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137 Trials |
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137 Trials |  |
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- | rifampicin / Generic mfg.
Journal: Legionella antimicrobial sensitivity testing: comparison of microbroth dilution with BCYE and LASARUS solid media. (Pubmed Central) - Jul 10, 2021
Traditional BCYE gave significantly elevated MIC results and its use should be discontinued for Legionella spp., while MIC determination using LASARUS solid medium gave results concordant (within one serial dilution) with BMD for all antimicrobials tested. To the best of our knowledge, this study is the first to identify the lpeAB gene in UK isolates.
- || clarithromycin / Generic mfg., rifampicin / Generic mfg., amoxicillin / Generic mfg.
Clinical, Journal: Helicobacter pylori antimicrobial resistance and gene variants in high and low gastric cancer risk populations. (Pubmed Central) - Jul 10, 2021
Our results indicate H. pylori from Colombians exhibit multi-drug antibiotic resistance. Continued surveillance of H. pylori antibiotic resistance in Colombia is warranted in order to establish appropriate eradication treatment regimens for this population.
- | Lamprene (clofazimine) / Novartis
Review, Journal: An overview of new antitubercular drugs, drug candidates, and their targets. (Pubmed Central) - Jul 9, 2021
The last 10 years have made sudden progress giving some new and highly promising drugs including bedaquiline, delamanid, and pretomanid...These targets are either involved in cell wall biosynthesis, protein synthesis, DNA/RNA synthesis, or metabolism. This review discusses recent progress in the discovery of newly developed and Food and Drug Administration approved drugs as well as repurposed drugs, their targets, mode of action, drug-target interactions, and their structure-activity relationship.
- || ampicillin / Generic mfg.
Clinical, Journal: Probiotic and Safety Properties Screening of Enterococcus faecalis from Healthy Chinese Infants. (Pubmed Central) - Jul 9, 2021
The virulence test of G. mellonella showed that, except for strains 106-1 and 113-1, the other strains had toxicity lower than 10%. Strain A3-1 may have the greatest potential to be developed as a probiotic.
- | Cubicin (daptomycin) / Merck (MSD), Timcynis (ticarcillin and clavulanic acid) / Emcure Pharma
Journal: Drug-induced tolerance: the effects of antibiotic pre-exposure in Stenotrophomonas maltophilia. (Pubmed Central) - Jul 9, 2021
In time-kill activity of levofloxacin, D25 presented a subpopulation of persisters with survival rate higher (1.6-fold) than the parental. Previous exposure of S. maltophilia to daptomycin can induce cross-tolerance to ceftazidime and ticarcillin-clavulanate and cross-persistence to levofloxacin.
- | clarithromycin / Generic mfg., tetracycline / Generic mfg., amoxicillin / Generic mfg.
Journal: Optimizing the MIC breakpoints of amoxicillin and tetracycline for antibiotic selection in the rescue therapy of H. pylori with bismuth quadruple regimen. (Pubmed Central) - Jul 9, 2021
Optimizing the MIC breakpoints of amoxicillin and tetracycline resistance better predicts the outcome of bismuth quadruple therapy. Further prospective studies using the revised MIC breakpoints to select antibiotics are warranted.
- | levofloxacin / Generic mfg., rosuvastatin / Generic mfg.
Preclinical, Journal: Potent Synergistic Combination of Rosuvastatin and Levofloxacin against Staphylococcus aureus; In Vitro and In Vivo Study. (Pubmed Central) - Jul 9, 2021
Further prospective studies using the revised MIC breakpoints to select antibiotics are warranted. This study unveils the potential effect of rosuvastatin when used in combination with levofloxacin can be used as a topical antibacterial agent to treat S. aureus skin infections.
- | levofloxacin / Generic mfg.
Journal: Fucosylated lipid nanocarriers loaded with antibiotics efficiently inhibit mycobacterial propagation in human myeloid cells. (Pubmed Central) - Jul 9, 2021
In an in vitro setting using infected human primary macrophages as well as dendritic cells, the encapsulated antibiotic cleared the pathogen more efficiently than free levofloxacin. In conclusion, our results point towards carbohydrate-functionalized nanocarriers as a promising tool for improving TB treatment by targeted delivery of antibiotics.
- | levofloxacin / Generic mfg.
Trial completion date, Trial primary completion date, Surgery: Levofloxacin Ocular Implant for Ocular Surgery (clinicaltrials.gov) - Jul 8, 2021
P1, N=5, Recruiting, Sponsor: PolyActiva Pty Ltd
In conclusion, our results point towards carbohydrate-functionalized nanocarriers as a promising tool for improving TB treatment by targeted delivery of antibiotics. Trial completion date: Jun 2021 --> Dec 2021 | Trial primary completion date: Apr 2021 --> Sep 2021
- | levofloxacin / Generic mfg.
Preclinical, Journal: Ameliorative effects of Moringa oleifera leaf extract on levofloxacin-induced hepatic toxicity in rats. (Pubmed Central) - Jul 8, 2021
Additionally, its presence attenuated the downregulation of IL-1 induced by Levofloxacin alone from hepatic tissue. It can be concluded that M. oleifera extract can help reduce the side effects caused by Levofloxacin administration.
- | levofloxacin / Generic mfg.
Journal: Phenotypic and molecular characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis isolates in Ningbo, China. (Pubmed Central) - Jul 8, 2021
It can be concluded that M. oleifera extract can help reduce the side effects caused by Levofloxacin administration. The mutations within pncA gene was the primary mechanism of PZA resistance among MDR-TB and DNA sequencing of pncA gene could provide a rapid detection evidence in PZA drug resistance of MDR-TB in Ningbo.
- || Clinical, Journal: Identification and Ranking of Clinical Compounds with Activity against Log-phase Growing Uropathogenic Escherichia coli. (Pubmed Central) - Jul 7, 2021
The mutations within pncA gene was the primary mechanism of PZA resistance among MDR-TB and DNA sequencing of pncA gene could provide a rapid detection evidence in PZA drug resistance of MDR-TB in Ningbo. Our findings provide possible effective drug candidates for more effective treatment of antibiotic-resistant UTIs.
- || rifampicin / Generic mfg.
Clinical, Journal: Efficacy of a Novel Ophthalmic Antimicrobial Drug Combination Toward a Large Panel of Staphylococcus aureus Clinical Ocular Isolates From Around the World. (Pubmed Central) - Jul 7, 2021
We established that antibiotic resistance is pervasive among clinical S. aureus isolates, underscoring the concern for the effectiveness of current ophthalmic antibiotics. The drug combination of PT + rifampin, however, eradicated 100% of isolates tested, demonstrating the ability to overcome existing circulating resistance factors, and as such, might represent a promising therapeutic for S. aureus keratitis.
- || colistin sulphate / Generic mfg.
Retrospective data, Review, Journal, Combination therapy: Comparative efficacy and safety of combination therapy with high-dose sulbactam or colistin with additional antibacterial agents for multiple drug-resistant and extensively drug-resistant Acinetobacter baumannii infections: a systematic review and network meta-analysis. (Pubmed Central) - Jul 7, 2021
The drug combination of PT + rifampin, however, eradicated 100% of isolates tested, demonstrating the ability to overcome existing circulating resistance factors, and as such, might represent a promising therapeutic for S. aureus keratitis. Therapeutic regimens including high-dose sulbactam in combination with levofloxacin, minocycline, or tigecycline for MDR-AB or XDR-AB infections were superior to all others examined.
- || aztreonam-avibactam (PF-06947387) / Pfizer, AbbVie
Clinical, Journal: Aztreonam/avibactam activity against clinical isolates of Enterobacterales collected in Europe, Asia and Latin America in 2019. (Pubmed Central) - Jul 7, 2021
Therapeutic regimens including high-dose sulbactam in combination with levofloxacin, minocycline, or tigecycline for MDR-AB or XDR-AB infections were superior to all others examined. Our results support clinical development of aztreonam/avibactam to treat infections caused by Enterobacterales, including MBL-producers.
- || Lamprene (clofazimine) / Novartis
Clinical, Observational data, Journal: Fluroquinolone drug resistance among MDR-TB patients increases the risk of unfavorable interim microbiological treatment outcome: An observational study. (Pubmed Central) - Jul 7, 2021
Our results support clinical development of aztreonam/avibactam to treat infections caused by Enterobacterales, including MBL-producers. The rate of FQ-resistance among RR/MDR-TB is high and it has strong association with un-successful interim microbiological outcome of conventional MDR-TB treatment.
- || ceftriaxone / Generic mfg., rifampicin / Generic mfg., cefuroxime / Generic mfg.
Clinical, Journal: Properties of Mucoid Serotype 3 Streptococcus pneumoniae From Children in China. (Pubmed Central) - Jul 7, 2021
All isolates were susceptible to penicillin, cefuroxime, ceftriaxone, meropenem, vancomycin, levofloxacin, trimethoprim/sulfamethoxazole, and rifampin but resistant to erythromycin...Antimicrobial susceptibility of ST180 and ST505 were compared, and the minimum inhibitory concentration (MIC) of ST505 isolates was significantly higher than that of ST180 for tetracycline, trimethoprim/sulfamethoxazole, and meropenem...It can cause noninvasive infection in children, and it has high susceptibility to a variety of antibiotics, especially β-lactams, but is resistant to macrolides. CC505 is the novel clonal complex found in China, which may be related to the worldwide mainstream clonal complex (CC180) but has its own biological characteristics.
- || Zeven (dalbavancin) / RaQualia, AbbVie
Clinical, Journal: Antimicrobial Activity of Dalbavancin and Comparators against Staphylococcus aureus Causing Pneumonia in Patients with and without Cystic Fibrosis. (Pubmed Central) - Jul 7, 2021
Among MRSA isolates from CF/non-CF patients (n = 99/208), susceptibility to ceftaroline, clindamycin, levofloxacin, and tetracycline were 91.9%/93.3%, 58.6%/64.4%, 40.4%/29.3%, 83.8%/89.4%, respectively. Dalbavancin demonstrated high potency against S. aureus from CF and non-CF patients and may represent a valuable treatment option for CF patients with MRSA pulmonary infection.
- | Retrospective data, Journal: Recovery of antimicrobial susceptibility in methicillin-resistant Staphylococcus aureus (MRSA): a retrospective, epidemiological analysis in a secondary care hospital, Sapporo, Japan. (Pubmed Central) - Jul 6, 2021
A recovery of MRSA antimicrobial susceptibility was observed in our antibiogram dataset. Our study supports the potential for appropriate antimicrobial agent use in reviving MRSA antimicrobial susceptibility.
- || Clinical, Journal: Antibiotic Selection for Suspected Neisseria gonorrhoeae Infection Among Penicillin-Allergic Patients in the Emergency Department. (Pubmed Central) - Jul 6, 2021
Those with penicillin allergies are significantly less likely to receive a cephalosporin antibiotic, though these remain the only universally accepted treatment for gonorrheal infections. These findings highlight the significant need for further physician and public education on allergies and antibiotic selection.
- | prednisone / Generic mfg., levofloxacin / Generic mfg., rifampicin/isoniazid/ethambutol/pyrazinamide / Generic mfg.
New P3 trial: NEW-STRAT TB: Testing New Strategies for Patients Hospitalised With HIV-associated Disseminated Tuberculosis (clinicaltrials.gov) - Jul 6, 2021
P3, N=732, Not yet recruiting, Sponsor: University of Cape Town
- || levofloxacin / Generic mfg.
What are you not treating with levofloxacin? (Twitter) - Jul 4, 2021
- || levofloxacin / Generic mfg.
#IDtwitter even better question, if it is Legionnaire's disease and is failing treatment with levofloxacin, what would you do? (Add or switch) @ArjetGega @alxpenguin @ClancyNeil @DMAronoff @DocWoc71 @davidvanduin @JonathanRyderMD @FungalDoc @GermHunterMD @id_cure (Twitter) - Jul 4, 2021
- || Xtoro (finafloxacin) / Horizon Therapeutics
PK/PD data, Journal: Influence of pH on the activity of finafloxacin against extracellular and intracellular Burkholderia thailandensis, Yersinia pseudotuberculosis, and Francisella philomiragia and on its cellular pharmacokinetics in THP-1 monocytes. (Pubmed Central) - Jul 4, 2021
These findings highlight the significant need for further physician and public education on allergies and antibiotic selection. Fluoroquinolones have proven to be effective in reducing the intracellular reservoirs of B. thailandensis, Y. pseudotuberculosis and F. philomiragia, with finafloxacin demonstrating an additional advantage in acidic environments.
- | levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Preclinical, Journal: In Vitro Activity of a Novel Quinolone, UB-8902, Against Ofloxacin-Resistant Mycobacterium tuberculosis Isolates. (Pubmed Central) - Jul 4, 2021
Moreover, it showed better activity than OFX and LFX and was equivalent to MOX against FQ-susceptible clinical isolates. UB-8902 can be considered as a drug with potential antituberculous activity, similar to MOX.
- | clarithromycin / Generic mfg., doxycycline / Generic mfg., tetracycline / Generic mfg.
Journal: Bismuth quadruple regimen with tetracycline or doxycycline versus three-in-one single capsule as third-line rescue therapy for Helicobacter pylori infection: Spanish data of the European Helicobacter pylori Registry (Hp-EuReg). (Pubmed Central) - Jul 4, 2021
Highest efficacy was found in compliant patients and those taking 10-day BQT-three-in-one or 14-day BQT-Tet. Doxycycline seems to be less effective and therefore should not be recommended.
- || clarithromycin / Generic mfg., amoxicillin / Generic mfg.
Retrospective data, Review, Journal: The increasing antimicrobial resistance of Helicobacter pylori in Iran: A systematic review and meta-analysis. (Pubmed Central) - Jul 4, 2021
In children, the resistance to furazolidone and a combination of clarithromycin and metronidazole is higher compared to adults. As a stable, high resistance to metronidazole was found in children and adults in all Iranian provinces, we suggest that metronidazole should not be included in the Iranian H pylori eradication scheme.
- || levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Clinical, Journal: Suboptimal moxifloxacin and levofloxacin drug exposure during treatment of patients with multidrug-resistant tuberculosis: results from a prospective study in China. (Pubmed Central) - Jul 4, 2021
As a stable, high resistance to metronidazole was found in children and adults in all Iranian provinces, we suggest that metronidazole should not be included in the Iranian H pylori eradication scheme. No abstract available
- | Journal: Prevalence, Antibiogram and Genetic Characterization of Listeria monocytogenes from Food Products in Egypt. (Pubmed Central) - Jul 4, 2021
While, high resistance was observed against oxytetracycline (76.4%), trimethoprim-sulfamethoxazole (76.4%), chloramphenicol (70.5%), doxycycline (64.6%), levofloxacin (41.2%) and azithromycin (41.2%)...The partial 16S rRNA gene sequencing of three L. monocytogenes isolates showed a high nucleotide similarity (99.1-99.8%) between the study isolates and various global clones, and phylogenetic analysis clustered these L. monocytogenes strains with other Listeria species including L. welshimeri, L. seeligeri and L. innocua. This study demonstrates the impact of L. monocytogenes as a major contaminant of various food products and suggests more attention to the awareness and hygienic measures in the food industry.
- | levofloxacin / Generic mfg.
Journal: Effect of the Combination of Levofloxacin with Cationic Carbosilane Dendron and Peptide in the Prevention and Treatment of Staphylococcus aureus Biofilms. (Pubmed Central) - Jul 3, 2021
The results showed the synergistic effect of the combination therapy to treat Staphylococcus aureus biofilms. In addition, we generated a fluorescein labeled peptide that allowed us to observe the conjugate (dendron-peptide) localization throughout the bacterial biofilm by confocal laser scanning microscopy.
- | levofloxacin / Generic mfg.
Journal: Sustainable management of cut flowers waste by activation and its application in wastewater treatment technology. (Pubmed Central) - Jul 3, 2021
The adsorption of levofloxacin and lead ions on all the adsorbents followed Langmuir isotherms and pseudo-second-order kinetic model. The results have been further explained via the prediction of interaction energies between the adsorbates and adsorbents using COSMO-RS simulation.
- | rifampicin / Generic mfg.
Journal: Saliva-based linezolid monitoring on a mobile UV spectrophotometer. (Pubmed Central) - Jul 3, 2021
We validated a UV spectrophotometric assay using non-invasive saliva sampling for linezolid. The next step is to demonstrate clinical feasibility and value to facilitate programmatic implementation of TDM.
- levofloxacin / Generic mfg.
[VIRTUAL] EVALUATION OF ANTIBIOTICOPROPHYLAXIS IN PROSTATIC BIOPSY AT HOSPITAL GERAL DE FORTALEZA () - Jul 2, 2021 - Abstract #ICUC2021ICUC_288;
Urine culture performance before prostate biopsy appears to be an important factor for our reduced rate of infectious complications after transrectal prostate biopsy. A continuation of the project, with an increase in the sample of patients, is necessary for a more detailed comparative evaluation between these antibiotics.
- | levofloxacin / Generic mfg.
Journal: Sustained release of levofloxacin from thermosensitive chitosan-based hydrogel for the treatment of postoperative endophthalmitis. (Pubmed Central) - Jul 2, 2021
© 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B, 2019
- | levofloxacin / Generic mfg.
Journal: Semi-Interpenetrated Hydrogels-Microfibers Electroactive Assemblies for Release and Real-Time Monitoring of Drugs. (Pubmed Central) - Jul 2, 2021
After demonstrating its properties, the platform is loaded with levofloxacin and its release monitored externally by UV-vis spectroscopy and in situ by using the PHMeDOT network. In situ real-time electrochemical monitoring of the drug release from the engineered platform holds great promise for the development of multi-functional devices for advanced biomedical applications.
- | levofloxacin / Generic mfg.
Journal: Antimicrobial therapeutic enhancement of levofloxacin via conjugation to a cell-penetrating peptide: An efficient sonochemical catalytic process. (Pubmed Central) - Jul 2, 2021
Through this synergistic effect, peptide/amide bond is formed during a short time (10 min), and high reaction yield (>90%) is obtained under mild conditions. Moreover, as a simple purification process, the catalyst nanoparticles are collected and separated through their high magnetic property.
- | levofloxacin / Generic mfg.
Journal: A mobile microvolume UV/visible light spectrophotometer for the measurement of levofloxacin in saliva. (Pubmed Central) - Jul 2, 2021
A simple UV/VIS spectrophotometric method to quantify levofloxacin in saliva using a mobile nanophotometer has been validated. This method can be evaluated in programmatic settings to identify patients with low levofloxacin drug exposure to trigger personalized dose adjustment.
- || levofloxacin / Generic mfg., colistin sulphate / Generic mfg.
Clinical, Journal: Clinical and molecular characterization of Acinetobacter seifertii in Taiwan. (Pubmed Central) - Jul 2, 2021
A. seifertii can transfer carbapenem-resistance determinants to other species of the A. baumannii group and warrants close monitoring.
- || Primaxin (cilastatin/imipenem) / Abbott
Clinical, Journal: Impact of an antimicrobial stewardship programme on reducing broad-spectrum antibiotic use and its effect on carbapenem-resistant Acinetobacter baumannii (CRAb) in hospitals in Jordan. (Pubmed Central) - Jul 2, 2021
seifertii can transfer carbapenem-resistance determinants to other species of the A. baumannii group and warrants close monitoring. The introduced antimicrobial stewardship interventions contributed to a reduction in the use of several broad-spectrum antibiotics, reversed the trends of increasing use of other antibiotics and were associated with a significant reduction in CRAb.
- ||| levofloxacin / Generic mfg.
Clinical, Journal, Adverse events, Real-world evidence: Adverse Event Profile During the Treatment of Helicobacter pylori: A Real-World Experience of 22,000 Patients From the European Registry on H. pylori Management (Hp-EuReg). (Pubmed Central) - Jul 2, 2021
Helicobacter pylori eradication treatment frequently induces AEs, although they are usually mild and of limited duration. Their appearance does not interfere significantly with treatment compliance.
- || Sivextro (tedizolid) / Merck (MSD)
Clinical, Journal: Tedizolid Activity against a Multi-center Worldwide Collection of Staphylococcus aureus and Streptococcus pneumoniae Recovered from Patients with Pneumonia (2017-2019). (Pubmed Central) - Jul 2, 2021
The in-vitro data presented here confirm the high potency of tedizolid against S. aureus and S. pneumoniae causing pneumonia worldwide. There is a need for further clinical evaluations of tedizolid for treating pneumonia caused by these pathogens.
- || levofloxacin / Generic mfg.
Review, Journal: Levofloxacin in veterinary medicine: a literature review. (Pubmed Central) - Jul 2, 2021
Since its introduction to clinical practice, many studies have been published on levofloxacin in animal species, including pharmacokinetic studies, tissue drug depletion, efficacy, and animal microbial isolate susceptibility to levofloxacin. This literature overview highlights the most clinically relevant and scientifically important levofloxacin studies linked to the field of veterinary medicine.
- | Retrospective data, Journal: Antimicrobial susceptibility pattern of Burkholderia cepacia complex & Stenotrophomonas maltophilia from North India: Trend over a decade (2007-2016). (Pubmed Central) - Jul 2, 2021
While Bcc showed increased resistance to ceftazidime, meropenem and minocycline, S. maltophilia maintained >80 per cent susceptibility to minocycline, levofloxacin and co-trimoxazole throughout the decade. By 2016, Bcc was most susceptible to co-trimoxazole, whereas S. maltophilia was most susceptible to minocycline and levofloxacin.
- | amoxicillin / Generic mfg.
Journal: Comparison of the bactericidal effects of quinolones against low-susceptible Haemophilus influenzae. (Pubmed Central) - Jul 2, 2021
In addition, higher concentrations of tosufloxacin at 2×C and 4×C had bactericidal effects on not only susceptible but also low-susceptible strains. These data strongly suggest that we should consider the presence of low-susceptible strains and reconsider the appropriate dosage of tosufloxacin for treatment, especially for paediatric patients.
- || Clinical, Journal: Forgotten disease: an atypical case of Lemierre syndrome presenting as a soft tissue abscess. (Pubmed Central) - Jul 1, 2021
A 29-year-old woman with sore throat, dyspnoea and left shoulder pain, who was on levofloxacin for 3 days, presented with worsening symptoms...She was started on clindamycin and ampicillin sulbactam for LS...Drainage of the left shoulder abscess grew Fusobacterium nucleatum After 2 weeks of a complicated intensive care unit stay, her haemodynamic status improved and she was transferred to the floor. LS has variable presentations, but regardless of the presentation, it is a potentially fatal disease-requiring prompt diagnosis and management.
- | Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
Journal: Fecal Microbiota Functional Gene Effects Related to Single-Dose Antibiotic Treatment of Travelers' Diarrhea. (Pubmed Central) - Jul 1, 2021
P=N/A
These results indicate that single-dose antibiotic regimens may not drastically alter the functional or antibiotic resistance composition of fecal microflora, which should inform clinical practice guidelines and antimicrobial stewardship. NCT01618591.
- | voriconazole / Generic mfg.
Journal: Simultaneous quantification of plasma levels of 12 antimicrobial agents including carbapenem, anti-methicillin-resistant Staphylococcus aureus agent, quinolone and azole used in intensive care unit using UHPLC-MS/MS method. (Pubmed Central) - Jul 1, 2021
We have developed an assay for simultaneous quantification of 12 antimicrobial agents using a small sample volume of 50 μL with a short assay time of 7 min. Our novel method may contribute to simultaneous calculation of pharmacokinetic and pharmacodynamic parameters.
- || ceftriaxone / Generic mfg., ampicillin / Generic mfg., cefuroxime / Generic mfg.
Clinical, Journal: Antimicrobial defined daily dose in neonatal population. (Pubmed Central) - Jun 30, 2021
A useful method for antimicrobial DDD measurement in neonatology has been designed to monitor antimicrobial consumption in hospital settings. It should be validated in further studies and thereby included in the design for neonatal antimicrobial stewardship programs in the future.
- || ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Clinical, Journal: Evaluation of pharmacist-led strategy to reduce outpatient fluoroquinolone prescribing from the emergency department. (Pubmed Central) - Jun 30, 2021
It should be validated in further studies and thereby included in the design for neonatal antimicrobial stewardship programs in the future. The results of this study reveal that pharmacist-led interventions, focused on multimodal provider education, were effective at reducing ED discharge prescriptions for fluoroquinolones.
- || clarithromycin / Generic mfg., tetracycline / Generic mfg., amoxicillin / Generic mfg.
Clinical, Journal: Amoxicillin or tetracycline in bismuth-containing quadruple therapy as first-line treatment for Helicobacter pylori infection. (Pubmed Central) - Jun 30, 2021
Adverse events were not significantly different between the two therapies. Modified quadruple therapy comprising rabeprazole, amoxicillin, metronidazole, and bismuth is an effective first-line treatment for the H. pylori infection in regions with high clarithromycin and metronidazole resistance.