Completed

4

150

 

One drop of gatifloxacin 0.3% eye gel was administration ;One drop of gatifloxacin 0.3% ophthalmic solution ;One drop of levofloxacin 0.5% ophthalmic solution

Zhejiang University; Zhejiang University, Zhejiang Key Innovation Team Project of China (2009R50039); Zhejiang Key Laboratory Fund of China (2011E10006)

endoophthalmitis after cataract surgery

 

 

Ongoing

4

120

Europe

AUGMENTINE INTRAVENOSO, TAVANIC, AUGMENTINE PLUS, 9857622, AUGMENTINE INTRAVENOSO, TAVANIC, AUGMENTINE PLUS, AUGMENTINE INTRAVENOSO, TAVANIC, AUGMENTINE PLUS

Hospital Universitario de Canarias

Neumonía adquirida en la comunidad de gravedad leve-moderada (PSI I-III)

 

 

Ongoing

4

8

Europe

TAVANIC, INVANZ, TAVANIC, INVANZ, TAVANIC, INVANZ

CHU DE POITIERS

infected foot ulcers in diabetic patient

 

 

Ongoing

4

30

Europe

Oftaquix Unit Dose 5mg/mL eye drops, Zinacef, Oftaquix Unit Dose 5mg/mL eye drops, Zinacef

Guys\' and St Thomas\' NHS Foundation Trust, Joint Clinical Trials Office

Cataracts and endophthalmitis

 

 

Ongoing

4

552

Europe

Tablet, Powder for solution for injection/infusion, Moxifloxacin, Levofloxacin, Metronidazole, Ertapenem

Turku University Hospital

Uncomplicated acute appendicitis, Appendicitis, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Therapeutic techniques [E02]

 

 

Ongoing

4

142

Europe

Powder for solution for injection/infusion, Capsule, soft, Invanz (Ertapenem), Metronidazole, Levofloxacin

Turku University Hospital

Acute uncomplicated appendicitis, Appendicitis, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Therapeutic techniques [E02]

 

 

Not yet recruiting

4

800

 

Bismuth plus triple therapy (clarithromycin) ;Bismuth plus triple therapy (levofloxacin) ;Bismuth plus triple therapy (metronidazole) ;Bismuth plus triple therapy adjusted according to medication history

Department of Gastroenterology, Peking University Third Hospital; Department of Gastroenterology, Peking University Third Hospital, Projects from the National Science Technology Pillar Program in the Twelfth Five-Year Plan Period, China

Helicobacter pylori infection

 

 

Not yet recruiting

4

310

Europe

AMOXICILLIN, AMOXICILLIN-CLAVULANATE, AMPICILLIN, ERYTHROMYCIN, CLARITHROMYCIN, PRISTINAMYCIN, CIPROFLOXACIN, LEVOFLOXACIN, MOXIFLOXACIN, OFLOXACIN, AZITHROMYCIN, Buccal tablet

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, DGOS

Community acquired pneumonia, Community acquired pneumonia, Diseases [C] - Respiratory Tract Diseases [C08]

 

 

Recruiting

4

60

RoW

Esomeprazole, Metronidazole, Levofloxacin

Shanghai Jiao Tong University School of Medicine

Helicobacter Pylori Infection, Intravenous Drug Usage

04/21

06/21

Not yet recruiting

4

60

Europe

Bactrim forte, Ciprofloxacine, Clindamycine, Doxycycline, Ceftazidime, Fucidine, Minocycline, Ofloxacine, Rifampicine, Teicoplanine, Levofloxacine, Tablet, Solution for infusion, Bactrim forte, Ciprofloxacine, Clindamycine, Doxyxycline, Ceftazidime, Fucidine, Minocycline, Ofloxacine, Rifampicine, Teicoplanine, Levofloxacine

Centre Hospitalier de Tourcoing, Centre Hospitalier de Tourcoing

Patients de plus de 18 ans et de moins de 80 ans.Présentant une ostéite du pied diabétique., Patients de plus de 18 ans et de moins de 80 ans.Présentant une ostéite du pied diabétique., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Therapeutic techniques [E02]

 

 

Not yet recruiting

4

360

Europe

amoxicillin, cefaclor, ciprofloxacin, clindamycin, Dicloxacillin, Fusidic acid, Fusidic Acid, Levofloxacin, levofloxacin, Linezolid, Moxifloxacin, Rifampicin, Sulfamethoxazole/trimethoprim, sulfamethoxazole /trimethoprin, Tedizolid, cefaclor, Dicloxacillin, Dicloxaxillin ev, Rifampicina, septrin, 49708-146-01, 856866-72-3, Tablet, Injection, Solution for injection, Solution for infusion, Capsule, Concentrate for solution for injection/infusion, , Film-coated tablet, Coated tablet, Solution for solution for infusion, Concentrate for solution for infusion, Concentrate and solvent for solution for infusion, Concentrate and solvent for concentrate for solution for infusion, Amoxicillin, ciprofloxacin

Fundació Clínic per a la Recerca Biomèdica, Instituto de Salud Carlos III

infective endocarditis endocarditis infecciosa, infective endocarditis endocarditis infecciosa, Diseases [C] - Cardiovascular Diseases [C14]

 

 

Completed

4

200

 

Sotirios Gatsos

Urinary tract infections, Infectious complications of transrectal ultrasound guided prostate biopsy, Prostate cancer, Prostatitis

 

 

Recruiting

4

723

 

One group receive topical 0.5% levofloxacin eyedrops six times a day for 1 day ;One group receive topical 0.5% levofloxacin eyedrops four times a day for 2 days ;One group receive topical 0.5% levofloxacin eyedrops four times a day for 3 days

Beijing Chaoyang Hospital, Capital Medical University; Beijing Chaoyang Hospital, Capital Medical University, Beijing Hospitals Authority Youth Programme (No. QML20190303)

Endophthalmitis after cataract surgery

 

 

Recruiting

4

144

RoW

Levofloxacin Injection, Zuoyangfushaxing Zhusheye, Compound Kushen Injection（CKI）, Yanshu injection

Shanxi Zhendong Pharmacy Co., Ltd

Radiation-induced Oral Mucositis

09/22

12/22

Terminated

4

205

RoW

Individualized TB treatment with multiple drugs, Standardized TB treatment with multiple drugs

Centre for the AIDS Programme of Research in South Africa

Tuberculosis, Multidrug-Resistant

12/22

12/22

Recruiting

4

388

RoW

Esomeprazole, Bismuth potassium citrate, Metronidazole, Clarithromycin, Levofloxacin, Amoxicillin, Tetracycline

Shanghai Zhongshan Hospital

Helicobacter Pylori Infection

12/22

03/23

Recruiting

4

360

RoW

ET, SGT

National Taiwan University Hospital

Helicobacter Pylori Infection

03/23

03/23

Terminated

4

5

US

Ceftriaxone, Amoxicillin clavulanic acid, Augmentin, Cefepime, Vancomycin, Levofloxacin

UConn Health

Aspiration, Aspiration Pneumonia

04/24

04/24

Completed

4

200

RoW

Comparing Load and Concomitant therapy, Clarithromycin - pantoprazole - Metronidazole - Amoxycyllin

Helwan University

H. Pylori Infection

07/23

07/23

Recruiting

4

80

RoW

Doxycycline, Tinadizole, Esomeprazole, levofloxacine, Levofloxacin 500mg, Amoxicilline, Esomeprazol

Damascus Hospital

Helicobacter Pylori Infection

12/23

05/24

Recruiting

4

70

RoW

group A : Amoxicillin Esomeprazole HDDT, group-B : Levofloxacin triple therapy

Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Helicobacter Pylori Infection, Helicobacter Pylori Eradication

02/24

02/24

4

US

Amoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid, metronidazole, moxifloxacin, rifampin, trimethoprim-sulfamethoxazole, Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem, meropenem, oritavancin, oxacillin, penicillin, piperacillin-tazobactam, tigecycline, vancomycin

West Virginia University

Endovascular Infection, Bone and Joint Infection, Skin and Soft Tissue Infection, Pulmonary Infection, Gastrointestinal Infection, Genitourinary Infection

4

360

Europe

Cefaclor, Ciprofloxacin Tablets, Ciprofloxacin Injection, Clindamycin Oral Capsule, Clindamycin Injection, Dicloxacillin Oral Capsule, Dicloxacillin, Fusidic Acid Only Product in Oral Dose Form, Fusidic Acid Only Product in Parenteral Dose Form, Levofloxacin Oral Tablet, Levofloxacin Injection, Linezolid Oral Tablet, Linezolid Injectable Product, Moxifloxacin tablet, Moxifloxacin Injectable Product, Rifampicin Only Product in Oral Dose Form, Rifampicin Only Product in Parenteral Dose Form, Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim], Sulfamethoxazole / Trimethoprim Injectable Product, Tedizolid Oral Tablet, Tedizolid Injection, Amoxicillin Capsules, Amoxicillin, Cefaclor Capsules

Fundacion Clinic per a la Recerca Biomédica

Endocarditis Infective

Recruiting

4

236

US

Ampicillin for Injection, Ceftriaxone for Injection, Rocephin, Amoxicillin, Ampicillin / Sulbactam Injection, Unasyn, Amoxicillin-clavulanate, Augmentin, Clindamycin, Cleocin, Cefprozil, Cefzil, Levofloxacin, Levaquin

Medical College of Wisconsin

Community Acquired Pneumonia in Children

05/27

05/27

Enrolling by invitation

4

20

US

Amoxycillin, Cefalexin, Dicloxacillin, Linezolid, Levofloxacin, Rifampicin, Ampicillin, Oxacillin, Vancomycin, Daptomycin, Ceftriaxone, Cefepime, Ceftaroline

Vinay Badhwar

Endocarditis

10/24

10/24

Enrolling by invitation

4

200

RoW

Levofloxacin, Cefmetazole (drug)

National Taiwan University Hospital

Retrograde Intrarenal Surgery, Renal Stones

06/26

06/26

Recruiting

4

180

 

Levofloxacin tablets, twice a day, one tablet at a time, with a treatment period of 7 days; Longqing tablets, twice a day, six tablet at a time, with a treatment period of 7 days; Levofloxacin + Longqing tablets, administered with an interval of 30min for 7 days

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Self-funded

acute uncomplicated lower urinary tract infection

 

 

Recruiting

4

212

RoW

Bedaquiline, SIRTURO, Levofloxacin, Linezolid, Cycloserine, Clofazimine, Pyrazinamide, Protionamide

Beijing Chest Hospital

Tuberculosis, Multidrug-Resistant

08/25

08/25

Not yet recruiting

4

160

Europe

Clarithromycin (mutations in the 23S rRNA gene, A2134G, A2142G and A2142C mutations) and levofloxacin resistance (mutations in the gyrA gene) PCR test, Empirically H. pylori eradication treatment with bismuth quadruple therapy (Pylera®), PPI, amoxicillin 1 g and clarithromycin 500 mg, twice daily, for 10 days, PPI, amoxicillin 1g and levofloxacin 250 mg, twice daily, for 10 days, Bismuth quadruple therapy (Pylera®) for 10 days

Manuel Coelho da Rocha

Helicobacter Pylori Infection

09/26

12/26

Not yet recruiting

4

334

 

Levofloxacin 50mg per dose, twice a day, orally taken half an hour before breakfast and dinner; Amoxicillin capsules 1000mg per dose, three times a day, orally taken half an hour after breakfast, lunch, and dinner. Oral administration for 14 days.; Lansoprazole 30mg per dose, twice a day, orally taken half an hour before breakfast and dinner; Bismuth potassium citrate capsules 240mg per dose, twice a day, orally taken half an hour before breakfast and dinner; Clarithromycin tablets 500mg per dose, twice a day, orally taken half an hour after breakfast and dinner; Amoxicillin capsules 1000mg per dose, twice a day, orally taken half an hour after breakfast and dinner.

The First Affiliated Hospital of Xiamen University; The First Affiliated Hospital of Xiamen University, Bethune Public Welfare Foundation

Helicobector pylori

 

 

Not yet recruiting

4

392

 

14-day dual regimen with Tegoprazan (Tegoprazan 50 mg bid + amoxicillin 1g TID); 14-day bismuth containing quadruple therapy (Esomeprazole 20 mg bid + bismuth potassium citrate 220 mg bid + antibiotic combination based on drug sensitive test (Combination 1. amoxicillin 1 g bid + clarithromycin 500 mg bid; Combination 2. amoxicillin 1 g bid + levofloxacin 500 mg qd or 200 mg bid; Combination 3. tetracycline 500 mg tid or qid + metronidazole 400 mg tid or qid; Combination 4. amoxicillin 1 g bid + metronidazole 400 mg tid or qid; Combination 5. amoxicillin 1 g bid + tetracycline 500 mg tid or qid. ))

The Eighth Affiliated Hospital, Sun Yet-san University; The Eighth Affiliated Hospital, Sun Yet-san University, Shenzhen Futian district health system research project (FTWS2023001)

helicobacter pylori

 

 

Recruiting

4

1000

 

NA

Women's Hospital School Of Medicine Zhejiang University; Women's Hospital School Of Medicine Zhejiang University, Self-financing

pregnancy

 

 

Ongoing

3

1000

Europe

Levofloxacin, Prixoter 250mg film-coated tablets, Prixoter 250mg film-coated tablets

University of Birmingham, University of Warwick, NIHR HTA

Infections during early symptomatic multiple myeloma

 

 

Not yet recruiting

3

1494

Europe

CEFTRIAXONE, levofloxacine kabi 5MG/Ml, METRONIDAZOL, Injection, Infusion, ceftriaxone mylan 2g, poudre pour solution injectable, LEVOFLOXACINE KABI 5 MG/ML, METRONIDAZOLBBRAUN

CHU Amiens-Picardie, DGOS

The value of post-operative antibiotic therapy after laparoscopic appendectomy for complicated acute appendicitis (other than for generalized peritonitis): a prospective, randomized, placebo-controlled Phase III study., The value of post-operative antibiotic therapy after laparoscopic appendectomy for complicated acute appendicitis (other than for generalized peritonitis), Diseases [C] - Digestive System Diseases [C06]

 

 

Completed

3

2006

 

University of Sydney, National Health and Medical Reserach Council

tuberculosis, tuberculosis, multi-drug resistant

 

 

Recruiting

3

362

Europe

Pantoprazole 40mg, Pantorc, Amoxicillin 1000 MG, Zimox, Clarithromycin 500mg, Klacid, Metronidazole, Flagyl, Tetracycline 125 MG, Ambramicina, Bismuth Subcitrate, Denol, Rifabutin 150 MG, Mycobutin, Levofloxacin 500mg, Levoxacin

University of Bari

Helicobacter Pylori Infection, Antibiotic Resistant Infection, Antibiotic Resistant Strain

02/21

04/22

Completed

3

918

RoW

10d bismuth quadruple therapy, rabeprazole 20 mg bid, tripotassium dicitrate bismuthate 300mg qid, tetracycline 500 mg qid, metronidazole 250 mg qid, 14d hybrid therapy, amoxicillin 1 g bid, clarithromycin 500 mg bid, metronidazole 500 mg bid, 14D high-dose dual therapy, rabeprazole 20 mg qid, amoxicillin 750 mg qid

Kaohsiung Veterans General Hospital.

Helicobacter Pylori Infection

12/21

12/21

Active, not recruiting

3

420

 

Alliance for Clinical Trials in Oncology, Australian and New Zealand Urogenital and Prostate Cancer Trials (ANZUP)

Germ Cell Tumor, Teratoma, Choriocarcinoma, Germinoma, Mixed Germ Cell Tumor, Yolk Sac Tumor, Childhood Teratoma, Malignant Germ Cell Neoplasm, Extragonadal Seminoma, Non-seminomatous Germ Cell Tumor, Seminoma, Cancer

 

 

Recruiting

3

100

RoW

Nitazoxanide, Alenia, nitclean, parazoxanide, Levofloxacin, Tavanic, levoxin, venaxan., Doxycyclin, Vibramycin, Doxymycin, Omeprazole, Omepak, Pepzole, Gasec, Risek.

Tanta University

Dyspepsia

12/22

12/22

Not yet recruiting

3

326

Europe

PIPERACILLINE/TAZOBACTAM PANPHARMA 4 g/500 mg, poudre pour solution pour perfusion, METRONIDAZOLE B BRAUN 0,5 %, solution pour perfusion, : LEVOFLOXACINE ARROW 5 mg/ml, solution pour perfusion en poche, Powder for solution for infusion, Solution for infusion, PIPERACILLINE/TAZOBACTAM PANPHARMA 4 g/500 mg, poudre pour solution pour perfusion, METRONIDAZOLE B BRAUN 0,5 %, solution pour perfusion, LEVOFLOXACINE ARROW 5 mg/ml, solution pour perfusion en poche

CHU de Rouen, Chu de Rouen

Patients with preoperative biliary stent treated by pancreaticoduodenectomy Patients avec stent biliaire préopératoire traités par duodénopancréatectomie, Patients with preoperative biliary stent treated by pancreaticoduodenectomy Patients avec stent biliaire préopératoire traités par duodénopancréatectomie, Not possible to specify

 

 

Completed

3

402

RoW

Bedaquiline Oral Tablet, Sirturo, Linezolid Oral Tablet, Zyvox, Delamanid in Oral Dosage Form, Deltyba, Clofazimine Oral Product, Lamprene, Levofloxacin Oral Tablet, Isoniazid Oral Product, INH, Ethambutol Oral Product, Pyrazinamide Oral Product

Wits Health Consortium (Pty) Ltd, Regents of the University of California, University of Cape Town, Perinatal HIV Research Unit of the University of the Witswatersrand

Tuberculosis, Pre-XDR-TB, Extensively Drug-Resistant Tuberculosis, Multi Drug Resistant Tuberculosis, Rifampicin Resistant Tuberculosis

04/24

04/24

Completed

3

320

RoW

Vonoprazan, Amoxicillin and Levofloxacin, Vonaspire 20 mg, Amoxil 1 gm, Tavanic 500 mg, Pantoprazole 40mg, Amoxicillin and Levofloxacin, controloc 40 mg

Ain Shams University

Helicobacter Pylori Infection

04/24

04/24

Recruiting

3

324

Europe

Levofloxacin, Fluoroquinolones, Rifampicin, Conventional IV treatment of staphylococci IE following European guidelines 2015 including cloxacilline, oxacilline,gentamicine,vancomycine,rifampicine

University Hospital, Tours

Infective Endocarditis

05/24

09/24

Not yet recruiting

3

100

NA

a novel short regimen

Taipei Medical University WanFang Hospital, Hualien Tzu Chi General Hospital, Chest Hospital, Ministry of Health and Welfare, Taiwan, Chang-Hua Hospital, Taichung Veterans General Hospital, Taichung Hospital, Ministry of Health and Welfare, Taoyuan General Hospital, Kaohsiung Veterans General Hospital., Kaohsiung Medical University Chung-Ho Memorial Hospital

Tuberculosis, Pulmonary

12/28

12/29

Not yet recruiting

3

120

RoW

bedaquiline, BDQ, B, delamanid, DLM, D, linezolid, LZD, L, Levofloxacin, LFX, Clofazimine, CFZ, C

Huashan Hospital, Beijing Chest Hospital

Drug-resistant Tuberculosis, Pulmonary Tuberculosis, Rifampin-resistant Tuberculosis

06/27

06/27

Recruiting

3

30

 

Take Life Enhancer probiotics capsules orally,Twice a day, two at a time; Placebo and Levofloxacin

Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China.; Shanghai Fourth People’s Hospital, Shanghai Fourth People's Hospital

Urinary Tract Infections

 

 

Recruiting

3

20000

Europe, Canada, Japan, US, RoW

Ceftriaxone, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam, Ceftaroline, Amoxicillin-clavulanate, Standard course macrolide, Extended course macrolide, No systemic corticosteroid, Fixed-duration Hydrocortisone, Shock-dependent hydrocortisone, Fixed-duration higher dose Hydrocortisone, No antiviral agent for influenza, Five-days oseltamivir, Ten-days oseltamivir, No antiviral agent for COVID-19, Lopinavir / Ritonavir, Hydroxychloroquine, Hydroxychloroquine + lopinavir/ritonavir, Ivermectin, No immune modulation for COVID-19, Interferon beta-1a, IFN-β1a, Anakinra, Tocilizumab, Sarilumab, Local standard venous thromboprophylaxis, Therapeutic dose anticoagulation, Conventional low dose thromboprophylaxis, Intermediate dose thromboprophylaxis, Continuation of therapeutic dose anticoagulation, No immunoglobulin, Convalescent plasma, Delayed administration of convalescent plasma, No vitamin C, Vitamin C, No antiplatelet, Aspirin, acetylsalicylic acid, P2Y12 inhibitor, Clopidogrel, Prasugrel, Ticagrelor, No simvastatin, Simvastatin, Eritoran, Apremilast, Clinician-preferred mechanical ventilation strategy, Protocolised mechanical ventilation strategy, No renin-angiotensin system inhibitor, Angiotensin converting enzyme inhibitor, Ramipril, Lisinopril, Perindopril, Enalapril, Trandolapril, Captopril, Angiotensin Receptor Blockers, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, ARB + DMX-200, No cysteamine, Cysteamine, Fixed-duration dexamethasone, Baloxavir Marboxil, Five-days oseltamivir + baloxavir marboxil, Ten-days oseltamivir + baloxavir marboxil, No endothelial modulator, Imatinib, No Immune Modulator for Influenza, Baricitinib, Nirmatrelvir/ritonavir, Paxlovid, Remdesivir, Nirmatrelvir/ritonavir + remdesivir

UMC Utrecht, Australian and New Zealand Intensive Care Research Centre, Medical Research Institute of New Zealand, Unity Health, Berry Consultants, Global Coalition for Adaptive Research, University of Pittsburgh Medical Center, Intensive Care National Audit & Research Centre, St. Marianna University School of Medicine, Nat Intensive Care Surveillance - MORU, National University Hospital, Singapore

Community-acquired Pneumonia, Influenza, COVID-19

02/26

02/28

Not yet recruiting

3

30

 

Take Life Enhancer probiotics capsules orally,Twice a day, two at a time; Placebo and Levofloxacin

Shanghai Fourth People's Hospital, Affiliated to Tongji University; Shanghai Fourth People's Hospital, Affiliated to Tongji University, Shanghai Fourth People's Hospital

Urinary tract infections

 

 

Recruiting

2

140

Japan

levofloxacin - Generic mfg., gemcitabine - Generic mfg., albumin-bound paclitaxel - Generic mfg.

JR SENDAI HOSPITAL, Tohoku Clinical Oncology Research and Education Society(T-CORE)

Pancreatic Cancer

 

 

Completed

2

252

Europe, RoW

RD03/2016 eye drops, Levofloxacin + Ketorolac Trometamol 0.5+0.5% w/v eye drops solution, Levofloxacin 0.5% eye drops solution (Oftaquix®), Oftaquix® 5 mg/ml eye drops solution

NTC srl, NTC s.r.l, NTC SRL, NTC s.r.l.

Conjunctivitis, Bacterial

06/23

09/23