nortriptyline / Generic mfg. 
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  • ||||||||||  sertraline / Generic mfg., paroxetine / Generic mfg.
    [VIRTUAL] Management of antidepressants drugs during breastfeeding (All Screens in Poster Area) -  Feb 20, 2020 - Abstract #EPA2020EPA_2196;    
    The first choice antidepressants would be sertraline, paroxetine and tricyclics (nortriptyline and imipramine), as there is sufficient scientific evidence of that the amount of drug that reaches breast milk is very low or undetectable and not It has no effect on the baby.
  • ||||||||||  Omeprazole RBX (omeprazole) / Generic mfg.
    Incomplete crural paraplegy for histoplasmosis: case report () -  Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1078;    
    These complications make diagnosis difficult and, therefore, demonstrate the need for the use of personal protective equipment, avoiding the contraction of the disease. A patient of productive age, without acquired immunodeficiency, presented atypical spinal cord injury, but, with the correct diagnosis, adequate clinical treatment and rehabilitation bring improvement in quality of life, recovering its physical functionality.
  • ||||||||||  amitriptyline / Generic mfg., topiramate / Generic mfg.
    EFFICACY OF TOPIRAMATE AS PROPHYLAXIS IN PATIENTS WITH CYCLIC VOMITING SYNDROME () -  Jan 28, 2020 - Abstract #DDW2020DDW_3411;    
    The utility of topiramate is hampered by the high incidence of side effects in more than half the patients. Efforts to develop novel therapies that are better tolerated by patients are warranted.
  • ||||||||||  Aimovig (erenumab) / Amgen, Novartis
    Ischemic Colitis Associated with Erenumab Use for Migraine () -  Jan 21, 2020 - Abstract #AAN2020AAN_2264;    
    Other contributing factors included concurrent use of rizatriptan and amphetamines, which are both vasoconstrictive. Prescribers should be cautious of use of CGRP antagonists in patients with vasoconstrictive disease (Raynaud’s in this patient) and on multiple other vasoactive medications.
  • ||||||||||  topiramate / Generic mfg., nortriptyline / Generic mfg.
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  Trial of Nortriptyline and Topiramate in the Initial Treatment of Vestibular Migraine (clinicaltrials.gov) -  Jan 18, 2020   
    P=N/A,  N=34, Terminated, 
    Both the drugs were well tolerated. N=100 --> 34 | Trial completion date: Dec 2020 --> Oct 2019 | Recruiting --> Terminated | Trial primary completion date: Jun 2020 --> Oct 2019; Lack of enrollment
  • ||||||||||  nortriptyline / Generic mfg.
    New P4 trial:  PeCon: Pediatric Concussion Outcomes (clinicaltrials.gov) -  Jan 12, 2020   
    P4,  N=100, Not yet recruiting, 
  • ||||||||||  lactulose / Generic mfg., nortriptyline / Generic mfg.
    Clinical, Journal:  Is the Treatment of Constipation Can Relieve the Migraine Symptoms? A Randomized Clinical Trial Study. (Pubmed Central) -  Jan 10, 2020   
    Short-term follow-up of this study showed that lactulose syrup could remove the constipation with no significant side effects--can be used as an adjunct for the treatment of patients with migraine. However, future studies suggested for long-term consequences of constipation control.
  • ||||||||||  amitriptyline / Generic mfg.
    P1 data, Journal:  Carbon monoxide releasing molecule 401 (CORM-401) modulates phase I metabolism of xenobiotics. (Pubmed Central) -  Dec 25, 2019   
    Overall, we demonstrate CO-mediated inhibitory effects on CYP activity when applying CORMs. Since CORMs are currently under drug development, the findings emphasize the importance to take into account that this class of compounds may interfere with xenobiotic metabolism.
  • ||||||||||  lithium / Generic mfg., nortriptyline / Generic mfg., Tirosint (levothyroxine) / IBSA Institute Biochemical SA
    Journal:  Commentary on "Synchrony Between Bipolar Mood Cycles and Lunar Tidal Cycles Ended After Initiation of Light Treatment and Treatment of Hypothyroidism". (Pubmed Central) -  Dec 22, 2019   
    After nortriptyline was discontinued, thyroid-stimulating hormone levels were normalized with treatment with levothyroxine, and consistent bright light treatment was started, the synchrony between mood cycles and lunar cycles disappeared, and rapid cycling eventually stopped. The possibility that lunar mood cycling is sometimes contingent on antidepressant treatment, decreased thyroid function, and certain types of light-dark cycles needs to be considered in future research on lunar tidal influences on the course of bipolar illness.
  • ||||||||||  duloxetine delayed release / Generic mfg.
    Preclinical, Journal:  Peripheral Delta Opioid Receptors Mediate Duloxetine Anti-allodynic Effect in a Mouse Model of Neuropathic Pain. (Pubmed Central) -  Dec 21, 2019   
    In addition, increased DOPeGFP translocation to the plasma membrane was observed in neuropathic conditions but not in duloxetine-treated neuropathic mice, which may represent an additional level of control of the neuronal activity by DOP receptors. Our results therefore established a parallel between changes in the expression profile of peripheral DOP receptors and mechanical allodynia induced by sciatic nerve cuffing.
  • ||||||||||  venlafaxine / Generic mfg., Decadron (dexamethasone) / Merck (MSD), nortriptyline / Generic mfg.
    Preclinical, Journal:  Venlafaxine and nortriptyline reverse acute dexamethasone-induced depressive-like behaviors in male and female mice. (Pubmed Central) -  Dec 21, 2019   
    In conclusion, the present findings suggest that a single administration of dexamethasone induces depressive-like states in male and female mice, and these behavioral alterations are counteracted by conventional antidepressants. Ultimately, these data provide new evidence for an acute neuroendocrine model of depression.
  • ||||||||||  nortriptyline / Generic mfg.
    Trial initiation date:  Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments (clinicaltrials.gov) -  Nov 18, 2019   
    P2,  N=400, Recruiting, 
    NOR seems more effective and better tolerated than AMI, but due to study limitations, more data are needed to confirm these results. Initiation date: Jul 2019 --> Nov 2019
  • ||||||||||  amitriptyline / generics, nortriptyline / generics
    Clinical, Journal:  Nortriptyline Abuse: A Case Report and Review of the Literature. (Pubmed Central) -  Nov 3, 2019   
    Prior literature has discussed this more for the tertiary amines such as amitriptyline, but currently, there are no documented cases of abuse with the secondary amine nortriptyline. This article reviews the prior literature in regard to tricyclic antidepressants and anticholinergics as substances of abuse, the proposed mechanisms of this, and susceptible populations, as well as a case review of a patient who admitted to using nortriptyline for its "buzz."
  • ||||||||||  citalopram / Generic Mfg.
    Journal:  Pattern of Antidepressant Utilization and Cost in Iran from 2006 to 2013 in Comparison with Other Countries. (Pubmed Central) -  Oct 24, 2019   
    The type of adverse reactions with new expensive antidepressants may seem convincing for the growing tendency toward using these medicines, but considering their high costs, health policymakers have to be aware of the risk of overprescription of newer antidepressant. Drivers of over-the-counter purchase of antidepressants need to be explored.
  • ||||||||||  Journal:  Short- and Long-term Effects of Neuromodulators for Unexplained Chronic Cough. (Pubmed Central) -  Sep 28, 2019   
    Conclusion While both neuromodulator classes demonstrated short-term benefit, the majority of patients discontinue treatment prior to 6 months, with patients taking TCAs discontinuing more frequently than patients on gabapentin. Future investigations are warranted evaluating tachyphylaxis and the utility of dual treatment therapies designed to address peripheral and central sensory pathways involved in UCC.
  • ||||||||||  citalopram / Generic Mfg., paroxetine / Generic Mfg.
    Treating Depression in Parkinson’s Disease: a Systematic Literature Review (Les Muses Terrace, Level 3) -  Sep 24, 2019 - Abstract #MDSCongress2019MDS_133;    
    To draw definitive conclusions, larger randomised control trials, examining all available antidepressant treatments and considering the heterogeneity of depression and PD, need to be undertaken. This abstract was also submitted for presentation at the 2019 European Academy of Neurology Conference.
  • ||||||||||  amitriptyline / generics, nortriptyline / generics
    Journal:  Nortriptyline safer than amitriptyline? (Pubmed Central) -  Sep 16, 2019   
    During in vitro Toxicity properties prediction, the Triazolo-benzodiazepines derivatives: M, M, M and M showed less toxicity than the other studied molecules against algae, for daphnia the molecules M, M, M, M, M and M showed less toxicity than the reference molecule (Nortriptyline). No abstract available
  • ||||||||||  loperamide hydrochloride / Generic Mfg.
    Journal:  Two-phase micro-electromembrane extraction with a floating drop free liquid membrane for the determination of basic drugs in complex samples. (Pubmed Central) -  Sep 15, 2019   
    At the optimized μ-EME conditions (250 V, 15 min, 300 rpm, acidic donor) and the optimized ratio of the sample to the FLM volume (500:14 μL), extraction recoveries between 49 and 100% and enrichment factors up to 35.7 were achieved. Quantitative analyses of the basic drugs in the resulting FLMs (diluted with methanol) were performed by capillary electrophoresis with ultraviolet detection and demonstrated excellent repeatability (RSD ≤ 4.9%) and linearity (r ≥ 0.9997), and low limits of detection (5-28 ng/mL) of the method.
  • ||||||||||  nortriptyline / generics, escitalopram / generics
    Journal:  Genetic disposition to inflammation and response to antidepressants in major depressive disorder. (Pubmed Central) -  Sep 12, 2019   
    Quantitative analyses of the basic drugs in the resulting FLMs (diluted with methanol) were performed by capillary electrophoresis with ultraviolet detection and demonstrated excellent repeatability (RSD ≤ 4.9%) and linearity (r ≥ 0.9997), and low limits of detection (5-28 ng/mL) of the method. A differential association between CRP-PRS and antidepressant drug that is in a direction opposite to that found with serum CRP measurement suggests that previously observed effect of inflammation on antidepressant efficacy may be driven by state factors distinct from genetic influences on systemic inflammation.
  • ||||||||||  NN1213 / Novo Nordisk
    Biomarker, Trial completion date, Trial primary completion date:  INGenious: A Prospective Trial to Assess Cost and Clinical Outcomes of a Clinical Pharmacogenomic Program (clinicaltrials.gov) -  Aug 9, 2019   
    P=N/A,  N=4465, Active, not recruiting, 
    More research is needed to assess the effectiveness of specific components that comprise behavioural support. Trial completion date: May 2019 --> Sep 2019 | Trial primary completion date: May 2019 --> Sep 2019
  • ||||||||||  nortriptyline / Generic mfg.
    Enrollment open:  Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments (clinicaltrials.gov) -  Aug 1, 2019   
    P2,  N=400, Recruiting, 
    The mechanism for each anodic process is proposed according to electroanalytical and computational chemistry findings, which show evidence that the methods herein employed may be a valuable alternative to study the redox behavior of structurally similar drugs. Not yet recruiting --> Recruiting
  • ||||||||||  paroxetine / generics, fluoxetine / generics
    Journal:  Analysis of four antidepressants in plasma and urine by gas chromatography-mass spectrometry combined with sensitive and selective derivatization. (Pubmed Central) -  Jun 30, 2019   
    Low, medium, and high concentrations of antidepressants were added in plasma and urine samples, spiked recovery ranged from 85.88%-110.34% for plasma and 80.64%-113.07% for urine, respectively. The derivatization reaction was very quickly, only 5 min was needed for the reaction process, in addition, the proposed method exhibited superior sensitivity and selectivity, it showed sufficient advantages for determination of Flu, Nor, Map, and Paro in plasma and urine of patients.