levofloxacin / Generic mfg. 
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  • ||||||||||  clarithromycin / Generic mfg.
    MYCOBACTERIUM ABSCESSUS CATHETER RELATED INFECTION BLOODSTREAM IN AUTOLOGOUS HEMATOPOEITIC STEM CELL TRANSPLANTATION (ePoster Area [VIRTUAL]) -  Jan 30, 2022 - Abstract #EBMT2022EBMT_1540;    
     At day +47 after Auto-HSCT, our patient was accepted at the emergency department whit fever, headache and myalgias. Physical examination was anodyne, the blood test and radiology thorax image showed no findings and he was discharged home with empiric antibiotic treatment with levofloxacin...Empiric antibiotic treatment with clarithromycin, ciprofloxacin and amikacin was started.  Fast growing NTM species such as M. abscesuss are a rare cause of CRBSI in patients with Auto- HSCT and usually affect lungs and skin.In our patient, despite suffering from MM and being recently transplanted, M. Abscessus infection only represented a febrile syndrome without other complications, which allowed continuing treatment on an outpatient basis with an excellent impact on his quality of life.
  • ||||||||||  AzaSite (1% azithromycin ophthalmic solution) / Sun Pharma, Akorn, Nicox
    Trial completion date, Trial primary completion date:  Healthy Patients & Effect of Antibiotics (clinicaltrials.gov) -  Jan 28, 2022   
    P=N/A,  N=20, Active, not recruiting, 
    Collectively, this research shows that the heterotrophic C. zofingiensis can be identified as a promising candidate for removing LEV in wastewater remediation. Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2021 --> Dec 2022
  • ||||||||||  levofloxacin / Generic mfg.
    Design and synthesis of fluoroquinolone hybrid conjugates as potential drug candidates (In-Person Room (Virtual Room)) -  Jan 28, 2022 - Abstract #ACSSp2022ACS_Sp_5432;    
    We synthesized the proposed hybrid conjugates from fluoroquinolones and aminophenol using amino acids as a linker. The details of the biological outcomes will be discussed at the conference.Target Levofloxacin Derivative as Analgesic and Anti-Bacterial Drug Candidate.
  • ||||||||||  levofloxacin / Generic mfg.
    Hypersensitization of Helicobacter pylori to antibiotics through perturbation of bacterial glycan armor (In-Person Room (Virtual Room)) -  Jan 28, 2022 - Abstract #ACSSp2022ACS_Sp_3255;    
    These small molecule-induced results were recapitulated by comparing levofloxacin sensitivity in wildtype H. pylori versus glycosylation mutants. Taken together, these data indicate that selectively altering different parts of H. pylori’s glycocalyx could be an effective way to re-potentiate our front-line antibiotics and help combat growing antibiotic resistance of this bacteria.
  • ||||||||||  levofloxacin / Generic mfg.
    Direct polymerization of aliphatic bis-piperazines compounds and their non-anti-microbial properties (In-Person Room (Virtual Room)) -  Jan 28, 2022 - Abstract #ACSSp2022ACS_Sp_3199;    
    We determined the anti-microbial activities using growth inhibition assays (with and without Levofloxacin) as well as live/dead fluorescence staining of planktonic and biofilms of each organism...We compared our growth inhibition results to 1-napthylpiperazine; a published anti-microbial agent. These collective data suggest polyester polypiperazines could be a novel thermoplastic, bioinert, biodegradable, scaffolding material for tissue engineering and environmental applications.
  • ||||||||||  Journal:  Characterization of Human Origin Salmonella Serovar 1,4,[5],12:i:- in Eastern China, 2014 to 2018. (Pubmed Central) -  Jan 27, 2022   
    The resistance to piperacillin/tazobactam, ceftazidime, cefepime, and levofloxacin was scarce (2.6-9.2%)...However, no association was indicated between the scale of biofilm formation ability and MDR. Our results indicate that the combination of these characteristics may together provide a selective and competitive advantage to those Salmonella 1,4,[5],12:i:- isolates, contributing to their increasing prevalence observed worldwide.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  In-situ growth of Co/Ni bimetallic organic frameworks on carbon spheres with catalytic ozonation performance for removal of bio-treated coking wastewater. (Pubmed Central) -  Jan 27, 2022   
    Taking levofloxacin as a model pollutant, the mechanism of catalytic process was discussed, and the catalytic reaction was successfully applied to the removal of residual organics in bio-treated coking wastewater (BTCW)...From the perspective of UV absorption and 3D EEM, catalytic ozonation was more conducive to breaking the electronic protection of inert organic molecules such as heterocyclic compounds, and achieving higher efficiency of mineralization. It provides a new idea for catalytic ozonation technology of wastewater treatment in the future from theory, technology and application.
  • ||||||||||  clarithromycin / Generic mfg., amoxicillin / Generic mfg.
    Clinical, Journal:  Multidrug resistance: The clinical dilemma of refractory Helicobacter pylori infection. (Pubmed Central) -  Jan 26, 2022   
    Dual resistance to both clarithromycin and levofloxacin was found in 73.2%. The antimicrobial resistance rate of refractory H. pylori was extremely high, which had become a major consideration in therapeutic challenge.
  • ||||||||||  levofloxacin / Generic mfg., tetracycline / Generic mfg.
    Journal:  Evaluation of Heterocyclic Carboxamides as Potential Efflux Pump Inhibitors in Pseudomonas aeruginosa. (Pubmed Central) -  Jan 26, 2022   
    TXA01182 was determined to lower the frequency of resistance (FoR) of the partner antimicrobials and enhance the killing kinetics of levofloxacin. Furthermore, TXA01182 demonstrated a synergistic effect with levofloxacin against several multidrug resistant P. aeruginosa clinical isolates.
  • ||||||||||  levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., minocycline / Generic mfg.
    Journal:  Phenotypic and Molecular Characteristics of the MDR Efflux Pump Gene-Carrying Stenotrophomonas maltophilia Strains Isolated in Warsaw, Poland. (Pubmed Central) -  Jan 26, 2022   
    Moreover, the presence of genes encoding ten different efflux pumps from the resistance-nodulation-division family and the ATP-binding cassette family was shown in the majority of the 94 isolates. The obtained knowledge about the prevalence of efflux pump genes in clinical S. maltophilia strains makes it possible to predict the scale of the risk of resistance emergence in strains as a result of gene overexpression.
  • ||||||||||  clarithromycin / Generic mfg., amoxicillin / Generic mfg.
    Biomarker, Journal, Next-generation sequencing:  Next-Generation Sequencing-Based Study of Helicobacter pylori Isolates from Myanmar and Their Susceptibility to Antibiotics. (Pubmed Central) -  Jan 26, 2022   
    The H. pylori eradication regimen with classical triple therapy, including amoxicillin and clarithromycin, can be used as the first-line therapy in Myanmar. In addition, next-generation sequencing is a powerful high-throughput method for identifying mutations within antibiotic resistance genes and monitoring the spread of H. pylori antibiotic-resistant strains.
  • ||||||||||  voriconazole / Generic mfg.
    PULMONARY ANGIOINVASIVE ASPERGILLOSIS IN A KIDNEY RECIPIENT: AN ATYPICAL CLINICAL PRESENTATION (Poster Area (Virtual)) -  Jan 21, 2022 - Abstract #ISNWCN2022ISN_WCN_1339;    
    Invasive mycoses, associated with significant morbidity and mortality, are a frequent difficulty in solid organ transplantation. The clinical pictures differ and we could be faced with an atypical presentation which affects the therapeutic management.
  • ||||||||||  NON-TUBERCULOUS MYCOBACTERIUM PERITONITIS: A SINGLE CENTRE EXPERIENCE (Poster Area (Virtual)) -  Jan 21, 2022 - Abstract #ISNWCN2022ISN_WCN_1283;    
    Fifteen patients (60%) receive combination of imipenem, amikacin, azithromycin and levofloxacin/moxifloxacin and ten patients (40%) receive other combination of antibiotics. NTM- peritonitis is associated with high technique failure and mortality and a further study need to be done to determine effective treatment.