- |||||||||| levofloxacin / Generic mfg.
Retrospective data, Journal: Management of isoniazid-monoresistant tuberculosis (Hr-TB) in Queensland, Australia: a retrospective case series. (Pubmed Central) - Jun 9, 2021
The current WHO-recommended regimen did not confer advantage over an appropriately constructed regimen containing first-line agents only. Our findings suggest that, in a well-resourced setting with good programmatic management, the addition of a fluoroquinolone may not substantially improve outcomes - potentially allowing these agents to be reserved for more extensively resistant disease.
- |||||||||| levofloxacin / Generic mfg.
Journal: Anaerobic biodegradation of levofloxacin by enriched microbial consortia: Effect of electron acceptors and carbon source. (Pubmed Central) - Jun 8, 2021
The predicted high gene abundance of xenobiotics biodegradation & metabolism, carbohydrate metabolism, and assimilatory sulfate reduction in the consortium, indicated a co-metabolism between carbohydrate metabolism, sulfate metabolism, and LEV degradation under glucose and sulfate added condition. The study revealed that simultaneous addition of glucose and sulfate is the favorable condition for LEV anaerobic degradation.
- |||||||||| levofloxacin / Generic mfg., clindamycin phosphate / Generic mfg., erythromycin / Generic mfg.
Clinical, Retrospective data, Journal: Prevalence of group B streptococcus colonization in pregnant women in Jiangsu, East China. (Pubmed Central) - Jun 8, 2021
It compared the difference of the sensitivity to detect GBS between PCR and culture. PCR was expected to become a quick method in pregnancy women conventional detection of GBS infection.
- |||||||||| ampicillin / Generic mfg., clarithromycin / Generic mfg.
Review, Journal: Prevalence and impact of antimicrobial resistance in gastrointestinal infections: A review. (Pubmed Central) - Jun 8, 2021
The microorganisms that demonstrated the highest percentage of resistance were Helicobacter pylori (metronidazole 50%-80%, clarithromycin 20%-40%, and levofloxacin 30%-35%), Clostridioides difficile (clindamycin 8.3%-100%, cephalosporines 51%), Campylobacter jejuni and Campylobacter coli (fluoroquinolones 85%), Escherichia coli (ampicillin 76.5%), Entamoeba histolytica (metronidazole 50%), and bacterial peritonitis (third-generation cephalosporines 40%, methicillin 85%). Antimicrobial resistance is reaching elevated percentages, making it necessary to evaluate the situation of each patient, to successfully treat gastrointestinal infections.
- |||||||||| Mycobutin (rifabutin) / Pfizer, Lupin, Pylera (bismuth subcitrate potassium/ metronidazole/tetracycline) / AbbVie
Journal: Rescue Therapies for H. pylori Infection in Italy. (Pubmed Central) - Jun 3, 2021
A therapy sequence based on the type of first-line therapy used was proposed. Data obtained through our review indicate that standard therapies for H. pylori eradication can be used when following an appropriate sequence, allowing clinicians to improve the cure rate without resorting to bacterial culture.
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Journal: Presence of plasmid-mediated quinolone resistance (PMQR) genes in non-typhoidal Salmonella strains with reduced susceptibility to fluoroquinolones isolated from human salmonellosis in Gyeonggi-do, South Korea from 2016 to 2019. (Pubmed Central) - Jun 3, 2021
In conclusion, qnr gene-positive Salmonella 4,[5],12:i:- and Salmonella Typhimurium were the main serovars responsible for reduced susceptibility to fluoroquinolones. Therefore, our findings suggest that PMQR-positive Salmonella strains, which can be isolated from various samples including human, food, and the environment, should be carefully monitored.
- |||||||||| clarithromycin / Generic mfg., amoxicillin / Generic mfg.
Journal: Protective effects of Helicobacter pylori membrane vesicles against stress and antimicrobial agents. (Pubmed Central) - Jun 2, 2021
In the presence of 50 µg OMVs ml, significantly enhanced H. pylori growth was observed at higher LL-37 concentrations compared with lower LL-37 concentrations, suggesting that OMV-LL-37 interactions might facilitate release of growth-promoting nutrients. Taken together, these data indicate that production of membrane vesicles could help H. pylori to survive exposure to antibiotics and host antimicrobial defences during infection.
- |||||||||| Fetroja (cefiderocol) / Shionogi
[VIRTUAL] COMPASSIONATE USE OF CEFIDEROCOL FOR VIM METALLO-BETA-LACTAMASE-PRODUCING PSEUDOMONAS AERUGINOSA INFECTION IN A TODDLER WITH BURKITT LYPHOMA () - Jun 2, 2021 - Abstract #ESPID2021ESPID_1447;
She was receiving chemotherapy and tuberculostatic treatment (isoniazid, pyrazinamide, ethambutol and levofloxacin; rifampicin was discontinued due to liver toxicity)...Despite in-vitro resistance to all antibiotics tested (cephalosporins, piperacillin/tazobactam, quinolones, aminoglycosides, colistin, carbapenems, and also the combination of aztreonam with ceftazidime-avibactam), the patient received high-dose colistin for 14 days and the infection was controlled...After 5 days, fever persisted so cefepime was switched to high-dose meropenem and teicoplanin...In this case, ecthyma was controlled when cefiderocol was started, but coincident with neutrophil recovery. More information is needed about novel antibiotics in pediatrics.
- |||||||||| [VIRTUAL] DISSEMINATED TUBERCULOSIS WITH FOCAL ADHESIVE PERITONITIS IN A PREVIOUSLY HEALTHY ADOLESCENT () - Jun 2, 2021 - Abstract #ESPID2021ESPID_1423;
Contained intestinal perforation was assumed and started therapy with cefotaxime, gentamicin and metronidazole...Due to lack of improvement after 23 days, levofloxacin was added...Learning Points/ Diagnosis of disseminated TB can be difficult, and a high index of suspicion on a severely debilitated patient allows prompt initiation of empirical therapy. The resolution of disseminated tuberculosis is slow, however the prognosis is excellent with early diagnosis and adequate therapy.
- |||||||||| rifampicin / Generic mfg.
[VIRTUAL] A RECURRENT MULTIFOCAL OSTEOARTICULAR INFECTION IN A CHILD () - Jun 2, 2021 - Abstract #ESPID2021ESPID_1355;
She was treated with doxycyclin and rifampin, and finally levofloxacin and rifampicin...When azythromycin and trimethoprim-sulfamethoxazole were added she experienced an improvement, without more surgery...Surgical debridement and prolonged antibiotic may be important, although the optimal therapy remains unclear. Recent therapies with INF-γ have shown some effectiveness.
- |||||||||| Deltyba (delamanid) / Otsuka
[VIRTUAL] MULTIDRUG RESISTANT TUBERCULOSIS IN A ONE YEAR OLD BOY () - Jun 2, 2021 - Abstract #ESPID2021ESPID_1178;
Learning Points/ The main obstacle in facing MDR TB is the long and expensive treatment, with frequent appearance of adverse effects, drug interactions and high rates of therapeutic failure. Delamanid, despite limited data available on its use in infants under 2 years old, showed good tolerability and efficacy in our experience.
- |||||||||| rifampicin / Generic mfg.
[VIRTUAL] CONGENITAL TUBERCULOSIS (TB) USE OF SECOND-LINE MEDICATION AND THERAPEUTIC DRUG MONITORING () - Jun 2, 2021 - Abstract #ESPID2021ESPID_1173;
Because of lack of clinical improvement, a paradoxical hyperinflammatory reaction to TB treatment was suspected, prednisone was prescribed for 4 weeks. From age 2 months the patient improved progressively Learning Points/ In premature neonates, TDM may be necessary to optimize therapy, and the use or addition of second-line medications should be considered due to limited dosing information for some first-line drugs and the aggressive nature of congenital TB.
- |||||||||| clarithromycin / Generic mfg., rifampicin / Generic mfg., amoxicillin / Generic mfg.
Journal: Helicobacter pylori infections in the Bronx, New York: Surveying Antibiotic Susceptibility and Strain Lineage by Whole-genome Sequencing. (Pubmed Central) - Jun 1, 2021
In summary, WGS allows for broad analyses of H. pylori isolates and our findings support the use of WGS for detection of clarithromycin and levofloxacin resistance. Additional studies are warranted to better define mutations conferring resistance to amoxicillin, tetracycline, and rifampin, but combinatorial analyses for rdxA gene truncations and R16H mutations have utility for determining metronidazole resistance.
- |||||||||| bortezomib / Generic mfg.
Clinical, Journal, Real-world evidence: Bacterial Infection Among Patients With Multiple Myeloma Treated With Bortezomib-based Induction Therapy: Real-World Experience in an Asian Cancer Center. (Pubmed Central) - Jun 1, 2021
Additional studies are warranted to better define mutations conferring resistance to amoxicillin, tetracycline, and rifampin, but combinatorial analyses for rdxA gene truncations and R16H mutations have utility for determining metronidazole resistance. The proportion of patients with significant bacterial infection during the first 12 weeks of bortezomib-based induction therapy without routine fluoroquinolone prophylaxis, but with routine Pneumocystis Carinii prophylaxis (mostly with trimethoprim-sulfamethoxazole), is low in a population with adequate access to health care facilities and timely supportive care.
- |||||||||| levofloxacin / Generic mfg., tetracycline / Generic mfg.
Clinical, Journal: MYCO WELL D-ONE detection of Ureaplasma spp. and Mycoplasma hominis in sexual health patients in Wales. (Pubmed Central) - Jun 1, 2021
Levofloxacin resistance rates, mediated by Ser83Leu mutation in ParC, for Ureaplasma spp...Tetracycline resistance rates, mediated by tet(M), were 0.54% and 2% for Ureaplasma spp...and M. hominis in genitourinary medicine samples, facilitating the accurate detection of these organisms within low-technology environments. While good for antibiotic resistance screening, accurate confirmation by MIC determination or molecular methods are required, and more optimally performed on urine samples.
- |||||||||| clarithromycin / Generic mfg., cefuroxime / Generic mfg.
Clinical, Review, Journal: Repurposing of antibiotics for clinical management of COVID-19: a narrative review. (Pubmed Central) - Jun 1, 2021
The heavy use of antibiotics during the COVID-19 pandemic would likely worsen antibiotic resistance crisis. Consequently, antibiotic stewardship should be strengthened in order to prevent the impacts of COVID-19 on the antibiotic resistance crisis.
- |||||||||| levofloxacin / Generic mfg., acyclovir / Generic mfg., minocycline / Generic mfg.
Clinical, Journal: Severe encephalitis caused by infection of Rickettsia felis: a case report (Pubmed Central) - Jun 1, 2021
After comprehensive treatment of antiviral by acyclovir, mannitol dehydration to reduce intracranial pressure, human immunoglobulin to regulateimmunity, minocycline hydrochloride capsule, levofloxacin mesylate and sodium chloride against Rickettsia felis infection, control of seizure and pulmonary infection, the patient's condition was improved and then discharged. By summarizing the experience and lessons in the treatment of this patient, we hope to remind everyone to strengthen the understanding of Rickettsia felis infection.
- |||||||||| levofloxacin / Generic mfg.
[VIRTUAL] Novel Antimicrobial Complex Does Not Result in Development of Resistance (Poster Hall) - May 31, 2021 - Abstract #WMF2021WMF_5294;
No mutational pattern was observed using WGS, and E. coli did not develop an elevated mutation rate. In view of common shared mechanisms for the development of resistance towards antibiotics and biocides, the potential for cross-resistance was investigated.
- |||||||||| Maxidex (dexamethasone eye drops, suspension) / Novartis
Journal: Post-surgical management of cataract: Light and dark in the 2020s. (Pubmed Central) - May 29, 2021
The study also showed that treatment for 1 week with dexamethasone results in complete resolution of inflammatory signs and symptoms in over 85% of patients, for whom further prolongation of corticosteroid treatment is, therefore, not necessary. This new treatment strategy can represent a significant step forward to reduce the unjustified use of prophylactic antibiotics after cataract surgery, limiting the emergence of bacterial resistance, as well as representing an opportunity to optimize the use and safety of the corticosteroid treatment.
- |||||||||| levofloxacin / Generic mfg., amikacin sulfate / Generic mfg.
Journal: Tuberculosis in the intensive care unit: alternative treatment regimens and association with mortality. (Pubmed Central) - May 28, 2021
Our findings suggested that the reduction in the use of third generation cephalosporins and quinolones correlates with observed decrease in the occurrence of antibiotic-resistant, ESBL-producing, and quinolone-resistant bacteria. TB programs in which IV rifampicin is not widely available should consider including it, especially for critically ill TB patients, for whom there may be improved survival.
- |||||||||| amoxicillin / Generic mfg.
Clinical, Journal: Antimicrobial susceptibility of multidrug-resistant Pseudomonas aeruginosa isolated from drinking water and hospitalized patients in Jordan. (Pubmed Central) - May 27, 2021
All water isolates (100%) were resistant to amoxicillin, oxytetracycline and doxycycline (93.3% and 86.7, respectively)...Results of this study indicate an alarming widespread presence of multidrug-resistant P. aeruginosa associated with chronic suppurative infections in hospitalized patients and apparently clean drinking water in Jordan. Treatment of clinical suppurative lesions must be based on culture and in vitro susceptibility testing using potent antimicrobial combinations to avoid emergence of resistant strains and to improve the clinical outcome of treated patients.
- |||||||||| levofloxacin / Generic mfg.
Retrospective data, Review, Journal: Treatment outcomes of pregnant women with drug resistant tuberculosis in Uganda: a retrospective review of 18 cases. (Pubmed Central) - May 27, 2021
Treatment of clinical suppurative lesions must be based on culture and in vitro susceptibility testing using potent antimicrobial combinations to avoid emergence of resistant strains and to improve the clinical outcome of treated patients. The treatment success among pregnant women with DRTB in Uganda was high despite a high prevalence of HIV co-infection.
- |||||||||| clarithromycin / Generic mfg.
Journal: Application of Visual Gene Clip-Based Tailored Therapy for the Eradication of Helicobacter pylori. (Pubmed Central) - May 27, 2021
Among the 242 patients who received tailored therapy, the H. pylori eradication rate was 90.9% (95% confidence interval 87.3%~94.6%) in the intention-to-treat analysis and 96.9% (95% confidence interval 94.7%~99.2%) in the per protocol analysis. Tailored therapy for H. pylori infection guided by determination of antibiotic resistance and CYP2C19 polymorphism using visual gene chip technology may provide high clinical effectiveness as initial H. pylori eradication therapy.
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