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137 Trials |
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137 Trials |  |
5343 News |  |
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- || clarithromycin / Generic mfg.
Retrospective data, Review, Journal: The effect of antibiotic resistance on Helicobacter pylori eradication efficacy: A systematic review and meta-analysis. (Pubmed Central) - Apr 29, 2021
Antibiotic resistance causes a decrease in the eradication rate of H pylori today. Quadruple concomitant therapy may overcome the declining H pylori eradication rate caused by metronidazole-only resistance.
- | levofloxacin / Generic mfg.
Journal: Potential Genes Related to Levofloxacin Resistance in Mycobacterium tuberculosis Based on Transcriptome and Methylome Overlap Analysis. (Pubmed Central) - Apr 28, 2021
The overlapping genes between transcriptome and methylome could be essential for studying the molecular mechanisms of LOF-resistant M. tuberculosis H37Rv. These results may provide informative evidence for TB treatment with LOF.
- || rifampicin / Generic mfg.
Clinical, Journal: Pneumococcal colonization among healthy and hospitalized vaccine-naive Sri Lankan children. (Pubmed Central) - Apr 28, 2021
Pneumococcal colonization rates were considerably higher in both study cohorts and the commonest serotypes were 19F, 6B, 6A, 23F and 14. Antibiotic resistance rates were also relatively higher among the pneumococcal isolates.
- | clarithromycin / Generic mfg., amoxicillin / Generic mfg.
Journal: An update on current and advancing pharmacotherapy options for the treatment H. pylori infection. (Pubmed Central) - Apr 28, 2021
Consequently, the performance of clarithromycin-containing triple therapies is now declining to unacceptable levels and should be abandoned unless a prior susceptibility test precludes clarithromycin resistance.Areas covered: This review summarizes updated evidence concerning new and advancing pharmacotherapy options for H. pylori eradication.Expert opinion: Due to the declining efficacy of legacy triple therapies, most guidelines recommend bismuth quadruple therapy as the best initial empiric treatment...Levofloxacin-, rifabutin-, furazolidone- and sitafloxacin-containing regimens remain useful, particularly as salvage options...High-dose dual therapy (proton-pump-inhibitor plus amoxicillin) and vonoprazan, a more potent acid inhibitor that likely enhances the activity of amoxicillin, are promising alternatives that could decrease misuse of antibiotics. Addition of certain probiotics could somewhat increase the performance of H. pylori eradication regimens, while improving tolerability.
- || oseltamivir / Generic mfg.
Clinical, Journal: Effect of early oseltamivir on outpatients without hypoxia with suspected COVID-19. (Pubmed Central) - Apr 28, 2021
Addition of certain probiotics could somewhat increase the performance of H. pylori eradication regimens, while improving tolerability. These findings suggest that early oseltamivir administration may lower the duration of fever in COVID-19 suspected outpatients without hypoxia when it is used in combination with antibacterial therapy.
- || levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Clinical, Journal: Acceptability of levofloxacin, moxifloxacin and linezolid among children and adolescents treated for TB. (Pubmed Central) - Apr 28, 2021
These findings suggest that early oseltamivir administration may lower the duration of fever in COVID-19 suspected outpatients without hypoxia when it is used in combination with antibacterial therapy. No abstract available
- || ceftriaxone / Generic mfg., clarithromycin / Generic mfg., amoxicillin / Generic mfg.
Clinical, Journal: Aetiology and antimicrobial susceptibility pattern of bacterial isolates in community acquired pneumonia patients at Asir region, Saudi Arabia. (Pubmed Central) - Apr 28, 2021
No abstract available The decreased susceptibility to macrolides and tetracyclines is a matter of concern and judicious use of antimicrobials should be done to prevent further rates of resistance.
- || ceftriaxone / Generic mfg.
Clinical, Retrospective data, Journal: Antimicrobial Susceptibility Trends of Streptococcus pneumoniae by Age Groups Over Recent 10 Years in a Single Hospital in South Korea. (Pubmed Central) - Apr 28, 2021
Erythromycin and ceftriaxone resistance rates and the MDR rate of S. pneumoniae significantly increased during the recent 10 years; the trends in individual antimicrobial resistance rates significantly differed between the age groups. This study indicates the need for caution when using ceftriaxone as an empirical antimicrobial against pneumococcal infections.
- | levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
Trial completion: Trimethoprim-Sulfamethoxazole vs Levofloxacin as Targeted Therapy for Stenotrophomonas Maltophilia Infections: a Retrospective Cohort Study (clinicaltrials.gov) - Apr 27, 2021
P=N/A, N=1621, Completed, Sponsor: National Institutes of Health Clinical Center (CC)
This study indicates the need for caution when using ceftriaxone as an empirical antimicrobial against pneumococcal infections. Active, not recruiting --> Completed
- levofloxacin / Generic mfg., amikacin sulfate / Generic mfg.
[VIRTUAL] Is adjuvant amikacin to oral levofloxacine effective for prevention of febrile complications following transrectal prostate biopsy in patients with fluoroquinolone-resistant E.coli in the rectal flora? (Virtual Room 9) - Apr 27, 2021 - Abstract #EAU2021EAU_476;
- || levofloxacin / Generic mfg.
Clinical, Journal: A Case Report of Anticoagulation Management in Acquired Hemophilia Associated With Levofloxacin. (Pubmed Central) - Apr 27, 2021
This case report supports existing literature associating levofloxacin with acquired hemophilia. Due to the complication of life-threatening bleeds, familiarity with the treatment course following coronary events will allow patients with acquired hemophilia to be adequately and safely anticoagulated.
- || ceftriaxone / Generic mfg.
Clinical, Journal: A new HPLC-DAD method for contemporary quantification of 10 antibiotics for therapeutic drug monitoring of critically ill pediatric patients. (Pubmed Central) - Apr 27, 2021
The recovery ranged between 97 and 103 % for all compounds. This method could represent a useful tool for TDM platform of antibiotics.
- | Journal: Determination of levofloxacin, ciprofloxacin, moxifloxacin and gemifloxacin in urine and plasma by HPLC-FLD-DAD using pentafluorophenyl core-shell column: Application to drug monitoring. (Pubmed Central) - Apr 27, 2021
The feasibility of method was demonstrated by analyzing urine and plasma samples of patients receiving orally levofloxacin, ciprofloxacin, or moxifloxacin. The developed method is suitable for therapeutic drug monitoring of these fluoroquinolones and can be applied to pharmacokinetic and toxicological studies.
- | levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Journal: Development and validation of a simple LC-MS/MS method for simultaneous determination of moxifloxacin, levofloxacin, prothionamide, pyrazinamide and ethambutol in human plasma. (Pubmed Central) - Apr 27, 2021
The signal of prothionamide was suppressed in samples with hemolysis which was solved by sample dilution. As the method is robust and sample preparation is simple, it can easily be implemented to facilitate TDM in programmatic MDR-TB treatment.
- || ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Clinical, Journal: Effect of Ciprofloxacin versus Levofloxacin on QTc-interval and Dysglycemia in Diabetic and Non-Diabetic Patients. (Pubmed Central) - Apr 27, 2021
The present study showed that the risk for QTc prolongation and hyperglycemia was greater with levofloxacin than ciprofloxacin in diabetic and non-diabetic patients. In addition, the risk for hypoglycemia was greater with levofloxacin than ciprofloxacin in non-diabetic patients.
- || levofloxacin / Generic mfg.
Clinical, Journal: Treatment Outcomes of Isoniazid-Resistant (Rifampicin Susceptible) Tuberculosis Patients in Uzbekistan, 2017-2018. (Pubmed Central) - Apr 27, 2021
The World Health Organization (WHO) recommends a 6 month regimen consisting of levofloxacin, rifampicin, ethambutol, and pyrazinamide (LRZE) to treat Hr-TB...Since the study was conducted in two regions of Uzbekistan only, the findings have limited generalizability. We recommend future research using an adequate sample size and an appropriate study design (randomized controlled trial or prospective cohort with a control group receiving the WHO-recommended regimen).
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Journal: Levofloxacin Versus Ciprofloxacin in the Treatment of Urinary Tract Infections: Evidence-Based Analysis. (Pubmed Central) - Apr 27, 2021
As for adverse event rate, the 2 drugs were comparable and both safe for clinical use. Based on one included trial and pharmacological research, we raised hypothesis that levofloxacin was superior to ciprofloxacin for treatment of E. coli-induced chronic bacterial prostatitis (CBP) and it required a further study to prove it.
- | levofloxacin / Generic mfg.
Journal: Increasing Natural Resistance Associated Macrophage Protein 1 serum level after Miana treatment in BALB/c induced Klebsiella pneumoniae experimental research. (Pubmed Central) - Apr 27, 2021
The highest increasing in protein levels was found in treatment group (Miana + levofloxacin) with an increase before treatment 3036,07 to 10010,30 pg/ml after treatment p < 0,0001. NRAMP1 protein level in BALB/c mice were highest increasing in protein levels after administration of Miana extract and Levofloxacin compared Miana or Levofloxacin only and clinical impact proved a comparable effect on suppressing Klebsiella pneumoniae growth.The institutional protocol number of this study is 1010/UN4.6.4.5.31/PP36/2019.
- || levofloxacin / Generic mfg.
Clinical, Journal: Conjunctival Microbiota in Patients With Type 2 Diabetes Mellitus and Influences of Perioperative Use of Topical Levofloxacin in Ocular Surgery. (Pubmed Central) - Apr 24, 2021
No difference was observed between initial status and 7 days after ceasing all postoperative medications in both diabetic and non-diabetic follow-up groups. The conjunctival microbiome of T2DM patients was more complex and may respond differently to topical antibiotics.
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., norfloxacin / Generic mfg.
Journal: Fluorescence Quenching Studies on the Interactions between Chosen Fluoroquinolones and Selected Stable TEMPO and PROXYL Nitroxides. (Pubmed Central) - Apr 23, 2021
Finally, the impact of the solvent's polarity on the values of bimolecular quenching rate constants has been explained. The significance of the project comes from many applications of nitroxides in chemistry, biology and industry.
- | levofloxacin / Generic mfg.
Journal: Preparation of AgPO/g-CN Composite Photocatalysts and Their Visible Light Photocatalytic Performance (Pubmed Central) - Apr 23, 2021
Compared with that of single AgPO and g-CN, the AgPO/g-CN composite had a higher catalytic efficiency for levofloxacin. According to the energy band analysis and free radical capture experiment, the mechanism of the Z-type heterostructure of the AgPO/g-CN composite was proposed.
- | AzaSite (1% azithromycin ophthalmic solution) / Sun Pharma, Akorn, Nicox
Trial completion date, Trial primary completion date: Healthy Patients & Effect of Antibiotics (clinicaltrials.gov) - Apr 22, 2021
P=N/A, N=20, Active, not recruiting, Sponsor: Washington University School of Medicine
According to the energy band analysis and free radical capture experiment, the mechanism of the Z-type heterostructure of the AgPO/g-CN composite was proposed. Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021
- | Sirturo (bedaquiline) / J&J, Pharmstandard, NN1213 / Novo Nordisk
Trial completion date: An Open-label RCT to Evaluate a New Treatment Regimen for Patients With Multi-drug Resistant Tuberculosis (clinicaltrials.gov) - Apr 22, 2021
P2/3, N=154, Active, not recruiting, Sponsor: University of Cape Town
Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021 Trial completion date: Dec 2020 --> Jun 2021
- | levofloxacin / Generic mfg.
Trial completion date, Trial primary completion date, Combination therapy: Efficacy and Safety of Levofloxacin for the Treatment of MDR-TB (clinicaltrials.gov) - Apr 22, 2021
P2, N=111, Active, not recruiting, Sponsor: Boston University
Trial completion date: Dec 2020 --> Jun 2021 Trial completion date: Mar 2021 --> Sep 2021 | Trial primary completion date: Mar 2021 --> Sep 2021
- || hydrocortisone / Generic mfg., ibuprofen / Generic mfg.
Clinical, Journal: Y-site physical compatibility of hydrocortisone continuous infusions with admixtures used in critically ill patients. (Pubmed Central) - Apr 22, 2021
Trial completion date: Mar 2021 --> Sep 2021 | Trial primary completion date: Mar 2021 --> Sep 2021 Acetaminophen, albumin, cefepime, ciprofloxacin, cisatracurium, doripenem, epinephrine, esomeprazole, ibuprofen, levofloxacin, levothyroxine, meropenem, and norepinephrine exhibited physical compatibility with hydrocortisone via Y-site infusion.
- | levofloxacin / Generic mfg.
Journal: Glycol chitosan/oxidized hyaluronic acid hydrogel film for topical ocular delivery of dexamethasone and levofloxacin. (Pubmed Central) - Apr 22, 2021
In lipopolysaccharide-activated RAW264.7 macrophages, the formulated hydrogel films displayed potent in vitro anti-inflammatory activity by significantly downregulating various inflammatory cytokines. Overall, the fabricated hydrogel film acting as a dual drug delivery system might be a promising vehicle for the treatment of postoperative endophthalmitis.
- || ceftriaxone / Generic mfg.
Clinical, Journal: Prevalence, Clinical Characteristics and Changes of Antibiotic Resistance in Children with Nontyphoidal Salmonella Infections from 2009-2018 in Chongqing, China. (Pubmed Central) - Apr 22, 2021
And drug resistance rates of NTS to piperacillin/tazobactam and ceftazidime decreased significantly in the last ten years...For severe or invasive infections caused by NTS infection in Southwest China, the use of ceftazidime is recommended until antibiotic sensitivity test results are available. And the choice of antibiotics should be based on the curative effect and the antibiotics sensitivity results.
- ||| levofloxacin / Generic mfg.
COVID as I know becomes serious when it causes severe pneumonia in lungs. Will Levofloxacin + Augmentin Duo help? (Twitter) - Apr 21, 2021
- || Clinical, Journal: The tcdA negative and tcdB positive Clostridium difficile ST81 clone exhibits high-level fluoroquinolone resistance: a multi-center study in Beijing, China. (Pubmed Central) - Apr 20, 2021
The test strains displayed resistance rates of 97.1%, 44.3% and 44.3% for ciprofloxacin, levofloxacin and moxifloxacin, respectively...The double-site mutation in GyrB, S366A+D426V was identified in all the ST81 (n=46) strains. In conclusion, the C. difficile ST81 clone showed high levels of fluoroquinolone resistance in Beijing, China, thus highlighting the need for nationwide surveillance of CDI.
- | levofloxacin / Generic mfg.
Journal: Micellar Liquid Chromatographic Green-Enantioseparation of Racemic Amino Alcohols and Determination of Elution Order. (Pubmed Central) - Apr 20, 2021
In this study, the derivatives of the amino alcohols were synthesized using highly reactive chiral esters of (S)-levofloxacin (Lfx) under microwave conditions, and an aqueous solution of the surfactants (Brij-35 and SDS) was used for the enantioseparation of the synthesized diastereomeric derivatives (DDs) of amino alcohols using reversed-phase HPLC...In addition, the density functional theory calculations were performed in order to develop lowest energy optimized structures of diastereomeric derivatives. The method was validated according to ICH guidelines and the retention factor (k), selectivity factor (α), resolution factor (R ), and limit of detection (0.198 ng mL or 0.291 pM mL ) and limit of quantification (0.594 ng mL or 0.873 pM mL ) were calculated.
- | Journal: Antimicrobial resistance and multilocus sequence types of Stenotrophomonas maltophilia isolated from dogs and cats in Japan. (Pubmed Central) - Apr 17, 2021
Rates of resistances to chloramphenicol, minocycline, and levofloxacin were low (2.6-5.3 %)...Phylogenetic analysis of MLSTs enabled categorization of 13 isolates (34.2 %) into genogroup 6, which is a major genogroup of human isolates. Multinational surveillance would be needed to clarify the significance of antimicrobial-resistant S. maltophilia isolates from companion animals.
- | amoxicillin / Generic mfg.
Journal: Isolation of multidrug-resistant Escherichia coli from turkeys in Dinajpur, Bangladesh, and their antibiogram profile. (Pubmed Central) - Apr 17, 2021
On the other hand, all the isolates were 100% resistant to amoxicillin, azithromycin, erythromycin, tetracycline, bacitracin, cephalexin, nalidixic acid, vancomycin, methicilin, piperacillin, pefloxacin, novobiocin, cefepime, trimethoprim, netilmicin, and aztreonam. This study's results uncover the occurrence and antibiotic resistance pattern of E. coli in the study area's turkeys.
- | ceftriaxone / Generic mfg., tigecycline / Generic mfg.
Preclinical, Journal: In-vitro activity of tigecycline against multidrug-resistant Gram negative bacteria: The experience of a university hospital. (Pubmed Central) - Apr 16, 2021
It is concluded that infections caused by multidrug-resistant Gram negative bacteria occur at a high rate. Most isolates were multi drug resistant, with 21.4% being resistant to tigecycline.
- || ceftriaxone / Generic mfg.
Clinical, Retrospective data, Journal: Double Infectious Aortic Aneurysms Followed by Positron Emission Tomography/Computed Tomography for Evaluation of Infection Control after Simultaneous Thoracic Endovascular Aortic Repair and Endovascular Aortic Repair:Report of a Case (Pubmed Central) - Apr 16, 2021
We used intravenous antibiotics( ceftriaxone 4 g/day) for seven days...We changed intravenous antibiotics to oral antibiotics( levofloxacin 500 mg/day)...Since surgery, no symptoms of reinfection have been observed at outpatient clinic. PET/CT was useful to evaluate the control of local infection in this case.
- || levofloxacin / Generic mfg.
Clinical, Journal: Efficacy and Safety of Ningmitai Capsules in Patients with Chronic Epididymitis: A Prospective, Parallel Randomized Controlled Clinical Trial. (Pubmed Central) - Apr 16, 2021
The patients were randomized (1 : 1 : 1) to receive levofloxacin (LVX), NMT, or NMT combined with LVX for 4 weeks...NMT significantly improved CESI scores and epididymal nodule diameter in patients with chronic epididymitis. The combination of NMT and LVX provides a much better effect than monotherapy, and this treatment regimen was well tolerated.
- | Preclinical, Journal: Combination inhibition activity of chlorhexidine and antibiotics on multidrug-resistant Acinetobacter baumannii in vitro. (Pubmed Central) - Apr 15, 2021
The combination of NMT and LVX provides a much better effect than monotherapy, and this treatment regimen was well tolerated. We concluded that, chlorhexidine combined with antibiotics could be used to control the risk of infection with A. baumannii.
- Synagis (palivizumab) / AbbVie, AstraZeneca, SOBI
[VIRTUAL] LEVOFLOXACIN PROPHYLAXIS FOR A PATIENT WITH INFANT ACUTE LYMPHOBLASTIC LEUKEMIA () - Apr 14, 2021 - Abstract #ASPHO2021ASPHO_549;
Patients with infant ALL are also high risk of infection throughout therapy requiring aggressive supportive care. Levofloxacin prophylaxis could be a potential addition to the supportive care armamentarium for these patients in an attempt to reduce bacteremia and infection related complications.
- Blincyto (blinatumomab) / Astellas, Amgen
[VIRTUAL] BLINATUMOMAB USE AS NOVEL BRIDGING THERAPY IN RELAPSED PEDIATRIC ALL WITH ACTIVE INVASIVE INFECTION () - Apr 14, 2021 - Abstract #ASPHO2021ASPHO_471;
Blinatumomab may be a bridging therapy for relapsed leukemia control while treating acute invasive infections. This treatment allowed for leukemia control during infection resolution and was well tolerated by both patients with minimal complications.
- ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
[VIRTUAL] LEVOFLOXACIN VERSUS CIPROFLOXACIN PROPHYLAXIS IN PEDIATRIC CANCER PATIENTS AT HIGH RISK OF INFECTION () - Apr 14, 2021 - Abstract #ASPHO2021ASPHO_283;
This treatment allowed for leukemia control during infection resolution and was well tolerated by both patients with minimal complications. Our data shows that the use of levofloxacin more effectively prevented neutropenic fever and bacteremia than ciprofloxacin in children with high-risk malignancies.
- || levofloxacin / Generic mfg.
PK/PD data, Preclinical, Journal: Pharmacokinetics and in vivo distribution of optimized PLGA nanoparticles for pulmonary delivery of levofloxacin. (Pubmed Central) - Apr 14, 2021
Augmentation in C (1.71-fold), AUC 0-∞ (5.46-fold), Mean Residence Time (6.64-fold) and AUC/MIC (6.21-fold) of LN through pulmonary route was found to significantly higher (P < 0.05) than levofloxacin (p. o.).
- || levofloxacin / Generic mfg., doripenem / Generic mfg.
Clinical, Journal, Combination therapy: Synergistic activities of ceftazidime-avibactam in combination with different antibiotics against colistin-nonsusceptible clinical strains of Pseudomonas aeruginosa. (Pubmed Central) - Apr 13, 2021
The findings of this study suggest that ceftazidime/avibactam with colistin, or tobramycin, were effective against colistin-nonsusceptible strains. This combination therapy could be an alternative antibiotic therapy for resistant P. aeruginosa strains.
- || rifampicin / Generic mfg.
Retrospective data, Review, Journal: Brucellar reproductive system injury: A retrospective study of 22 cases and review of the literature. (Pubmed Central) - Apr 13, 2021
Doxycycline combined with levofloxacin or moxifloxacin should be used in patients with brucellosis-induced reproductive system damage who have rifampicin intolerance. The treatment course should be at least 6 weeks.
- || clarithromycin / Generic mfg.
Clinical, Journal: Membrane interactions of non-membrane targeting antibiotics: The case of aminoglycosides, macrolides, and fluoroquinolones. (Pubmed Central) - Apr 13, 2021
To note, all antibiotics partitioned into the lipid head groups, while macrolides and fluoroquinolones also partitioned into the bilayer core. The results suggest that the bacterial membrane is relatively inert in the direct mechanisms of actions of these antibiotics.
- | levofloxacin / Generic mfg., azithromycin / Generic mfg., acyclovir / Generic mfg.
Retrospective data, Journal: The clinicopathological features of drug-induced acute kidney injury-a single-center retrospective analysis. (Pubmed Central) - Apr 13, 2021
Allergic interstitial nephritis, interstitial nephritis, and tubular epithelial cell injury were the main pathological manifestations of drug-induced AKI. The novel predictive nomogram achieved a good performance of prediction recovery within 2 weeks in drug-induced AKI patients.
- Teflaro (ceftaroline fosamil) / Sumitomo Dainippon, AstraZeneca, AbbVie
[VIRTUAL] Costs-Consequences Analysis of Ceftaroline Fosamil for the Treatment of Community-Acquired Pneumonia in the Brazilian Private Healthcare System () - Apr 12, 2021 - Abstract #ISPOR2021ISPOR_652;
Cost-savings ranged from BRL 174,675 when compared to ceftriaxone, to BRL 5720,221 when compared to levofloxacin. CONCLUSIONS : Ceftaroline fosamil demonstrated potential as an initial antibiotic therapy when compared to alternative therapies for patients with moderate to severe CAP, as it can result in an increase in early response and a decrease in total costs for the BPHS.
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., norfloxacin / Generic mfg.
Journal: Evaluation of the intracellular accumulation of fluoroquinolones in mycobacteria by fluorometric assays. (Pubmed Central) - Apr 10, 2021
The addition of CCCP failed to influence the accumulation of each of these quinolones. The findings of dose-related accumulation of OFX, LFX NFX, and CIF suggest simple diffusion as the possible mechanism of transport of these drugs.
- || levofloxacin / Generic mfg., erythromycin / Generic mfg.
Clinical, Journal: Surveillance of antimicrobial resistance and evolving microbial populations in Vermont: 2011-2018. (Pubmed Central) - Apr 10, 2021
The findings of dose-related accumulation of OFX, LFX NFX, and CIF suggest simple diffusion as the possible mechanism of transport of these drugs. Comprehensive electronic surveillance of antimicrobial resistance utilizing routine clinical microbiology data with free software tools offers early recognition and tracking of emerging community and healthcare resistance threats at the local and state level.
- | levofloxacin / Generic mfg.
Journal: Studies on non-gelatinous & thermo-responsive chitosan with the N-isopropylacrylamide by RAFT methodology for control release of levofloxacin. (Pubmed Central) - Apr 10, 2021
Further, beads were prepared with the sodium alginate and loaded the water-soluble levofloxacin drug (60% w/w loading was achieved). The drug delivery process was studied in-vitro at 37 ± 0.1 °C & pH 7.4, which shown controlled release of drug up to 32 h and it was 71% of the loaded levofloxacin.
- || Jakafi oral (ruxolitinib) / Novartis, Incyte
Clinical, Review, Journal: Cryptococcal fungemia and Mycobacterium haemophilum cellulitis in a patient receiving ruxolitinib: a case report and literature review. (Pubmed Central) - Apr 10, 2021
This is the first case of C. neoformans and M. haemophilum coinfection in a patient receiving ruxolitinib treatment. Although uncommon, clinicians should be aware of the potential for multiple opportunistic infections that may be caused by atypical pathogens in patients receiving ruxolitinib.
- || rifampicin / Generic mfg.
Clinical, Journal: Microbiological pattern of prosthetic hip and knee infections: a high-volume, single-centre experience in China. (Pubmed Central) - Apr 10, 2021
The results of antibiotic susceptibility testing showed that gentamicin and clindamycin β-lactam antibiotics were poorly susceptible to Gram-positive isolates, but they were sensitive to rifampicin, linezolid and vancomycin...Empirical antibiotic treatment should combine vancomycin and cephalosporin, levofloxacin or clindamycin...Attention should be paid to the high incidence of MRS, such as MRSA and MR-CNS, among PJI patients. Empirical antibiotic treatment should cover Gram-positive isolates, especially Staphylococcus.