levofloxacin News - LARVOL Sigma

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|||||||||| levofloxacin / Generic mfg.
Journal: Consumption of quinolones in the community, European Union/European Economic Area, 1997-2017. (Pubmed Central) - Aug 13, 2021
Quinolone consumption in the community is no longer increasing in the EU/EEA, but its seasonal variation continues to increase significantly as is the proportion of quinolones to treat respiratory infections.

|||||||||| levofloxacin / Generic mfg.
Journal: Superoxide dismutase 3 as an inflammatory suppressor in A549 cells infected with Mycoplasma pneumoniae. (Pubmed Central) - Aug 12, 2021
Levofloxacin (LVFX) was used as an anti-inflammatory drug while recombinant TNF-α was used as an inflammatory promotor in MP-infected cells...Inspiringly, SOD3 overexpression induced anti-inflammatory effect and the inactivation of NF-κB was similar to that of 2 lg/ml of LVFX, but reversed by additional TNF-α treatment. Therefore, we can conclude that transcriptional activity of NF-jB was the underlying mechanism, by which SOD3 regulated inflammatory response in MP infection in vitro.

|||||||||| levofloxacin / Generic mfg.
PK/PD data, Journal: Quantification of persister formation of Escherichia coli leveraging electronic cell counting and semi-mechanistic pharmacokinetic/pharmacodynamic modelling. (Pubmed Central) - Aug 12, 2021
The developed pharmacokinetic/pharmacodynamic model adequately characterized growth-kill behaviour of three E. coli isolates and unveiled strain-specific levofloxacin potencies and persister formation. The mimicked dosing regimens did not eradicate the resistant isolates and enhanced persister formation to a strain-specific extent.

|||||||||| tigecycline / Generic mfg.
Retrospective data, Journal: Tigecycline in the Treatment of Ventilator-Associated Pneumonia Due to Stenotrophomonas maltophilia: A Multicenter Retrospective Cohort Study. (Pubmed Central) - Aug 11, 2021
The standard dose of tigecycline therapy was associated with a lower clinical and microbiological cure rate but not associated with an increased 28-day mortality in patients with S. maltophilia VAP compared with fluoroquinolones. Considering the unfavorable clinical outcomes, we therefore recommend against using the standard dose of tigecycline in treating S. maltophilia VAP unless new clinical evidence emerges.

|||||||||| levofloxacin / Generic mfg.
Clinical, Journal: Quinic acid: a potential antibiofilm agent against clinical resistant Pseudomonas aeruginosa. (Pubmed Central) - Aug 8, 2021
Considering the unfavorable clinical outcomes, we therefore recommend against using the standard dose of tigecycline in treating S. maltophilia VAP unless new clinical evidence emerges. In summary, the study verified the in vitro and in vivo antibiofilm effects of LJF against P. aeruginosa and elucidated the active ingredients in LJF and its conceivable pharmacological mechanism, indicating that quinic acid could have the potential of an antibiofilm agent against P. aeruginosa and related infections.

|||||||||| levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Clinical, Journal: Efficacy of moxifloxacin combined with levofloxacin in the treatment of drug-resistant tuberculosis. (Pubmed Central) - Aug 8, 2021
For multidrug-resistant tuberculosis, levofloxacin tablets and moxifloxacin tablets have similar effects in the treatment of multidrug-resistant tuberculosis, adverse drug reactions, and economically difficult multidrug-resistant patients. Drug sensitivity indicates that they are sensitive to levofloxacin.

|||||||||| levofloxacin / Generic mfg.
Journal: Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer. (Pubmed Central) - Aug 8, 2021
Last, we show that patients undergoing chemotherapy and adhering to prophylactic levofloxacin in the large placebo-controlled randomized phase 3 SIGNIFICANT trial had significantly increased (P = 0.048) long-term overall survival times. Hence, we suggest that RSK4 inhibition may represent an effective therapeutic strategy for treating lung and bladder cancer.

|||||||||| vancomycin / Generic mfg., levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
Clinical, Journal: Antibiotic prophylaxis and the gastrointestinal resistome in paediatric patients with acute lymphoblastic leukaemia: a cohort study with metagenomic sequencing analysis. (Pubmed Central) - Aug 7, 2021
Over the course of induction therapy, there was an overall increase in the relative abundance of trimethoprim-sulfamethoxazole resistance genes (estimated mean fold change 5·9, 95% CI 3·6-9·6; p<0·0001), which was not modified by levofloxacin prophylaxis (p=0·46)...There was no significant difference between prophylaxis groups with respect to changes in aminoglycoside, β-lactam, vancomycin, or multidrug resistance genes after completion of induction or consolidation therapy...More research is needed to determine the longer-term effects of antibacterial prophylaxis on colonisation with antibiotic-resistant bacteria. Children's Infection Defense Center at St Jude Children's Research Hospital, American Lebanese Syrian Associated Charities, and National Institutes of Health.

|||||||||| Clinical, Journal: Detection of diverse carbapenem and multidrug resistance genes and high-risk strain types among carbapenem non-susceptible clinical isolates of target gram-negative bacteria in Kenya. (Pubmed Central) - Aug 7, 2021
High-risk STs of A. baumannii (ST1475, ST2), E. cloacae ST182, K. pneumoniae ST147, P. aeruginosa (ST357, 654), and E. coli ST167, ST648 were identified which present considerable therapeutic danger. The study recommends urgent carbapenem use regulation and containment of high-risk carbapenem-resistant bacteria.

|||||||||| levofloxacin / Generic mfg.
Journal: Formulation and Evaluation of Levofloxacin and Betamethasone Ophthalmic Emulgel. (Pubmed Central) - Aug 6, 2021
Simultaneous and extended release of the two drugs was achieved using one formulation of emulgel. The ability to deliver hydrophilic and hydrophobic drug through the same formulation without the need to use two drops will improve patient compliance and hence patient adherence to treatment.

|||||||||| levofloxacin / Generic mfg., clindamycin phosphate / Generic mfg.
Clinical, Journal: Increasing Multidrug Antibiotic Resistance in MRSA Infections of the Hand: A 10-Year Analysis of Risk Factors. (Pubmed Central) - Aug 6, 2021
There remains a trend for increased clindamycin resistance for patients with history of intravenous drug use and nosocomial infections. Our findings indicate that clindamycin and levofloxacin should be avoided for empiric treatment for hand infections in patients with these risk factors.

|||||||||| ceftriaxone / Generic mfg.
[VIRTUAL] Comparison between Quinolones and other Antibiotics in Preventing Infective Complications in Transrectal Prostate Biopsy (Bellini 2101) - Aug 5, 2021 - Abstract #AUA2021AUA_2713;
A standard number of 12 biopsy samples was planned. Biopsy complications (fever, haematuria, haematospermia, rectal bleeding, rectal pain and sepsis) were evaluated in patients undergoing prophylaxis with quinolones (levofloxacin, ciprofloxacin, plurifloxacin), cephalosporins (cefixime, ceftriaxone) and trimethoprim /sulfamethoxazole. After EMA note in 2018, the European Association Urology guidelines recommended the use of cephalosporins or phosphomycin as the first-choice antibiotic prophylaxis of prostate biopsy in patients at risk of aortic aneurysm. In our study quinolone-based prophylaxis was associated with a lower incidence of complications after prostate biopsy in comparison with other antibiotics.

|||||||||| levofloxacin / Generic mfg., benzylpenicillin / Generic mfg.
Journal: Corynebacterium Species of the Conjunctiva and Nose: Dominant Species and Species-Related Differences of Antibiotic Susceptibility Profiles. (Pubmed Central) - Aug 5, 2021
Drug resistance against fluoroquinolones and macrolides was observed in Corynebacterium species, with the antibiotic susceptibility profiles correlating with differences of the species and niche. Nasal and conjunctival Corynebacterium profiles of drug resistance suggest habitat segregation strictly at the species level.

|||||||||| levofloxacin / Generic mfg.
Preclinical, Journal: Prebiotic-like effects of chitosan on the intestinal microflora in mice. (Pubmed Central) - Aug 5, 2021
Subsequently, they were treated with levofloxacin (65mg/kg) for 6 days...ERIC-PCR fingerprint, UPGMA dendrogram, PCA and diversity analysis showed that the intestinal microflora composition was changed with antibiotics treatment, and that samples were significantly separated from those of the control and long-term CS-treated groups. Together, our results demonstrated that CS could be regarded as a potential food supplement for protecting intestinal microflora and regulate imbalance.

||||||||||  Voquezna (vonoprazan) / Takeda, Phathom Pharma
New trial:  Efficacy and Safety of 14-day Concomitant Therapy for Helicobacter Pylori Infection (clinicaltrials.gov) -  Aug 4, 2021
P=N/A, N=60, Not yet recruiting,  Sponsor: Shandong University

|||||||||| cisplatin / Generic mfg., lansoprazole / Generic mfg.
Journal: Selected pharmacotherapy agents as antiproliferative and anti-inflammatory compounds. (Pubmed Central) - Aug 4, 2021
Levofloxacin as well as ciprofloxacin superbly superseded the antineoplastic cisplatin activity against the K562 cell line (respective IC50 values [μM] 10.4 and 19.5 vs. 29.3; p .05). Collectively, this work reveals acidic chelator drugs (atorvastatin, gemifloxacin, and lansoprazole with dual anti-inflammation and antiproliferation propensities) as authentic agents for the repurposing approach in anticancer chemotherapy/prevention.

|||||||||| rifampicin / Generic mfg.
Review, Journal: Periprosthetic Joint Infection: A Review of Antibiotic Treatment. (Pubmed Central) - Aug 4, 2021
Levofloxacin in combination with rifampin has shown favorable outcomes for Staphylococcus PJI treatment. No abstract available

|||||||||| ciprofloxacin oral / Generic mfg., ondansetron / Generic mfg., levofloxacin / Generic mfg.
[VIRTUAL] Analysis of EMR Generated QTc Interval Prolongation Alerts in Head and Neck Cancer Patients () - Aug 3, 2021 - Abstract #AHNS2021AHNS_496;
The frequency of QTc alerts in HNC patients is rising rapidly consistent with trends identified across other primary malignancies. These alerts may represent distractions, contributing to alert fatigue and potentially discouraging physicians from prescribing medications demonstrated to improve patient’s quality of life and ability to tolerate therapy.

|||||||||| levofloxacin / Generic mfg., erythromycin / Generic mfg.
Journal: Increase of serotype 8, ST53 clone, as the prevalent strain of Streptococcus pneumoniae causing invasive disease in Madrid, Spain (2012-2015). (Pubmed Central) - Jul 31, 2021
On the contrary, the 8-ST63 clone decreased. Since clone 8-ST63 has the theoretical advantage of its levofloxacin-erythromycin resistance in comparison to 8-ST53, the predominance of 8-ST53 over 8-ST63 is striking.

|||||||||| levofloxacin / Generic mfg.
Clinical, Journal: Effect of topical povidone-iodine 10% plus levofloxacin 0.5% one hour before cataract surgery in eliminating perioperative conjunctival flora: randomized clinical trial. (Pubmed Central) - Jul 31, 2021
Since clone 8-ST63 has the theoretical advantage of its levofloxacin-erythromycin resistance in comparison to 8-ST53, the predominance of 8-ST53 over 8-ST63 is striking. Results showed that a single adjuvant application of PVI 10% plus levofloxacin 0.5% eyedrops at 1 hour before operation leads to a further increase in the rate of sterile conjunctiva just preoperatively.

|||||||||| levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., ceftazidime / Generic mfg.
Clinical, Journal: Insights for the Growth of Stenotrophomonas maltophilia in a Diabetic Patient with Long-Term Antibiotic Use: A Case Study. (Pubmed Central) - Jul 30, 2021
Understanding the implication of long-term broad-spectrum antibiotic treatment in the diabetic patient is important in managing postoperative complications and determining the correct course of treatment. The emergence of atypical pathogens in diabetic wounds must be managed appropriately.

|||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Journal: Validation of a Gradient Diffusion Method (Etest®) for Antimicrobial Susceptibility Testing of Aerococcus urinae to Fluoroquinolones. (Pubmed Central) - Jul 30, 2021
Major and minor error rates were 0.6% and 4.3% for ciprofloxacin, and 1.2% and 1.9% for levofloxacin, respectively. Overall, AST using Etest® on sheep blood agar showed a good agreement with reference methods and can be considered by clinical laboratories wishing to perform AST on Aerococcus urinae isolates.

|||||||||| Journal: Reversing the Trend of Antimicrobial Resistance in ICU: Role of Antimicrobial and Diagnostic Stewardship. (Pubmed Central) - Jul 29, 2021
There was a significant reduction in usage of antimicrobials for the treatment of GPCs (linezolid, doxycycline, chloramphenicol, levofloxacin, BLBLI, macrolide, and cephalosporin) and GNBs (levofloxacin, cephalosporin, carbapenem, and colistin), which caused BSI...Agarwal J, Singh V, Das A, Nath SS, Kumar R, Sen M. Reversing the Trend of Antimicrobial Resistance in ICU: Role of Antimicrobial and Diagnostic Stewardship. Indian J Crit Care Med 2021;25(6):635-641.

|||||||||| levofloxacin / Generic mfg.
Clinical, Journal: Gait improvement after levofloxacin administration in a progressive supranuclear palsy patient. (Pubmed Central) - Jul 29, 2021
Indian J Crit Care Med 2021;25(6):635-641. No abstract available

|||||||||| levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
[VIRTUAL] Genetic polymorphism and phenotypic resistance of Mycobacterium tuberculosis to fluoroquinolones of different generations (Channel 2) - Jul 29, 2021 - Abstract #ERS2021ERS_4610;
Using exclusively molecular genetic methods to determine the resistance of Mtb to fluoroquinolones is not possible. It is necessary to confirm the results obtained by the phenotyping DST.

|||||||||| ceftriaxone / Generic mfg., amoxicillin / Generic mfg.
[VIRTUAL] The frequency of prescribing antimicrobial drugs in the initial therapy of COVID-19 at the outpatient stage () - Jul 29, 2021 - Abstract #ERS2021ERS_4099;
Despite the fact that bacterial co-infection occurs in less than 10% of cases with Covid-19 in the first weeks of the disease, doctors often prescribe AMDs unreasonably. Additional educational and administrative work is required for physicians caring for patients with Сovid-19.

|||||||||| ceftriaxone / Generic mfg., cefuroxime / Generic mfg.
[VIRTUAL] Analysis of the microbial profile and antimicrobial resistant pattern of empyema thoracis () - Jul 29, 2021 - Abstract #ERS2021ERS_3970;
Our finding differ from most studies locally and globally. Local protocols on initiation of empirical therapy should be based on the resistance profile of aetiological agents prevalent in a locality and should be reviewed from time to time.

|||||||||| levofloxacin / Generic mfg.
[VIRTUAL] Efficiency of intravenous treatment with levofloxacin in patients with MDR pulmonary tuberculosis in the intensive phase of chemotherapy () - Jul 29, 2021 - Abstract #ERS2021ERS_3932;
Intravenous administration of levofloxacin in the intensive phase of treatment in patients with MDR TB is more effective than the oral form of this drug. The use of the intravenous form of levofloxacin promotes a more rapid cessation of clinical symptoms, an early cessation of bacterial excretion and an X-ray regression of the tuberculous process in the lungs during the intensive phase of treatment.

|||||||||| levofloxacin / Generic mfg., amikacin sulfate / Generic mfg.
[VIRTUAL] Clinical and mutational profile of extensively drug resistant tuberculosis cases in northern India. () - Jul 29, 2021 - Abstract #ERS2021ERS_3931;
The most prevalent mutations conferring resistance to rifampicin, isoniazid, fluoroquinolones and second-line injectables were rpoB S531L, katG S315T1, gyrA D94G, and rrs a1401g respectively. In addition to being resistant to rifampicin, isoniazid, levofloxacin and kanamycin, 52.83%, 75.47%, 91.30% and 17.39% were resistant to high dose moxifloxacin, amikacin/capreomycin, high dose isoniazid and ethionamide respectively.

|||||||||| Lamprene (clofazimine) / Novartis
[VIRTUAL] Outcomes of modified all-oral 9-month treatment regimen for rifampicin-resistant tuberculosis in Belarus (Channel 3) - Jul 29, 2021 - Abstract #ERS2021ERS_2498;
Modified shorter all-oral RR-TB regimen shows excellent treatment outcomes. Patients with radiologically extensive disease at treatment start and those, with later conversion to smear negative have lower chances for cure.

|||||||||| Sirturo (bedaquiline) / J&J, Pharmstandard
[VIRTUAL] New definitions of extensively drug resistant tuberculosis: update from the World Health Organization (Channel 3) - Jul 29, 2021 - Abstract #ERS2021ERS_2497;
Table 1: The new definition of pre-XDR-TB and the revised definition of XDR-TB, effective from January 2021 a The fluoroquinolones include levofloxacin and moxifloxacin, which are the fluoroquinolones currently recommended by WHO for inclusion in shorter and longer regimens. b The Group A drugs are currently levofloxacin or moxifloxacin, bedaquiline and linezolid.

|||||||||| levofloxacin / Generic mfg., azithromycin / Generic mfg.
[VIRTUAL] The practice of empiric antibiotic therapy in patients with coronavirus disease 2019 (COVID-19). () - Jul 29, 2021 - Abstract #ERS2021ERS_2140;
In 35%- azithromycin.To assess the attitude of doctors to the empiric prescription of antibacterial drugs, an anonymous survey of 97 doctors was conducted. The results of our study indicate a high frequency of inappropriate prescription of antibiotics in the detection of COVID-19 and a high readiness of doctors to prescribe its for the treatment of mild viral infection.

|||||||||| clarithromycin / Generic mfg.
Retrospective data, Review, Journal: Efficacy of second-line regimens for Helicobacter pylori eradication treatment: a systemic review and network meta-analysis. (Pubmed Central) - Jul 29, 2021
The results of our study indicate a high frequency of inappropriate prescription of antibiotics in the detection of COVID-19 and a high readiness of doctors to prescribe its for the treatment of mild viral infection. We conducted a detailed comparison of second-line H. pylori regimens according to different antibiotic resistance rates and the results suggest alternative treatment choices with potential benefits beyond those that could be achieved using salvage therapies recommended by guidelines.

|||||||||| Deltyba (delamanid) / Otsuka, Lamprene (clofazimine) / Novartis
Clinical, P2 data, Journal: QT effects of bedaquiline, delamanid, or both in patients with rifampicin-resistant tuberculosis: a phase 2, open-label, randomised, controlled trial. (Pubmed Central) - Jul 29, 2021
P2
Combining bedaquiline and delamanid has a modest, no more than additive, effect on the QTc interval, and initial microbiology data are encouraging. This study provides supportive evidence for use of these agents together in patients with multidrug-resistant or rifampicin-resistant tuberculosis with normal baseline QTc values.

|||||||||| levofloxacin / Generic mfg.
Preclinical, Journal: Development of a dual delivery of levofloxacin and prednisolone acetate via PLGA nanoparticles/ thermosensitive chitosan-based hydrogel for postoperative management: An in-vitro and ex-vivo study. (Pubmed Central) - Jul 28, 2021
In ex-vivo rabbit model of S. aureus keratitis, the anti-inflammation and anti-bacterial property have been demonstrated. These results suggest that thermosensitive PAgel-LNPs may have the potential to use for the prevention of POE.

|||||||||| Clinical, Journal: High Prevalence of Extended-Spectrum Beta-Lactamases in Escherichia coli Strains Collected From Strictly Defined Community-Acquired Urinary Tract Infections in Adults in China: A Multicenter Prospective Clinical Microbiological and Molecular Study. (Pubmed Central) - Jul 27, 2021
However, susceptibilities to cephalosporins (varying from 58.6% to 74.9%) and levofloxacin (48.8%) were relatively low...Antimicrobial susceptibilities of imipenem, cefmetazole, colistin, ertapenem, amikacin, and nitrofurantoin against ESBL-producing E. coli strains were greater than 90%...bla is the predominant esbl gene in ESBL-producing and ESBL-uncertain strains. Our study indicated that the use of cephalosporins and fluoroquinolone needs to be restricted for empirical treatment of CA-UTIs in China.

|||||||||| Clinical, Journal: Complex analysis of the personalized pharmacotherapy in the management of COVID-19 patients and suggestions for applications of predictive, preventive, and personalized medicine attitude. (Pubmed Central) - Jul 27, 2021
Fourteen drugs (ritonavir, daclatasvir, prednisone, dexamethasone, ribavirin, HCQ, ceftriaxone, zinc, interferon beta-1a, remdesivir, levofloxacin, lopinavir, human immunoglobulin G and losartan) showed significantly different pharmacogenomic characteristics in relation to the ethnic origin of the patient...In summary, the proposed PPPM/3 PM attitude should be obligatory considered for the overall COVID-19 management. The online version contains supplementary material available at 10.1007/s13167-021-00247-0.

|||||||||| clarithromycin / Generic mfg., rifampicin / Generic mfg., amoxicillin / Generic mfg.
Retrospective data, Review, Journal: An Updated Systematic Review and Meta-Analysis on the Helicobacter pylori Antibiotic Resistance in Iran (2010-2020). (Pubmed Central) - Jul 24, 2021
Furthermore, the trend of H. pylori resistance has increased between 1997 and 2020. Hence, continuous surveillance on resistance patterns, logical prescription and appropriate consumption of antibiotics, and selecting effective therapeutic regimens in accordance with local resistance patterns are required to prevent further spread of resistance and ensuing treatment failures.

|||||||||| Clinical, Journal: Exploring the Interplay of Resistance Nodulation Division Efflux Pumps, AmpC and OprD in Antimicrobial Resistance of Burkholderia cepacia Complex in Clinical Isolates. (Pubmed Central) - Jul 24, 2021
Increased mexA expression showed significant association with reduced susceptibility to β-lactam antimicrobials (ceftazidime, piperacillin-tazobactam, and meropenem) and co-trimoxazole. To conclude, this study explored the high-level expression of mexC, mexE, and mexX efflux pumps genes and ampC in the clinical isolates of Bcc, which can be targeted at treating infections caused by Bcc.

|||||||||| levofloxacin / Generic mfg.
Journal: Insight into chitosan/zeolite-A nanocomposite as an advanced carrier for levofloxacin and its anti-inflammatory properties; loading, release, and anti-inflammatory studies. (Pubmed Central) - Jul 24, 2021
The loading of LVOX into CH/ZA induced its anti-inflammatory effect against the cytokine production (IL-6 and IL-8) within the human bronchial epithelia cells (NL20). The cytotoxicity studies on the normal cells demonstrated a high safety value for the composite.

|||||||||| levofloxacin / Generic mfg.
Clinical, Journal: Unusual Recurrence of Antituberculosis Drug-Induced Hepatotoxicity in Children: A Case Series. (Pubmed Central) - Jul 24, 2021
The patient with pulmonary tuberculosis, HIV infection, and dilated cardiomyopathy experienced secondary episodes of ADIH and received levofloxacin and ethambutol as additional drugs...Reintroduction of previous treatment regimens should be tailored individually. There is an urgent need for standardized guidelines for ADIH in children.

|||||||||| Clinical, Journal: Prescripción e indicaciones de uso de fluoroquinolonas en un grupo de pacientes ambulatorios de Colombia (Pubmed Central) - Jul 22, 2021
Conclusión. Las fluoroquinolonas, en particular la ciprofloxacina, se están prescribiendo especialmente a mujeres con infecciones de las vías urinarias, pero hasta la cuarta parte de los pacientes las recibieron para usos no aprobados por las agencias reguladoras.

|||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., vincristine / Generic mfg.
Clinical, Journal: Fluoroquinolone prophylaxis does not increase risk of neuropathy in children with acute lymphoblastic leukemia. (Pubmed Central) - Jul 22, 2021
Las fluoroquinolonas, en particular la ciprofloxacina, se están prescribiendo especialmente a mujeres con infecciones de las vías urinarias, pero hasta la cuarta parte de los pacientes las recibieron para usos no aprobados por las agencias reguladoras. The results of this observational study do not show an association between exposure to fluoroquinolone antibiotics during induction therapy for ALL and subsequent development of vincristine-induced peripheral neuropathies, and suggest that a large increase in VIPN is unlikely.

|||||||||| ampicillin / Generic mfg.
Clinical, Journal: Prevalence, serotypes, and antimicrobial resistance of Salmonella isolates from patients with diarrhea in Shenzhen, China. (Pubmed Central) - Jul 21, 2021
The high level of antibiotic resistance is of public health significance and ongoing monitoring combined with rational use of antibiotics are recommended. Point mutations in gyrA gene might play an important role in the resistance to fluoroquinolones.

|||||||||| levofloxacin / Generic mfg.
Clinical, Journal: Micelles self-assembled by 3-O-β-D-glucopyranosyl latycodigenin enhance cell membrane permeability, promote antibiotic pulmonary targeting and improve anti-infective efficacy. (Pubmed Central) - Jul 21, 2021
Point mutations in gyrA gene might play an important role in the resistance to fluoroquinolones. GP-682 micelles are another nanoparticle-based pulmonary drug delivery system and provide a new lung-targeting therapy option.

|||||||||| Revlimid (lenalidomide) / BMS
Journal: Repurposing of existing therapeutics to combat drug-resistant malaria. (Pubmed Central) - Jul 21, 2021
Among antibiotics, moxifloxacin exhibited better antimalarial prospective than levofloxacin, roxithromycin and erythromycin. 5-Fluorouracil, imiquimod and moxifloxacin displayed 97.64, 81.18 and 91.77 % parasite inhibition in treated animals and attained superiority in their respective groups thus could be exploited further in combination with suitable antimalarials.

|||||||||| levofloxacin / Generic mfg.
Preclinical, Journal: Tea polyphenols and Levofloxacin alleviate the lung injury of hepatopulmonary syndrome in common bile duct ligation rats through Endotoxin -TNF signaling. (Pubmed Central) - Jul 21, 2021
TP and Levofloxacin could alleviate pulmonary injury for short and long period, respectively, while at the same time preventing endotoxin and the development of HPS in CBDL rats. These effects are possibly associated with the regulation of the Endotoxin -TNF-α pathways.

|||||||||| clarithromycin / Generic mfg., cefuroxime / Generic mfg.
Journal, Adverse events: Delirium Associations with Antibiotics: A Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS). (Pubmed Central) - Jul 20, 2021
These effects are possibly associated with the regulation of the Endotoxin -TNF-α pathways. This study found statistically significant increased risk of reporting delirium with ertapenem, cefepime, imipenem, ofloxacin, ceftazidime, clarithromycin, cefaclor, ampicillin-sulbactam, levofloxacin, linezolid, moxifloxacin, azithromycin, piperacillin-tazobactam, trimethoprim-sulfamethoxazole, metronidazole, ciprofloxacin, and cefuroxime.

|||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Retrospective data, Journal: Fluoroquinolone and no risk of Achilles-tendinopathy in childhood pneumonia under eight years of age-a nationwide retrospective cohort. (Pubmed Central) - Jul 20, 2021
AT was a rare adverse event of FQ use for childhood pneumonia, particularly under eight years of age. Clinicians could consider using FQs as a second-line option in the treatment of childhood pneumonia when there are no alternative therapeutic options.

|||||||||| levofloxacin / Generic mfg., lamivudine / Generic mfg.
Journal: Probing the degradation of pharmaceuticals in urine using MFC and studying their removal efficiency by UPLC-MS/MS. (Pubmed Central) - Jul 20, 2021
The voltage curve obtained showed that the presence of pharmaceuticals had an initial negative impact on power generation along with increased organic content; however, after the reactor acclimatization, increased power output was achieved with maximum organics removal at 30 h of retention time. This work opens a new perspective for the anoxic biodegradation of pharmaceuticals and can be useful in future bioremediation studies.



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