- |||||||||| hydroxychloroquine / Generic mfg.
[VIRTUAL] ONE STEP AWAY FROM ANOTHER HOSPITAL OUTBREAK: TALE OF ELIZABETHKINGIA MENINGOSEPTICA () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1336; meningoseptica is a gram-negative nonmotile, oxidase-positive bacillus mainly found in water and soil [2] In hospital settings, saline, lipid and chlorhexidine gluconate solutions have been identified as sources of infection [3]... As the reported number of nosocomial infections with E. meningoseptica increases, the inherent multi-drug resistance nature of this gram negative organism to common antibiotics used for empiric gram negative coverage, mandates raising awareness regarding potential outbreaks in hospital settings.
- |||||||||| voriconazole / Generic mfg.
[VIRTUAL] POST-COVID-19-ASSOCIATED ASPERGILLUS EMPYEMA AND PARENCHYMAL ABSCESS () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1318; It is imperative for clinicians to have a high index of suspicion for superimposed fungal infections associated with COVID-19 even in those without the more well-described risk factors of prior tretament with corticosteroids and/or IL-6 agents, due to the risk of significant mortality and morbidity. Early initiation of treatment with close surveillance to include thoracic imaging should be done for patients who develop post COVID-19 necrotizing pneumonia.
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
[VIRTUAL] A MAN CRIED FOWL: A RARE CAUSE OF A ZOONOTIC EMPYEMA () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1309; In conclusion, P. multocida is a rare cause of empyema [2]. Health care providers need to have a high clinical suspicion of P. multocida infection in patients that handle fowl.
- |||||||||| levofloxacin / Generic mfg., fluconazole IV / Generic mfg., linezolid oral / Generic mfg.
[VIRTUAL] A CRYPTIC COUGH: A RARE CASE OF CRYPTOCOCCAL PNEUMONIA () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1284; Cryptococcal pneumonia caused by Cryptococcus neoformans is an opportunistic fungal infection, but has the ability to cause severe illness in those immunocompetent. Blood cryptococcal antigen, lumbar puncture, and at times surgical pathology may be required for those with severe illness, and early antifungal therapy may hasten recovery.
- |||||||||| [VIRTUAL] LEGIONNAIRES' DISEASE: A FATAL FORM OF COMMUNITY-ACQUIRED PNEUMONIA () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1264;
Even with timely diagnosis and treatment of Legionnaires' disease, renal involvement portends a high mortality rate. At the earliest evidence of renal injury in Legionnaires' disease complicated by rhabdomyolysis, immediate placement of central venous catheters and early initiation of CRRT is mandatory and may be life saving.
- |||||||||| levofloxacin / Generic mfg., doxycycline / Generic mfg., azithromycin / Generic mfg.
[VIRTUAL] RARE NTM COMPLICATING UNDERLYING SEVERE PERSISTENT ASTHMA () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1252; Treatment was started with levofloxacin, doxycycline, and azithromycin. Further studies are warranted to delineate management, treatment given rise of these rare indolent pulmonary infections and their possible impact on patients with chronic asthma.
- |||||||||| levofloxacin / Generic mfg.
[VIRTUAL] COUGH RESPONSE TO INTRAPLEURAL FIBRINOLYTICS PREDICTING BRONCHOPLEURAL FISTULA () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1066; In our patient, initial bronchoscopy was nondiagnostic for BPF but suspicion remained high due to her repeated cough response to fibrinolytics. We believe her cough response was directly related to the presence of a BPF, and although the sensitivity and specificity of such an exam sign are likely low, it may be a simple, inexpensive and useful hint that raises suspicion for BPF in the correct clinical context.
- |||||||||| levofloxacin / Generic mfg., azithromycin / Generic mfg.
[VIRTUAL] 39-YEAR-OLD WITH LEGIONELLA MYOCARDITIS () - Oct 13, 2021 - Abstract #CHEST2021CHEST_678; Clinicians should be aware of Legionella in the setting of unexplained myocarditis with findings as above. Treatment should be initiated for this reversible cause of myocarditis without delay, resulting in favorable prognosis.
- |||||||||| ceftriaxone / Generic mfg.
[VIRTUAL] SALMONELLOSIS AND ULCERATIVE COLITIS: COINCIDENCE? () - Oct 13, 2021 - Abstract #CHEST2021CHEST_507; Infectious colitis has the potential to cause significant morbidity and mortality in hospitalized patients with underlying inflammatory colitis. With prompt recognition and treatment, outcomes for the patients can be significantly improved.
- |||||||||| rifampicin / Generic mfg.
Clinical, Journal: Analysis of bacterial infection and drug sensitivity in patients with chronic suppurative otitis media (Pubmed Central) - Oct 12, 2021 Among them, MSSA has a high resistance rate to levofloxacin, moxifloxacin, clindamycin, and gentamicin, and high sensitivity to oxacillin, vancomycin, linezolid, and rifampin...The Gram-negative bacilli have higher resistance rates to levofloxacin, aztreonam, ciprofloxacin, ceftazidime, and piperacillin/tazobactam, and to meropenem, imipenem, amika star, cefepoxime, cefoperazone/sulbactam, and tobramycin are more sensitive...Whether it is combined with bacterial infection and age are independent factors related to whether patients with chronic suppurative otitis media could have dry ears. Therefore, patients with chronic suppurative otitis media should be treated with specific antibiotics or surgical interventions as soon as possible in combination with drug sensitivity results to avoid prolonging disease course or causing serious infectious complications.
- |||||||||| amikacin/fosfomycin inhalation (AFIS) / Savara
Journal: Identification and Antibiotic Profiling of Wohlfahrtiimonas chitiniclastica, an Underestimated Human Pathogen. (Pubmed Central) - Oct 12, 2021 A combination of in silico and in vitro analyses revealed a first insight into the antimicrobial resistance profile and the molecular basis of antimicrobial resistance. Based on our findings, trimethoprim/sulfamethoxazole, levofloxacin, and cephalosporins (e.g., ceftazidime) may be the best antibiotics to use in order to treat infections caused by W. chitiniclastica, while resistance to fosfomycin, amikacin and tobramycin is observed.
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Clinical, Journal: The determination of gyrA and parC mutations and the prevalence of plasmid-mediated quinolone resistance genes in carbapenem resistant Klebsiella pneumonia ST11 and ST76 strains isolated from patients in Heilongjiang Province, China. (Pubmed Central) - Oct 8, 2021 CRKP strains were identified that were insensitive or even resistant to quinolones,and this resistance is common in Heilongjiang Province of eastern China;fluoroquinolone-resistance in these clinical CRKP strains is a complex interplay between PMQR determinants and mutations in gyrA and parC.The resistance level caused by QRDR mutation is higher than that caused by PMQR, however, the high frequency of PMQR genes in the isolated CRKP strains suggests the potential for impact of these genes.PMQR determinants are often found in carbapenemase-producing or ESBLs-producing Klebsiella pneumoniae,and some resistance genes,such as:SHV,TEM, CTX-M-15,and OXA-1 are closely associated with FQ-R. Finally, geographical factors can affect the emergence and spread of PMQR and QRDR.Some genetic lineages have higher potential risks, and continuous close monitoring is required.
- |||||||||| levofloxacin / Generic mfg.
Journal: Delayed toxicity of three fluoroquinolones and their mixtures after neonatal or embryonic exposure, in Daphnia magna. (Pubmed Central) - Oct 7, 2021 This study investigated the delayed toxic effects of enrofloxacin (ENR), flumequine (FLU), levofloxacin (LEV) and their binary mixtures in D. magna...Overall, these studies have shown two relevant features related to the toxicity of the three FQs: (1) they give rise to delayed toxic effects in D. magna that are undetectable by the standard immobilization test; (2) their interaction in mixtures follow the principle of Concentration Addition. Both these indications concern the Environmental Risk Assessment of FQs and may be of interest to regulatory authorities.
- |||||||||| Journal: Amending the Efficiency of Antimicrobials against Multidrug-Resistant Pseudomonas aeruginosa by Low-Frequency Magnetic Fields. (Pubmed Central) - Oct 6, 2021
After 2-h exposure to 0.42 mT, susceptibility of P. aeruginosa to antimicrobial drugs aztreonam, ceftazidime, colistin, imipenem, levofloxacin, and meropenem significantly increased. In addition, resensitization of P. aeruginosa to carbapenems, penicillin, quinolones, and aminoglycosides groups was observed.
- |||||||||| levofloxacin / Generic mfg.
Journal: Photoelectrocatalytic treatment of levofloxacin using Ti/MMO/ZnO electrode. (Pubmed Central) - Oct 6, 2021 The mineralization rate, the formation of reaction intermediates and short chain carboxylic acids (acetic, maleic, oxalic and oxamic acid), in addition to the formation of N-mineral species (NO and NH) was dependent on the pH of the solution and the investigated processes: photoelectrolysis was more efficient than photolysis, which, in turn, was more efficient than electrolysis. The synergistic effect and the high rate of degradation of LFX after 4.0 h of treatment (100%) observed in photoelectrolysis at alkaline pH, was associated with the high stability of the Ti/MMO/ZnO electrode at this pH, the photoactivation of sulfate ions and the ease generation of oxidizing radicals, such as OH.
- |||||||||| Teflaro (ceftaroline fosamil) / Sumitomo Dainippon, AstraZeneca, AbbVie
[VIRTUAL] Antimicrobial Activity of Ceftaroline and Comparator Agents against Ceftriaxone-Non-Susceptible Streptococcus pneumoniae from the United States (2008-2020) () - Oct 6, 2021 - Abstract #IDWeek2021IDWeek_2200; The most active comparator agents against CRO-NS SPN were linezolid (MIC 50/90 , 0.5/1 mg/L; 100.0%S), levofloxacin (MIC 50/90 , 1/1 mg/L; 98.1%S), tigecycline (MIC 50/90 , ≤0.03/0.06 mg/L; 95.5%S), and vancomycin (MIC 50/90 , ≤1/≤1 mg/L; 100.0%S). CPT demonstrated potent and consistent activity over time (2008-2020) against a large collection of SPN from US medical centers, including CRO-NS, MDR, and XDR isolates.
- |||||||||| Orapenem (tebipenem pivoxil) / Spero Therap, Meiji Seika
[VIRTUAL] An Evaluation of Tebipenem In Vitro Activity Against a Panel of Pseudomonas aeruginosa Isolates with Efflux, AmpC, and OprD Mutations () - Oct 6, 2021 - Abstract #IDWeek2021IDWeek_2176; A panel of 20 P. aeruginosa isolates was subjected to tebipenem and five other challenge compounds (meropenem, ertapenem, levofloxacin, tetracycline, and carbenicillin) in order to determine minimum inhibitory concentration (MIC) values, in triplicate, using standard agar dilution methodologies. These data provide insight into the effect that alterations in efflux pump, outer-membrane porins, and expression of AmpC enzymes have on the activity of tebipenem and comparison antibiotics.
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