levofloxacin / Generic mfg. 
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  • ||||||||||  clarithromycin / Generic mfg., amoxicillin / Generic mfg.
    Clinical, Journal:  Rescue Therapy with Furazolidone in Patients with at Least Five Eradication Treatment Failures and Multi-Resistant H. pylori infection. (Pubmed Central) -  Sep 29, 2021   
    Adverse effects were reported in two (25%) patients, and all were mild. Even after five or more previous H. pylori eradication failures, and a multi-resistant infection, rescue treatment with furazolidone may be effective in approximately two-thirds of the cases, constituting a valid strategy after multiple previous eradication failures with key antibiotics such as clarithromycin, metronidazole, tetracycline, levofloxacin, and rifabutin.
  • ||||||||||  ceftriaxone / Generic mfg.
    Journal:  Non-Penicillin-Susceptible Streptococcus suis Isolated from Humans. (Pubmed Central) -  Sep 29, 2021   
    Almost all isolates were resistant to tetracycline (98.2%), clindamycin (94%), erythromycin (92.4%), and azithromycin (82.6%)...ST25 isolates exhibited fewer amino acid substitutions than isolates of other STs in all five PBPs. The antimicrobial resistance of S. suis is increasing worldwide; therefore, restrictions on antimicrobial use, continuous control, and the surveillance of this bacterium throughout the pork supply chain are crucial for ensuring public health and must be a priority concern.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery. (Pubmed Central) -  Sep 29, 2021   
    Then, the ophthalmic drug levofloxacin (LEV) was encapsulated into the nanogels...As a result, the optimized contact lens with nanogel-loading content of 8 wt% could sustainably deliver LEV for ten days, with critical lens properties within the range of recommended values for commercial contact lenses. Moreover, cell viability assays revealed that the prepared contact lenses were cytocompatible, suggesting their significant potential as an alternative to traditional eye drops or ointment formulations for long-term oculopathy treatment.
  • ||||||||||  Lamprene (clofazimine) / Novartis, Sirturo (bedaquiline) / J&J, Pharmstandard, NN1213 / Novo Nordisk
    Trial primary completion date:  STREAM: The Evaluation of a Standard Treatment Regimen of Anti-tuberculosis Drugs for Patients With MDR-TB (clinicaltrials.gov) -  Sep 29, 2021   
    P3,  N=588, Active, not recruiting, 
    Moreover, cell viability assays revealed that the prepared contact lenses were cytocompatible, suggesting their significant potential as an alternative to traditional eye drops or ointment formulations for long-term oculopathy treatment. Trial primary completion date: Jul 2021 --> Dec 2021
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Growth arrest or drug target inactivity is not sufficient for persister formation in E. coli. (Pubmed Central) -  Sep 29, 2021   
    Similarly, knockdown of GyrA, a quinolone drug target, did not induce persister cells tolerant to levofloxacin...Thus, we conclude that growth arrest or target inactivation is not sufficient to produce persister phenotype as commonly assumed and that cellular ATP levels did not correlate with persister formation. Further studies are needed to better understand how persisters are formed for improved treatment of persistent infections.
  • ||||||||||  levofloxacin / Generic mfg., gentamicin sulfate / Generic mfg.
    Journal:  Antibiotic susceptibility test under a linear concentration gradient using travelling surface acoustic waves. (Pubmed Central) -  Sep 29, 2021   
    Two ASTs, namely Pseudomonas aeruginosa against gentamicin and levofloxacin were chosen for the case of slowly proliferating bacteria, and one AST, namely Escherichia coli against gentamicin, were chosen for the rapidly proliferating case. Appropriate antibiotic doses for Pseudomonas aeruginosa and Escherichia coli were each obtained in an efficient manner.
  • ||||||||||  rifampicin / Generic mfg.
    [VIRTUAL] An Old Foe in a New Spot – TB in the Sella () -  Sep 25, 2021 - Abstract #AAPNCE2021AAP_NCE_1675;    
    Concurrent tuberculomas may manifest as space occupying lesions, often requiring a high index of suspicion for diagnosis. CNS tuberculomas are typically in the frontoparietal regions, but in this case found in the suprasellar space causing pituitary dysfunction and endocrinopathies.
  • ||||||||||  Clinical, Journal:  Successful management of a pregnant woman with COVID-19 and multiple severe complications. (Pubmed Central) -  Sep 25, 2021   
    Blood culture grew Enterococcus galinarum Meanwhile, bleeding of the incisional wound occurred, which was controlled by the cessation of heparin therapy and regular wound care. With intensive monitoring and multidisciplinary management, the patient's condition improved, and she was discharged from the hospital on day 25 from admission.
  • ||||||||||  Gatiflox (gatifloxacin) / Orient Europharma
    Journal:  Fluoroquinolones: Blessings Or Curses. (Pubmed Central) -  Sep 23, 2021   
    The subsequent agents like levofloxacin, ofloxacin, norfloxacin, gatifloxacin, moxifloxacin, clinafloxacin, sparfloxacin, and ciprofloxacin were derived through side chain and nuclear manipulation from basic pharmacophore...The post marketing surveillance pointed out the favorable side effects associated with fluoroquinolones such as phototoxicity, QT interval prolongation and anaphylaxis. The discovery, development and clinical use of fluoroquinolone antibiotics in the last century contributed to a decline in morbidity and mortality rates.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  The POM@MOF hybrid derived hierarchical hollow Mo/Co bimetal oxides nanocages for efficiently activating peroxymonosulfate to degrade levofloxacin. (Pubmed Central) -  Sep 23, 2021   
    By altering the surface porosity, electronic structure, and oxygen vacancies of CoO, hetero-metal Mo doping induced Mo/Co HHBONs significantly promote the generation of reactive oxygen species, including OH, SO, O, and O. Density functional theory indicated that Mo/Co HHBONs had better adsorption, enhanced electron-transfer abilities, and a longer O-O bond length than did CoO, for improved catalytic reactivity. This research provides a new strategy to design the POM@MOF hybrids derived hierarchical hollow nanocages with highly PMS activating capacity for the removal of antibiotics and other refractory contaminants.
  • ||||||||||  levofloxacin / Generic mfg.
    Observational data, Journal:  Levofloxacin or gonadotropin releasing hormone agonist treatment decreases intrauterine microbial colonization in human endometriosis. (Pubmed Central) -  Sep 23, 2021   
    Further investigation of the predisposing factors and the development of more effective strategies for the prevention of BSI should be a significant public health priority. These findings suggest that clinical administration of a broad-spectrum antibiotic with or without GnRHa may be effective in improving uterine infection with decrease of tissue inflammation, cell proliferation, and angiogenesis in human endometriosis.
  • ||||||||||  rifampicin / Generic mfg.
    Tuberculosis as a common cause of post-liver transplant ascites () -  Sep 19, 2021 - Abstract #IDDF2021IDDF_173;    
    One of the patients developed ATT-induced liver injury and graft dysfunction after switching from rifampicin to rifabutin...Although global data suggest vascular etiologies as a common cause of persistent ascites post-transplant, in the Indian scenario, tuberculosis should always be considered as a differential diagnosis while evaluating these patients. Being a potentially curable cause, it significantly improves graft survival after treatment.
  • ||||||||||  clarithromycin / Generic mfg.
    Review, Journal:  Helicobacter pylori Treatment Strategies in Singapore. (Pubmed Central) -  Sep 19, 2021   
    Identifying options to further improve treatment success rates is challenging. Strategies being considered include the use of potent acid suppressants, such as vonoprazan, and H. pylori culture and antibiotic susceptibility testing-guided therapy.
  • ||||||||||  clarithromycin / Generic mfg.
    Clinical, Journal:  Comparing the Efficacy of Sequential and Standard Quadruple Therapy for Eradication of H. Pylori Infection. (Pubmed Central) -  Sep 19, 2021   
    Group B (sequential regimen) received omeprazole and amoxicillin in 5 days and omeprazole, tinidazole and levofloxacin in 5 days...No significant difference was seen between two groups, regarding H. pylori eradication (p = 0.15). The most common side effects in group A, B were bitterness of mouth (63.8%) and nausea (16.2%), respectively (p H. pylori infection, higher rate of H. pylori eradication was seen in group B than group A. Thus, sequential regimen was a more appropriate regimen with fewer complications.
  • ||||||||||  Clinical, Journal:  Epidemiological analysis of pneumococcal strains isolated at Yangon Children's Hospital in Myanmar via whole-genome sequencing-based methods. (Pubmed Central) -  Sep 19, 2021   
    A minimum inhibitory concentration assay indicated that several pneumococcal strains had acquired azithromycin and tetracycline resistance, whereas no strains were found to be resistant against levofloxacin and high-dose penicillin G. Phylogenetic and pangenome analysis showed various pneumococcal lineages and that the pneumococcal strains contain a rich and mobile gene pool, providing them with the ability to adapt to selective pressures. This molecular epidemiological information can help in tracking global infection and supporting AMR control in addition to public health interventions in Myanmar.
  • ||||||||||  levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
    Journal:  Genomic insights into evolution of extensive drug resistance in Stenotrophomonas maltophilia complex. (Pubmed Central) -  Sep 17, 2021   
    There is also need for surveillance of the usage of disinfectants and other antimicrobials for environmental hygiene and linked/rapid co-evolution of XDR in nosocomial pathogens. Repositories: Complete genome sequence of Stenotrophomonas maltophilia SM866: CP031058.
  • ||||||||||  ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., norfloxacin / Generic mfg.
    Journal:  Fluoroquinolone use in a rural practice. (Pubmed Central) -  Sep 17, 2021   
    Appropriate clinical caution should be exercised in the prescribing of FQs. Common overuse seems to occur in the treatment of uncomplicated community-acquired pneumonia and cystitis, despite recommendations to use other antimicrobial agents as first-line treatments.
  • ||||||||||  Invanz (ertapenem) / Merck (MSD), Timcynis (ticarcillin and clavulanic acid) / Emcure, NN1213 / Novo Nordisk
    Trial completion, Trial completion date:  The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial (clinicaltrials.gov) -  Sep 16, 2021   
    P=N/A,  N=1552, Completed, 
    The isolates also exhibited a strong biofilm formation ability and low susceptibility to eradication, indicating that more effective drugs and treatment methods are needed to combat these infections. Active, not recruiting --> Completed | Trial completion date: Mar 2021 --> Sep 2021
  • ||||||||||  ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
    Journal:  Hydrophilic deep eutectic solvents modified phenolic resin as tailored adsorbent for the extraction and determination of levofloxacin and ciprofloxacin from milk. (Pubmed Central) -  Sep 16, 2021   
    The choline chloride-glycerol-based resin (DES-R) with the highest adsorption amounts was selected and the adsorption behavior of it was studied with static adsorption and the dynamic adsorption performance; the adsorption process followed Freundlich isotherm (R ≥ 0.9337) and pseudo-second-order (R ≥ 0.9951). The present DES-R-SPE method showed good linear range from 0.5 to100 μg mL (R ≥ 0.9998), good recoveries of spiked milk samples (LEV, 96.7%; CIP, 101.5%), and satisfied repeatability for intra-day and inter-day (LEV, RSD≤5.4%; CIP, RSD≤4.6%).