplementary material available at 10.1007/s10616-025-00707-9.
- | LY294002 / Eli Lilly
Journal: SLC39A14 promotes the development of esophageal squamous cell carcinoma through PI3K/Akt/mTOR signaling pathway. (Pubmed Central) - Jan 15, 2025
The online version contains supplementary material available at 10.1007/s10616-025-00707-9. Our findings suggest that SLC39A14 may serve as a potential biomarker for ESCC due to its pro-oncogenic role during ESCC progression.
- | LY294002 / Eli Lilly
Journal: Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging and mitochondrial dysfunction via PI3K/Akt/mTOR signaling pathway. (Pubmed Central) - Jan 15, 2025
PSP exhibits significant ameliorative effects on skeletal muscle aging and atrophy, as well as mitochondrial dysfunction by activating the PI3K/Akt/mTOR signaling pathway. Our study uniquely investigates the effects of PSP on skeletal muscle aging and mitochondrial dysfunction with a specific focus on the PI3K/Akt/mTOR signaling pathway, which highlights the potential of PSP as a novel therapeutic agent for sarcopenia, offering an alternative to current treatment strategies.
- | LY294002 / Eli Lilly
Journal: MCM4 Promotes the Progression of Malignant Melanoma by Activating the PI3K/AKT Pathway. (Pubmed Central) - Jan 13, 2025
The PI3K inhibitor (LY294002) could reverse the effects of MCM4 on MM cells. MCM4 could substantially prompt the tumor growth of MM in mice through the PI3K/AKT pathway in
- | LY294002 / Eli Lilly
Preclinical, Journal: Umbilical cord mesenchymal stem cell-derived exosomal Follistatin inhibits fibrosis and promotes muscle regeneration in mice by influencing Smad2 and AKT signaling. (Pubmed Central) - Jan 12, 2025
MCM4 could substantially prompt the tumor growth of MM in mice through the PI3K/AKT pathway in This study demonstrated that Follistatin in UMSCs-Exo inhibits fibrosis and promotes muscle regeneration in mice by regulating Smad and AKT signaling.