- |||||||||| Nuzyra (omadacycline) / Paratek
[VIRTUAL] Omadacycline in Vitro Activity Against Bacillus Anthracis () - Oct 6, 2021 - Abstract #IDWeek2021IDWeek_2103;
Based on the in vitro activity in both studies, omadacycline has the potential to be effective in treating anthrax infection. Reproducibility of omadacycline in vitro activity against B. anthracis was observed at 2 independent study sites .
- |||||||||| levofloxacin / Generic mfg.
[VIRTUAL] Covering Your Tracts? The Effect of Antibiotic Prophylaxis on Respiratory Tract Infections in Pediatric Acute Lymphoblastic Leukemia () - Oct 6, 2021 - Abstract #IDWeek2021IDWeek_2013;
There was no observed difference in RTI, hospitalization, oxygen supplementation, or ICU admission for RTI between participants receiving or not receiving antibiotic prophylaxis in this cohort. B ecause of the relatively low number and severity of respiratory infections, and the high proportion that are viral in etiology, it would likely take a very large sample size to determine the impact of antibacterial prophylaxis on respiratory infections during induction therapy for pediatric ALL.
- |||||||||| levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
[VIRTUAL] Short-Course Therapy and Transition to Enteral Antibiotics for Uncomplicated Bacteremia Due to Enterobacterales Species () - Oct 6, 2021 - Abstract #IDWeek2021IDWeek_1984;
This quality improvement initiative demonstrates the potential benefits of education and electronic documentation tools to facilitate evidence-based practice changes, but also highlights the difficulty in changing practice even amongst ID clinicians. Further PDSA cycles will be targeted at increasing more consistent awareness among a large ID division in addition to other stakeholders.
- |||||||||| [VIRTUAL] In vitro Activity of PLG0206 Against Isolates Commonly Found in Periprosthetic Joint Infections (PJI) () - Oct 6, 2021 - Abstract #IDWeek2021IDWeek_1967;
Imipenem, levofloxacin, tigecycline, linezolid, vancomycin, oxacillin, ceftazidime, colistin, and amikacin were tested as comparators. PLG0206 was found to have potent antimicrobial activity when evaluated in RPMI against S. epidermidis , CoNS non-epidermidis, S. aureus , Enterobacterales, P. aeruginosa , and A. baumannii, including isolates with multi-drug resistance.
- |||||||||| Mycobutin (rifabutin) / Pfizer, Lupin
[VIRTUAL] A Patient with Anemia and Sepsis three weeks Post-partum. () - Oct 6, 2021 - Abstract #IDWeek2021IDWeek_1867;
Hence IV levofloxacin, IV linezolid and IV streptomycin were started...Rifampin was switched to rifabutin secondary to ongoing liver injury and she remains on two drug regimen with isoniazid and rifabutin anticipating a total of twelve months of therapy...This allowed for a greater concentration of interferon-gamma to be produced in the later assay. Final Diagnosis: Disseminated T uberculosis.
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
[VIRTUAL] Fluoroquinolone Stewardship at a Community Health-System: A Decade in Review () - Oct 6, 2021 - Abstract #IDWeek2021IDWeek_1004;
The Norton Healthcare antimicrobial stewardship program has been effective in reducing unnecessary fluoroquinolone usage and improving inpatient fluoroquinolone susceptibility rates. Future studies should examine opportunities to translate successes to the outpatient phase of care.
- |||||||||| clarithromycin / Generic mfg., amoxicillin / Generic mfg.
Clinical, Journal: Efficacy of a tailored PCR-guided triple therapy in the treatment of Helicobacter pylori infection. (Pubmed Central) - Oct 3, 2021
P=N/A
ASU must remain agile during pandemics to detect emerging problems and adapt processes to counter early. In a country with a high level of clarithromycin resistance, tailored PCR-guided therapy was superior to empirical triple therapy for H. pylori eradication (https://www.ClinicalTrials.gov: NCT01168063).
- |||||||||| Evolution of empirical antibiotic therapy among septic patients in an emergency department () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2969;
The initiation of early antibiotic therapy in the ED among septic patients has improved significantly from 2014 to 2018. There is a progressive decrease in the use of levofloxacin, in favor of the use of third generation cephalosporins and carbapenemics, the rest of antibiotic therapy that is used seems punctual in selected cases.
- |||||||||| Evolution of empirical antibiotic therapy among septic patients in an emergency department () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2968;
The initiation of early antibiotic therapy in the ED among septic patients has improved significantly from 2014 to 2018. There is a progressive decrease in the use of levofloxacin, in favor of the use of third generation cephalosporins and carbapenemics, the rest of antibiotic therapy that is used seems punctual in selected cases.
- |||||||||| Evolution of empirical antibiotic therapy among septic patients in an emergency department () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2967;
The initiation of early antibiotic therapy in the ED among septic patients has improved significantly from 2014 to 2018. There is a progressive decrease in the use of levofloxacin, in favor of the use of third generation cephalosporins and carbapenemics, the rest of antibiotic therapy that is used seems punctual in selected cases.
- |||||||||| Evolution of empirical antibiotic therapy among septic patients in an emergency department () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2966;
The initiation of early antibiotic therapy in the ED among septic patients has improved significantly from 2014 to 2018. There is a progressive decrease in the use of levofloxacin, in favor of the use of third generation cephalosporins and carbapenemics, the rest of antibiotic therapy that is used seems punctual in selected cases.
- |||||||||| levofloxacin / Generic mfg.
An old acquaintance in the water () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2945;
He took levofloxacin without improving...It is so important to have a high suspicion to diagnose this pathology. A good medical history and a good physical examination is essential for a wide differential diagnosis and to be able to guide patients in the best possible way.
- |||||||||| levofloxacin / Generic mfg.
An old acquaintance in the water () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2944;
He took levofloxacin without improving...It is so important to have a high suspicion to diagnose this pathology. A good medical history and a good physical examination is essential for a wide differential diagnosis and to be able to guide patients in the best possible way.
- |||||||||| levofloxacin / Generic mfg.
An old acquaintance in the water () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2943;
He took levofloxacin without improving...It is so important to have a high suspicion to diagnose this pathology. A good medical history and a good physical examination is essential for a wide differential diagnosis and to be able to guide patients in the best possible way.
- |||||||||| levofloxacin / Generic mfg.
An old acquaintance in the water () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2942;
He took levofloxacin without improving...It is so important to have a high suspicion to diagnose this pathology. A good medical history and a good physical examination is essential for a wide differential diagnosis and to be able to guide patients in the best possible way.
- |||||||||| amoxicillin / Generic mfg.
NOT ALL INFILTRATE IS A PNEUMONIA () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2869;
A 45-year-old woman who went to the emergency room due to persistent irritative cough, sometimes accompanied by mucus described as "reddish", despite treatment antibiotic with Amoxicillin and Azithromycin started 48 hours before...Treatment with Levofloxacin 500mg iv is started, cross-tests are requested to carry out a transfusion of 2 red blood cell concentrates and oxygen therapy is started with nasal glasses at 2 lpm...The majority of patients with respiratory symptoms and infiltrates on chest radiography will have an infectious pathology, but we must know other syndromes that can present with a similar clinical picture and are much more infrequent in diagnosis, as in the case presented to us. The knowledge of these entities and a quick approach in the management of these patients can greatly improve the associated prognosis.
- |||||||||| amoxicillin / Generic mfg.
NOT ALL INFILTRATE IS A PNEUMONIA () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2868;
A 45-year-old woman who went to the emergency room due to persistent irritative cough, sometimes accompanied by mucus described as "reddish", despite treatment antibiotic with Amoxicillin and Azithromycin started 48 hours before...Treatment with Levofloxacin 500mg iv is started, cross-tests are requested to carry out a transfusion of 2 red blood cell concentrates and oxygen therapy is started with nasal glasses at 2 lpm...The majority of patients with respiratory symptoms and infiltrates on chest radiography will have an infectious pathology, but we must know other syndromes that can present with a similar clinical picture and are much more infrequent in diagnosis, as in the case presented to us. The knowledge of these entities and a quick approach in the management of these patients can greatly improve the associated prognosis.
- |||||||||| amoxicillin / Generic mfg.
NOT ALL INFILTRATE IS A PNEUMONIA () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2867;
A 45-year-old woman who went to the emergency room due to persistent irritative cough, sometimes accompanied by mucus described as "reddish", despite treatment antibiotic with Amoxicillin and Azithromycin started 48 hours before...Treatment with Levofloxacin 500mg iv is started, cross-tests are requested to carry out a transfusion of 2 red blood cell concentrates and oxygen therapy is started with nasal glasses at 2 lpm...The majority of patients with respiratory symptoms and infiltrates on chest radiography will have an infectious pathology, but we must know other syndromes that can present with a similar clinical picture and are much more infrequent in diagnosis, as in the case presented to us. The knowledge of these entities and a quick approach in the management of these patients can greatly improve the associated prognosis.
- |||||||||| amoxicillin / Generic mfg.
NOT ALL INFILTRATE IS A PNEUMONIA () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2866;
A 45-year-old woman who went to the emergency room due to persistent irritative cough, sometimes accompanied by mucus described as "reddish", despite treatment antibiotic with Amoxicillin and Azithromycin started 48 hours before...Treatment with Levofloxacin 500mg iv is started, cross-tests are requested to carry out a transfusion of 2 red blood cell concentrates and oxygen therapy is started with nasal glasses at 2 lpm...The majority of patients with respiratory symptoms and infiltrates on chest radiography will have an infectious pathology, but we must know other syndromes that can present with a similar clinical picture and are much more infrequent in diagnosis, as in the case presented to us. The knowledge of these entities and a quick approach in the management of these patients can greatly improve the associated prognosis.
- |||||||||| levofloxacin / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Can bedside pulmonary ultrasound replace other tests to diagnose pneumonia? () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2725;
Brief clinical history: A 25-year-old woman who came to the Emergency Room (ER) with dyspnea of minimum efforts, audible wheezing, aphonia and cough with greenish sputum and fever around 37.5-38.5 ºC with 7-days of evolution and with poor evolution even though he was taking amoxicillin+clavulanic acid...It was decided to carry out treatment with Levofloxacin due to suspicion of Pseudomonas or atypical germs, with clinical and imaging resolution in 10 days...It is also relatively cheap, widely available (and increasingly, and more portable), and has no side effects. This work highlights the use of bedside thoracic ultrasound for the differential diagnosis between pneumonia and atelectasis, thus reducing the number of CT scans or fiberoptic bronchoscopies.
- |||||||||| levofloxacin / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Can bedside pulmonary ultrasound replace other tests to diagnose pneumonia? () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2724;
Brief clinical history: A 25-year-old woman who came to the Emergency Room (ER) with dyspnea of minimum efforts, audible wheezing, aphonia and cough with greenish sputum and fever around 37.5-38.5 ºC with 7-days of evolution and with poor evolution even though he was taking amoxicillin+clavulanic acid...It was decided to carry out treatment with Levofloxacin due to suspicion of Pseudomonas or atypical germs, with clinical and imaging resolution in 10 days...It is also relatively cheap, widely available (and increasingly, and more portable), and has no side effects. This work highlights the use of bedside thoracic ultrasound for the differential diagnosis between pneumonia and atelectasis, thus reducing the number of CT scans or fiberoptic bronchoscopies.
- |||||||||| levofloxacin / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Can bedside pulmonary ultrasound replace other tests to diagnose pneumonia? () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2723;
Brief clinical history: A 25-year-old woman who came to the Emergency Room (ER) with dyspnea of minimum efforts, audible wheezing, aphonia and cough with greenish sputum and fever around 37.5-38.5 ºC with 7-days of evolution and with poor evolution even though he was taking amoxicillin+clavulanic acid...It was decided to carry out treatment with Levofloxacin due to suspicion of Pseudomonas or atypical germs, with clinical and imaging resolution in 10 days...It is also relatively cheap, widely available (and increasingly, and more portable), and has no side effects. This work highlights the use of bedside thoracic ultrasound for the differential diagnosis between pneumonia and atelectasis, thus reducing the number of CT scans or fiberoptic bronchoscopies.
- |||||||||| levofloxacin / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Can bedside pulmonary ultrasound replace other tests to diagnose pneumonia? () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_2722;
Brief clinical history: A 25-year-old woman who came to the Emergency Room (ER) with dyspnea of minimum efforts, audible wheezing, aphonia and cough with greenish sputum and fever around 37.5-38.5 ºC with 7-days of evolution and with poor evolution even though he was taking amoxicillin+clavulanic acid...It was decided to carry out treatment with Levofloxacin due to suspicion of Pseudomonas or atypical germs, with clinical and imaging resolution in 10 days...It is also relatively cheap, widely available (and increasingly, and more portable), and has no side effects. This work highlights the use of bedside thoracic ultrasound for the differential diagnosis between pneumonia and atelectasis, thus reducing the number of CT scans or fiberoptic bronchoscopies.
- |||||||||| levofloxacin / Generic mfg.
Trial completion date, Trial primary completion date, Combination therapy: Efficacy and Safety of Levofloxacin for the Treatment of MDR-TB (clinicaltrials.gov) - Oct 1, 2021
P2, N=111, Active, not recruiting,
This work highlights the use of bedside thoracic ultrasound for the differential diagnosis between pneumonia and atelectasis, thus reducing the number of CT scans or fiberoptic bronchoscopies. Trial completion date: Sep 2021 --> Feb 2022 | Trial primary completion date: Sep 2021 --> Feb 2022
- |||||||||| levofloxacin / Generic mfg.
Clinical, Journal: Levofloxacin-Associated Mania: A Case Report. (Pubmed Central) - Oct 1, 2021
Trial completion date: Sep 2021 --> Feb 2022 | Trial primary completion date: Sep 2021 --> Feb 2022 No abstract available
- |||||||||| ribavirin / Generic mfg.
Journal, Adverse events: Acute and severe ribavirin-associated hyperuricemia and acute kidney injury: An underrecognized adverse effect. (Pubmed Central) - Oct 1, 2021
We report a case of severe hyperuricemia and acute kidney injury that developed early after initiation of ribavirin for RSV infection and suspected bacterial pneumonia in an immunocompromised patient without hepatitis C, requiring ribavirin discontinuation and rasburicase administration. To our knowledge, this is the first reported case of severe hyperuricemia in a patient treated with ribavirin for RSV infection rather than chronic hepatitis C. Clinicians should be aware of the possibility of acute and severe hyperuricemia following ribavirin administration.
- |||||||||| moxifloxacin intravenous / Generic mfg.
Clinical, Journal: Data in Brief of: Clinical benefits of moxifloxacin as initial treatment of community-acquired pneumonia: Data from meta-analyses. (Pubmed Central) - Sep 30, 2021
Several clinical outcomes comparing the efficacy and safety profiles of moxifloxacin versus levofloxacin through a meta-analysis were reported in paper 'Clinical benefits and cost-effectiveness of moxifloxacin as initial treatment for community-acquired pneumonia: a meta-analysis and economic evaluation'. In this dataset, we aimed at investigating more clinical endpoints comparing the efficacy and safety of moxifloxacin and levofloxacin in the treatment of CAP.
- |||||||||| clarithromycin / Generic mfg., amoxicillin / Generic mfg.
Clinical, Journal: Rescue Therapy with Furazolidone in Patients with at Least Five Eradication Treatment Failures and Multi-Resistant H. pylori infection. (Pubmed Central) - Sep 29, 2021
Adverse effects were reported in two (25%) patients, and all were mild. Even after five or more previous H. pylori eradication failures, and a multi-resistant infection, rescue treatment with furazolidone may be effective in approximately two-thirds of the cases, constituting a valid strategy after multiple previous eradication failures with key antibiotics such as clarithromycin, metronidazole, tetracycline, levofloxacin, and rifabutin.
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