levofloxacin / Generic mfg. 
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  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  A versatile multicomponent mesoporous silica nanosystem with dual antimicrobial and osteogenic effects. (Pubmed Central) -  Dec 16, 2021   
    These nanosystems, containing two antimicrobial agents, levofloxacin and Zn, have been synthetized by external functionalization of MSNs with a polycationic dendrimer (MSNs-G3), which favours its internalization inside the bacteria and lead the complexation with metal ions through the amines of the dendrimer. The nanosystems offer a notable improvement of the antibiofilm effect (above 99%) than both components separately as well as osteogenic capability with positive effect on the osteoblastic differentiation and preserved cell viability.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Diagnostic performance of whole-genome sequencing for identifying drug-resistant TB in Thailand. (Pubmed Central) -  Dec 16, 2021   
    High agreement between the two methods was observed for most drugs (>91%), except EMB (57%, 95% CI 53-61) and ETH (70%, 95% CI 66-74)...The current genomic database is insufficient for the identification of CPM resistance. Challenges remain for routine usage of WGS-based DST, especially for second-line anti-TB drugs.
  • ||||||||||  clarithromycin / Generic mfg., amoxicillin / Generic mfg.
    Observational data, Retrospective data, Journal:  Antibiotic resistances and eradication rates in Helicobacter pylori infection. (Pubmed Central) -  Dec 16, 2021   
    The first line treatment, when this is indicated must be given following the antibiotic sensitivity studies, and in the cases where these cannot be done or are not available, at least in accordance with the regional resistance rates. The correct application of the new guidelines significantly improves the eradication rate.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Melt-extrusion 3D printing of resorbable levofloxacin-loaded meshes: Emerging strategy for urogynaecological applications. (Pubmed Central) -  Dec 16, 2021   
    Meshes released 80% of the loaded levofloxacin in the first 3 days and were capable of producing an inhibitory effect against S. Aureus and E. coli bacterial strains with an inhibition zone equal to 12.8 ± 0.45 mm and 15.8 ± 0.45 mm respectively. Thus, the strategy adopted in this work holds great promise for the manufacturing of custom-made surgical meshes with antibacterial properties.
  • ||||||||||  ceftriaxone / Generic mfg., levofloxacin / Generic mfg.
    Trial completion date, Trial primary completion date:  Antibiotics to Decrease Post ERCP Cholangitis (clinicaltrials.gov) -  Dec 8, 2021   
    P4,  N=200, Recruiting, 
    The high rate of multidrug resistance should be given additional attention. Trial completion date: Feb 2021 --> Feb 2023 | Trial primary completion date: Feb 2021 --> Feb 2023
  • ||||||||||  Journal:  Evaluation of the Vitek 2, Phoenix and Microscan for Antimicrobial Susceptibility Testing of Stenotrophomonas maltophilia. (Pubmed Central) -  Dec 8, 2021   
    We assessed performance of Vitek 2, MicroScan WalkAway, and Phoenix relative to that of reference broth microdilution for trimethoprim-sulfamethoxazole (SXT), levofloxacin (LEV), minocycline (MIN), and ceftazidime (CAZ) with 109 S. maltophilia bloodstream isolates...Data were analyzed with EUCAST pharmacokinetic/pharmacodynamic CAZ, LEV, ciprofloxacin (CIP), and tigecycline (TGC) breakpoints when possible...Minor errors (MI) were >10% for all agents and systems, by EUCAST breakpoints with an intermediate category (LEV, CAZ, CIP). Laboratories should use caution with cASTs for S. maltophilia as a high rate of errors may be observed.
  • ||||||||||  levofloxacin / Generic mfg.
    Trial completion, Surgery:  Levofloxacin Ocular Implant for Ocular Surgery (clinicaltrials.gov) -  Dec 7, 2021   
    P1,  N=5, Completed, 
    Laboratories should use caution with cASTs for S. maltophilia as a high rate of errors may be observed. Recruiting --> Completed
  • ||||||||||  Gatiflox (gatifloxacin) / Orient Europharma
    Clinical, Journal:  Plasmid-Mediated Mechanism of Quinolone Resistance on E. coli Isolates from Different Clinical Samples. (Pubmed Central) -  Dec 6, 2021   
    Levofloxacin resistance was seen in 37.5%, 75.0%, and 37.5% of the isolates carrying the qnrA, qnrB, and qnrS genes, respectively. The lowest resistance rates of qnrA, B, and S-positive E.coli strains were against gatifloxacin (0,0, and 25%, respectively).A high prevalence of qnr genes enhances the increasing resistance rate of E.coli against the quinolone antibiotic under study.
  • ||||||||||  Enrollment open:  Early Antibiotics After Aspiration in ICU Patients (clinicaltrials.gov) -  Dec 5, 2021   
    P4,  N=100, Recruiting, 
    The lowest resistance rates of qnrA, B, and S-positive E.coli strains were against gatifloxacin (0,0, and 25%, respectively).A high prevalence of qnr genes enhances the increasing resistance rate of E.coli against the quinolone antibiotic under study. Not yet recruiting --> Recruiting
  • ||||||||||  Lamprene (clofazimine) / Novartis
    Journal:  The Treatment of Tuberculosis. (Pubmed Central) -  Dec 2, 2021   
    Isoniazid is excellent at the former, and rifampin is excellent at the latter...Drug-resistant TB is an increasing concern, being met, in part, with repurposed drugs (including moxifloxacin, levofloxacin, linezolid, clofazimine, and beta-lactams) and new drugs (including bedaquiline, pretomanid, and delamanid)...These experiments may hasten the selection of the most potent, shortest possible regimens to treat even extremely drug resistant TB. These findings can be translated to humans by optimizing drug exposure in each patient, using therapeutic drug monitoring and dose individualization.
  • ||||||||||  ampicillin / Generic mfg.
    Journal:  Spread Patterns of Antibiotic Resistance in Faecal Indicator Bacteria Contaminating an Urbanized Section of the Brda River. (Pubmed Central) -  Nov 29, 2021   
    The highest percentage of strains was resistant to imipenem (23%), and the lowest, to ampicillin (2%)...The percentage of antibiotic resistant strains of Escherichia coli was negatively correlated with dissolved oxygen concentration (r = - 0.9; p < 0.001) and BOD (r = - 0.85; p < 0.05). The percentage of antibiotic resistant strains of enterococci was most strongly correlated with water pH (r = - 0.92; p < 0.001).
  • ||||||||||  clarithromycin / Generic mfg.
    Journal:  Dual Clarithromycin and Metronidazole Resistance is the Main Cause of Failure in Ultimate Helicobacter pylori Eradication. (Pubmed Central) -  Nov 29, 2021   
    Initial therapy with an antibiotic active against Legionella (levofloxacin or macrolides) reduces the probability to be transferred to ICU and should be provided in all cases until Legionella etiology is excluded. Dual CLA/MET-R was the main cause of failure in ultimate H. pylori eradication, and 7-day bismuth quadruple or concomitant regimen would not be suitable for H. pylori eradication in the dual CLA/MET-R group.
  • ||||||||||  Lamprene (clofazimine) / Novartis
    Clinical, Journal:  Effectiveness and safety of fully oral modified shorter treatment regimen for multidrug-resistant tuberculosis in Georgia, 2019-2020. (Pubmed Central) -  Nov 29, 2021   
    Regimen consisted of 9-month daily administration of bedaquilline, linezolid, levofloxacin, clofazimine and cycloserine...Our findings demonstrate that good treatment outcomes are achievable in people with fluoroquinolone-sensitive tuberculosis within routine programmatic conditions using fully oral modified short treatment regimen. The extensive use of fully oral modified shorter treatment regimen in Georgia and other high priority countries in the World Health Organization European Region is warranted.
  • ||||||||||  clarithromycin / Generic mfg., amoxicillin / Generic mfg.
    Clinical, Journal:  Helicobacter pylori: When to look for an infection and treat it in adults? (Pubmed Central) -  Nov 29, 2021   
    By default, probabilistic quadruple therapies of 14 days are possible and interchangeable (PPI with amoxicillin, clarithromycin, metronidazole, or a combination of bismuth salt, tetracycline and metronidazole). Eradication control is necessary.
  • ||||||||||  cefepime hydrochloride / Generic mfg., levofloxacin / Generic mfg.
    Clinical, Journal:  Citrobacter braakii CLABSI in a hematopoietic stem cell transplant patient. (Pubmed Central) -  Nov 29, 2021   
    This clinical scenario can aid health care providers in making informed treatment decisions when faced with patients diagnosed with this relatively uncommon pathogen. Further reports should be published to determine C. braakii bacteremia management in hematopoietic stem cell transplant patients.
  • ||||||||||  clarithromycin / Generic mfg., amoxicillin / Generic mfg.
    Journal, Adverse events:  Pharmacovigilance network as an additional tool for the surveillance of antimicrobial resistance. (Pubmed Central) -  Nov 29, 2021   
    National Pharmacovigilance centers could play a proactive role in stimulating the reporting of AMR-relevant ADRs which can serve as a basis for resistance suspicion alerts. Further studies focusing on the narrative and other clinical pharmacology details in ADR reports are required.
  • ||||||||||  ampicillin / Generic mfg., amoxicillin / Generic mfg.
    Journal:  Prevalence of antibiotic-resistant bacterial strains in wastewater streams: molecular characterization and relative abundance. (Pubmed Central) -  Nov 29, 2021   
    More than 30% isolated microorganisms were found resistant to more than three antibiotics. These findings concluded the presence of predominant microbial population resistant to antibiotics in wastewater channels near hospitals and its surroundings, which requires further investigation regarding their existence and spread in other environmental media having potential community health implications.
  • ||||||||||  Spectracef (cefditoren pivoxil) / Meiji Seika
    Review, Journal:  Oral antibiotic treatment of exacerbation of COPD. Beyond COVID-19 (Pubmed Central) -  Nov 29, 2021   
    This review updates the problem of acute exacerbation with infectious origin from the perspective of etiology, antimicrobial resistance, microbiological studies, risk stratification, and antimicrobial management. The risk, prognosis and characteristics of COPD patients who develop COVID19 are analyzed.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Hydroxyl regulating effect on surface structure of BiOBr photocatalyst toward high-efficiency degradation performance. (Pubmed Central) -  Nov 29, 2021   
    Herein, photocatalytic degradation of levofloxacin hydrochloride (LVF) by a simple surface hydroxyl strategy on BiOBr photocatalyst was studied under simulated visible light irradiation...Following, the biotoxicity of antibiotics to Escherichia coli DH5a could be eliminated after LVF photocatalytic degradation. This strategy proposed in this work can provide new ideas for tuning the surface structures of photocatalysts via specific functional groups for the highly efficient degradation and efficient removal of antibiotics in wastewater.
  • ||||||||||  rifampicin / Generic mfg.
    Clinical, Journal:  Skin and soft tissue infection caused by Streptococcus pneumoniae: report of 15 cases (Pubmed Central) -  Nov 29, 2021   
    Its involvement in infections such as lactational mastitis and necrotizing fasciitis should be highlighted. The clinical evolution is favorable in most patients, but it is important to pay special attention to cases of necrotizing fasciitis due to the severity of these infections.