- |||||||||| levofloxacin / Generic mfg.
Clinical, Journal: A Rare Case of Elizabethkingia meningoseptica Bacteremia After Liver Transplantation. (Pubmed Central) - Nov 29, 2021
Intravenous levofloxacin was administered for 10 days...CONCLUSIONS E. meningoseptica, a multidrug-resistant gram-negative bacteria, can be considered an emerging pathogen in the hospital environment, especially in patients receiving organ transplants. Early recognition helps physicians to improve patient outcomes.
- |||||||||| ceftriaxone / Generic mfg.
Journal: A Culture Change: Impact of a Pediatric Antimicrobial Stewardship Program Based on Guideline Implementation and Prospective Audit with Feedback. (Pubmed Central) - Nov 29, 2021
There was a concomitant increase in organism susceptibility and a reduction in yearly drug purchasing costs of over USD 560,000 from baseline without changes in sepsis-related mortality. Our study highlights that a pediatric ASP based primarily on the principles of guideline development and PAF can improve antibiotic utilization and institutional bacterial susceptibilities without a detrimental impact on patient outcomes by changing the culture of antimicrobial utilization within the institution.
- |||||||||| levofloxacin / Generic mfg.
Journal: Defining Fluoroquinolone Resistance-Mediating Mutations from Non-Resistance Polymorphisms in Mycoplasma hominis Topoisomerases. (Pubmed Central) - Nov 29, 2021
However, both isolates spontaneously developed a second spontaneous E85K parC mutation and resistance following prolonged incubation in 4 mg/L levofloxacin for an extra 24-48 h. Continued AST surveillance and investigation is required to understand how gyrA QRDR mutations predispose M. hominis to rapid spontaneous mutation and fluoroquinolone resistance, absent from other susceptible isolates. The unusually high prevalence of polymorphisms in M. hominis also warrants increased genomics' surveillance.
- |||||||||| ceftriaxone / Generic mfg.
Journal: Antimicrobial Drug-Resistant Salmonella in Urban Cats: Is There an Actual Risk to Public Health? (Pubmed Central) - Nov 29, 2021
No resistance was expressed against ciprofloxacin, ertapenem, imipenem, levofloxacin, piperacillin/tazobactam, and tobramycin. The results of this study highlight a substantial public health issue and medical concern, especially in vulnerable people, such as children, the elderly, and immunocompromised individuals.
- |||||||||| levofloxacin / Generic mfg.
Clinical, Journal: Electrocatalytic Degradation of Levofloxacin, a Typical Antibiotic in Hospital Wastewater. (Pubmed Central) - Nov 29, 2021
The degradation pathway of LVX was analyzed using high-performance liquid chromatography-mass spectrometry (LC-MS). Subsequently, the bench-scale electrooxidation equipment was changed into onboard-scale electrooxidation equipment, and the onboard-scale equipment was promoted to several hospitals in Dalian.
- |||||||||| Gatiflox (gatifloxacin) / Orient Europharma
Clinical, Journal: Genetic Diversity of Staphylococcus aureus Strains from a Tertiary Care Hospital in Rawalpindi, Pakistan. (Pubmed Central) - Nov 29, 2021
ST772-t657 (Bengal Bay clone) was the most commonly identified clone in this study although other clones circulating around different regions of the world were also found indicating the diversity in MRSA isolates from this area of Pakistan. This study emphasizes the need to monitor MRSA in the clinical setting for improved infection control and treatment options.
- |||||||||| levofloxacin / Generic mfg.
Trial primary completion date: Early De-escalation of Empirical Antibiotics Treatment for Neutropenic Fever (clinicaltrials.gov) - Nov 26, 2021
P3, N=200, Recruiting,
Our study emphasizes the need for additional experiments to assess the role biofilms have in the pathogenesis of A. baumannii infections. Trial primary completion date: Sep 2021 --> Dec 2021
- |||||||||| levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
Retrospective data, Journal: Healthcare-Associated Stenotrophomonas maltophilia Bacteraemia: Retrospective Evaluation of Treatment and Outcome. (Pubmed Central) - Nov 24, 2021
We found that TMP/SMX and levofloxacin combination did not significantly improve patient prognosis. Conclusion Due to the high mortality rates associated with nosocomial SM bacteraemia, adequate antibiotic therapy should be initiated immediately in the suspicion of infection, and prompt removal of any indwelling central venous catheter is important.
- |||||||||| Clinical, Journal: Prevalence of Bacteria and Antimicrobial Resistance Genes in Hospital Water and Surfaces. (Pubmed Central) - Nov 21, 2021
Conclusions This study presented the ground reality of antibiotic resistance in Pakistan and how its subsequent spread poses a great threat to the strides made in the field of medicine and public health. Strict regulations regarding antibiotic usage, hospital effluent, and urban water sanitation must be imposed to curb the devastating effects of this increasing phenomenon.
- |||||||||| levofloxacin / Generic mfg.
Journal: New mechanistic insight into rapid adsorption of pharmaceuticals from water utilizing activated biochar. (Pubmed Central) - Nov 21, 2021
In this study, coffee bean waste (CBW) was utilized to synthesize pristine (CBW) and activated (CBW) biochars for the elimination of diclofenac (DF) and levofloxacin (LEV) from water...Electrostatic attraction, π-π bonding, and hydrophobic interaction were prominently responsible mechanisms for the adsorption of DF and LVX. Furthermore, continuous-flow mode studies confirmed that CBW can be successfully utilized in large-scale treatment applications.
- |||||||||| levofloxacin / Generic mfg.
Journal: Synergistic antibacterial effect of graphene-coated titanium loaded with levofloxacin. (Pubmed Central) - Nov 21, 2021
When loaded with levofloxacin, the graphene coating exhibited a synergistic antibacterial effect and effectively prevented bacterial infections following the implantation. The graphene coating is promising to improve the antibacterial functions of oral implant surfaces to prevent bacterial infection.
- |||||||||| tetracycline / Generic mfg.
Trial completion date, Trial primary completion date: Helicobacter Pylori First-line Treatment in Patients Allergic to Penicillin (clinicaltrials.gov) - Nov 18, 2021
P4, N=250, Recruiting,
Therefore, the susceptibility of azithromycin, especially, should be monitored henceforth. Trial completion date: Oct 2021 --> Dec 2022 | Trial primary completion date: Apr 2021 --> Oct 2022
- |||||||||| ampicillin / Generic mfg.
Journal: Characterization and antimicrobial resistance of Campylobacter jejuni and Campylobacter coli isolated from chicken and pork. (Pubmed Central) - Nov 18, 2021
Among the C. jejuni isolates from chickens, 25.6% of 2013 isolates were resistant to nalidixic acid, ciprofloxacin, and levofloxacin, and 7% to ampicillin and minocycline, while 30.8% of the isolates were resistant to minocycline, 23.1% to nalidixic acid, ciprofloxacin, and levofloxacin, and 15.4% to ampicillin in 2019...All the C. coli isolates from pork in 2019 were resistant to five antibiotics. The high frequency of AMR strains in C. coli isolates from pork suggests that appropriate use of antimicrobials is required in swine husbandry.
- |||||||||| levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Clinical, Journal: Fluoroquinolone susceptibility in first-line drug-susceptible M. tuberculosis isolates in Lima, Peru. (Pubmed Central) - Nov 17, 2021
Of 238 isolates in Cohort 1, no resistance to OFX was detected (95% CI 0-0.016); likewise, in Cohort 2, no resistance to OFX was detected in 41 isolates (95% CI 0-0.086). Our findings suggest that FQ use remains a viable option for the treatment of first-line drug-susceptible TB in Peru.
- |||||||||| levofloxacin / Generic mfg., amikacin sulfate / Generic mfg.
Journal: Tropical Cellulolytic Bacteria: Potential Utilization of Sugarcane Bagasse as Low-Cost Carbon Source in Aquaculture. (Pubmed Central) - Nov 17, 2021
More importantly, CFW-C18 and MW-M19 displayed a relatively low MAR index, 0.47 and 0.1, respectively, especially MW-M19, with the lowest MAR index (0.1), which was resistant to only three antibiotics, streptomycin, amikacin, and levofloxacin, indicating that this strain was safe and non-drug resistance for further use. Overall, tropical cellulolytic bacteria isolated from Hainan Island, especially CFW-C18 and MW-M19, will provide the proficient candidates as probiotics for further construction of the recirculating aquaculture system based on the supplement of low-cost external carbon source-SB.
- |||||||||| ampicillin / Generic mfg.
Journal: Multiple-Replicon Resistance Plasmids of Klebsiella Mediate Extensive Dissemination of Antimicrobial Genes. (Pubmed Central) - Nov 17, 2021
The isolates from Malayan pangolin were particularly highly resistant to cephalosporins, chloramphenicol, levofloxacin, and sulfamethoxazole...In conclusion, multiple-replicon plasmids are better able to carry resistance genes than non-multiple-replicon plasmids, which may be an important mechanism underlying bacterial responses to environments with high-antibiotic pressure. This phenomenon will be highly significant for exploring bacterial resistance gene transmission and diffusion mechanisms in the future.
- |||||||||| levofloxacin / Generic mfg.
Journal: Application of a novel thermo-sensitive injectable hydrogel in therapy in situ for drug accurate controlled release. (Pubmed Central) - Nov 10, 2021
in vitro and in vivo experiments proved that precise encapsulation toward tumors with different volumes was achieved by the hydrogels, with minimal damage to surrounding normal tissues and higher utilization of drugs in tumor sites, ultimately achieving better tumor therapeutic effect. In conclusion, the new thermo-sensitive hydrogels with precisely regulated gelling time showed great significance and potential for drug delivery and neoadjuvant chemotherapy.
- |||||||||| levofloxacin / Generic mfg.
Journal: Development of an Antimicrobial-Coated Absorbable Monofilament Suture from a Medical-Grade Poly(l-lactide-co-ε-caprolactone) Copolymer. (Pubmed Central) - Nov 10, 2021
For healing enhancement, the fiber was dip-coated with "levofloxacin" by adding the drug into a solution mixture of acetone, poly(ε-caprolactone) (PCL), and calcium stearate (CaSt) in the ratio of acetone/PCL/CaSt = 100:1% w/v:0.1% w/v...For fiber antimicrobial activity, it was found that a concentration of 1 mg/mL was sufficient to inhibit the growth of Staphylococcus aureus (MRSA), Escherichia coli O157:H7, and Pseudomonas aeruginosa, giving a clear inhibition zone range of 20-24 mm for 90 days. Cytotoxicity testing of the drug-coated fibers showed a %viability of more than 70%, indicating that they were nontoxic.
- |||||||||| 1. S. thoraltensis is susceptible to clindamycin, erythromycin, levofloxacin, tigecycline, and vancomycin, but resistant to ampicillin, oxacillin, cefotaxime, ceftriaxone, and gentamicin 2. Vanco AUC/MIC is used in MRSA and Enterococcus bacteriemia AAC 2018; 62:e01602 (Twitter) - Nov 9, 2021
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma, Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Kineret (anakinra) / SOBI
Trial completion date, Trial primary completion date: Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants (clinicaltrials.gov) - Nov 8, 2021
P=N/A, N=1600, Recruiting,
Cytotoxicity testing of the drug-coated fibers showed a %viability of more than 70%, indicating that they were nontoxic. Trial completion date: Sep 2021 --> Sep 2024 | Trial primary completion date: Sep 2021 --> Sep 2024
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
Pancytopenia with multiple opportunistic infections in a lupus patient () - Nov 7, 2021 - Abstract #APLAR2021APLAR_766;
She received pulse intravenous (IV) methylprednisolone for presumed haematological flare followed by prednisolone 40 mg daily...She was treated with multiple antibiotics (Levofloxacin, Azithromycin, IV Imipenem and Amikacin for atypical Mycobacterium), anti-tuberculous medications (ethambutol, isoniazid, rifampicin and pyrazinamide), antifungal (amphotericin B, followed by itraconazole and later fluconazole) and anti-viral (ganciclovir) agents...Her prednisolone dose was tapered to 5 mg daily and subsequently converted to replacement hydrocortisone. Opportunistic infections should be considered as a potential cause of pancytopenia especially in lupus patients.
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Journal: Acquired fluoroquinolone resistance genes in corneal isolates of Pseudomonas aeruginosa. (Pubmed Central) - Nov 6, 2021
Resistance to fluoroquinolones was observed in those strains which possessed crpP, qnrVC1 and that had QRDRs mutations. The presence of crpP on its own was not associated with increased resistance to fluoroquinolones.
- |||||||||| levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
Clinical, Journal: Stenotrophomonas maltophilia bacteremia in children: risk factors and mortality rate. (Pubmed Central) - Nov 6, 2021
Therefore, early diagnosis and prompt management based on local susceptibility data are crucial. Various risk factors, especially ICU admission prior to bacteremia episode and neutropenia, are associated with S. maltophilia bacteremia mortality.
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