- |||||||||| levofloxacin / Generic mfg.
Journal: An inhalable nanoparticle enabling virulence factor elimination and antibiotics delivery for pneumococcal pneumonia therapy. (Pubmed Central) - Oct 17, 2024
Here we report an inhalable catalase (CAT)-tannic acid (TA) nanoassembly for local antibiotic (levofloxacin) delivery and simultaneously neutralizing the secreted H2O2 virulence factors to treat pneumococcal pneumonia...In synergy with antibiotic LVX-mediated S. pneumoniae elimination, CT@LVX significantly decreases lung injury companied with reduced inflammatory, resulting in 100?% survival of mice with pneumonia. In a clinically isolated S. pneumoniae strain-induced pneumonia mouse model, CT@LVX also shows superior outcomes compared to the traditional antibiotic treatment, highlighting its potential clinical application prospects.
- |||||||||| levofloxacin / Generic mfg.
Journal: Dual osmotic controlled release platform for antibiotics to overcome antimicrobial-resistant infections and promote wound healing. (Pubmed Central) - Oct 17, 2024
Levofloxacin, an antibiotic that inhibits DNA replication, was chosen as the model drug to be incorporated into nanoparticles...Our virus-inspired nanoparticles displayed long-acting antibacterial effects and powerful biofilm elimination to overcome antimicrobial-resistant infections and promote skin wound healing. This work demonstrates the ability of virus-inspired nanoparticles to achieve a dual penetration of microbial cell membranes and biofilm structures to address antimicrobial-resistant infections and trigger skin wound healing.
- |||||||||| levofloxacin / Generic mfg.
Preclinical, Journal: Curcumin and Vitamin D Reduce HMGB-1 mRNA Levels in Mice Infected with Salmonella typhi. (Pubmed Central) - Oct 17, 2024
Mice in group A were treated with the antibiotic levofloxacin (1.95 mg/kg once daily) as the positive control; group B mice were administered curcumin at a dose of 200 mg/kg body weight; group C mice were treated with a curcumin dose of 200 mg/kg BW and vitamin D; and group D mice received distilled water (placebo) as the negative control...HMGB-1 mRNA level in group C decreased significantly by 5.76-fold (95% confidence interval: 2.55, 8.98). In contrast, HMGB-1 mRNA levels did not decrease significantly in group B. These results suggest that the combination of curcumin and vitamin D reduced HMGB-1 mRNA levels in infected mice, highlighting the potential of this combination as an antimicrobial and anti-inflammatory agent.
- |||||||||| levofloxacin / Generic mfg., clarithromycin / Generic mfg.
Review, Journal: The Challenges of Treating a Helicobacter pylori Infection following the COVID-19 Pandemic in Croatia: A Review. (Pubmed Central) - Oct 16, 2024
The COVID-19 pandemic has significantly affected antibiotic use and resistance patterns, posing new challenges for H. pylori eradication. Addressing these challenges requires a multifaceted approach, including the development of new drugs and advanced diagnostics, coupled with sustained efforts in antimicrobial stewardship to combat emerging resistance threats.
- |||||||||| Journal: Antimicrobial Consumption and Resistance of Restricted Antibiotics in a Level III Government Hospital. (Pubmed Central) - Oct 14, 2024
Antibiotic resistance of Acinetobacter baumannii against ciprofloxacin, levofloxacin, and piperacillin-tazobactam were statistically significantly different between the wards...In Ward 3, a significantly moderately positive association was observed for ceftazidime consumption and A. baumannii resistance (r = 0.61), positive correlation between piperacillin-tazobactam and E. coli resistance (r = 0.65), and a strong positive correlation in Ward 3 between levofloxacin and Pseudomonas aeruginosa resistance (r = 0.71)...This study has supported the involvement of pharmacists in the AMS team by conducting auditing activities that promote safe compliance of restricted antibiotic use among patients. Pharmacists can greatly participate on either prospective or retrospective review of antibiotic utilization and analyze trends of antibiotic consumption data to provide feedback to prescribing physicians on prescribing patterns and possible correlation with occurrence of antibiotic resistance.
- |||||||||| levofloxacin / Generic mfg.
Journal: Myroides odoratus Induced Cellulitis and Bacteremia in an Elderly Male. (Pubmed Central) - Oct 14, 2024
Though infection with Myroides species is uncommon and typically limited to immunocompromised individuals, the wide range of antimicrobial resistance it exhibits makes treatment challenging. In this report, we present the case of a 76-year-old male with compensated cirrhosis who presented with cellulitis complicated by bacteremia secondary to M. odoratus and was managed successfully with levofloxacin.
- |||||||||| A Rare Case of Stenotrophomonas maltophilia-Refractory Peritonitis in a Patient on Automated Peritoneal Dialysis () - Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_5128;
Treated with empiric intra-peritoneal vancomycin and cefepime followed by cefpodoxime for 4-weeks...Antibiotics were changed to trimethoprim/sulfamethoxazole and levofloxacin, and PD catheter was removed...International guidelines recommend dual antibiotic coverage for environmental gram-negative bacteria such as Pseudomonas and Stenotrophomonas; special attention was paid to treatment of Stenotrophomonas in most recent guideline update. This case highlights the importance of considering this organism in patients with PD peritonitis regardless of their immunocompetence, the importance of hand hygiene, and also spotlights the resistant nature of the organism prompting us to be more vigilant when presented with such case..
- |||||||||| Cat-Induced Pasteurella Peritonitis in a Patient on Peritoneal Dialysis () - Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_5110;
Intraperitoneal ceftazidime was initiated and peritoneal fluid cultures were drawn, which would later reveal Pasteurella multocida...Oral levofloxacin was added to her antibiotic regimen...She was hospitalized for IV ceftriaxone and PD catheter removal, and then transitioned to oral cefdinir...She was discharged on 10 days of oral cefixime, recovered well and has since had a new PD catheter placed...Additionally, our case suggests that prolonged IV antibiotics may be necessary when intraabdominal pathology is identified to prevent abscess formation.. . .
- |||||||||| ciprofloxacin oral / Generic mfg., amikacin sulfate / Generic mfg.
Role of AcrAB and OqxAB Efflux Pumps in Amikacin and Ciprofloxacin Resistance among Clinical Isolates of Klebsiella pneumoniae in Lima, Peru (Convention Center - Hall I-1 (1st Floor); In-Person-Only) - Oct 11, 2024 - Abstract #ASTMH2024ASTMH_3037;
The 93.75% were resistant to ciprofloxacin and piperacillin/tazobactam; 87.5% were resistant to trimethoprim/sulfamethoxazole; 56.25% were resistant to fosfomycin; 25% were resistant to levofloxacin and 18.75% to amikacin...The prevalence of resistance genes show AcrA gene was detected in 43.75% isolates, the AcrB gene in 56.25%, OqxA in 31.25%, and OqxB in 25.00%. In conclusion, our findings suggest that efflux pumps are major mechanisms for ciprofloxacin and amikacin resistance in K. pneumoniae , with the AcrAB and OqxAB systems being significant contributors to this resistance
- |||||||||| A Case of Pre-Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa (Convention Center - Hall I-1 (1st Floor); In-Person-Only) - Oct 11, 2024 - Abstract #ASTMH2024ASTMH_2241;
For the management of at minimum pre-extensively drug-resistant TB, he was to restart/continue linezolid for 1 year; start delamanid for 0.5-1 year; continue bedaquiline for 1 year; stop ethambutol, pyrazinamide, and high-dose isoniazid. Levofloxacin was continued given patient
- |||||||||| Aeromonas hydrophila as a cause of acute diarrhea from western and coastal regions in Kenya (Convention Center - Hall I-1 (1st Floor); In-Person-Only) - Oct 11, 2024 - Abstract #ASTMH2024ASTMH_2176;
The isolation of Aeromonas hydrophila is indicative that it may be a potential pathogen that causes acute diarrhea. The isolates were also found to be more resistant to the sulfonamide and beta lactams hence possible transfer to other gut pathogens or normal flora leading to increased antimicrobial resistance.
- |||||||||| Journal: Exploring diflunisal as a synergistic agent against Staphylococcus aureus biofilm formation. (Pubmed Central) - Oct 10, 2024
In the case of imipenem, doripenem, levofloxacin, and ciprofloxacin, lower doses and absence of diflunisal showed higher control over biofilm growth with longer exposure...In the absence of antibiotics, diflunisal significantly reduced biofilm formation by 53.12% (p?<?0.05). This study suggests that diflunisal could be a potential treatment to control S. aureus biofilms, but it does not enhance biofilm inhibition when combined with antibiotics.
- |||||||||| levofloxacin / Generic mfg.
Journal: Levofloxacin induces erythrocyte contraction leading to red cell death. (Pubmed Central) - Oct 10, 2024
In conclusion, our findings showed that the indicated levofloxacin doses caused oxidative stress, which leads to erythrocyte death via eryptosis and hemolysis. These findings emphasize the importance of using levofloxacin with caution and the need for additional research to mitigate these side effects.
- |||||||||| levofloxacin / Generic mfg., clarithromycin / Generic mfg.
Review, Journal: An Update on Eradication of Helicobacter Pylori in Iran: A Review. (Pubmed Central) - Oct 10, 2024
Various H. pylori eradication regimens can be used as first-line therapy; however, choices for second-line therapy are limited. We recommend the quinolone-containing regimens as the preferred second-line therapy.
- |||||||||| Review, Journal: Interaction of drug molecules with surfactants below (Benesi-Hildebrand equation) and above the critical micelle concentration (Kawamura equation). (Pubmed Central) - Oct 9, 2024
Various surfactants were analyzed with diphenhydramine hydrochloride, levofloxacin, phenothiazine, moxifloxacin, and chlorpromazine hydrochloride to determine monomeric binding constants, while sulfathiazole, sodium valproate, cefotaxime, losartan, and metformin hydrochloride were assessed for partitioning coefficient values. Errors in Benesi-Hildebrand plots may arise from considering surfactant concentrations above the CMC, while mistakes in Kawamura plots may stem from neglecting to determine the CMC in the presence of drug molecules, which can alter the surfactant's behavior.
- |||||||||| levofloxacin / Generic mfg.
Journal: Mechanochemical comparison of ball milling processes for levofloxacin amorphous polymeric systems. (Pubmed Central) - Oct 9, 2024
DVS studies of LVXh:EL100 samples showed different stability properties depending on the mill used and % LVXh present. Overall, a more sustainable approach for achieving full amorphization of the fluoroquinolone drug, LVXh, was accomplished, and advancements to the fast-growing world of pharmaceutical mechano- and tribo-chemistry were made.
- |||||||||| Journal: Antibiotic Resistance and Virulence Factors in Clinical Isolates of Stenotrophomonas maltophilia from Hospitalized Patients in Tehran, Iran. (Pubmed Central) - Oct 9, 2024
Minocycline and levofloxacin demonstrated the highest susceptibility rates, with 70 (87.5%) and 80 (100%), respectively...Resistance to SXT isolate belong to the sequence type (ST15) and exhibits allelic profiles of (10, 29, 21, 21, 32, 32, and 10). The data obtained from our investigation have indicated that SXT remains an efficacious antibiotic and also highlighted the importance of effective management, identification of resistant isolates, and typing methods to address the global prevalence of antibiotic resistance in S. maltophilia.
- |||||||||| levofloxacin / Generic mfg.
Journal: A biomimetic human disease model of bacterial keratitis using a cornea-on-a-chip system. (Pubmed Central) - Oct 8, 2024
We validate this model by evaluating the efficacy of antibiotics, such as levofloxacin, tobramycin, and chloramphenicol, through simultaneously observing the reactions of bacteria and the two cell types to these antibiotics...Altogether, the cornea on chip enables the assessment of ocular antibiotics, distinguishing the impact on corneal cells and structural integrity. This study introduced a biomimetic in vitro disease model to evaluate drug efficacy and provided significant insights into the extensive effects of antibiotics on diverse cell populations within the cornea.
- |||||||||| levofloxacin / Generic mfg.
Journal: Mucosal infection with Tsukamurella species following nasal septum procedure: a rare case report. (Pubmed Central) - Oct 3, 2024
The patient was treated with augmentin, fluconazole, and levofloxacin, leading to the resolution of symptoms and discharge with ongoing treatment...This case underscores the need for vigilance in diagnosing rare infections like Tsukamurella, even in immunocompetent individuals. The successful resolution with combination therapy highlights the importance of appropriate antibiotic selection in managing such infections.
- |||||||||| levofloxacin / Generic mfg.
Trial completion date, Trial primary completion date: Safety and Efficacy of Levofloxacin Combined With Intravenous Thrombolysis for Acute Ischemic Stroke (clinicaltrials.gov) - Oct 2, 2024
P=N/A, N=100, Recruiting,
The current study showed Levofloxacin prophylaxis is effective in reducing the incidence of febrile with neutropenia, fever without neutropenia and CDI & MDI requiring parenteral antibiotics in children with ALL in induction period. Trial completion date: Sep 2024 --> Dec 2024 | Trial primary completion date: Jun 2024 --> Dec 2024
- |||||||||| levofloxacin / Generic mfg.
Trial completion date, Trial primary completion date: Safety and Efficacy of Levofloxacin for Acute Ischemic Stroke (clinicaltrials.gov) - Oct 1, 2024
P=N/A, N=100, Recruiting,
Trial completion date: Jul 2025 --> Jul 2026 | Trial primary completion date: Apr 2025 --> Apr 2026 Trial completion date: Sep 2024 --> Dec 2024 | Trial primary completion date: Jun 2024 --> Dec 2024
- |||||||||| levofloxacin / Generic mfg., clarithromycin / Generic mfg.
Journal: Prevalence and resistance of Helicobacter pylori in a predominantly Hispanic population. (Pubmed Central) - Oct 1, 2024
pylori infection appears to be associated with low socioeconomic status and poor living conditions early in life. Clarithromycin and levofloxacin based treatment regimens should be avoided as first line therapy in this region, particularly in patients of Latin American origin.
- |||||||||| levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., cefadroxil / Generic mfg.
Trial completion, Enrollment change, Trial completion date, Trial primary completion date, Gram negative: BALANCE+ Vanguard Phase (clinicaltrials.gov) - Oct 1, 2024
P=N/A, N=174, Completed,
Clarithromycin and levofloxacin based treatment regimens should be avoided as first line therapy in this region, particularly in patients of Latin American origin. Recruiting --> Completed | N=72 --> 174 | Trial completion date: Jul 2027 --> Aug 2024 | Trial primary completion date: Jun 2027 --> Jul 2024
- |||||||||| Biomarker, Journal, Next-generation sequencing: Prediction of antimicrobial resistance in Klebsiella pneumoniae using genomic and metagenomic next-generation sequencing data. (Pubmed Central) - Sep 30, 2024
Our results provide evidence for clinicians and decision-makers when balancing fluoroquinolones risks and benefits. These preliminary results demonstrated that the performance of prediction model for a clinically significant antimicrobial-species pair was comparable to that of phenotypic methods, thereby encouraging the expansion of sequence-based susceptibility prediction and its clinical validation and application.
- |||||||||| levofloxacin / Generic mfg.
Journal: Zn/Cr-MOFs/TiO2 Composites as Adsorbents for Levofloxacin Hydrochloride Removal. (Pubmed Central) - Sep 29, 2024
Additionally, Langmuir and Freundlich isotherm models were used to study equilibrium adsorption behavior and showed good agreement with both kinetic modeling and Langmuir isotherm analysis results. These observations suggest that monolayer adsorption predominates during the removal process of levofloxacin hydrochloride by Zn/Cr-MOFs/TiO2 composites.
- |||||||||| levofloxacin / Generic mfg., azithromycin / Generic mfg.
MYCOPLASMA PNEUMONIAE INDUCED REACTIVE INFECTIOUS MUCOCUTANEOUS ERUPTION ASSOCIATED WITH COAGULOPATHY (Monitor 15; Hall A) - Sep 29, 2024 - Abstract #ACAAI2024ACAAI_966;
Respiratory viral panel was positive for Mycoplasma pneumoniae, and he was treated with azithromycin and prednisolone...He was started on levofloxacin, steroids, and given intravenous immunoglobulin...We Abstracts: Medically Challenging Case Abstracts / Ann Allergy Asthma Immunol 00 (2024) 1?110 105 hypothesize the coagulopathy was secondary to lupus anticoagulant or a unknown factor deficiency, but further investigation was limited by prior FFP administration. The association between RIME and coagulopathy has not been previously described in the literature and requires further research.
- |||||||||| CONTRAST UNVEILED: NAVIGATING THE ENIGMA OF GENERALIZED FIXED DRUG ERUPTION (Monitor 2; Hall A) - Sep 29, 2024 - Abstract #ACAAI2024ACAAI_953;
Initially admitted for arteriovenous fistula abscess cellulitis, he received cefepime and vancomycin. Following a CT pulmonary embolism protocol with iohexol contrast, ceftriaxone was added to his regimen...The patient was switched to cefdinir for two weeks, resolving the cellulitis but with persistent rash...The patient was given levofloxacin due to concern for prior reactions to cephalosporins...He also received midazolam, fentanyl, and local anesthetics...A) Deep brown and grey patches, consistent with postinflammatory hyperpigmentation, on the patient
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
ASSESSMENT OF POTENTIAL CROSSREACTIVITY REACTIONS AND CHARACTERISTICS OF HOSPITAL INPATIENTS CLAIMING A QUINOLONE DRUG ALLERGY (Monitor 17; Hall A) - Sep 29, 2024 - Abstract #ACAAI2024ACAAI_783;
Despite our relatively small sample size, these results highlighted the likely low risk of experiencing a cross-reaction when exposed to a different quinolone. With further research and larger sample sizes, this low cross-reactivity frequency can offer practitioners clinical guidance for implications of in-class alternatives.
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