- |||||||||| Monjuvi (tafasitamab-cxix) / MorphoSys, Xencor, Incyte, Specialised Therap, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Enrollment open: Chemotherapy (DA-EPOCH+/-R) and Targeted Therapy (Tafasitamab) for the Treatment of Newly-Diagnosed Philadelphia Chromosome Negative B Acute Lymphoblastic Leukemia (clinicaltrials.gov) - Mar 17, 2023 P2, N=30, Recruiting, Active, not recruiting --> Recruiting Not yet recruiting --> Recruiting
- |||||||||| Venclexta (venetoclax) / Roche, AbbVie, DS-1594 / Daiichi Sankyo
Trial completion date, Trial primary completion date, Combination therapy: DS-1594b With or Without Azacitidine, Venetoclax, or Mini-HCVD for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia (clinicaltrials.gov) - Mar 16, 2023 P1/2, N=20, Active, not recruiting, Not yet recruiting --> Recruiting Trial completion date: Nov 2022 --> Nov 2024 | Trial primary completion date: Nov 2022 --> Nov 2024
- |||||||||| Yonsa (abiraterone acetate) / Churchill Pharma, Sun Pharma, Erleada (apalutamide) / J&J
Biomarker, Trial completion date, Trial primary completion date, Metastases: NCI-2018-01054: Apalutamide, Abiraterone Acetate, and Prednisone in Treating Participants With Metastatic Castration Resistant Prostate Cancer (clinicaltrials.gov) - Mar 8, 2023 P2, N=60, Suspended, Suspended --> Recruiting Trial completion date: Oct 2022 --> Apr 2024 | Trial primary completion date: Oct 2022 --> Apr 2024
- |||||||||| prednisone delayed-release tablet / Generic mfg.
Journal: Evaluaci (Pubmed Central) - Mar 4, 2023 Trial completion date: Jan 2023 --> Jan 2024 Although none of the measures applied through the FMEA made the failure mode impossible, they made it more detectable and less frequent and reduced the RPN for each failure mode; however, a periodic update of the process is necessary.
- |||||||||| Yonsa (abiraterone acetate) / Churchill Pharma, Sun Pharma, Erleada (apalutamide) / J&J
Trial primary completion date, Metastases: Abiraterone Acetate, Prednisone, and Apalutamide in Treating Patients With Hormone-Naive Metastatic Prostate Cancer (clinicaltrials.gov) - Feb 27, 2023 P2, N=60, Active, not recruiting, Trial completion date: Sep 2029 --> Dec 2029 | Trial primary completion date: Sep 2029 --> Dec 2029 Trial primary completion date: Oct 2022 --> Oct 2023
- |||||||||| Blincyto (blinatumomab) / Astellas, Amgen, Besponsa (inotuzumab ozogamicin) / Pfizer, UCB
Trial completion date, Trial primary completion date: NCI-2017-00596: Blinatumomab, Inotuzumab Ozogamicin, and Combination Chemotherapy as Frontline Therapy in Treating Patients With B Acute Lymphoblastic Leukemia (clinicaltrials.gov) - Dec 21, 2022 P2, N=80, Recruiting, Recruiting --> Suspended Trial completion date: Nov 2021 --> Nov 2023 | Trial primary completion date: Nov 2021 --> Nov 2023
- |||||||||| Zynyz (retifanlimab-dlwr) / Incyte, Monjuvi (tafasitamab-cxix) / Incyte
Enrollment open, Combination therapy: Tafasitamab, Retifanlimab, and Rituximab in Combination With Chemotherapy (Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) for the Treatment of Diffuse Large B-cell Lymphoma (clinicaltrials.gov) - Dec 9, 2022 P1/2, N=35, Recruiting, Trial completion date: Sep 2021 --> May 2022 Not yet recruiting --> Recruiting
- |||||||||| Kesimpta (ofatumumab subcutaneous) / Novartis, Genmab, Arzerra (ofatumumab) / Novartis, Genmab, Rituxan (rituximab) / Biogen, Zenyaku Holdings, Roche
Trial completion date, Trial primary completion date, Combination therapy: NCI-2014-01707: Dose Adjusted EPOCH Regimen in Combination With Ofatumumab or Rituximab in Treating Patients With Newly Diagnosed or Relapsed or Refractory Burkitt Lymphoma or Relapsed or Refractory Acute Lymphoblastic Leukemia (clinicaltrials.gov) - Dec 8, 2022 P2, N=40, Active, not recruiting, Not yet recruiting --> Recruiting Trial completion date: Dec 2022 --> Jun 2023 | Trial primary completion date: Dec 2022 --> Jun 2023
- |||||||||| Opdivo (nivolumab) / Ono Pharma, BMS, Yervoy (ipilimumab) / Ono Pharma, BMS
Enrollment closed, Checkpoint inhibition, Checkpoint block, Metastases: Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers (clinicaltrials.gov) - Oct 25, 2022 P1, N=16, Active, not recruiting, Active, not recruiting --> Completed Suspended --> Active, not recruiting
- |||||||||| Yonsa (abiraterone acetate) / Churchill Pharma, Sun Pharma, Talzenna (talazoparib) / Pfizer
Enrollment closed, Enrollment change: Talazoparib With Androgen Deprivation Therapy and Abiraterone for the Treatment of Castration Sensitive Prostate Cancer (clinicaltrials.gov) - Sep 30, 2022 P2, N=20, Active, not recruiting, Active, not recruiting --> Recruiting | N=20 --> 70 Recruiting --> Active, not recruiting | N=70 --> 20
- |||||||||| Sarclisa (isatuximab-irfc) / Sanofi
Trial completion date, Trial primary completion date: Isatuximab, Bendamustine, and Prednisone in Refractory Multiple Myeloma (clinicaltrials.gov) - Sep 22, 2022 P1/2, N=37, Recruiting, Recruiting --> Active, not recruiting Trial completion date: Oct 2028 --> Oct 2029 | Trial primary completion date: Oct 2023 --> Oct 2024
- |||||||||| Darzalex (daratumumab) / J&J
Trial completion date, Trial primary completion date: A Study of Daratumumab and Dose-Adjusted EPOCH in Plasmablastic Lymphoma (clinicaltrials.gov) - Sep 14, 2022 P1, N=15, Recruiting, Trial completion date: Oct 2028 --> Oct 2029 | Trial primary completion date: Oct 2023 --> Oct 2024 Trial completion date: Aug 2024 --> Aug 2027 | Trial primary completion date: Aug 2022 --> Jul 2025
- |||||||||| Venclexta (venetoclax) / Roche, AbbVie, DS-1594 / Daiichi Sankyo
Enrollment closed, Enrollment change, Combination therapy: DS-1594b With or Without Azacitidine, Venetoclax, or Mini-HCVD for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia (clinicaltrials.gov) - Sep 8, 2022 P1/2, N=20, Active, not recruiting, Recruiting --> Suspended Recruiting --> Active, not recruiting | N=122 --> 20
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