- |||||||||| Post Covid-19 Tuberculosis: Reactivation of Latent TB in the Pleura (Area K, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_1516;
He was treated with intravenous piperacillin-tazobactam and vancomycin...Acid-fast bacillus (AFB) and fungal stains of the pleural fluid were negative for any bacteria, and antimicrobial therapy was switched to levofloxacin and cephalexin...Additionally, timely and accurate diagnosis of TB pleural effusion remains a challenge due to the lack of sensitive detection methods. Conventional testing such as AFB staining and mycobacterial cultures on pleural effusion fluids are commonly negative and need a pleural biopsy and AFB culture on pleural tissue to make a diagnosis.
- |||||||||| levofloxacin / Generic mfg.
Endobronchial Tuberculosis (EBTB) - A Hidden Danger (Area K, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_1512;
She had been treated with bronchodilators and periodic courses of Levofloxacin in the outpatient setting with no lasting improvement...Further bacterial, fungal and viral testing was negative.The patient was diagnosed with endo-bronchial tuberculosis(EBTB) and started on treatment with isoniazid, rifampin, ethambutol and pyrazinamide.EBTB is highly infectious and remains a challenging diagnosis due to its indolent course, diagnosis is usually delayed until onset of significant bronchial stenosis and resultant atelectasis/bronchiectasis. Early treatment with steroid therapy can be effective in certain groups however patients often require balloon dilatation or stent placement even after adequate antimicrobial treatment
- |||||||||| dexamethasone / Generic mfg., levofloxacin / Generic mfg., rifampicin/isoniazid/ethambutol/pyrazinamide / Generic mfg.
Multiple Tuberculosis Brain Abscesses in an Immunocompetent Adult (Area K, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_1508;
However, because 1/3 of patients can have paradoxical worsening within three months of starting therapy, duration and dosage of steroid therapy should be tailored based off individual’s clinical neurological recovery. Adjunctive levofloxacin has been studied as an additional agent given its excellent CNS penetration.
- |||||||||| levofloxacin / Generic mfg.
Development of Achalasia and Broncho-Esophageal Fistula in the Setting of Active Pulmonary Tuberculosis (Area K, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_1504;
His infection was treated with ethambutol, pyrazinamide, rifampin, and levofloxacin... This is the first case report of a patient with active tuberculosis concurrently presenting with achalasia and BEF suggesting a strong association between the mechanism of the latter two conditions.
- |||||||||| dexamethasone / Generic mfg., levofloxacin / Generic mfg., rifampicin / Generic mfg.
Hemophagocytic Lymphohistiocytosis as the Presenting Finding in a Pregnant Patient with Disseminated Tuberculosis (Area K, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_1497;
Given the high morbidity and mortality associated with both disseminated TB and HLH, early recognition and treatment is paramount. The clinician is faced with challenges when deciding if a patient with disseminated TB should receive steroids for treatment of suspected HLH highlighting the importance of a multidisciplinary approach.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
A Rare Bacterial Superinfection in Immunocompetent COVID-19 Patient, a Case Report (Area K, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_1494;
The presence of B.Cepecia bacterial superinfection in Critically ill covid-19 patient is rare and potentially lethal. Further research is needed to identify the risk factors involved and the role of the immunomodulatory regimen used.
- |||||||||| Fulminant Sepsis Secondary to Bacillus Cereus in a Pediatric Patient with Acute Lymphoblastic Leukemia (Area E, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_1322;
Other prognostic indicators include liver disfunction and delayed administration of appropriate antibiotics. In these case series all strains were sensitive to imipenem, vancomycin, levofloxacin, and gentamicin, whereas only one isolate was sensitive to penicillins or cephalosporins in vitro. Given the gravity of this infection we recommend immediate broad-spectrum coverage with antimicrobials such as vancomycin and meropenem as soon as B. cereus septicemia is suspected.
- |||||||||| vancomycin / Generic mfg., levofloxacin / Generic mfg., meropenem / Generic mfg.
Nonrespiratory Stenotrophomonas Maltophilia Infection: A Case Report (Area K, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_1218;
She was diagnosed with urosepsis and was treated with intravenous fluids, norepinephrine infusion, and intravenous vancomycin and meropenem...She was started on levofloxacin...Stenotrophomonas maltophilia is an emerging pathogen that can cause severe life-threatening infections and has inherited resistance to various antimicrobials. Increased awareness regarding this pathogen is necessary to decrease the incidence, transmission spread, and case fatality related to the infection.
- |||||||||| Antibiotic Usage in Patients Experiencing Readmissions for Acute Exacerbations of Chronic Obstructive Pulmonary Disease (Area H, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_1055;
GOLD guidelines allow for various antibiotic choices (e.g., aminopenicillin with clavulanic acid, macrolide or tetracycline) and hospitalized patients with AECOPD receive a variety of antibiotics...Of the 31 patients who received azithromycin during their index admission, 51.6% had 1 or more readmissions within 60 days compared with 55.5% of 45 patients who received levofloxacin and 59.5% of 42 patients who received doxycycline (p=0.80 by Chi-square)...Patients received the same antibiotics when readmitted within 60 days, occasionally over multiple readmissions. Antibiotic selection did not influence outcomes in patient’s frequently hospitalized for AECOPD, but specific guidelines for antibiotic usage are needed for these patients.
- |||||||||| Acute Eosinophilic Pneumonia Caused by Cigar Smoking (Room 3009/3011 (West Building, Level 3), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_708;
The patient was provided supplemental oxygen via nasal cannula and started on ceftriaxone and azithromycin for community acquired pneumonia...Antibiotic coverage was broadened to vancomycin, piperacillin-tazobactam, doxycycline and levofloxacin... AEP is a rare cause of acute respiratory failure that can be confidently diagnosed with careful history, a constellation of symptoms and signs, and BAL eosinophilia (>20-25%).
- |||||||||| Cubicin (daptomycin) / Merck (MSD)
Drug-Induced Lung Disease: Who Is the Culprit? (Room 212-214 (South Building, Level 2), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_685;
She was started on daptomycin one week earlier for left femur osteomyelitis and Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia as previously administered vancomycin led to acute renal failure...Daptomycin was discontinued and replaced with levofloxacin and linezolid...Symptoms usually resolve upon discontinuing daptomycin, although corticosteroids may be helpful in refractory cases. Physicians should be aware of daptomycin-induced lung disease for timely management and to reduce morbidity and mortality.
- |||||||||| levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Journal: The characteristics of lactic acid bacteria isolated from fermented food as potential probiotics. (Pubmed Central) - Feb 16, 2022
Mutation in the gyrA gene affect the occurrence of bacterial resistance of E. coli to levofloxacin. The results showed that Lactobacillus acidophilus and Lactobacillus reuteri from fermented soursop fruit juice and cow's milk respectively fulfilled the characteristics of probiotic and could potentially be used as adjunct therapy in tuberculosis drug-resistance.
- |||||||||| clarithromycin / Generic mfg.
Preclinical, Journal: In Silico Screening and In Vitro Assessment of Natural Products with Anti-Virulence Activity against Helicobacter pylori. (Pubmed Central) - Feb 15, 2022
Therefore, in the last part, we extended the research with a number of further experiments and observed the ability of dioscin to significantly reduce the formation of H. pylori biofilm under Bioflux-generated flow conditions and its capacity for additive enhancement of the antibacterial activity of all three commonly used antibiotics (clarithromycin, metronidazole, and levofloxacin). Based on these results, we suggest that dioscin may be an interesting candidate for new therapies targeting H. pylori survivability and virulence.
- |||||||||| ceftriaxone / Generic mfg.
Journal: Antimicrobial resistance profile of extended-spectrum beta-lactamases, adenosine-monophosphate-cyclic, and carbapenemase-producing Gram-negative bacteria isolated from domestic animals. (Pubmed Central) - Feb 15, 2022
The best effectiveness rates were observed for cefepime, streptomycin, amoxicillin-clavulanate, aztreonam, nalidixic acid, tobramycin, levofloxacin, amikacin, and meropenem...The results found in the present work raise concern about the level of antimicrobial resistance among pathogens isolated from domestic animals in Brazil. The results highlight the need for the development and implementation of anti-resistance strategies to avoid the dissemination of multiresistant pathogens, including the prudent use of antimicrobials and the implementation of bacterial culture, antimicrobial sensitivity, and phenotypic tests for the detection of beta-lactamase enzymes in bacteria isolated from animals.
- |||||||||| ampicillin / Generic mfg., rifampicin / Generic mfg.
Review, Journal: Literature review on the distribution characteristics and antimicrobial resistance of bacterial pathogens in neonatal sepsis. (Pubmed Central) - Feb 11, 2022
Klebsiella pneumoniae and Escherichia coli are highly resistant to ampicillin, but there are drugs with high efficacy for both, including imipenem, piperacillin/tazobactam, aminoglycosides (gentamicin, amikacin), and quinolones (levofloxacin, ciprofloxacin)...The resistance rate of K. pneumoniae to third-generation cephalosporins was higher than the national average drug resistance level (p < .01), but this organism was most sensitive to carbapenems (carbapenem resistance refers to resistance to any of imipenem, meropenem, or ertapenem)...Compared to the CARSS data on bacterial resistance, the data in this review on the resistance of pathogens causing NS were not favorable. The next goal in antibiotic management in NICUs must be to develop strategies to reduce the use of antibiotics.
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Journal: Ploidy is an important determinant of fluoroquinolone persister survival. (Pubmed Central) - Feb 8, 2022
In addition, non-persisters in monoploid-enriched subpopulations elongated minimally following FQ treatment, resembling previous observations of HR-deficient strains, whereas non-persisters in diploid-enriched subpopulations on average filamented extensively. Together, these results identify a phenotypic variable with a significant impact on FQ persistence, establish the existence of more than one type of persister to the same antibiotic in an isogenic culture, and reveal roles for RecA and RecB in FQ persistence, even in the absence of homologous chromosomes.
- |||||||||| ceftriaxone / Generic mfg.
Shigellosis: a not-to-be-overlooked STD in MSM (PAVILLON 2; ROOM: LIEGE [VIRTUAL]) - Feb 7, 2022 - Abstract #BWG2022BWG_124;
The treatment with amoxicillin/clavulanic acid was substituted for a one-time dose of ceftriaxone 1gr via intramuscular injection and 1gr of oral azithromycin, followed by oral azithromycin 500mg once daily for the two following days, thus treating both S. flexneri and N. gonorrhea...Fecal cultures were positive for Shigella sonnei and antibiotic susceptibility testing showed multi-drug resistance to amoxicillin, levofloxacin, cefotaxime, erythromycin, and cotrimoxazole, and susceptibility to meropenem...Accordingly, active screening and treatment for Chlamydia trachomatis, Neisseria gonorrhea, HIV, syphilis, hepatitis A-B-C, Entamoeba spp., and Giardia lamblia should be performed. Lastly, case 2 demonstrates an important Shigella-associated acalculous cholecystitis, which resolved completely with antibiotic therapy, without the need for surgical intervention.
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., norfloxacin / Generic mfg.
Journal: Estimating combined health risks of nanomaterials and antibiotics from natural water: a proposed framework. (Pubmed Central) - Feb 5, 2022
Although the expected risk values were observed to be less than 1 (both hazard quotients and hazard interactions less than 1) for all the conditions and assumptions made, still a thorough monitoring and analysis of the studied contaminants in water is required to protect humans from their adverse effects, if any. Maximum allowable concentrations (C) at which no risk can occur to humans was found to be (maximum values): ABs (233.8 µg/L, NOR); metal ions (1.02 × 10 mg/L, Ti ions), and NPs (6.68 × 10 mg/L, TiO), respectively.
- |||||||||| levofloxacin / Generic mfg.
Preclinical, Journal: Probing the chemical constituents of Cassia javanica and its in vitro analyses as a potent drug. (Pubmed Central) - Feb 5, 2022
The antibacterial assay showed maximum zone of inhibition for ethyl acetate fraction, i.e. 20 mm against Proteus mirabilis and 18 mm against Klebsiella pneumoniae in the comparison with Levofloxacin used as standard (40 mm)...The minimum inhibitory concentrations and minimum bactericidal concentrations were recorded as 187.5 µg ml against Proteus mirabilis and 93.75 µg ml against Klebsiella pneumoniae. The scavenging free radical assay was noted as 69.61% at the concentration of 100 ppm.
- |||||||||| Lamprene (clofazimine) / Novartis
Traditional and Short course treatment for Multidrug resistant Tuberculosis () - Feb 3, 2022 - Abstract #IWLH2022IWLH_98;
Shorter treatment can increase the cure rate and cooperation and adherence of the patients however there is no difference between two groups. It would be better shorter treatment with considering of high rate of the default among standard group, in national TB program.
- |||||||||| levofloxacin / Generic mfg.
Journal: ICU-like Care of Nonhuman Primates with Ebola Virus Disease. (Pubmed Central) - Feb 2, 2022
It would be better shorter treatment with considering of high rate of the default among standard group, in national TB program. While an obvious survival difference was not observed with ICU-like care, clinical observations from this model may aid in EVD supportive care NHP model refinement.
- |||||||||| Journal: MALDI-TOF MS Based Bacterial Antibiotics Resistance Finger Print for Diabetic Pedopathy. (Pubmed Central) - Feb 1, 2022
This strategy was successfully used in the research of drug resistance in patients with diabetic foot infections and achieved several biomarkers that could be used as a finger print for 4 different drugs, including ceftazidime, piperacillin, levofloxacin, and tetracycline. This method can quickly confirm the drug resistance of clinical diabetic foot infections, which can help aid in the early treatment of patients.
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