levofloxacin / Generic mfg. 
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  • ||||||||||  [VIRTUAL] TonB Systems Involved in Antibiotic Influx and Efflux in Vibrio vulnificus (Poster Hall) -  May 9, 2021 - Abstract #WMF2021WMF_3718;    
    In contrast, our MIC’s decreased when testing doxycycline, suggesting these deleted proteins may help power the efflux of this antibiotic. Intriguingly, deletions in the newly discovered TtpB2 and/or TtpD2 in the TonB2 system had to be present in order to see a decrease in MIC value, not a TonB protein specifically.
  • ||||||||||  [VIRTUAL] Streptococcus agalactiae Belonging to CC103 Recovered from Bovine Milk in Rio De Janeiro, Brazil (Poster Hall) -  May 9, 2021 - Abstract #WMF2021WMF_3550;    
    Different PFGE and CRISPR-RFLP profiles were detected within ST314 strains recovered from a same region and herd. The results point out that ST314 is a successful clone in Brazilian herds, and, despite sharing some phenotypic characteristics, ST314 GBS strains can show different antimicrobial susceptibility profiles, pilus genes and genetic background, suggesting intra-herd diversity.
  • ||||||||||  levofloxacin / Generic mfg.
    [VIRTUAL] Resveratrol Derivatives as Promising Strategy Against Helicobacter pylori Resistance (Poster Hall) -  May 9, 2021 - Abstract #WMF2021WMF_3152;    
    RSV, RSV-3 and RSV-4 were able to synergize with LVX restoring its effect in two out of seven clinical resistant strains tested for the study. RSV, and the RSV derivatives, alone and combined with LVX at sub-MIC and sub-synergistic concentrations, significantly reduced the biofilm formation.
  • ||||||||||  [VIRTUAL] Analysis of the Microbial Landscape of Purulent-septic Conditions Pathogens in Surgical Hospitals (Poster Hall) -  May 9, 2021 - Abstract #WMF2021WMF_1471;    
    Our analysis shows a high prevalence of antibiotic-resistant microorganisms of the ESKAPE group, as well as epidermal staphylococci, which play a role in the occurrence of postoperative purulent-septic infectious conditions in patients treated in surgical hospitals. This situation requires constant monitoring of antibiotic susceptibility of microorganisms, the implementation of anti-epidemic measures to curb the spread of infection.
  • ||||||||||  tigecycline / Generic mfg.
    [VIRTUAL] In Vitro Activity of Tigecycline and Comparator Agents Against Gram-negative Isolates, Global 2016-2019 (Poster Hall) -  May 9, 2021 - Abstract #WMF2021WMF_1459;    
    Based on percent susceptibility (S), tigecycline (TGC), amikacin (AMK), and meropenem (MEM) were the most active agents against Enterobacterales isolates...Only TGC exhibited good activity against CRE, with 93.1% S. Cefepime, levofloxacin and piperacillin/tazobactam had reduced activity against all Enterobacterales and against the CRE subset. The most active agents tested against this global collection of GN isolates were TGC, MEM, and AMK, with >95% S. Antibiotic surveillance programs such as ATLAS are essential to determine global resistance patterns and to monitor changes worldwide.
  • ||||||||||  rifampicin / Generic mfg.
    [VIRTUAL] Short-chain Fatty Acids and Antibiotics Affect Local and Systemic Processes Relevant for Bone Healing () -  May 9, 2021 - Abstract #WMF2021WMF_1101;    
    Although butyrate treated animals only show a mild difference regarding bone healing outcomes compared to control mice, rifampicin-levofloxacin treated mice trend to have reduced mineral apposition at the healed fracture site and different mechanical properties of the contralateral, unoperated femur. In conclusion, the composition of the gut microbiota and the presence of bacterial-derived metabolites such as SCFAs may be an important contributor to numerous local and systemic processes relevant to general health and also bone healing.
  • ||||||||||  levofloxacin / Generic mfg., tolfenamic acid / Generic mfg.
    Journal:  Influences of tolfenamic acid and flunixin meglumine on the disposition kinetics of levofloxacin in sheep. (Pubmed Central) -  May 8, 2021   
    Tolfenamic acid and flunixin meglumine caused a slow elimination and increased plasma concentrations of levofloxacin in combination administration. Levofloxacin, with an alteration in the dosage regimen, can be used effectively with tolfenamic acid and flunixin meglumine for the therapy of infections and inflammatory conditions in sheep.
  • ||||||||||  clarithromycin / Generic mfg., rifampicin / Generic mfg., amoxicillin / Generic mfg.
    Journal:  Management of antibiotic-resistant Helicobacter pylori infection: current perspective in Iran. (Pubmed Central) -  May 8, 2021   
    Due to increased antibiotic resistance in our region, empirical therapy must be replaced by more targeted treatment based on antimicrobial drug resistance profiles obtained from patients. Although we limited our investigation on the H. pylori eradication regimens in Iran, the results can be generalized to any region as long as the patterns of resistance are the same.
  • ||||||||||  levofloxacin / Generic mfg.
    Trial completion date, Trial primary completion date:  Short Compared With Standard Duration of Antibiotic Treatment for AECOPD (clinicaltrials.gov) -  May 3, 2021   
    P2,  N=360, Completed, 
    This study provided evidence of the usefulness of new anti-TB drugs in the treatment of MDR-TB in China. Trial completion date: Jan 2017 --> Jan 2021 | Trial primary completion date: Jan 2017 --> Jan 2021
  • ||||||||||  metoclopramide / Generic mfg., amoxicillin / Generic mfg.
    [VIRTUAL] Intractable Nausea and Vomiting—Sometimes the Shrink Has a Cure! A Case Report of Gastroparesis, and Role of C-L Psychiatry in Diagnosis and Management () -  May 2, 2021 - Abstract #APA2021APA_529;    
    The patient was seen in the ED for abdominal pain diagnosed with diverticulitis, and sent home with treatment with Amoxicillin for 10 days, with the subsequent course of Metronidazole with no reported improvement...During her 10 day stay at the hospital, initially failed conservative management with another course of antibiotics Levofloxacin and Metronidazole Followed by surgical resection of small bowel resection with end colostomy...The patient was started on Ciprofloxacin and Metronidazole; surgery and GI were consulted...The patient was diagnosed with gastroparesis, started on scheduled Metoclopramide...No reported ED visits since discharge (2+ years ago). This case outlines the unique position of consultation & liaison psychiatry at the helm of psychiatry and medicine.
  • ||||||||||  levofloxacin / Generic mfg., nalidixic acid / Generic mfg.
    Clinical, Journal:  Antimicrobial Susceptibility Pattern of Salmonella spp. Isolated from Enteric Fever Patients in Nepal. (Pubmed Central) -  May 1, 2021   
    Hence, conventional first-line-drugs and third-generation cephalosporins may find potential usage as the empirical drugs for enteric fever. Although our reporting was free of MDR strains, extensive surveillance, augmentation of diagnostic facilities and treatment protocol aided by AST report are recommended for addressing the escalating drug-resistance in the country.
  • ||||||||||  clarithromycin / Generic mfg., amoxicillin / Generic mfg.
    Biomarker, Review, Journal, Next-generation sequencing:  Next Generation Sequencing for the Prediction of the Antibiotic Resistance in Helicobacter pylori: A Literature Review. (Pubmed Central) -  May 1, 2021   
    Next Generation Sequencing enabled the detection of novel, rare and complex resistance mechanisms. The prediction of resistance to clarithromycin, levofloxacin and amoxicillin is accurate; for other antimicrobials, such as metronidazole, rifabutin and tetracycline, potential genetic determinants of the resistant status need further investigation.
  • ||||||||||  selenomethionine (SLM) / University of Iowa, Holden Comprehensive Cancer Center
    Journal:  An efficient method for the determination of enantiomeric purity of racemic amino acids using micellar chromatography, a green approach. (Pubmed Central) -  Apr 30, 2021   
    A simple, sensitive and green micellar liquid chromatographic method (RP-HPLC) was developed for enantioseparation of four racemic amino acids, namely, (RS)-selenomethionine, (RS)-methionine, (RS)-cysteine and (RS)-penicillamine...Activated esters of (S)-ibuprofen, (S)-ketoprofen and (S)-levofloxacin were synthesized by reacting them with N-hydroxybenzotriazole...A.02 and hybrid density functional B3LYP with 6-31G* basis set program, in order to develop lowest energy optimized structures of diastereomeric derivatives. The method was validated according to ICH guidelines and the retention factor (k), selectivity factor (α), resolution factor (R ), and limit of detection (0.295 ng mL ) and limit of quantification (0.896 ng mL ) were calculated.