- |||||||||| Bridion (sugammadex) / Merck (MSD)
Journal: Novel Insights on MRGPRX2-Mediated Hypersensitivity to Neuromuscular Blocking Agents And Fluoroquinolones. (Pubmed Central) - Oct 22, 2021
Here, we address three of them, namely whether primary human mast cells show similar activation by these drugs as murine mast cells and mast cell lines, how sugammadex protects from atracurium-induced MRGPRX2-mediated mast cell activation, and why some but not all patients treated with rocuronium develop anaphylaxis...Atracurium, ciprofloxacin, and levofloxacin activated and degranulated primary human mast cells, but only MRGPRX2-positive and not MRGPRX2-negative or -silenced mast cells...The mast cells of patients with IgE-independent anaphylaxis to rocuronium were similar, in their MRGPRX2 expression and function, to those of patients with IgE-mediated anaphylaxis. These findings further improve our understanding of the role and relevance of MRGPRX2-driven mast cell activation in anaphylactic reactions to NMBAs and FQs and may help to improve their prediction, prevention, and treatment.
- |||||||||| ampicillin / Generic mfg.
Clinical, Observational data, Journal: Clinical Profile and Outcome of Group B Streptococcal Colonization in Mothers and Neonates in Ras Al Khaimah, United Arab Emirates: A Prospective Observational Study. (Pubmed Central) - Oct 22, 2021
Resistance to trimethoprim/sulfamethoxazole, clindamycin, erythromycin, and levofloxacin were about 77%, 57%, 57%, and 10%, respectively...IAP is effective in preventing early-onset sepsis in newborn, and thus should be initiated in those with GBS colonization. The cultured GBS showed sensitivity to most antibiotics.
- |||||||||| ceftriaxone / Generic mfg.
[VIRTUAL] EPIDEMIOLOGY OF INFECTIONS IN HOSPITALIZED PATIENTS WITH CIRRHOSIS () - Oct 21, 2021 - Abstract #AASLD2021AASLD_2262;
Among hospitalized patients with cirrhosis, we observed a high prevalence of antibiotic resistant infections . Further studies are warranted to understand broader antibiotic resistance patterns and guide strategies for implementation of prophylactic or empiric antibiotic use .
- |||||||||| ceftriaxone / Generic mfg., levofloxacin / Generic mfg.
Clinical, Journal: Levofloxacin versus ceftriaxone for treatment of acute pyelonephritis in Iranian adults. (Pubmed Central) - Oct 20, 2021
The resistance of uropathogens to the most used antibiotics was relatively high. Choosing the treatment regimen based on susceptibility testing results and shortening the duration of the therapy are now recommended to be the most important approaches to decrease the spread of antibiotic resistance worldwide.
- |||||||||| clarithromycin / Generic mfg.
Journal: Management of Helicobacter pylori. (Pubmed Central) - Oct 20, 2021
Choosing the treatment regimen based on susceptibility testing results and shortening the duration of the therapy are now recommended to be the most important approaches to decrease the spread of antibiotic resistance worldwide. Increased emphasis on measuring H. pylori-related clinical outcomes in practice is needed to identify implementation gaps, and to suggest means to best apply the knowledge gained on H. pylori for the prevention of gastric symptoms and disease.
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Clinical, Review, Journal: The effects of adding quinolones to beta-lactam antibiotics for sepsis. (Pubmed Central) - Oct 20, 2021
The effects of adding quinolones to beta-lactam antibiotics for the treatment of sepsis were unclear for all outcomes. Additional trial data are warranted to support the recommendation of empirical use of quinolones for sepsis.
- |||||||||| levofloxacin / Generic mfg., cefotaxime / Generic mfg.
Journal: Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations. (Pubmed Central) - Oct 20, 2021
In the first set of 96-well plates, Muller-Hinton broth is added followed by the first required drug (e.g., Cefotaxime here) to serially dilute it...The third step is done by adding the required concentrations of the third drug (e.g., Levofloxacin), to the appropriate plates in the initial set containing combination of drug 1 and 2...This method is important to evaluate all the possible combinations and has a wider range of possibilities to be tested furthermore for in vivo testing. Despite being a tiring technique requiring a lot of focus, the results are remarkable and time saving where a lot of combinations can be tested in a single experiment.
- |||||||||| levofloxacin / Generic mfg., amoxycillin/clavulanate / Generic mfg., moxifloxacin intravenous / Generic mfg.
[VIRTUAL] Respiratory Fluoroquinolones and the Risk of Sudden Cardiac Death Among Patients Receiving Hemodialysis () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_2283;
Conclusion Respiratory fluoroquinolone (vs. amoxicillin-based antibiotic) treatment was associated with an increased risk of SCD. Future research is needed to determine optimal strategies for cardiac monitoring when these medications are prescribed to patients receiving hemodialysis.
- |||||||||| Sirturo (bedaquiline) / J&J, Pharmstandard
Journal: Evidence-based Definition for Extensively Drug-resistant Tuberculosis. (Pubmed Central) - Oct 16, 2021
Future research is needed to determine optimal strategies for cardiac monitoring when these medications are prescribed to patients receiving hemodialysis. Our study supports a new definition of XDR-TB as MDR plus additional resistance to FQ plus bedaquiline and/or linezolid, and helps assess the adequacy of this definition for surveillance and treatment choice.
- |||||||||| ceftriaxone / Generic mfg.
Clinical, Journal: Uropathogens Antimicrobial Sensitivity and Resistance Pattern From Outpatients in Balochistan, Pakistan. (Pubmed Central) - Oct 15, 2021
High rates of resistance in E. coli were observed to most commonly prescribed broad-spectrum antibiotics; ceftriaxone (64.35%), cefotaxime (76.54%), ceftazidime (49.43%), cefepime (53.44%), levofloxacin (71.26%), and amoxicillin/clavulanate (70.31%)...Physicians should judiciously prescribe antibiotics and practice the culture and sensitivity of urine samples rather than blind prescription. Continued surveillance on uropathogens prevalence and resistance, new and next-generation antibiotics, and rapid diagnostic tests to differentiate viral from bacterial infections is the need of time.
- |||||||||| Vimpat (lacosamide) / UCB, Daiichi Sankyo, Cytovene (ganciclovir) / Roche
[VIRTUAL] HYPERAMMONEMIA SYNDROME AFTER LUNG TRANSPLANTATION: A CALL FOR BROADENING OF THE PERI-OPERATIVE ANTIMICROBIAL COVERAGE () - Oct 13, 2021 - Abstract #CHEST2021CHEST_2457;
Furthermore, she developed generalized tonic clonic seizures on POD 17 requiring initiation of levetiracetam and lacosamide...Patient was transitioned to dual therapy treatment with azithromycin and levofloxacin given the severity of illness and risk of resistance... We, therefore, recommend including antibiotics with efficacy against atypical infections in the post-operative period among all LT patients.
- |||||||||| ceftriaxone / Generic mfg., ampicillin / Generic mfg.
[VIRTUAL] THE TALE OF THE TRAVELING CHEESE: SHIGELLA IN A LUNG TRANSPLANT PATIENT () - Oct 13, 2021 - Abstract #CHEST2021CHEST_2451;
On day 4 of admission Shigella flexneri (sensitive to Levofloxacin and Ceftriaxone, resistant to Ampicillin) was isolated and infectious disease consultation obtained... This case highlights the importance of educating transplant patients on how to reduce certain harmful exposures that may be fatal in immunosuppressed individuals.
- |||||||||| [VIRTUAL] SWEET SYNDROME WITH PULMONARY INVOLVEMENT () - Oct 13, 2021 - Abstract #CHEST2021CHEST_2217;
Overall, the aim of this case is to recognize the clinical and radiographic findings of pulmonary Sweet syndrome and to confirm the diagnosis based on the clinical criteria presented. Early initiation of corticosteroid therapy can result in favorable patient outcomes as discussed in this case.
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, Humira (adalimumab) / Eisai, AbbVie
[VIRTUAL] ISOLATED SEGMENTAL BRONCHIAL STENOSIS RELATED TO CROHN'S DISEASE () - Oct 13, 2021 - Abstract #CHEST2021CHEST_2166;
He later transitioned to adalimumab in 2017...His bronchitis was managed with inhaled fluticasone and as needed albuterol.Computed tomography (CT) in February 2019 for surveillance of pulmonary nodules showed stable nodules with interval appearance of concentric narrowing in the proximal segmental bronchus to the superior segment of the left lower lobe (LLL)...The patient was treated with a course of prednisone and levofloxacin and was started inhaled budesonide and formoterol... This case highlights the role of interventional pulmonology in management of a rare case of isolated segmental bronchial stenosis related to CD.
- |||||||||| naltrexone / Generic mfg.
[VIRTUAL] EOSINOPHILIC PNEUMONIA AND EXTENDED-RELEASE INJECTABLE NALTREXONE () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1864;
She was evaluated at urgent care two days prior and sent home on a course of Levofloxacin for bronchitis. This case highlights the rare but important association between drug-induced eosinophilic pneumonia and extended-release injectable naltrexone.
- |||||||||| [VIRTUAL] SUPERIOR VENA CAVA STENT MIGRATION TO THE RIGHT ATRIUM () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1815;
A computed tomography (CT) chest angiogram showed bilateral pleural effusions, infiltrates, and a right upper lung cavitary lesion that was treated empirically with vancomycin and piperacillin-tazobactam before transitioning to meropenem after sputum cultures demonstrated pseudomonas resistant to ceftazidime, levofloxacin, and piperacillin-tazobactam. This case of SVC stent migration to the RA represents the diagnostic utility of POCUS and reveals an area of future study as patient outcomes in endovascular correction of migration compared to systemic anticoagulation are unclear.
- |||||||||| prednisone / Generic mfg., levofloxacin / Generic mfg.
[VIRTUAL] NEUROFIBROMATOSIS-ASSOCIATED LUNG DISEASE: A CASE REPORT () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1778;
Levofloxacin was ordered, but 5 days later symptoms persisted so he was referred to the ED.He reported a prior tube thoracostomy after spontaneous right-sided pneumothorax.Family history was remarkable for neurofibromatosis in his mother and spontaneous pneumothorax in his brother...He was started on bronchodilators with a 5-day course of prednisone... NF-DLD is considered one of the rare etiologies of cystic lung disease characterized by upper lobe cystic and bullous disease and lower lobe interstitial changes.
- |||||||||| daunorubicin / Generic mfg., levofloxacin / Generic mfg., cytarabine / Generic mfg.
[VIRTUAL] A RARE CASE OF LEUKEMIC INVOLVEMENT IN PLEURAL EFFUSION () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1696;
These are a rare occurrence in patients with AML also known as granulocytic sarcoma or pleural chloroma. This demonstrates the importance of the cytopathology specimens obtained in pleural fluid since an early detection of any determined disease could guide effective therapy.
- |||||||||| rifampicin / Generic mfg.
[VIRTUAL] MILIARY PNEUMONITIS AND INTRAVESICULAR BACILLUS CALMETTE-GUERIN TREATMENT () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1440;
A seven-day course of levofloxacin was prescribed for empiric treatment of presumed community acquired pneumonia (CAP)...The decision was made to administer isoniazid and rifampin for treatment of miliary pneumonitis found to be Mycobacterium bovis in origin... This case explores the critical features involved in the diagnosis and treatment of BCG-associated miliary pneumonitis.
- |||||||||| piperacillin sodium/tazobactam sodium / Generic mfg., levofloxacin / Generic mfg., meropenem / Generic mfg.
[VIRTUAL] SECONDARY SPONTANEOUS PNEUMOTHORAX FROM INVASIVE ASPERGILLUS () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1397;
Secondary pneumothorax from invasive aspergillus is a rare entity and carries high mortality from described cases. Aspergillus infection should be considered in cases of progressive cavitary lung disease for appropriate management.
- |||||||||| Mycobutin (rifabutin) / Pfizer, Lupin
[VIRTUAL] MULTIDISCIPLINARY APPROACH TO THE MANAGEMENT OF COMPLICATED TB IN SYSTEMIC LUPUS ERYTHEMATOSUS () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1377;
She was diagnosed with SLE, antiphospholipid syndrome and Raynaud's syndrome, 10 years, well controlled on prednisone, Cellcept, and warfarin...Her liver enzymes and tachycardia improved, and she was discharged on rifabutin, ethambutol and levofloxacin along with prednisone... Side effects encountered with anti-MTB therapy tend to be higher in SLE patients.
- |||||||||| Mycobutin (rifabutin) / Pfizer, Lupin, Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Mycamine (micafungin) / Astellas
[VIRTUAL] DISSEMINATED HEMATOGENOUS TB PRESENTING AFTER SPONTANEOUS ABORTION () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1376;
Treatment was initiated with rifabutin, levofloxacin, pyrazinamide, ursodiol, and solumedrol...Micafungin and valganciclovir were added to the treatment regimen... Our case highlights the importance of considering disseminated tuberculosis as a differential in a post-partum patient presenting with respiratory symptoms with cavitary lesions.
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