levofloxacin / Generic mfg. 
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  • ||||||||||  levofloxacin / Generic mfg., furosemide / Generic mfg.
    Journal:  Uremic pericarditis in a not-so-terminal chronic kidney disease (Pubmed Central) -  Nov 7, 2024   
    Diagnosis is guided by clinical and paraclinical findings and a high index of suspicion. Early recognition and treatment remain critical to prevent complications even in pre-end stage renal disease.
  • ||||||||||  Retrospective data, Journal:  Low penicillin susceptibility in Streptococcus mitis/oralis from bloodstream infections in pediatric populations. (Pubmed Central) -  Nov 7, 2024   
    Therefore, this study evaluated the clinical characteristics and drug resistance patterns of bloodstream infections caused by S. mitis/oralis across the entire pediatric populations, explicitly excluding cases of blood culture contamination. The observed low susceptibility rate to penicillin, coupled with the emergence of multi-drug-resistant strains, underscores the imperative for continuous monitoring of the evolving antimicrobial resistance in S. mitis/oralis.
  • ||||||||||  ethambutol / Generic mfg., levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
    Retrospective data, Journal:  Transmission of multidrug-resistant tuberculosis in Jiangxi, China, and associated risk factors. (Pubmed Central) -  Nov 7, 2024   
    The findings revealed that individuals in the farming sector, those who are unemployed, and patients with a history of tuberculosis treatment are at elevated risk. Consequently, targeted public interventions for these at-risk groups are imperative.
  • ||||||||||  piperacillin sodium/tazobactam sodium / Generic mfg., levofloxacin / Generic mfg.
    Journal:  Salmonella pneumonia and empyema in a patient with end-stage liver disease. (Pubmed Central) -  Nov 6, 2024   
    Patient was subsequently transitioned to oral levofloxacin with 2 month treatment course as well as regular follow up with pulmonology and infectious disease. Repeat Chest CT after antibiotic treatment was remarkable for a 6.6 cm right lower lobe abscess.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  A complex case of disseminated histoplasmosis triggering hemophagocytic lymphohistiocytosis in a patient with lupus. (Pubmed Central) -  Nov 6, 2024   
    On admission, she was diagnosed with acute pyelonephritis and started on levofloxacin...This study underscores the role of timely diagnosis of disseminated histoplasmosis in patients with underlying autoimmune diseases for favorable outcomes, thereby emphasizing the necessity of heightened clinical suspicion. By addressing the nuanced challenges that arise in managing multiple complications in the domain of disseminated histoplasmosis, advocates a comprehensive interdisciplinary approach to optimize patient care.
  • ||||||||||  Darzalex (daratumumab) / J&J
    The Microbiome and Clinical Outcome Among Patients with Multiple Myeloma (MM) Following CD38-Directed Antibody Treatment (Halls G-H (San Diego Convention Center)) -  Nov 6, 2024 - Abstract #ASH2024ASH_5475;    
    For prophylaxis during Dara therapy, all patients received acyclovir, and 7 patients received sulfamethoxazole and trimethoprim for prophylaxis...Levofloxacin, azithromycin and sulfamethoxazole/trimethoprim did not significantly affect microbiome diversity...If our results are confirmed, it could inform potential future trials to evaluate the use of probiotics to encourage growth of predominant species in responders to promote better responses to CD-38 directed antibody treatment. Alternatively, probiotic trials among MM patients to inhibit growth of dominant microbes in non-responders can potentially be considered.
  • ||||||||||  Invanz (ertapenem) / Merck (MSD), Noxafil (posaconazole) / Merck (MSD)
    At-Home Allogeneic Stem Cell Transplantation: A Single Centre Experience (Halls G-H (San Diego Convention Center)) -  Nov 6, 2024 - Abstract #ASH2024ASH_3347;    
    Patients were planned to be admitted to the SCT unit to receive as inpatient the conditioning regimen, stem cells infusion and post-transplant cyclophosphamide on days +3 and +4...Antimicrobial prophylaxis was performed with oral levofloxacin 500 mg qd, posaconazole 300 mg qd and acyclovir 800 mg bid and intravenous ertapenem 1g qd...The rate of readmission was low which was associated to a significant avoidance of days of admission in the SCT unit. In this sense, this study highlights the relevance of expanding at-home programs to avoid unnecessary admissions among other potential benefits.
  • ||||||||||  Orencia (abatacept) / BMS
    Abatacept and Post Transplant Cyclophosphamide Based Regimen for Graft Versus Host Disease Prevention in High-Risk Stem Cell Transplantation from Unrelated Donor Is Safe and Feasible, with Low Non- Relapse Mortality (Halls G-H (San Diego Convention Center)) -  Nov 6, 2024 - Abstract #ASH2024ASH_3253;    
    Introduction The combination of Abatacept (ABA) with tacrolimus and methotrexate is FDA-approved for the prevention of acute graft versus host disease in patients undergoing allogeneic hematopoietic stem cell transplantation (HCT) from matched unrelated donors (MUD) or one allele mismatched unrelated donors (MMUD)...Conditioning regimens were Busulfan based (Flu-Bu) in12 patients, Melphalan based (Flu-Mel) in 9 patients and Fludarabine/Cyclophosphamide/Total Body Irradiation in 4 patients...Patients received institutional antimicrobial prophylaxis with Acyclovir, Levofloxacin, Posaconazole, letermovir and Bactrim...However, there was a gradual recovery of T and B cell by day 100. This is a single institution, limited patient cohort, and prospective studies are undergoing to further evaluate and optimize the proposed regimen for GVHD prevention in MUD/MMUD recipients.
  • ||||||||||  levofloxacin / Generic mfg.
    Retrospective data, Journal:  Treatment outcomes among patients with isoniazid mono-resistant tuberculosis in Mumbai, India: A retrospective cohort study. (Pubmed Central) -  Nov 5, 2024   
    This is the first reported case of SR lung cancer among Filipino. This retrospective cohort study was conducted at Shatabdi Hospital in Mumbai between 2019-2021.We described the clinical and demographic characteristics, treatment outcomes, and risk factors for unfavourable outcomes among patients with INH mono-resistant TB treated with rifampicin, ethambutol, pyrazinamide, and levofloxacin (LfxREZ) for a duration of 6
  • ||||||||||  Journal:  Pathogenicity potential of enterococci isolated from a Veterinary Biological Isolation and Containment Unit. (Pubmed Central) -  Nov 5, 2024   
    Furthermore, in terms of pathogenicity, three isolates (8.8%) were classified as high threats and two (5.9%) as moderate threats. The degree of resistance, production of virulence factors and the percentage of isolates classified as moderate or high threat means that a constant vigilance of such strains in veterinary units, but also in clinics and hospitals in general, is an important tool in terms of infection prevention and consequent reduction of HAIs.
  • ||||||||||  Journal:  Virulence and Antimicrobial Resistance Patterns of Salmonella spp. Recovered From Migratory and Captive Wild Birds. (Pubmed Central) -  Nov 4, 2024   
    The degree of resistance, production of virulence factors and the percentage of isolates classified as moderate or high threat means that a constant vigilance of such strains in veterinary units, but also in clinics and hospitals in general, is an important tool in terms of infection prevention and consequent reduction of HAIs. Salmonella has been found in captive wild and migratory birds and could act as reservoirs for the transmission of MDR and ESBL bacteria.
  • ||||||||||  tigecycline / Generic mfg.
    Preclinical, Journal:  In vitro evaluation of tigecycline synergy testing with nine antimicrobial agents against Enterobacter cloacae clinical strains. (Pubmed Central) -  Nov 4, 2024   
    The aim of the study was to evaluate the synergistic effect of tigecycline in combination with nine antimicrobial agents-ceftazidime/avibactam, colistin, ertapenem, gentamicin, imipenem, levofloxacin, meropenem/vaborbactam, polymyxin B, and rifampicin...In conclusion, tigecycline appears more suitable for use in combination therapy rather than as monotherapy and can be effectively paired with various antimicrobial agents against MDR E. cloacae. Further research will be necessary to confirm these results.
  • ||||||||||  Journal:  Activity of antibiotics against Burkholderia cepacia complex in artificial sputum medium. (Pubmed Central) -  Nov 3, 2024   
    The observed frequencies of suboptimal and supratherapeutic concentrations underscore the necessity for dose optimization and therapeutic drug monitoring in children and adolescents undergoing DR-TB treatment. This work underscores the urgent need to develop more clinically relevant susceptibility testing approaches for Bcc.
  • ||||||||||  Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  Early Antibiotics After Aspiration in ICU Patients (clinicaltrials.gov) -  Oct 31, 2024   
    P4,  N=5, Terminated, 
    The regime of OAL achieved a satisfactory rate of H. pylori infection eradication with good tolerance in patients with PUD, without any acute side effects. Trial completion date: Dec 2024 --> Apr 2024 | Recruiting --> Terminated | Trial primary completion date: Dec 2024 --> Apr 2024 | N=100 --> 5; Under-enrollment
  • ||||||||||  Journal:  Biofilm-mediated antibiotic tolerance in Staphylococcus aureus from spinal cord stimulation device-related infections. (Pubmed Central) -  Oct 29, 2024   
    Identifying more effective alternatives, such as oxacillin, rifampin, and teicoplanin, provides valuable insight for clinicians when managing biofilm-related S. aureus infections in patients with SCS implants. This research contributes to the growing evidence that biofilm formation is crucial in treating device-related infections, emphasizing the importance of tailoring antimicrobial strategies to the biofilm phenotype.
  • ||||||||||  levofloxacin / Generic mfg., clarithromycin / Generic mfg.
    Journal:  Subinhibitory concentrations of antibiotics affect development and parameters of Helicobacter pylori biofilm. (Pubmed Central) -  Oct 29, 2024   
    Through assessing the membrane fatty acid profiles of antibiotic-exposed cells, we confirmed that metronidazole and levofloxacin induced a biofilm-like phenotype, while clarithromycin kept bacteria in a planktonic form. Our results suggest that sub-MICs of antibiotics affect the biochemical and biophysical properties of the developing biofilm of H. pylori strains and may impact the effectiveness of antibiotic treatment.
  • ||||||||||  Journal:  A single-center analysis of clonal transmission of carbapenem-resistant Acinetobacter baumannii among intensive care unit patients during the COVID-19 pandemic. (Pubmed Central) -  Oct 29, 2024   
    In the microbroth dilution test all isolates were resistant to imipenem, 98% (49/50) to meropenem, 68% (34/50) to colistin, and 20% (10/50) to polymyxin (B) Based on the PCR findings, all isolates harbored blaOXA-40, ISAba-1, and int-2 genes...Our study confirms a clonal transmission of CRAB during the study period and suggests using molecular typing methods like MLVA in healthcare settings to identify dominant clones, antibiotic resistance patterns, and transmission routes. This will help to better manage the emergence and spread of antibiotic-resistant strains in future outbreaks.
  • ||||||||||  linezolid oral / Generic mfg.
    Journal:  Synergistic oral beta-lactam combinations for treating tuberculosis. (Pubmed Central) -  Oct 24, 2024   
    Clinicians should be aware of its potential as a pathogen in the diagnosis and treatment of CAP. Beta-lactam synergy may provide viable combination therapies for the treatment of TB.
  • ||||||||||  levofloxacin / Generic mfg.
    Therapeutic Results and Management of Isoniazid Mono-resistant Tuberculosis Patients in Northern Malaysia (RUBY; 3F) -  Oct 21, 2024 - Abstract #KATRDIC2024KATRDIC_244;    
    For patients with rifampicin-susceptible, isoniazid-resistant tuberculosis (Hr-TB), the World Health Organisation (WHO) suggests a six-month treatment regimen of Rifampicin, Ethambutol, Pyrazinamide, and Levofloxacin (REZL)...There was one patient who died and two who were lost to follow-up. Conclusion Despite delays in diagnosing isoniazid resistance through mycobacterial culture and drug susceptibility testing, most patients adhered to the treatment regimen and achieved positive outcomes.
  • ||||||||||  New Paradigm Shift: The Novel Approach to Tuberculosis Treatment (CRYSTAL 3; 3F) -  Oct 21, 2024 - Abstract #KATRDIC2024KATRDIC_54;    
    However, moxifloxacin is efficient and safe for the treatment of drug-resistant TB. The emergence of multidrug/rifampin-resistant tuberculosis (MDR/RR-TB) has become a significant global health challenge...Notably, new drugs such as bedaquiline, delamanid, and pretomanid have shown promising results, offering high efficacy and tolerability in treating drug-resistant TB...The recommended 6-month BPaLM regimen
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Enhanced Antibacterial Activity of Levofloxacin with Cucurbit[7]uril-Functionalized Gold Nanoparticles. (Pubmed Central) -  Oct 21, 2024   
    Detailed antibacterial studies of LOFL, both as complexed with CB7 and CB7AuNP, were carried out using four food-borne pathogens (Escherichia coli, S. Typhimurium, Bacillus cereus, and Staphylococcus aureus), which revealed a creditable enhancement in the antibacterial property, irrespective of the bacterium strain. These results are quite promising at this stage for the development of drugs customized for multidrug-resistant bacteria.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  IgA Vasculitis Associated With Levofloxacin Use in an Adult Female: A Case Report. (Pubmed Central) -  Oct 18, 2024   
    Although the use of some antibiotics is known as a risk factor for the development of IgA vasculitis, it may not be considered when approaching and treating an adult with a related clinical condition, since its frequency is rare. We present the case of a 26-year-old woman with a history of an upper respiratory tract infection who required treatment with levofloxacin and subsequently developed palpable purpura.