- |||||||||| NN1213 / Novo Nordisk, Noxafil (posaconazole) / Merck (MSD)
Trial completion, Enrollment change, Trial completion date, Trial primary completion date: Observational Evaluation of Infective Risk in Myelodysplastic Syndrome Patients (clinicaltrials.gov) - Sep 12, 2021
P=N/A, N=229, Completed,
Trial completion date: Apr 2021 --> Aug 2023 | Trial primary completion date: Sep 2020 --> Jun 2023 Recruiting --> Completed | N=1000 --> 229 | Trial completion date: Dec 2018 --> Oct 2020 | Trial primary completion date: Dec 2018 --> Oct 2020
- |||||||||| amodiaquine hydrochloride / Generic mfg.
Preclinical, Journal: In Vivo Activity of Repurposed Amodiaquine as a Host-Targeting Therapy for the Treatment of Anthrax. (Pubmed Central) - Sep 11, 2021
Lastly, a systematic literature review of the safety and pharmacokinetics of AQ in humans from over 2 000 published articles revealed that AQ is likely safe when taken as prescribed, and its pharmacokinetics predicts anthrax efficacy in humans. Our results support the future examination of AQ as adjunctive therapy for the prophylactic anthrax treatment.
- |||||||||| ketamine / Generic mfg.
Neurological Impact of Hyperammonemia Induced by Ureaplasma Parvum Infection Post Lung Transplantation — A Case Series () - Sep 10, 2021 - Abstract #NCS2021NCS_261;
Although use of pharmacologic agents and continuous renal replacement therapy (CRRT) helped lower ammonia level, patient failed to wean off high dose Ketamine drip for SRSE and ultimately succumbed to his disease.Case 2:A 63- year-old male presented for bilateral lung transplant due to acute respiratory distress syndrome following Coronavirus Disease 2019 (COVID-19) pneumonia...Conclusions Unexplained hyperammonemia in post-transplant patients should raise the concern for underlying Ureaplasma or Mycoplasma infection as a possible etiology. Aggressive treatment strategies to lower serum ammonia and bacterial source control may help prevent irreversible brain injury with poor neurologic outcome.
- |||||||||| levofloxacin / Generic mfg., clindamycin phosphate / Generic mfg.
Journal: A Comparative Analysis of Antibiotic Usage in Diabetic Foot Infections Against Healing Time. (Pubmed Central) - Sep 9, 2021
The use of empiric antibiotic therapy before targeted therapy and the topical use of gentamycin did not reduce the healing time of diabetic foot infection. The healing time of diabetic foot infection was longer in obese patients than in nonobese patients.
- |||||||||| tetracycline / Generic mfg.
Journal: Synthesis of multi-color fluorine and nitrogen co-doped graphene quantum dots for use in tetracycline detection, colorful solid fluorescent ink, and film. (Pubmed Central) - Sep 9, 2021
Finally, large-area flexible multi-color fluorescent films are realized. Our synthesized F, N-GQDs, with tunable fluorescence in wavelength and intensity, have numerous opportunities for optical molecular sensors, information security, flexible optics, and others.
- |||||||||| vancomycin / Generic mfg., levofloxacin / Generic mfg.
Can Heavy Opioid Use Mask the Symptoms of C. difficile Colitis? A Case Report (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_1567;
Case Description/ A 77-year-old female with myelodysplastic syndrome, recent hospitalization for cholangitis treated with levofloxacin and bilateral lower extremity fractures on opioids presented to the ED with weakness and was found to have symptomatic anemia...On HD#5, a GI PCR panel was collected from a formed stool, which resulted positive for C. Diff antigen and toxin, and oral vancomycin was started...It would be worthwhile to avoid or reduce opioids in patients that carry risk factors of CDI and are admitted with sepsis. Alternatively, CDI testing should be considered in a patient who is taking opioids that shows signs of colitis without diarrhea.
- |||||||||| ceftriaxone / Generic mfg., cyclosporine / Generic mfg.
TB or Not TB: Tuberculous Peritonitis in a Patient With Decompensated Cirrhosis (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_1559;
Ceftriaxone was started for presumed spontaneous bacterial peritonitis despite inconsistent fluid studies...Empiric treatment with isoniazid, ethambutol, linezolid and levofloxacin was initiated with resolution of fevers...He then developed diffuse maculopapular rash and cyclosporine was switched to amikacin...First line antitubercular treatment is not recommended with existing liver dysfunction. This case demonstrates the high index of suspicion required for diagnosis of tuberculous peritonitis as well as the imperativeness of initiating a tailored regimen in patients with underlying liver disease to avoid undue complications and mortality.Figure: Ascitic fluid cytopathology: Scattered reactive appearing mesothelial cells and mild inflammation
- |||||||||| clarithromycin / Generic mfg.
Helicobacter pylori Antibiotic Resistance in the United States Over the Last 10 Years: A Systematic Review and Meta-Analysis (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_1487;
The pooled resistance prevalence to metronidazole was 36.3% [95% CI 23.4%-51.4%], levofloxacin 31.9% [95% CI 15.8%-53.8%], clarithromycin 31.4% [95% CI 22.6%-41.7%], amoxicillin 2.7% [95% CI 1.4%-5.2%], tetracycline 0.4% [95% CI 0.1%-3.5%], clarithromycin/metronidazole combination (CM) 9.2% [95% CI 3.7%-21.2%], and clarithromycin/metronidazole/levofloxacin combination 3.7% [95% CI 1.3%-9.9%] (see forest plots in figure). Rifabutin resistance was 0% and 0.5% (2 studies only).
- |||||||||| levofloxacin / Generic mfg.
Acute Appendicitis Resulting in Sigmoid Obstruction (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_1460;
He was treated with levofloxacin and metronidazole for suspected diverticulitis...J West Afr Coll Surg. 2017;7(3):94-115.Figure: A) Appendiceal base; microscopic description consistent with acute appendicitisB) Opened sigmoid colon with an attached 3.5 cm x 0.5 cm tubular shaped portion of appendix vermiformisC) Closer view of mucosal surface of the sigmoid colon composed of multiple diverticula occluded with fecaliths as well as several areas with perforations of diverticula into the pericolonic fat with exudate
- |||||||||| levofloxacin / Generic mfg., warfarin / Generic mfg.
Budd-Chiari Syndrome Secondary to an Amebic Liver Abscess (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_1441;
Predominantly necrotic/degenerating cellular debris and many neutrophils 1(c): Colon. H&E.; 10x: Active chronic colitis with focal surface ulceration 1(d): Colonoscopy demonstrating mild to moderate inflammatory changes of the cecum and ascending colon
- |||||||||| levofloxacin / Generic mfg., paracetamol / Generic mfg.
Celiacomesenteric Trunk Variant Occlusion: A Culprit of Mesenteric Ischemia (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_1138;
Acute hepatitis and autoimmune serologies were negative, as were acetaminophen, salicylate, and ethanol levels...Due to the temporality of levofloxacin prescription, elevated liver enzymes were attributed to drug-induced liver injury...Compromised blood flow from the CMT to hepatic artery likely contributed to ischemic hepatitis as well. Gastroenterologists should be cognizant of CMT variant occlusion as a cause of mesenteric ischemia.Figure: (a) Coronal, (b) sagittal, and (c) axial views of the celiacomesenteric trunk, with green arrows indicating the bifurcation as the SMA originates from the celiac trunk.
- |||||||||| ceftriaxone / Generic mfg., amoxicillin / Generic mfg.
A Tale of Two Cultures: A Case of a Recurrence of Multi-Drug-Resistant Spontaneous Bacterial Peritonitis (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_888;
Ceftriaxone was switched to ertapenem and ultimately levofloxacin...While 3rd generation cephalosporins are commonly used for therapy and prophylaxis, our case sheds light on some of the therapeutic challenges in treating SBP effectively, particularly with regards to potential selection for drug-resistant gram-positive organisms. As resistant organisms and gram-positive organisms are encountered more frequently in SBP, it is imperative that antibiotics are selected and used appropriately.
- |||||||||| Prevymis (letermovir) / Merck (MSD), Noxafil (posaconazole) / Merck (MSD)
Pseudomelanosis Duodeni: A Rare and Incidental Endoscopic Finding (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_613;
His home medications included hydralazine, metoprolol, doxazosin, famciclovir, letermovir, atovaquone, posaconazole, prednisone, montelukast, and famotidine...His symptoms resolved after several days, and he was discharged on oral levofloxacin and vancomycin...Upper endoscopy demonstrates diffuse speckled dark pigmentation throughout the duodenal bulb (A). Histological examination of duodenal biopsies reveals pigment deposition within the lamina propria (B, hematoxylin and eosin stain) that stains negatively for iron (C, Prussian blue stain).
- |||||||||| levofloxacin / Generic mfg.
Radiofrequency Ablation of Recurrent Pancreatic Neuroendocrine Tumor in Multiple Neuroendocrine Neoplasia Type 1 (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_521;
The patient received antibiotic prophylaxis with levofloxacin...Figure: Figure 1: Endosonographic images using a 7.5MHz linear echoendoscope demonstrating small neuroendocrine tumors in the pancreatic body pre-ablation (A and B). Post-ablation images (C and D) showing the radiofrequency trocar in the lesions with the characteristic hyperechoic bubbling appearance confirming the distribution of the ablation zone.
- |||||||||| levofloxacin / Generic mfg.
Cholangiocarcinoma Unmasked by Cholangitis (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_401;
Intravenous Fluids and Levofloxacin led to improvement in mental status and renal function...US and CT sensitivity for choledocholithiasis vary between 50-75% and 72-88% respectively. A high degree of clinical suspicion is required and often Magnetic Resonance Cholangiopancreatography and/or ERCP may be required to diagnose underlying cholangiocarcinoma in cholangitis.
- |||||||||| clarithromycin / Generic mfg.
Mycobacterium celatum: A New Pathogen of the Pancreas (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_387;
Treatment regimens include combinations of azithromycin, clarithromycin, ciprofloxacin, ethambutol, rifabutin, and amikacin for long periods. These organisms should be suspected when acid-fast organisms do not respond to standard mycobacterial therapy.Figure: Figure 1: A: Computed tomography of the abdomen and pelvis demonstrating dilatation of the common bile duct to 13 mm as well as a large, cystic or necrotic pancreatic mass measuring 64 mm by 25 mm by 45 mm; B: Endoscopic Ultrasound demonstrating multiple anechoic, septated cystic lesions in the pancreatic head, body, and tail with the largest measuring 60 mm by 44 mm.
- |||||||||| Sivextro (tedizolid) / Merck (MSD), Nabriva Therap
Trial completion: TEDIZOAM: Tedizolid Prolonged Treatment for Prosthetic Joint Infections (clinicaltrials.gov) - Sep 8, 2021
P=N/A, N=35, Completed,
These organisms should be suspected when acid-fast organisms do not respond to standard mycobacterial therapy.Figure: Figure 1: A: Computed tomography of the abdomen and pelvis demonstrating dilatation of the common bile duct to 13 mm as well as a large, cystic or necrotic pancreatic mass measuring 64 mm by 25 mm by 45 mm; B: Endoscopic Ultrasound demonstrating multiple anechoic, septated cystic lesions in the pancreatic head, body, and tail with the largest measuring 60 mm by 44 mm. Active, not recruiting --> Completed
- |||||||||| levofloxacin / Generic mfg., ceftazidime / Generic mfg.
Clinical, Journal: Clinico-microbiological profile of Burkholderia cepacia keratitis: a case series. (Pubmed Central) - Sep 8, 2021
cepacia keratitis primarily affects patients with preexisting ocular disease, particularly herpetic keratitis, and responds well to ceftazidime or fluoroquinolones. However, the visual outcomes are generally poor.
- |||||||||| levofloxacin / Generic mfg., lopinavir/ritonavir / Generic mfg.
Clinical, Journal: Swab and Sputum SARS-CoV-2 RNA-Negative, CT-Positive, Symptomatic Contacts of COVID-19 Cases: A Hypothesis-Generating Prospective Population-Based Cohort Study of Eight Clusters. (Pubmed Central) - Sep 7, 2021
Lopinavir/ritonavir was more often administered in Groups 1 and 2 than in Group 3...Such cases might add to the complexity and difficulty of COVID-19 control. Our hypothesis-generating study might suggest that SARS-CoV-2 RNA testing by rRT-PCR assays of common respiratory (throat swab and sputum) specimens alone, the widely accepted "golden standard" for diagnosing COVID-19, might be sometimes insufficient, and that further studies with some further procedures (e.g., testing via bronchoalveolar lavage or specific antibodies) would be warranted for Group 2-like patients, namely, the SARS-CoV-2 RNA-negative (tested using common respiratory specimens), radiographically positive, symptomatic contacts of COVID-19 cases, to further reveal their nature.
- |||||||||| levofloxacin / Generic mfg.
Comparative efficacy of a short 48-hour treatment with levofloxacin versus a treatment with the same molecule for a period guided by the monitoring of inflammation biomarkers (CRP) in COPD exacerbation (Room 5C) - Sep 7, 2021 - Abstract #EUSEM2021EUSEM_1413;
Our hypothesis-generating study might suggest that SARS-CoV-2 RNA testing by rRT-PCR assays of common respiratory (throat swab and sputum) specimens alone, the widely accepted "golden standard" for diagnosing COVID-19, might be sometimes insufficient, and that further studies with some further procedures (e.g., testing via bronchoalveolar lavage or specific antibodies) would be warranted for Group 2-like patients, namely, the SARS-CoV-2 RNA-negative (tested using common respiratory specimens), radiographically positive, symptomatic contacts of COVID-19 cases, to further reveal their nature. This study showed that the antibiotic therapy strategy of standard duration (7 days) or guided by monitoring of CRP in the management of COPD exacerbation is not superior to a short treatment of 2 days only.
- |||||||||| Evolution of empirical antibiotic therapy among septic patients in an emergency department (Posters) - Sep 7, 2021 - Abstract #EUSEM2021EUSEM_448;
The initiation of early antibiotic therapy in the ED among septic patients has improved significantly from 2014 to 2018. There is a progressive decrease in the use of levofloxacin, in favor of the use of third generation cephalosporins and carbapenemics, the rest of antibiotic therapy that is used seems punctual in selected cases.
- |||||||||| levofloxacin / Generic mfg.
An old acquaintance in the water (Posters) - Sep 7, 2021 - Abstract #EUSEM2021EUSEM_442;
He took levofloxacin without improving...It is so important to have a high suspicion to diagnose this pathology. A good medical history and a good physical examination is essential for a wide differential diagnosis and to be able to guide patients in the best possible way.
- |||||||||| amoxicillin / Generic mfg.
NOT ALL INFILTRATE IS A PNEUMONIA (Posters) - Sep 7, 2021 - Abstract #EUSEM2021EUSEM_423;
A 45-year-old woman who went to the emergency room due to persistent irritative cough, sometimes accompanied by mucus described as "reddish", despite treatment antibiotic with Amoxicillin and Azithromycin started 48 hours before...Treatment with Levofloxacin 500mg iv is started, cross-tests are requested to carry out a transfusion of 2 red blood cell concentrates and oxygen therapy is started with nasal glasses at 2 lpm...The majority of patients with respiratory symptoms and infiltrates on chest radiography will have an infectious pathology, but we must know other syndromes that can present with a similar clinical picture and are much more infrequent in diagnosis, as in the case presented to us. The knowledge of these entities and a quick approach in the management of these patients can greatly improve the associated prognosis.
- |||||||||| levofloxacin / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Can bedside pulmonary ultrasound replace other tests to diagnose pneumonia? (Posters) - Sep 7, 2021 - Abstract #EUSEM2021EUSEM_387;
Brief clinical history: A 25-year-old woman who came to the Emergency Room (ER) with dyspnea of minimum efforts, audible wheezing, aphonia and cough with greenish sputum and fever around 37.5-38.5 ºC with 7-days of evolution and with poor evolution even though he was taking amoxicillin+clavulanic acid...It was decided to carry out treatment with Levofloxacin due to suspicion of Pseudomonas or atypical germs, with clinical and imaging resolution in 10 days...It is also relatively cheap, widely available (and increasingly, and more portable), and has no side effects. This work highlights the use of bedside thoracic ultrasound for the differential diagnosis between pneumonia and atelectasis, thus reducing the number of CT scans or fiberoptic bronchoscopies.
- |||||||||| ethambutol / Generic mfg., levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Journal: WQ-3810: A new fluoroquinolone with a high potential against fluoroquinolone-resistant Mycobacterium tuberculosis. (Pubmed Central) - Sep 5, 2021
However, the combination of WQ-3810 and ethambutol showed the greatest degree of synergistic activity against recombinant strains. Since FQs and ethambutol have been used in multi-drug therapy for tuberculosis, WQ-3810 might represent a new, potent anti-tuberculosis drug that can be effective even against FQ-resistant Mtb strains.
- |||||||||| Journal: Development of antibiotic resistance in the ocular Pseudomonas aeruginosa clone ST308 over twenty years. (Pubmed Central) - Sep 5, 2021
All isolates contained genes encoding for aminoglycoside (aph(6)-Id, aph(3')-lIb, aph(3″)-Ib), beta-lactam (blaPAO), tetracycline (tet(G)), fosfomycin (fosA), chloramphenicol (catB7), sulphonamide (sul1), quaternary ammonium (qacEdelta1) and fluoroquinolone (crpP) resistance...These findings suggest that genomes of P. aeruginosa ocular clonal strains with >95% nucleotide identity isolated twenty years apart had changed over time with the acquisition of resistance genes. The pattern of gene mutations also varied with more insertions and deletions in their chromosomal genes which confer resistance to antibiotics.
- |||||||||| levofloxacin / Generic mfg.
Clinical, Journal: Vertebral Artery Dissection after Exposure to Levofloxacin: A Report of Two Cases. (Pubmed Central) - Sep 5, 2021
These two cases indicate that quinolone exposure can be a risk factor for vertebral artery dissection. Considering the possible mechanism, it is better to avoid the prescription of quinolones to patients who have insufficient connective tissues to avoid vertebral artery dissection.
- |||||||||| levofloxacin / Generic mfg.
Retrospective data, Journal: Infectious keratitis after corneal crosslinking for keratoconus caused by levofloxacin-resistant microorganisms. (Pubmed Central) - Sep 2, 2021
Infectious keratitis after CXL caused by microbes resistant to LVFX is increasing. In addition to careful postoperative observation of the cornea, preoperative evaluation of bacteria within the conjunctival sac evident on nasal swab cultures may be useful to identify potentially problematic microbes and inform the selection of appropriate antibiotics.
- |||||||||| amoxicillin / Generic mfg.
Retrospective data, Journal: Venous leg ulcer healing time is increased with each subsequent bacterial strain identified in the ulcer. A retrospective study. (Pubmed Central) - Sep 2, 2021
In addition to careful postoperative observation of the cornea, preoperative evaluation of bacteria within the conjunctival sac evident on nasal swab cultures may be useful to identify potentially problematic microbes and inform the selection of appropriate antibiotics. Venous leg ulcer healing time was prolonged with each subsequent bacterial strain in the ulcer, and it was independent from systemic antibiotic therapy.
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