- |||||||||| levofloxacin / Generic mfg., rifampicin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Journal: Comparative Efficacy and Safety of Moxifloxacin and Levofloxacin in a Short Standardised Rifampicin Resistant TB Regimen: A STREAM 2 Secondary Analysis. (Pubmed Central) - Sep 27, 2024
The difference in proportions between regimens was estimated for favourable outcome, any grade 3/4 adverse event, QTcF increase to ?500 ms, QTcF increase from baseline by at least 60 ms, and any grade 3/4 adverse event excluding QT events, using weighted analyses; (3) In efficacy analyses (n = 123), the weighted risk difference (moxifloxacin-levofloxacin, wRD) for a favourable outcome was -0.045 (-0.213, 0.123), p = 0.60. Similarly, estimates from the safety analyses (n = 127) showed no evidence of a difference between the fluoroquinolones, other than a suggestion of fewer QTcF increases from baseline on levofloxacin (wRD 0.160 (-0.026, 0.346), p = 0.091); (4) In this small dataset, we found no statistically significant difference in key efficacy or safety outcomes between the moxifloxacin- and levofloxacin-containing regimens; there was a suggestion that QTcF increases from baseline were fewer on levofloxacin.
- |||||||||| Minocin for injection (minocycline intravenous) / Melinta Therap
Journal, Cytokine storm: Administration of Corticosteroids for Prompt Suppression of Cytokine Storm in Severe Cases of Japanese Spotted Fever. (Pubmed Central) - Sep 27, 2024
Considering the high levels of C-reactive protein, procalcitonin, ferritin, and soluble interleukin-2 receptor, intravenous hydrocortisone (200 mg/day) was administered to control the cytokine storm...Early administration of corticosteroids along with antibiotics effectively suppressed the cytokine storm in this case. Reports have shown mixed results, indicating the need for further research to determine the optimal type, dosage, and duration of corticosteroid treatment.
- |||||||||| levofloxacin / Generic mfg., benzylpenicillin / Generic mfg.
Journal: Prosthetic Valve Endocarditis Caused by Pasteurella dagmatis, Germany. (Pubmed Central) - Sep 25, 2024
We surgically treated a paravalvular abscess and administered definitive antibiotic therapy consisting of penicillin G and levofloxacin. The patient was discharged from the intensive care unit in good condition 21 days after the surgery.
- |||||||||| Clinical, Journal: Bacterial Epidemiology and Antimicrobial Resistance Profiles of Bloodstream Infections Caused by Negative Bacteria in Children's: A Multicenter Study in China (2016-2022). (Pubmed Central) - Sep 25, 2024
To imipenem and meropenem were 3.6% and 3.9% among neonatal isolates, which was lower than 4.7% and 5.8 among pediatric BSIs caused by E. coli...However, only the prevalence of piperacillin/tazobactam resistance was statistically lower than that in pediatric BSIs caused by P. aeruginosa...The first average detection rates for carbapenem resistance, extended-spectrum cephalosporin resistance, and fluoroquinolone resistance were obtained for A. baumannii, K. pneumoniae, and Escherichia coli, respectively. Those data showed a high level of antimicrobial resistance, which has posed an urgent threat to Children's health, suggested that effective monitoring of antimicrobial resistance and antimicrobial stewardship among children in China are required.
- |||||||||| Sirturo (bedaquiline) / J&J, Pharmstandard
Journal: Emergence of a multidrug-resistant tuberculosis through inadequate (Pubmed Central) - Sep 23, 2024
Diagnostic latency, rising rates of drug resistances and lengthy treatment courses contribute to the complexity of treatment. In Germany, specialized outpatient clinics are available since 2014 for diagnosis and treatment of patients with tuberculosis or non-tuberculous mycobacterial diseases, even in the event of mere suspicion.
- |||||||||| Journal, Adverse events, Real-world evidence, Real-world: Pregnancy related adverse events and congenital disorders associated with fluoroquinolones: A real-world pharmacovigilance study of the FDA adverse event reporting system (FAERS). (Pubmed Central) - Sep 23, 2024
Fluoroquinolones, including ciprofloxacin, levofloxacin, and moxifloxacin, are extensively employed as broad-spectrum antibacterial agents...Additionally, in-depth comparative analyses were carried out between various fluoroquinolones and a reference drug (azithromycin)...We present compelling evidence regarding pregnancy-related AEs and congenital disorders linked to fluoroquinolones. Considering perinatal and genotoxicity aspects, we explore whether levofloxacin or moxifloxacin might be preferable when fluoroquinolones are deemed necessary to balance the benefits of pregnant women and fetuses.
- |||||||||| A Double Therapeutic Challenge: Handling Acremonium sp. Hyalohyphomycosis and Atypical Mycobacteriosis in Tandem in a Kidney Transplant Recipient (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3392;
Direct examination and culture of his hand and thigh lesions yielded positive for Acremonium sp., while abdominal lesions were biopsied and cultured, revealing Mycobacterium chelonae positivity and chronic inflamation.Oral voriconazole was prescribed to address the fungal infection for twelve months, whereas a combination of Levofloxacin, Linezolid and Azithromycin was initiated for the atypical mycobacteriosis...While transplantation stands as a top renal replacement choice, suspicion for these rare but highly morbid infections must be raised given their demanding follow-up. When combined, they challenge even experienced nephrologists and infectious disease specialists, but therapy can be effective and optimal response achieved when adequate surveillance and care are provided.
- |||||||||| levofloxacin / Generic mfg.
Legionella-Induced Rhabdomyolysis Unmasks Underlying Metabolic Myopathy (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_974;
Myopathies can be dormant, until there is a second hit that can unmask them making individuals susceptible to severe rhabdomyolysis with a common condition such as legionella pneumonia. Hence, broad differential and thorough work up should be sought in the cases where clinical scenario does not explain the findings.
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Preclinical, Journal: In (Pubmed Central) - Sep 21, 2024
Ser83Arg in GyrA was the most common site of mutations. No mutation in ParC nor ParE was identified in the selected mutants.
- |||||||||| Lamprene (clofazimine) / Novartis, Sirturo (bedaquiline) / J&J, Pharmstandard
Journal, Head-to-Head: Nine months of bedaquiline, linezolid, levofloxacin, clofazimine, and cycloserine chemotherapy for rifampicin/multidrug-resistant tuberculosis: a multicenter, randomized, open-label non-inferiority trial in China. (Pubmed Central) - Sep 21, 2024
The 9-month, all-oral regimen is safe and efficacious for the treatment of pulmonary rifampicin/multidrug-resistant tuberculosis. The high incidence of QTc prolongation associated with the use of BDQ highlights the urgent need of routine electrocardiogram monitoring under treatment with BDQ-containing regimens in the Chinese population.
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Trial completion: Ciprofloxacin Versus Levofloxacin in Stem Cell Transplant (clinicaltrials.gov) - Sep 20, 2024
P2, N=308, Completed,
The high incidence of QTc prolongation associated with the use of BDQ highlights the urgent need of routine electrocardiogram monitoring under treatment with BDQ-containing regimens in the Chinese population. Active, not recruiting --> Completed
- |||||||||| chlorpromazine / Generic mfg.
A RARE CASE OF CHLORPROMAZINE-INDUCED IMMUNE HEMOLYTIC ANEMIA (Convention Center Exhibit Hall: Poster Area 2) - Sep 19, 2024 - Abstract #CHEST2024CHEST_7313;
The hematologist was consulted immediately, and the patient received one dose of IV Epoetin alfa 20000 units, one dose of IV Venofer 200 mg and she was also started on IV methylprednisolone 80 mg...The patient's home medications included Chlorpromazine, Divalproex, and Fluoxetine...He was discharged to home with prednisone and divalproex...Cephalosporins, nonsteroidal anti-inflammatory agents, levofloxacin, oxaliplatin, and teicoplanin have been reported to cause IHA... Chlorpromazine is a widely used drug in psychiatry and physicians should be aware of this rare adverse event of hemolytic anemia.
- |||||||||| Journal: Genomic characterization of an uncommon Delftia acidovorans isolate obtained from a (Pubmed Central) - Sep 19, 2024
Unlike the majority of reports in the literature, Dac759 affected a patient with no malignancies or other preexisting comorbidities. With this in mind, its genome sequence is a valuable resource for the fundamental study of uncommon bacterial pathogens of public health importance.
- |||||||||| levofloxacin / Generic mfg.
Preclinical, Journal: Hepatoprotective Effect of Ethanolic Pomegranate Peel Extract Against Levofloxacin via Suppression of Oxidative Stress, Proinflammation, and Apoptosis in Male Rats. (Pubmed Central) - Sep 18, 2024
Also, normalization of gene expressions (cyclooxygenase-2, transforming growth factor-beta1, caspase-3, heme oxygenase-1, B cell lymphoma-2, interleukin [IL]-10, and IL-1) and improvement in liver architecture, and immunohistochemical alpha-smooth muscle actin, were seen in comparison to the LEV group. Conclusively, PGPE exhibits strong anti-inflammatory, antiapoptotic, and antioxidant properties that shield rat liver from the damaging effects of LEV and offer a fresh viewpoint on the application of fruit waste products.
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Journal: Safety analysis of fluoroquinolone drugs in elderly patients over 65 based on FAERS. (Pubmed Central) - Sep 13, 2024
Enhanced monitoring and evaluation of FQs are crucial for promptly identifying and managing adverse reactions. Personalized medication plans for elderly patients should also be strengthened.
- |||||||||| levofloxacin / Generic mfg.
Journal: Fluoroquinolone-Associated Tendinopathy: An Important Complication of Cyst Infection Management in Polycystic Kidney Disease. (Pubmed Central) - Sep 11, 2024
A 68-year-old man on hemodialysis treatment for end-stage kidney disease secondary to autosomal dominant polycystic kidney disease (ADPKD) complained of right ankle pain that impaired walking ability two weeks after the initiation of intravenous levofloxacin as a treatment for concomitant liver cyst infection...However, reports on fluoroquinolone-associated tendinopathy in patients with ADPKD associated with cyst infection are sparse. We believe the current report illustrates the pitfalls associated with managing patients with ADPKD who are subjected to the administration of fluoroquinolones due to infectious complications.
- |||||||||| levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
DIAGNOSIS OF HODGKIN LYMPHOMA IN A PATIENT WITH HIV/AIDS PRESENTING FOR EVALUATION OF CHRONIC DYSPNEA AND COUGH (Convention Center Exhibit Hall: Poster Area 5) - Sep 11, 2024 - Abstract #CHEST2024CHEST_7100;
Early diagnosis and multidisciplinary management are crucial for Hodgkin's Lymphoma in HIV patients, given its aggressive nature. Further research is needed to optimize treatment strategies and improve outcomes for these complex conditions, emphasizing the importance of comprehensive evaluation and timely intervention in such cases.
- |||||||||| SERIAL BILATERAL ROBOTIC-ASSISTED LOBECTOMIES FOR SEVERE BRONCHIECTASIS (Convention Center Exhibit Hall: Rapid Fire Area 1B) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6681;
Robotic-assisted thoracoscopic surgery is a significant advance that led to improved management of this complicated patient with three respiratory infections. She has had a dramatic recovery and improved quality of life.
- |||||||||| THE MYSTERIOUS VISITOR: A CHILLING ENCOUNTER WITH ELIZABETHKINGIA MIRICOLA (Convention Center Exhibit Hall: Rapid Fire Area 1B) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6435;
She received ampicillin-sulbactam for aspiration pneumonia, zoledronic acid for hypercalcemia, and promethazine/diphenhydramine for nausea...Levetiracetam was administered, and she was intubated for airway protection. Midazolam and propofol were started for analgosedation and she was transferred to our hospital for continuous electroencephalogram (EEG).Objective data at our facility: hypernatremia (146 mmol/L), normal anion gap acidosis (bicarbonate: 15 mmol/L, chloride: 120 mmol/L), severe hypocalcemia (6 mg/dL), normocytic anemia (hemoglobin: 8.9 g/dL), elevated lipase (239 U/L), and AKI (creatinine: 1.64 mg/dL)...leading to initiation of vancomycin, piperacillin-tazobactam and doxycycline...Susceptibility testing indicated resistance to piperacillin-tazobactam, tetracycline, cefepime, and sensitivity to ciprofloxacin, levofloxacin, and trimethoprim-sulfamethoxazole...Some research studies demonstrate resistance to beta lactam, monobactam, vancomycin, carbapenems, and aminoglycosides, with variable susceptibility to minocycline, trimethoprim-sulfmethoxazole, piperacillin-tazobactam and levofloxacin [10
- |||||||||| SEPTIC SHOCK MIMIC IN A SYSTEMIC LUPUS ERYTHEMATOSUS FLARE: A DIAGNOSTIC CHALLENGE (Convention Center Exhibit Hall: Poster Area 2) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6363;
This case reinforces the importance of considering underlying autoimmune conditions in patients presenting with sepsis-like symptoms, especially those with a history of autoimmune diseases. A systematic approach to evaluation, including routine checks of specific autoimmune markers, is essential for accurate diagnosis and effective management in such complex cases.
- |||||||||| Mycobutin (rifabutin) / Pfizer, Lupin
BREATHING NEW LIFE INTO RARE LUNG INFECTIONS: A SHIMOIDEI SAGA (Convention Center Exhibit Hall: Poster Area 1) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6305;
This case summarizes and adds to the literary evidence of responsible pathogens present within the scope of NTM. It is the hope that the body of evidence continues to grow in efforts to help clinicians and patients alike navigate this disease process.
- |||||||||| Cubicin (daptomycin) / Merck (MSD)
AN UNUSUAL CASE OF DAPTOMYCIN-INDUCED ACUTE EOSINOPHILIC PNEUMONIA (Convention Center Exhibit Hall: Poster Area 3) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6156;
Three weeks later, he presented with fever and shortness of breath and was initially treated with Levofloxacin for suspected pneumonia...Considering the suspicion of Daptomycin induced eosinophilic pneumonia, Daptomycin was switched to Linezolid and Zosyn, and prednisone therapy was initiated, leading to significant clinical improvement and extubation to nasal cannula on day 5 of hospitalization... A high index of suspicion is crucial to timely recognition of this rare but fatal adverse effect, and clinicians should remember that BAL fluid analysis may show a borderline picture.
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