- |||||||||| ciprofloxacin oral / Generic mfg.
Journal: Effect of Polymerization Time on the Binding Properties of Ciprofloxacin-Imprinted nanoMIPs Prepared by Solid-Phase Synthesis. (Pubmed Central) - Aug 29, 2021 The results show that different polymerization times produce nanoMIPs with different binding properties: short polymerization times (15 min) produced nanoMIPs with high binding affinity but low selectivity (K > 10 mol L, α ≈ 1); medium polymerization times (30 min-2 h) produced nanoMIPs with high binding affinity and selectivity (K ≥ 10 mol L, α 2 h) produced nanoMIPs with low binding affinity, fast dissociation kinetics and low selectivity (K ≤ 10 mol L, k > 0.2 min, α ≈ 1). The results can be explained as the combined effect of rearrangement and progressive stiffening of the polymer chains around the template molecules.
- |||||||||| levofloxacin / Generic mfg.
Journal: Development of Chitosan/Cyclodextrin Nanospheres for Levofloxacin Ocular Delivery. (Pubmed Central) - Aug 29, 2021 This surface property could promote the interaction of NPs with the negatively charged ocular tissue, increasing their residence time and, consequently, LVF efficacy. In vitro, antibacterial activity against Gram-positive and Gram-negative bacteria showed a double higher activity of CH/SBE-β-CD NPs loading LVF compared to the free drug, suggesting that chitosan NPs based on SBE-β-CD could be a useful system for the treatment of ocular infections.
- |||||||||| Retrospective data, Journal: Therapeutic Approach of Chronic Pseudomonas Infection in Cystic Fibrosis-A Network Meta-Analysis. (Pubmed Central) - Aug 28, 2021
Eighteen trials which reported on treatment with aztreonam lysine, tobramycin, colistin, levofloxacin, fosfomycin/tobramycin, and amikacin in various dosages were eligible for inclusion...Regarding change in CFQR-RSS, aztreonam lysine (t.i.d., 75 mg) and aztreonam lysine (b.i.d., 75 mg) with a 28-day run in the tobramycin inhalation solution phase had the highest probability of being the most effective treatments (SUCRA:74% and 72%, respectively)...According to CFQR-RSS no significant differences were found. Given the limitations of the studies included, validation trials are called for.
- |||||||||| rifampicin / Generic mfg.
Journal: Antimicrobial Resistance of Enterococcus sp. Isolated from Sheep and Goat Cheeses. (Pubmed Central) - Aug 28, 2021 Continuous identification of Enterococcus sp. and monitoring of their incidence and emerging antibiotic resistance is important in order to prevent a potential risk to public health caused by the contamination of milk and other dairy products, such as cheeses, made on farm level.
- |||||||||| Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi
COVID-19 MANAGEMENT IN PATIENTS AFTER HEART TRANSPLANTATION (Room H - White 1) - Aug 28, 2021 - Abstract #ESOT2021ESOT_592; Starting treatment from the 1 st day of the onset of the disease allows you to manage successfully this infectious process. In addition to standard management (antibacterial and antiviral therapy, mucoactive agents, anticoagulants), temporal reduction of immunosuppression is a key to manage COVID-19.
- |||||||||| levofloxacin / Generic mfg.
Journal: Adsorption behaviours and transfer simulation of levofloxacin in silty clay. (Pubmed Central) - Aug 28, 2021 Acidity, cations and soil organic matter could affect the adsorption of LVFX, with adsorption variation ratio of 3.3%, 3.4% and 0.6%, respectively. In addition, numerical simulation with Hydrus-1D was utilized, and the results show that LVFX may infiltrate into underground water through silty clay after 28 days and completely penetrate in 100 days.
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Journal: TiO2 thin-walled nanofiber burst tube doped with Fe2O3 nanograss for efficient degradation of levofloxacin: Effect of precursor. (Pubmed Central) - Aug 25, 2021 However, the composite prepared by adding 2% K3[Fe(C2O4)3]·3H2O has the best synergistic effect, showing the best photoresponse performance and catalytic efficiency, and achieving the degradation of 94% levofloxacin within 90 min. In this study, a simple and economical synthesis strategy was proposed, that is, TiO2/Fe2O3 heterostructure with special structure was prepared by introducing a small amount of acid or metallic acid salts into the precursor as a high-performance photocatalyst.
- |||||||||| levofloxacin / Generic mfg., clarithromycin / Generic mfg., amoxicillin / Generic mfg.
New trial: CRIHEP: Helicobacter Pylori Resistance (clinicaltrials.gov) - Aug 24, 2021 P, N=185, Completed,
- |||||||||| levofloxacin / Generic mfg., clindamycin phosphate / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
Enrollment open: Susceptibility Testing of Biofilm to Guide Treatment of Periprosthetic Joint Infections (clinicaltrials.gov) - Aug 23, 2021 P=N/A, N=40, Recruiting, This work will improve the knowledge about the mechanism underlying the effects of antibiotics on the larval development of house flies in the environment and provide guidance for improving the application of house fly bioconversion. Not yet recruiting --> Recruiting
- |||||||||| rifampicin / Generic mfg., amoxicillin / Generic mfg.
Journal: Assessment of Anaplasma phagocytophilum presence in early Lyme borreliosis manifested by erythema migrans skin lesions. (Pubmed Central) - Aug 22, 2021 phagocytophilum may be present in early Lyme borreliosis characterized by erythema migrans and should always be considered as a differential diagnostic following a tick bite and considered in treatment schemes, as these differs (in early stage of Lyme borreliosis doxycycline, amoxicillin, cefuroxime axetil and azithromycin are recommended, while in anaplasmosis the most effective courses of treatment are doxycycline, rifampin and levofloxacin). Consequently, the role of A. phagocytophilum in erythema migrans should be further studied.
- |||||||||| levofloxacin / Generic mfg., oseltamivir / Generic mfg.
Journal: Feature selection based multivariate time series forecasting: An application to antibiotic resistance outbreaks prediction. (Pubmed Central) - Aug 20, 2021 Finally, to the best of our knowledge, this is the first time that a feature selection based multivariate time series methodology is proposed for antibiotic resistance forecasting. Final results show that the best model according to the proposed multi-criteria decision making process provides a RMSE = (0.1349, 0.1304, 0.1325) and a MAE = (0.1003, 0.096, 0.0987) for 1, 2, and 3 steps-ahead predictions.
- |||||||||| levofloxacin / Generic mfg., metronidazole oral / Generic mfg.
Clinical, Journal: "Effectiveness of Jinying capsule on pelvic inflammatory disease in patients with symptom pattern of damp and heat accumulation: a double-blinded, multicenter, randomized, placebo-controlled clinical trial". (Pubmed Central) - Aug 20, 2021 Final results show that the best model according to the proposed multi-criteria decision making process provides a RMSE = (0.1349, 0.1304, 0.1325) and a MAE = (0.1003, 0.096, 0.0987) for 1, 2, and 3 steps-ahead predictions. Jinying capsule can reduce the dosage of antibiotics needed for PID treatment, and improve the symptoms in PID patients.
- |||||||||| clarithromycin / Generic mfg., amoxicillin / Generic mfg.
[VIRTUAL] What to Do With Antibiotic Resistant H. Pylori Infection? () - Aug 19, 2021 - Abstract #APDW2021APDW_560; Vonoprazan-based dual or triple therapies are promising alternative...Bismuth-based quadruple therapy or Levofloxacin/bismuth-based quadruple therapy combining either amoxicillin or tetracycline are recommended for rescue therapy...Bismuth has a synergistic effect with anti biotics, and overcomes clarithromycin resistance. Susceptibility-guided therapy or genotype resistance-guided therapy is recommended after multiple failures.
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[VIRTUAL] H. Pylori Eradication Strategy – East vs. West () - Aug 19, 2021 - Abstract #APDW2021APDW_559; The keys to curing the infection are to treat it as an infectious disease and rely on what works locally instead of guideline that have no relevance to local conditions. All guidelines must be developed locally.
- |||||||||| Sirturo (bedaquiline) / J&J, Pharmstandard
Review, Journal: Principles of chemotherapy for tuberculosis in national tuberculosis programmes of low- and middle-income countries. (Pubmed Central) - Aug 18, 2021 The use of WHO-recommended bedaquiline-containing regimens in the treatment of MDR-/RR-TB patients with undetected resistance to fluoroquinolones runs a high risk of acquired bedaquiline resistance, especially in settings with a high prevalence of fluoroquinolone resistance. It is crucial to mitigate the risks of both primary and acquired resistance of rifampicin, fluoroquinolone and bedaquiline by rational design of regimens and effective management of TB patients.
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Clinical, Journal: Global Testicular Infarction during Treatment for Epididymitis (Pubmed Central) - Aug 15, 2021 He was diagnosed with epididymitis and was prescribed levofloxacin...Inflammatory cell infiltration and thrombus formation were observed in almost all veins of the testis and spermatic cord, and the diagnosis of global testicular infarction associated with epididymitis was made. Global testicular infarction has been reported as a rare complication of epididymitis and should be considered in the case of atypical course of epididymitis.
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