levofloxacin / Generic mfg. 
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  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Superoxide dismutase 3 as an inflammatory suppressor in A549 cells infected with Mycoplasma pneumoniae. (Pubmed Central) -  Aug 12, 2021   
    Levofloxacin (LVFX) was used as an anti-inflammatory drug while recombinant TNF-α was used as an inflammatory promotor in MP-infected cells...Inspiringly, SOD3 overexpression induced anti-inflammatory effect and the inactivation of NF-κB was similar to that of 2 lg/ml of LVFX, but reversed by additional TNF-α treatment. Therefore, we can conclude that transcriptional activity of NF-jB was the underlying mechanism, by which SOD3 regulated inflammatory response in MP infection in vitro.
  • ||||||||||  levofloxacin / Generic mfg.
    Clinical, Journal:  Quinic acid: a potential antibiofilm agent against clinical resistant Pseudomonas aeruginosa. (Pubmed Central) -  Aug 8, 2021   
    Considering the unfavorable clinical outcomes, we therefore recommend against using the standard dose of tigecycline in treating S. maltophilia VAP unless new clinical evidence emerges. In summary, the study verified the in vitro and in vivo antibiofilm effects of LJF against P. aeruginosa and elucidated the active ingredients in LJF and its conceivable pharmacological mechanism, indicating that quinic acid could have the potential of an antibiofilm agent against P. aeruginosa and related infections.
  • ||||||||||  levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
    Clinical, Journal:  Efficacy of moxifloxacin combined with levofloxacin in the treatment of drug-resistant tuberculosis. (Pubmed Central) -  Aug 8, 2021   
    For multidrug-resistant tuberculosis, levofloxacin tablets and moxifloxacin tablets have similar effects in the treatment of multidrug-resistant tuberculosis, adverse drug reactions, and economically difficult multidrug-resistant patients. Drug sensitivity indicates that they are sensitive to levofloxacin.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer. (Pubmed Central) -  Aug 8, 2021   
    Last, we show that patients undergoing chemotherapy and adhering to prophylactic levofloxacin in the large placebo-controlled randomized phase 3 SIGNIFICANT trial had significantly increased (P = 0.048) long-term overall survival times. Hence, we suggest that RSK4 inhibition may represent an effective therapeutic strategy for treating lung and bladder cancer.
  • ||||||||||  vancomycin / Generic mfg., levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
    Clinical, Journal:  Antibiotic prophylaxis and the gastrointestinal resistome in paediatric patients with acute lymphoblastic leukaemia: a cohort study with metagenomic sequencing analysis. (Pubmed Central) -  Aug 7, 2021   
    Over the course of induction therapy, there was an overall increase in the relative abundance of trimethoprim-sulfamethoxazole resistance genes (estimated mean fold change 5·9, 95% CI 3·6-9·6; p<0·0001), which was not modified by levofloxacin prophylaxis (p=0·46)...There was no significant difference between prophylaxis groups with respect to changes in aminoglycoside, β-lactam, vancomycin, or multidrug resistance genes after completion of induction or consolidation therapy...More research is needed to determine the longer-term effects of antibacterial prophylaxis on colonisation with antibiotic-resistant bacteria. Children's Infection Defense Center at St Jude Children's Research Hospital, American Lebanese Syrian Associated Charities, and National Institutes of Health.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Formulation and Evaluation of Levofloxacin and Betamethasone Ophthalmic Emulgel. (Pubmed Central) -  Aug 6, 2021   
    Simultaneous and extended release of the two drugs was achieved using one formulation of emulgel. The ability to deliver hydrophilic and hydrophobic drug through the same formulation without the need to use two drops will improve patient compliance and hence patient adherence to treatment.
  • ||||||||||  ceftriaxone / Generic mfg.
    [VIRTUAL] Comparison between Quinolones and other Antibiotics in Preventing Infective Complications in Transrectal Prostate Biopsy (Bellini 2101) -  Aug 5, 2021 - Abstract #AUA2021AUA_2713;    
    A standard number of 12 biopsy samples was planned. Biopsy complications (fever, haematuria, haematospermia, rectal bleeding, rectal pain and sepsis) were evaluated in patients undergoing prophylaxis with quinolones (levofloxacin, ciprofloxacin, plurifloxacin), cephalosporins (cefixime, ceftriaxone) and trimethoprim /sulfamethoxazole. After EMA note in 2018, the European Association Urology guidelines recommended the use of cephalosporins or phosphomycin as the first-choice antibiotic prophylaxis of prostate biopsy in patients at risk of aortic aneurysm. In our study quinolone-based prophylaxis was associated with a lower incidence of complications after prostate biopsy in comparison with other antibiotics.
  • ||||||||||  levofloxacin / Generic mfg.
    Preclinical, Journal:  Prebiotic-like effects of chitosan on the intestinal microflora in mice. (Pubmed Central) -  Aug 5, 2021   
    Subsequently, they were treated with levofloxacin (65mg/kg) for 6 days...ERIC-PCR fingerprint, UPGMA dendrogram, PCA and diversity analysis showed that the intestinal microflora composition was changed with antibiotics treatment, and that samples were significantly separated from those of the control and long-term CS-treated groups. Together, our results demonstrated that CS could be regarded as a potential food supplement for protecting intestinal microflora and regulate imbalance.
  • ||||||||||  cisplatin / Generic mfg., lansoprazole / Generic mfg.
    Journal:  Selected pharmacotherapy agents as antiproliferative and anti-inflammatory compounds. (Pubmed Central) -  Aug 4, 2021   
    Levofloxacin as well as ciprofloxacin superbly superseded the antineoplastic cisplatin activity against the K562 cell line (respective IC50 values [μM] 10.4 and 19.5 vs. 29.3; p  .05). Collectively, this work reveals acidic chelator drugs (atorvastatin, gemifloxacin, and lansoprazole with dual anti-inflammation and antiproliferation propensities) as authentic agents for the repurposing approach in anticancer chemotherapy/prevention.
  • ||||||||||  ciprofloxacin oral / Generic mfg., ondansetron / Generic mfg., levofloxacin / Generic mfg.
    [VIRTUAL] Analysis of EMR Generated QTc Interval Prolongation Alerts in Head and Neck Cancer Patients () -  Aug 3, 2021 - Abstract #AHNS2021AHNS_496;    
    The frequency of QTc alerts in HNC patients is rising rapidly consistent with trends identified across other primary malignancies. These alerts may represent distractions, contributing to alert fatigue and potentially discouraging physicians from prescribing medications demonstrated to improve patient’s quality of life and ability to tolerate therapy.
  • ||||||||||  Journal:  Reversing the Trend of Antimicrobial Resistance in ICU: Role of Antimicrobial and Diagnostic Stewardship. (Pubmed Central) -  Jul 29, 2021   
    There was a significant reduction in usage of antimicrobials for the treatment of GPCs (linezolid, doxycycline, chloramphenicol, levofloxacin, BLBLI, macrolide, and cephalosporin) and GNBs (levofloxacin, cephalosporin, carbapenem, and colistin), which caused BSI...Agarwal J, Singh V, Das A, Nath SS, Kumar R, Sen M. Reversing the Trend of Antimicrobial Resistance in ICU: Role of Antimicrobial and Diagnostic Stewardship. Indian J Crit Care Med 2021;25(6):635-641.
  • ||||||||||  levofloxacin / Generic mfg., amikacin sulfate / Generic mfg.
    [VIRTUAL] Clinical and mutational profile of extensively drug resistant tuberculosis cases in northern India. () -  Jul 29, 2021 - Abstract #ERS2021ERS_3931;    
    The most prevalent mutations conferring resistance to rifampicin, isoniazid, fluoroquinolones and second-line injectables were rpoB S531L, katG S315T1, gyrA D94G, and rrs a1401g respectively. In addition to being resistant to rifampicin, isoniazid, levofloxacin and kanamycin, 52.83%, 75.47%, 91.30% and 17.39% were resistant to high dose moxifloxacin, amikacin/capreomycin, high dose isoniazid and ethionamide respectively.
  • ||||||||||  Sirturo (bedaquiline) / J&J, Pharmstandard
    [VIRTUAL] New definitions of extensively drug resistant tuberculosis: update from the World Health Organization (Channel 3) -  Jul 29, 2021 - Abstract #ERS2021ERS_2497;    
    Table 1: The new definition of pre-XDR-TB and the revised definition of XDR-TB, effective from January 2021 a The fluoroquinolones include levofloxacin and moxifloxacin, which are the fluoroquinolones currently recommended by WHO for inclusion in shorter and longer regimens. b The Group A drugs are currently levofloxacin or moxifloxacin, bedaquiline and linezolid.
  • ||||||||||  levofloxacin / Generic mfg., azithromycin / Generic mfg.
    [VIRTUAL] The practice of empiric antibiotic therapy in patients with coronavirus disease 2019 (COVID-19). () -  Jul 29, 2021 - Abstract #ERS2021ERS_2140;    
    In 35%- azithromycin.To assess the attitude of doctors to the empiric prescription of antibacterial drugs, an anonymous survey of 97 doctors was conducted. The results of our study indicate a high frequency of inappropriate prescription of antibiotics in the detection of COVID-19 and a high readiness of doctors to prescribe its for the treatment of mild viral infection.
  • ||||||||||  clarithromycin / Generic mfg.
    Retrospective data, Review, Journal:  Efficacy of second-line regimens for Helicobacter pylori eradication treatment: a systemic review and network meta-analysis. (Pubmed Central) -  Jul 29, 2021   
    The results of our study indicate a high frequency of inappropriate prescription of antibiotics in the detection of COVID-19 and a high readiness of doctors to prescribe its for the treatment of mild viral infection. We conducted a detailed comparison of second-line H. pylori regimens according to different antibiotic resistance rates and the results suggest alternative treatment choices with potential benefits beyond those that could be achieved using salvage therapies recommended by guidelines.
  • ||||||||||  clarithromycin / Generic mfg., rifampicin / Generic mfg., amoxicillin / Generic mfg.
    Retrospective data, Review, Journal:  An Updated Systematic Review and Meta-Analysis on the Helicobacter pylori Antibiotic Resistance in Iran (2010-2020). (Pubmed Central) -  Jul 24, 2021   
    Furthermore, the trend of H. pylori resistance has increased between 1997 and 2020. Hence, continuous surveillance on resistance patterns, logical prescription and appropriate consumption of antibiotics, and selecting effective therapeutic regimens in accordance with local resistance patterns are required to prevent further spread of resistance and ensuing treatment failures.
  • ||||||||||  levofloxacin / Generic mfg.
    Clinical, Journal:  Unusual Recurrence of Antituberculosis Drug-Induced Hepatotoxicity in Children: A Case Series. (Pubmed Central) -  Jul 24, 2021   
    The patient with pulmonary tuberculosis, HIV infection, and dilated cardiomyopathy experienced secondary episodes of ADIH and received levofloxacin and ethambutol as additional drugs...Reintroduction of previous treatment regimens should be tailored individually. There is an urgent need for standardized guidelines for ADIH in children.
  • ||||||||||  ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., vincristine / Generic mfg.
    Clinical, Journal:  Fluoroquinolone prophylaxis does not increase risk of neuropathy in children with acute lymphoblastic leukemia. (Pubmed Central) -  Jul 22, 2021   
    Las fluoroquinolonas, en particular la ciprofloxacina, se están prescribiendo especialmente a mujeres con infecciones de las vías urinarias, pero hasta la cuarta parte de los pacientes las recibieron para usos no aprobados por las agencias reguladoras. The results of this observational study do not show an association between exposure to fluoroquinolone antibiotics during induction therapy for ALL and subsequent development of vincristine-induced peripheral neuropathies, and suggest that a large increase in VIPN is unlikely.
  • ||||||||||  Revlimid (lenalidomide) / BMS
    Journal:  Repurposing of existing therapeutics to combat drug-resistant malaria. (Pubmed Central) -  Jul 21, 2021   
    Among antibiotics, moxifloxacin exhibited better antimalarial prospective than levofloxacin, roxithromycin and erythromycin. 5-Fluorouracil, imiquimod and moxifloxacin displayed 97.64, 81.18 and 91.77 % parasite inhibition in treated animals and attained superiority in their respective groups thus could be exploited further in combination with suitable antimalarials.
  • ||||||||||  clarithromycin / Generic mfg., cefuroxime / Generic mfg.
    Journal, Adverse events:  Delirium Associations with Antibiotics: A Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS). (Pubmed Central) -  Jul 20, 2021   
    These effects are possibly associated with the regulation of the Endotoxin -TNF-α pathways. This study found statistically significant increased risk of reporting delirium with ertapenem, cefepime, imipenem, ofloxacin, ceftazidime, clarithromycin, cefaclor, ampicillin-sulbactam, levofloxacin, linezolid, moxifloxacin, azithromycin, piperacillin-tazobactam, trimethoprim-sulfamethoxazole, metronidazole, ciprofloxacin, and cefuroxime.
  • ||||||||||  levofloxacin / Generic mfg., lamivudine / Generic mfg.
    Journal:  Probing the degradation of pharmaceuticals in urine using MFC and studying their removal efficiency by UPLC-MS/MS. (Pubmed Central) -  Jul 20, 2021   
    The voltage curve obtained showed that the presence of pharmaceuticals had an initial negative impact on power generation along with increased organic content; however, after the reactor acclimatization, increased power output was achieved with maximum organics removal at 30 h of retention time. This work opens a new perspective for the anoxic biodegradation of pharmaceuticals and can be useful in future bioremediation studies.