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137 Trials |
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137 Trials |  |
5343 News |  |
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- | levofloxacin / Generic mfg.
Journal: Acute pancreatitis associated with levofloxacin. (Pubmed Central) - Jun 30, 2021
According to some series, 0.3-1.5% of all cases of acute pancreatitis are drug induced. Acute pancreatitis due to levofloxacin is included in its safety data sheet as an adverse effect.
- || ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Review, Journal: Quinolone-induced psychosis: an updated review. (Pubmed Central) - Jun 30, 2021
Finally, it is important to perform further research on this issue. Keywords: Quinolones, Psychosis, Ciprofloxacin, Levofloxacinn, Psychotic Induced.
- || Clinical, Observational data, Journal: Antibiotic resistant Cutibacterium acnes among acne patients in Jordan: a cross sectional study. (Pubmed Central) - Jun 30, 2021
The findings of this study demonstrate the distribution of antibiotic resistance of C. acnes towards used antibiotics and emphasizes the influence of antibiotic consumption on development of antibiotic resistance. The similar pattern of resistance between skin bacteria tested in this study highlights the genetic transfer of resistance between skin commensals including S. aureus and S. epidermidis hence promoting its circulation in the community.
- || ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Clinical, Journal: Outpatient Fluoroquinolone Prescription Fills in the United States, 2014-2020: Assessing the Impact of Food and Drug Administration Safety Warnings. (Pubmed Central) - Jun 30, 2021
US outpatient fluoroquinolone prescription fills significantly decreased from August 2014-February 2020, most strongly in association with May 2016 FDA warnings. FDA safety warnings are useful tools for leveraging outpatient antimicrobial stewardship.
- || ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., meropenem / Generic mfg.
Clinical, Retrospective data, Journal: Keratitis associated with contact lens correction in children and adolescents (Pubmed Central) - Jun 30, 2021
FDA safety warnings are useful tools for leveraging outpatient antimicrobial stewardship. Considering the number of contact lens users in the world, keratitis associated with contact lenses poses a serious problem.
- | levofloxacin / Generic mfg., tetracycline / Generic mfg.
Journal: 2-Heptylcyclopropane-1-Carboxylic Acid Disperses and Inhibits Bacterial Biofilms. (Pubmed Central) - Jun 29, 2021
Furthermore, 2CP supported fibroblast viability above 80% for concentrations below 1 mg/ml. This study demonstrates that 2CP shows similar or improved efficacy in biofilm dispersion, inhibition, and eradication compared to C2DA and T2DA and thus may be promising for use in preventing infection for healthcare applications.
- | levofloxacin / Generic mfg., clarithromycin / Generic mfg.
Journal: Current status of Helicobacter pylori resistance to Clarithromycin and Levofloxacin in Malaysia-findings from a molecular based study. (Pubmed Central) - Jun 29, 2021
The primary resistance rate of H. pylori to clarithromycin has increased compared to the previous report in Malaysia. Therefore, molecular screening could aid and is important for the selection of antibiotics for H. pylori eradication therapies.
- | levofloxacin / Generic mfg.
Trial completion, Enrollment change: Pharmacokinetic Evaluation of Fluoroquinolone Antibiotics Administered Intravenously in Intensive Care Patients With Normal Renal Function and With Renal Hyperfiltration (clinicaltrials.gov) - Jun 29, 2021
P3, N=14, Completed, Sponsor: University Ghent
Therefore, molecular screening could aid and is important for the selection of antibiotics for H. pylori eradication therapies. Recruiting --> Completed | N=40 --> 14
- |||| Enrollment open: Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum (clinicaltrials.gov) - Jun 29, 2021
P4, N=325, Recruiting, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting --> Completed | N=40 --> 14 Not yet recruiting --> Recruiting
- | Emrok (levonadifloxacin) / Wockhardt
Preclinical, Journal: In vitro activity of a novel antibacterial agent, levonadifloxacin, against clinical isolates collected in a prospective, multicentre surveillance study in India during 2016-18. (Pubmed Central) - Jun 27, 2021
Levonadifloxacin displayed potent activity against contemporary MRSA and fluoroquinolone-resistant staphylococcal isolates, thus offering a valuable IV as well as an oral therapeutic option for the treatment of ABSSSIs. Furthermore, levonadifloxacin exhibited a broad-spectrum activity profile as evident from its activity against streptococci and levofloxacin-susceptible Gram-negative isolates.
- | levofloxacin / Generic mfg., meropenem / Generic mfg.
Journal: Metallo-β-lactamase resistance in Enterobacteriaceae is an artefact of currently utilized antimicrobial susceptibility testing methods. (Pubmed Central) - Jun 26, 2021
Results indicate that meropenem in vivo efficacy is best represented by the pharmacodynamic profile generated using MICs determined in zinc-depleted media for MBL-producing Enterobacteriaceae. These translational data suggest that the use of conventional CAMHB for MBL susceptibility testing is inappropriate in distinguishing meaningful in vivo resistance given that zinc concentrations are supraphysiological in conventional CAMHB and negligible at infection sites.
- | clarithromycin / Generic mfg.
Journal: Repurposing drugs for treatment of Mycobacterium abscessus: a view to a kill. (Pubmed Central) - Jun 26, 2021
The low MICs and efficacy at clinically achievable concentrations mean that tebipenem/avibactam, daunorubicin, omadacycline and bedaquiline give a view of components of a three-drug regimen likely to effectively kill Mab. We propose pharmacokinetic/pharmacodynamic studies to identify such a regimen and the doses to be combined.
- | Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie
Preclinical, Journal: In vitro activity of ceftazidime/avibactam and comparators against Gram-negative bacterial isolates collected from Latin American centres between 2015 and 2017. (Pubmed Central) - Jun 26, 2021
We propose pharmacokinetic/pharmacodynamic studies to identify such a regimen and the doses to be combined. Ceftazidime/avibactam susceptibility rates in Latin American countries are stable and high; ceftazidime/avibactam can be an appropriate treatment for patients with infections caused by Enterobacterales or P. aeruginosa and for whom treatment options may be limited.
- | Fetroja (cefiderocol) / Shionogi
Journal: Activity of cefiderocol against high-risk clones of multidrug-resistant Enterobacterales, Acinetobacter baumannii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia. (Pubmed Central) - Jun 26, 2021
Ceftazidime/avibactam susceptibility rates in Latin American countries are stable and high; ceftazidime/avibactam can be an appropriate treatment for patients with infections caused by Enterobacterales or P. aeruginosa and for whom treatment options may be limited. Cefiderocol showed excellent activity against MDR-GNB, including carbapenem-resistant isolates, and was the most active antimicrobial tested against this collection.
- || rifampicin / Generic mfg.
Clinical, Journal: Bacterial population kinetics in heteroresistant Mycobacterium tuberculosis harbouring rare resistance-conferring mutations in gyrA and rpoB imply an epistatic interaction of mutations in a pre-XDR-TB patient. (Pubmed Central) - Jun 26, 2021
Cefiderocol showed excellent activity against MDR-GNB, including carbapenem-resistant isolates, and was the most active antimicrobial tested against this collection. To the best of our knowledge, this is the first case showing the emergence of such a rare variant that dominated the population within a patient during treatment of TB.
- || PK/PD data, Journal: Results from the Survey of Antibiotic Resistance (SOAR) 2015-17 in the Middle East (Kuwait, Lebanon and Saudi Arabia): data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (Pubmed Central) - Jun 26, 2021
Isolates of H. influenzae from Saudi Arabia were susceptible to most antibiotics. These factors are important in decision making for empirical therapy of CA-RTIs.
- || PK/PD data, Journal: Results from the Survey of Antibiotic Resistance (SOAR) 2015-17 in Latin America (Argentina, Chile and Costa Rica): data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (Pubmed Central) - Jun 26, 2021
Antibiotic susceptibility of H. influenzae isolates was generally high in the Latin American countries studied; however, susceptibility profiles varied for S. pneumoniae by country and depending on the breakpoints used, especially for cefaclor. These factors are important in decision making for empirical therapy of bacterial infections.
- || PK/PD data, Journal: Results from the Survey of Antibiotic Resistance (SOAR) 2015-17 in Pakistan: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (Pubmed Central) - Jun 26, 2021
Antibiotic susceptibility in these important respiratory tract pathogens varied in Pakistan based on different breakpoints. These data are important for empirical therapy choices in the treatment of CA-RTIs.
- || PK/PD data, Journal: Results from the Survey of Antibiotic Resistance (SOAR) 2015-18 in Tunisia, Kenya and Morocco: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (Pubmed Central) - Jun 26, 2021
influenzae from Tunisia were highly susceptible to most antibiotics. These factors are important in decision making for empirical therapy of CA-RTIs.
- || PK/PD data, Journal: Results from the Survey of Antibiotic Resistance (SOAR) 2016-17 in Ukraine: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (Pubmed Central) - Jun 26, 2021
Antibiotic susceptibility in these respiratory tract pathogens was generally high in Ukraine. These data are important for empirical therapy choices in the treatment of CA-RTIs.
- || ceftriaxone / Generic mfg., ampicillin / Generic mfg., clarithromycin / Generic mfg.
PK/PD data, Journal: Results from the Survey of Antibiotic Resistance (SOAR) 2016-18 in Vietnam, Cambodia, Singapore and the Philippines: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (Pubmed Central) - Jun 26, 2021
Antibiotic susceptibility varied across countries and species, with isolates from Vietnam demonstrating the lowest susceptibility. Knowledge of resistance patterns can be helpful for clinicians when choosing empirical therapy options for CA-RTIs.
- || PK/PD data, Journal: Results from the Survey of Antibiotic Resistance (SOAR) 2015-17 in Turkey: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (Pubmed Central) - Jun 26, 2021
influenzae susceptibility was high. These data are important for empirical therapy of CA-RTIs.
- | Emrok (levonadifloxacin) / Wockhardt
Preclinical, Journal: Levonadifloxacin, a recently approved benzoquinolizine fluoroquinolone, exhibits potent in vitro activity against contemporary Staphylococcus aureus isolates and Bengal Bay clone isolates collected from a large Indian tertiary care hospital. (Pubmed Central) - Jun 26, 2021
The present study demonstrated potent activity of levonadifloxacin against contemporary S. aureus isolates, which included MRSA isolates, hVISA isolates, Bengal Bay clone isolates and a high proportion of quinolone-non-susceptible isolates. The potent activity of levonadifloxacin observed in this study supports its clinical use for the treatment of S. aureus infections.
- | Nuzyra (omadacycline) / Paratek
Preclinical, Journal: In vitro activity of omadacycline and levofloxacin against Escherichia coli, Klebsiella pneumoniae and Staphylococcus saprophyticus in human urine supplemented with calcium and magnesium. (Pubmed Central) - Jun 26, 2021
Omadacycline displayed slightly reduced activity when excess calcium was present, but, overall, the differences were ≤2-fold. These observations should be considered along with the pharmacokinetics of the agent for clinical context.
- | Baxdela (delafloxacin) / Menarini, Melinta Therap, Cubicin (daptomycin) / Merck (MSD)
Journal: Delafloxacin activity against Staphylococcus aureus with reduced susceptibility or resistance to methicillin, vancomycin, daptomycin or linezolid. (Pubmed Central) - Jun 26, 2021
These observations should be considered along with the pharmacokinetics of the agent for clinical context. Delafloxacin demonstrates superior activity to levofloxacin against recent MRSA blood isolates, VISA, VRSA and DNSSA, and demonstrates good activity against blood isolates most commonly found in the community.
- | Gracevit (sitafloxacin) / Daiichi Sankyo
Journal: Sitafloxacin has a potent activity for eradication of extended spectrum β-lactamase-producing fluoroquinolone-resistant Escherichia coli forming intracellular bacterial communities in uroepithelial cells. (Pubmed Central) - Jun 26, 2021
Delafloxacin demonstrates superior activity to levofloxacin against recent MRSA blood isolates, VISA, VRSA and DNSSA, and demonstrates good activity against blood isolates most commonly found in the community. The present study suggests that STFX is a promising optional agent for the eradication of ESBL-producing fluoroquinolone-resistant E. coli in the urinary tract before urological procedures.
- || clarithromycin / Generic mfg., amoxicillin / Generic mfg.
Clinical, Journal: High prevalence and risk factors of multiple antibiotic resistance in patients who fail first-line Helicobacter pylori therapy in southern China: a municipality-wide, multicentre, prospective cohort study. (Pubmed Central) - Jun 26, 2021
The rates of secondary resistance of H. pylori to multiple antibiotics were high in southern China. Certain population-level risk factors were associated with levofloxacin + metronidazole resistance.
- | levofloxacin / Generic mfg., tigecycline / Generic mfg., minocycline / Generic mfg.
Journal: Cigarette smoke extract induces the Pseudomonas aeruginosa nfxC drug-resistant phenotype. (Pubmed Central) - Jun 26, 2021
Overall, our results showed that CSE may induce antibiotic resistance in P. aeruginosa. The results of antimicrobial susceptibility tests, transcriptome sequencing and qRT-PCR showed that CSE induced P. aeruginosa to the nfxC drug-resistant phenotype.
- || ampicillin / Generic mfg.
Clinical, Journal: Bacteriological analysis of Neisseria lactamica isolated from the respiratory tract in Japanese children. (Pubmed Central) - Jun 26, 2021
N. lactamica STs may vary in Japanese children, and penicillin- and quinolone-resistant strains may be prevalent. We should pay attention not only to the drug resistance of N. meningitidis but also to the drug susceptibility of N. lactamica whose drug-resistance genes may transfer to N. meningitidis.
- | clarithromycin / Generic mfg.
Retrospective data, Journal: Meta-analysis of fluoroquinolones versus macrolides for treatment of legionella pneumonia. (Pubmed Central) - Jun 26, 2021
FQs exhibited superior effects in terms of mortality and length of hospital stay in Legionella pneumonia. These results support current guidelines recommending FQs for the treatment of Legionella pneumonia.
- | levofloxacin / Generic mfg.
Journal: Removal of levofloxacin through adsorption and peroxymonosulfate activation using carbothermal reduction synthesized nZVI/carbon fiber. (Pubmed Central) - Jun 25, 2021
The nZVI/CF-900-0.3 exhibited excellent long-term stability given that it was able to activate PMS after it was stored for 6 months. ·SO played an important role in LEV degradation in the presence of PMS.
- | ampicillin / Generic mfg., cefuroxime / Generic mfg.
Clinical, Journal: Distribution and antibiotic resistance profile of key gram-negative bacteria that cause community-onset urinary tract infections in the Russian Federation: RESOURCE multicentre surveillance 2017 study. (Pubmed Central) - Jun 24, 2021
·SO played an important role in LEV degradation in the presence of PMS. The prevalence of fluoroquinolone and cephalosporin resistance among common UTI-causing gram-negative bacteria highlights the growing challenge of successfully treating community-onsetUTIs.
- | minocycline / Generic mfg.
Journal: The impact of serum protein binding on bacterial killing of minocycline. (Pubmed Central) - Jun 24, 2021
If validated, these results implied dose escalation might not the best approach to improve the clinical efficacy of minocycline for bacteremia. Future investigations will focus on the specificity and mechanism(s) of minocycline protein binding.
- | levofloxacin / Generic mfg., amikacin sulfate / Generic mfg.
Preclinical, Journal: In vitro bactericidal activity of 3-Cinnamoyl-4-hydroxy-6-methyl-2-pyrone (CHP) against drug-susceptible, resistant and tolerant isolates of Mycobacterium tuberculosis. (Pubmed Central) - Jun 24, 2021
Future investigations will focus on the specificity and mechanism(s) of minocycline protein binding. Our results show strong bactericidal potential of CHP against M.tuberculosis that warrant its immediate mechanistic, pharmacokinetic and pharmacodynamic studies.
- | levofloxacin / Generic mfg.
Journal: Mutation rate and efflux response of bacteria exposed to a novel antimicrobial iodo-thiocyanate complex. (Pubmed Central) - Jun 24, 2021
Our results show strong bactericidal potential of CHP against M.tuberculosis that warrant its immediate mechanistic, pharmacokinetic and pharmacodynamic studies. ITC usage most likely will not promote resistance development via increased mutation rates, and that efflux-mediated resistance emergence to it is less likely than for some other antimicrobials.
- | levofloxacin / Generic mfg.
Journal: Levaquin gets a pass. (Pubmed Central) - Jun 24, 2021
We evaluated the effect of levofloxacin (LEVO), the most commonly used prophylactic antibacterial antibiotic during intensive chemotherapy and allogeneic hematopoietic cell transplantation (allo-HCT), on the gut microbiota in 2 cohorts of patients, 1 cohort comprising 20 patients with acute leukemia receiving intensive chemotherapy and the other cohort comprising 20 allo-HCT recipients...Other taxa and microbiota diversity were unaffected. Overall, the effect of LEVO on the gut microbiota in these cohorts was mild.
- | levofloxacin / Generic mfg.
Journal: Fluoroquinolone Prophylaxis in Autologous Stem Cell Transplantation: Worthy of a Second Look. (Pubmed Central) - Jun 24, 2021
In accordance with institutional policy, patients undergoing ASCT for multiple myeloma routinely receive levofloxacin prophylaxis during their period of neutropenia, whereas patients undergoing the ASCT for lymphoma do not...Fluoroquinolone prophylaxis reduces the rate BSI in patients undergoing ASCT but increase the incidence of resistant organisms. We recommend routine antimicrobial prophylaxis in patients undergoing ASCT to reduce the risk of BSI with systematic and regular review of outcomes.
- || rifampicin / Generic mfg.
Clinical, Journal: Draft genome sequence of carbapenem-resistant Elizabethkingia anophelis strain BP8467 clinical isolate from India. (Pubmed Central) - Jun 24, 2021
This genome analysis provides insights on the antibiotic resistance and pathogenicity mechanisms of multidrug-resistant E. anophelis that can helps in the management of Elizabethkingia sp. infections in the future.
- | trimethoprim/sulfamethoxazole / Generic mfg., tetracycline / Generic mfg.
Preclinical, Journal: Comparative genomics and antimicrobial resistance profiling of Elizabethkingia isolates reveals nosocomial transmission and in vitro susceptibility to fluoroquinolones, tetracyclines and trimethoprim-sulfamethoxazole. (Pubmed Central) - Jun 24, 2021
Like other international strains, our isolates expressed susceptibility to minocycline and levofloxacin and the less common trimethoprim/sulfamethoxazole. Our study demonstrates important new insights into the genetic diversity, environmental persistence, transmission of and potential effective therapy for Australian Elizabethkingia species.
- || levofloxacin / Generic mfg., clarithromycin / Generic mfg.
Clinical, Journal: High rates of clarithromycin and levofloxacin resistance of Helicobacter pylori in patients with chronic gastritis in the South East area of Vietnam. (Pubmed Central) - Jun 24, 2021
These results revealed high rates of resistance of H. pylori to CLR and LVX in patients with chronic gastritis in the South East area of Vietnam. This suggests that CLR-based triple therapy should not be used for the eradication treatment of H. pylori, and LVX susceptibility testing of H. pylori strains should be performed before choosing alternative regimens.
- || ceftriaxone / Generic mfg.
Clinical, Journal: Which Nursing Home Residents With Pneumonia Are Managed On-Site and Which Are Hospitalized? Results from 2 Years' Surveillance in 14 US Homes. (Pubmed Central) - Jun 24, 2021
Respiratory rate is associated with hospitalization but was not documented for more than a quarter of residents, suggesting the clinical benefit of more consistently conducting this assessment. Differential hospitalization rates for persons with dementia and on hospice suggest that care is being tailored to individuals' wishes, but this assumption merits study, as does use of fluoroquinolones (due to side effects) and treatment duration (due to potential contribution to antibiotic resistance).
- || levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., minocycline / Generic mfg.
Clinical, Journal: Characteristic antimicrobial resistance of clinical isolated strain Stenotrophomonas maltophilia CYZ via complete genome sequence. (Pubmed Central) - Jun 24, 2021
Differential hospitalization rates for persons with dementia and on hospice suggest that care is being tailored to individuals' wishes, but this assumption merits study, as does use of fluoroquinolones (due to side effects) and treatment duration (due to potential contribution to antibiotic resistance). The current results give us a better understanding of the genetic characteristics of the antimicrobial resistance of S. maltophilia CYZ, and provide well genetic basis for further studying on the phenotype.
- || Baxdela (delafloxacin) / Menarini, Melinta Therap
Clinical, Journal: Update on the activity of delafloxacin on acute bacterial skin and skin structure infection isolates from European hospitals (2014-2019). (Pubmed Central) - Jun 24, 2021
Delafloxacin had broad-spectrum activity and improved potency against Gram-positive pathogens compared to levofloxacin and moxifloxacin. These data suggest that delafloxacin may be a useful therapeutic choice for the most common causes of ABSSSI.
- | levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., meropenem / Generic mfg.
Journal: Resistance among urinary tract pathogens collected in Europe during 2018. (Pubmed Central) - Jun 24, 2021
In contrast, intravenous carbapenems retain activity against resistant UTI pathogens. New oral options with the spectrum of the carbapenems would address an unmet need for managing resistant UTIs.
- | levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Preclinical, Journal: A mouse model of rapidly progressive fatal hemorrhagic pneumonia caused by Stenotrophomonas maltophilia. (Pubmed Central) - Jun 24, 2021
We established a mouse model of rapidly progressive fatal hemorrhagic pneumonia caused by Stenotrophomonas maltophilia which is useful for determining the therapeutic effect of various agents. We believe that this model will prove useful to further elucidate the mechanisms underlying hemorrhagic pneumonia, as well as in the design and development of novel therapeutic modalities and targets.
- | amoxicillin / Generic mfg.
Journal: Antibiotic Therapy and the Gut Microbiome: Investigating the Effect of Delivery Route on Gut Pathogens. (Pubmed Central) - Jun 24, 2021
The degree of dysbiosis was significantly reduced toward the end of the sampling period, as bacterial populations began to return to pretreatment composition. Richness and diversity levels appeared to return to pretreatment levels more quickly in intravenous groups, suggesting convenient parenteral delivery systems may have a role to play in reducing longer term gut dysbiosis in the treatment of infection.
- | cefotaxime / Generic mfg.
Journal: Predominance and clonal spread of CTX-M-15 in cefotaxime-resistant Klebsiella pneumoniae in Korea and their association with plasmid-mediated quinolone resistance determinants. (Pubmed Central) - Jun 23, 2021
Richness and diversity levels appeared to return to pretreatment levels more quickly in intravenous groups, suggesting convenient parenteral delivery systems may have a role to play in reducing longer term gut dysbiosis in the treatment of infection. CTX-M-15 was predominant among the cefotaxime-resistant K. pneumoniae and co-harboring CTX-M-15 and PMQR genes, especially qnrB, seems to contribute the spread of high risk clones.
- || cefazolin / Generic mfg., piperacillin sodium/tazobactam sodium / Generic mfg., levofloxacin / Generic mfg.
Clinical, Journal: Nationwide surveillance of bacterial pathogens isolated from patients with acute uncomplicated cystitis in 2018: Conducted by the Japanese Research Group for Urinary Tract Infections (JRGU). (Pubmed Central) - Jun 23, 2021
Such surveillance, consisting of the collecting only clinical data, could be conducted easily and inexpensively. It is expected to be continuously performed as an alternative survey to conventional one collecting bacterial strains.
- | levofloxacin / Generic mfg.
Journal: Drug Release from Thermo-Responsive Polymer Brush Coatings to Control Bacterial Colonization and Biofilm Growth on Titanium Implants. (Pubmed Central) - Jun 23, 2021
In particular, thermo-responsive poly(di(ethylene glycol) methyl ether methacrylate) (PDEGMA) brushes on titanium implants synthesized via a surface-initiated atom transfer radical polymerization with activators regenerated through the electron transfer technique (ARGET ATRP) allows for a controlled and thermally triggered release of the antibiotic levofloxacin at the wound site...At temperatures of the infection site >37 °C the lower critical solution temperature behavior of the brushes afforded the triggered release. Hence, in addition to the known antifouling effects, the PDEGMA coating ensured enhanced bactericidal effects, as demonstrated in initial in vivo tests with rodents infected with Staphylococcus aureus.
- | OPC-167832 / Otsuka
Journal: OPC-167832, a novel carbostyril derivative with potent anti-tuberculosis activity as a DprE1 inhibitor. (Pubmed Central) - Jun 22, 2021
Finally, 3-4 drug regimens comprised of delamanid and OPC-167832 as the core along with bedaquiline, moxifloxacin, or linezolid showed superior efficacy in reducing bacterial burden and preventing relapse compared to the standard treatment regimen. In summary, these results suggest that OPC-167832 is a novel and potent anti-TB agent and regimens containing OPC-167832 and new or repurposed anti-TB drugs may have the potential to shorten the duration of treatment for TB.