 |
0 Diseases |  |
137 Trials |
|
137 Trials |  |
5343 News |  |
| «12...4950515253545556575859...9091» |
- | Gracevit (sitafloxacin) / Daiichi Sankyo
New P4 trial: Efficacy and Safety of Sitafloxacin in the Treatment of Acute Exacerbation of Bronchiectasis in Adults (clinicaltrials.gov) - Apr 5, 2022
P4, N=256, Active, not recruiting, Sponsor: Shanghai Pulmonary Hospital, Shanghai, China
- | levofloxacin / Generic mfg.
Journal: Isolation, characterization and prediction of biologically active glycoside compounds quercetin-3-rutinoside from the fruits of Ficus sycomorus. (Pubmed Central) - Apr 5, 2022
The maximum inhibition was shown by compound 1 at concentration 200 μg/ml against S. aureus (IZ = 13 mm) in comparison with the standard levofloxacin...The structure was deduced on the basis of H NMR, -NMR, DEPT, COSY, HMBC, and MS. The results showed that the isolated pure compound 1 has significant antibacterial activity, which can be used as natural antibiotics for the treatment of different infection diseases.
- | nifedipine immediate release / Generic mfg., cyclosporine / Generic mfg.
Preclinical, Journal: Importance of Gastric Secretion and the Rapid Gastric Emptying of Ingested Water along the Lesser Curvature ("Magenstraße") in Predicting the In Vivo Performance of Liquid Oral Dosage Forms in the Fed State Using a Modeling and Simulation. (Pubmed Central) - Apr 5, 2022
These results clearly indicate the importance of including gastric secretion and the kinetics of Magenstraße when predicting the in vivo performance of dosage forms using an in silico modeling and simulation of fed humans. This simulation model should be further optimized to allow for the different physiological mechanisms following the ingestion of different types of meals, as well as modifications for interindividual and intraindividual variabilities in gastrointestinal physiology in the fed state in the future.
- | Retrospective data, Journal, Real-world evidence: Real-World, Multicenter Evaluation of the Incidence and Risk Factors for Non-susceptible Stenotrophomonas maltophilia Isolates. (Pubmed Central) - Apr 5, 2022
maltophilia non-susceptibility had a prevalence of ∼50% to at least one first-line or commonly used agent. More research is needed to delineate risk factors for non-susceptible isolates.
- | clarithromycin / Generic mfg.
Journal: Drugs for GERD and peptic ulcer disease. (Pubmed Central) - Apr 5, 2022
More research is needed to delineate risk factors for non-susceptible isolates. No abstract available
- | Timcynis (ticarcillin and clavulanic acid) / Emcure Pharma
Journal: Genetic Diversity, Distribution, and Genomic Characterization of Antibiotic Resistance and Virulence of Clinical Pseudomonas aeruginosa Strains in Kenya. (Pubmed Central) - Apr 5, 2022
Although most high-risk clones were detected in Nairobi County, high-risk and clones of interest were found throughout the country, indicating the local spread of global epidemic clones and the emergence of new strains. Thus, this study illustrates the urgent need for coordinated local, regional, and international antimicrobial resistance surveillance efforts.
- ||| levofloxacin / Generic mfg.
Clinical: Should we give patients a refill for early therapy? If they are home and develop fever, take levofloxacin and come to the hospital? Like treating cystitis? Would giving an early dose of FQ do the difference by potentially starting treatment earlier if no MDRO colonization (Twitter) - Apr 4, 2022
- || hydroxychloroquine / Generic mfg., levofloxacin / Generic mfg.
Clinical, Journal: Levofloxacin induced bullous fixed drug eruption: a rare case report. (Pubmed Central) - Apr 2, 2022
It was found that ADRs such as bullous fixed drug eruptions are not fatal but can cause patient anxiety and a reduced quality of life. This case report will help physicians and clinicians to become aware and vigilant about the ADR caused by levofloxacin, facilitating its early detection and management.
- | ceftriaxone / Generic mfg.
Journal: Antibiotic utility and susceptibility changes of multidrug-resistant Escherichia coli and Klebsiella spp: 5-year experience in a tertiary healthcare centre. (Pubmed Central) - Apr 2, 2022
This case report will help physicians and clinicians to become aware and vigilant about the ADR caused by levofloxacin, facilitating its early detection and management. Implementation of antimicrobial stewardship programmes with early detection and close monitoring of MDR bacterial strains of E. coli and Klebsiella spp may be a crucial step in reducing the menace of antimicrobial resistance, which is now a global problem.
- | Spectracef (cefditoren pivoxil) / Meiji Seika
Observational data, Journal: A national longitudinal study evaluating the activity of cefditoren and other antibiotics against non-susceptible Streptococcus pneumoniae strains during the period 2004-20 in Spain. (Pubmed Central) - Apr 2, 2022
Hence, more than 80% of the clinical strains were susceptible to cefditoren throughout the period 2004-20. The proportion of resistant isolates to cefditoren and cefotaxime was scarce, being less than 0.4% for cefditoren and lower than 5% for cefotaxime, despite the increased rates of serotypes not covered by the 13-valent pneumococcal conjugate vaccine.
- | clarithromycin / Generic mfg.
Journal: E-Test or Agar Dilution for Metronidazole Susceptibility Testing of Helicobacter pylori: Importance of the Prevalence of Metronidazole Resistance. (Pubmed Central) - Apr 2, 2022
As for metronidazole, the CA was 98.7%, no major error was identified, and the rate of a very major error was 1.8%. E-test can be an alternative method to detect the metronidazole susceptibility of H. pylori.
- || levofloxacin / Generic mfg., norfloxacin / Generic mfg.
Clinical, Journal: Prevalence of resistance genes to biocides in antibiotic-resistant Pseudomonas aeruginosa clinical isolates. (Pubmed Central) - Apr 1, 2022
Our results revealed that chlorhexidine digluconate is the most effective biocide against P. aeruginosa isolates in Ardabil hospitals. However, we recommend continuous monitoring of the antimicrobial activity of biocides and the prevalence of biocide-associated resistance genes for a better prevention of microorganism dissemination and infection control in hospitals.
- || clarithromycin / Generic mfg., amoxicillin / Generic mfg.
Clinical, Journal: Mutations associated with Helicobacter pylori antimicrobial resistance in the Ecuadorian population. (Pubmed Central) - Apr 1, 2022
However, we recommend continuous monitoring of the antimicrobial activity of biocides and the prevalence of biocide-associated resistance genes for a better prevention of microorganism dissemination and infection control in hospitals. This study carried out in an Ecuadorian population indicates that the resistance of HP to first-line antibiotics is high, which may contribute to the high rates of treatment failure, and other treatment alternatives should be considered.
- || levofloxacin / Generic mfg., doxycycline / Generic mfg.
Clinical, Journal: Pneumonia, endocarditis of two valves and pulmonary artery embolism in a 26-year-old male patient (Pubmed Central) - Apr 1, 2022
Under antibiotic treatment with levofloxacin and doxycycline there was an improvement of the symptoms and a normalization of the inflammation parameters. The treatment of the endocarditis was successful.
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Journal: A novel parC mutation potentiating fluoroquinolone resistance in Klebsiella pneumoniae and Escherichia coli clinical isolates. (Pubmed Central) - Apr 1, 2022
This study suggests that the indiscriminate use of fluoroquinolones resulted in the increase of development of resistance either through mutations in the quinolone resistance-determining regions of either gyrA or parC genes augmented by plasmid mediated resistance. The irrational use of new fluoroquinolones such as moxifloxacin has created selective pressure for the appearance of new mutation.
- | levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., gentamicin sulfate / Generic mfg.
Journal: Sphingomonas paucimobilis infection in subcutaneous abdominal preservation of bone flap after craniotomy. (Pubmed Central) - Apr 1, 2022
The irrational use of new fluoroquinolones such as moxifloxacin has created selective pressure for the appearance of new mutation. Although S. paucimobilis characteristically presents low virulence, for better patient management and outcome, the diagnosis should be immediately followed by appropriate antibiotic therapy guided by susceptibility test results of each case.
- | clarithromycin / Generic mfg., amoxicillin / Generic mfg.
Journal: Antimicrobial resistance patterns and genetic elements associated with the antibiotic resistance of Helicobacter pylori strains from Shanghai. (Pubmed Central) - Apr 1, 2022
Our study revealed multidrug antibiotic resistance in H. pylori strains from Shanghai, which was characterized by high metronidazole and moderate levofloxacin resistance, and identified specific genomic characteristics in relation to H. pylori AR. Continued surveillance of H. pylori AR in Shanghai is warranted in order to establish appropriate eradication treatment regimens for this population.
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Journal: Immediate Hypersensitivity to Fluoroquinolones: A Cohort Assessing Cross-Reactivity. (Pubmed Central) - Apr 1, 2022
Our data suggest that patients with a history of immediate hypersensitivity reaction to ciprofloxacin, levofloxacin, and/or moxifloxacin are at low risk of experiencing a cross-reaction when exposed to a different fluoroquinolone. Avoidance of all fluoroquinolones in this patient population may not be warranted.
- || levofloxacin / Generic mfg.
Here is a totally useless statistic. "urinary levofloxacin concentrations have been reported to be as high as 128–343 mg/L" (Twitter) - Apr 1, 2022
- || ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
It shows that Cipro R with Levofloxacin 0.5 is fairly common but <0.5 unusual in this dataset. Useful info. Are these all source isolates or just blood? (Twitter) - Apr 1, 2022
- | Sirturo (bedaquiline) / J&J, Pharmstandard
New P4 trial: PROSPECT: A Study of an Oral Short-course Regimen Including Bedaquiline for the Treatment of Participants With Multidrug-resistant Tuberculosis in China (clinicaltrials.gov) - Apr 1, 2022
P4, N=212, Not yet recruiting, Sponsor: Beijing Chest Hospital
- || ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
The AAC(6’)-Ib-cr variants add an acetyl group to quinolones with a piperazinyl group, which includes ciprofloxacin, but importantly not levofloxacin - https://t.co/OJnIhbndHT. These lead to high level cipro resistance, and are increasingly commonly identified in the US (Twitter) - Mar 31, 2022
- || ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
This is fun! If sticking just to the FQ explanation then there are specific codon mutation patterns (eg 83 and 87) of the QRDR of GyrA that associate R to ciprofloxacin and others R to levofloxacin. (Twitter) - Mar 31, 2022
- |||| levofloxacin / Generic mfg.
Clinical, Retrospective data: Just had this convo recently! Even in this post hoc analysis of the ASPECT-cUTI trial, patients with levofloxacin-resistant organisms treated with 750 mg IV levo had 76% clinical response. Link: https://t.co/IShAq95oNo (Twitter) - Mar 31, 2022
- || levofloxacin / Generic mfg.
How do you feel about levofloxacin? @OncIDPharmd #IDPRN #BagBugs (Twitter) - Mar 31, 2022
- | prednisone / Generic mfg., levofloxacin / Generic mfg., rifampicin/isoniazid/ethambutol/pyrazinamide / Generic mfg.
Enrollment open: NEW-STRAT TB: Testing New Strategies for Patients Hospitalised With HIV-associated Disseminated Tuberculosis (clinicaltrials.gov) - Mar 31, 2022
P3, N=732, Recruiting, Sponsor: University of Cape Town
Avoidance of all fluoroquinolones in this patient population may not be warranted. Not yet recruiting --> Recruiting
- || levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., amoxicillin / Generic mfg.
New P1 trial: GRAAL: Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome (clinicaltrials.gov) - Mar 31, 2022
P1, N=10, Not yet recruiting, Sponsor: Central Hospital, Nancy, France
- | Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie
Journal: Antimicrobial activity of ceftazidime-avibactam and comparators against levofloxacin-resistant Escherichia coli collected from four geographic regions, 2012-2018. (Pubmed Central) - Mar 29, 2022
Antimicrobial susceptibility to ceftazidime-avibactam among levofloxacin-resistant E. coli isolates, including ESBL-positive isolates, collected from four geographical regions between 2012 and 2018 was consistently high. Susceptibility to the comparator agents colistin, tigecycline, imipenem and meropenem was also high.
- levofloxacin / Generic mfg., rifampicin / Generic mfg.
Double in vivo emergence of rifampicin and levofloxacin resistance in osteoarticular Cutibacterium avidum () - Mar 28, 2022 - Abstract #ECCMID2022ECCMID_4285;
- levofloxacin / Generic mfg.
Clinical case of a community-acquired pneumonia due to levofloxacin-resistant Streptococcus pneumoniae () - Mar 28, 2022 - Abstract #ECCMID2022ECCMID_4283;
- levofloxacin / Generic mfg., doripenem / Generic mfg.
MPC-based prediction of the efficacy of doripenem and levofloxacin combinations against Pseudomonas aeruginosa with reduced susceptibility to both antibiotics () - Mar 28, 2022 - Abstract #ECCMID2022ECCMID_3206;
- levofloxacin / Generic mfg.
Time for individualised doses of levofloxacin in prosthetic and joint infections using therapeutic drug monitoring? () - Mar 28, 2022 - Abstract #ECCMID2022ECCMID_3203;
- CF-370 / ContraFect
Lysin CF-370 suppresses in vitro resistance in Pseudomonas aeruginosa to meropenem, tobramycin and levofloxacin () - Mar 28, 2022 - Abstract #ECCMID2022ECCMID_3139;
- | amoxicillin / Generic mfg.
Journal: Discrepancies in Antimicrobial Susceptibility between the JP2 and the Non-JP2 Genotype of Aggregatibacter actinomycetemcomitans. (Pubmed Central) - Mar 26, 2022
The Aggregatibacter actinomycetemcomitans JP2 genotype is associated with high leukotoxin production and severe (aggressive) periodontitis...Cefotaxime, meropenem, levofloxacin, and trimethoprim-sulfamethoxazole MICs were all ≤0.25 mg/L, while MIC values for amoxicillin, azithromycin and tetracycline were 1 mg/L...The discrepant findings indicate that A. actinomycetemcomitans may be divided into two separate wild types, with a suggested intrinsic reduced susceptibility for benzylpenicillin in the majority of non-JP2 genotype strains. Possible implications for the treatment of A. actinomycetemcomitans infections are discussed.
- | ceftriaxone / Generic mfg.
Journal: Clinical and Microbiological Effects of an Antimicrobial Stewardship Program in Urology-A Single Center Before-After Study. (Pubmed Central) - Mar 26, 2022
No significant increase in infection-related readmissions or infectious complications after prostate biopsies was observed (p = 0.42). Due to the potential to reduce antibiotic use and resistance rates with no surge of infection-related complications, AMS programs should be widely implemented in urologic departments.
- | ceftriaxone / Generic mfg.
Journal: Comparison of Fluoroquinolones and Other Antibiotic Prophylaxis Regimens for Preventing Complications in Patients Undergoing Transrectal Prostate Biopsy. (Pubmed Central) - Mar 26, 2022
The ceftriaxone/fosfomycin (OR 0.21, 95% CI 0.04-0.92, p = 0.04) and fluoroquinolone (OR 0.07, 95% CI 0.00-0.70, p = 0.048) prophylaxis were associated with a lower risk of infective sequelae. Fluoroquinolone-based prophylaxis was associated with a lower risk of infective complications after TRUSBx compared to other prophylaxis regimens although its clinical application was recently forbidden by European Medical Agency restrictions.
- | levofloxacin / Generic mfg.
Journal: Combination of Amphiphilic Cyclic Peptide [RW] and Levofloxacin against Multidrug-Resistant Bacteria. (Pubmed Central) - Mar 26, 2022
Furthermore, the time-kill kinetic study of the combination of [RW] and Levo demonstrate rapid killing action at 4 h for MRSA (ATCC BAA-1556) and 12 h for E. coli (ATCC BAA-2452), P. aeruginosa (ATCC BAA-1744), and K. pneumoniae (ATCC BAA-1705). These results provide the effectiveness of a combination of Levo with cyclic [RW] peptide, which may provide an opportunity to solve the intriguing puzzle of treating bacterial resistance.
- | Cubicin (daptomycin) / Merck (MSD)
Journal: Ceviche-Natural Preservative: Possibility of Microbiota Survival and Effect on L. monocytogenes. (Pubmed Central) - Mar 26, 2022
For the remaining species the reduction did not exceed 10%, for E. faecalis it was 92.76%, for S. liqefaciens 91.44%, H. alvei 93.68%. In addition, the study of the antibacterial properties of individual ingredients showed that habanero and coriander did not show any bactericidal effect, while for onions the amount of live cells was 99.11%, and for lime juice 97.26%, Additionally, the study of changes in virulence, antibiotic resistance and gene expression showed that the stress during the preparation of ceviche has different effects depending on the strain and may cause virulence potential increase, levofloxacin and daptomycin minimum inhibiotory concentration increase and some crucial virulence gene expression induction; therefore, it is important to take care of the quality of the products used to prepare the ceviche and accurate pretreatment.
- | Mycobutin (rifabutin) / Pfizer, Lupin
Journal: Experience with Rifabutin-Containing Therapy in 500 Patients from the European Registry on Helicobacter pylori Management (Hp-EuReg). (Pubmed Central) - Mar 26, 2022
In addition, the study of the antibacterial properties of individual ingredients showed that habanero and coriander did not show any bactericidal effect, while for onions the amount of live cells was 99.11%, and for lime juice 97.26%, Additionally, the study of changes in virulence, antibiotic resistance and gene expression showed that the stress during the preparation of ceviche has different effects depending on the strain and may cause virulence potential increase, levofloxacin and daptomycin minimum inhibiotory concentration increase and some crucial virulence gene expression induction; therefore, it is important to take care of the quality of the products used to prepare the ceviche and accurate pretreatment. Rifabutin-containing therapy represents an effective and safe strategy after one or even several failures of H. pylori eradication treatment.
- || ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
I am just curious, can you explain why levofloxacin instead of ciprofloxacin, considering that ciprofloxacin has better activity against Pseudomonas (lower MICs)? (Twitter) - Mar 25, 2022
- | levofloxacin / Generic mfg., timolol maleate ophthalmic solution / Generic mfg.
Journal: Lollipop-Inspired Multilayered Drug Delivery Hydrogel for Dual Effective, Long-Term, and NIR-Defined Glaucoma Treatment. (Pubmed Central) - Mar 25, 2022
More importantly, the designed HB also shows good biocompatibility and antibacterial properties in vitro and in vivo. In summary, ZnO-BC-SA-CS HB can effectively reduce IOP and is expected to replace the classical tedious eye drop strategy, having potential utilization value in the treatment of glaucoma.
- | rifampicin / Generic mfg.
Journal: Simultaneous Measurement of 11 Antibiotics for use in the Intensive Care Unit by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry. (Pubmed Central) - Mar 24, 2022
Minimal sample preparation was required to ensure a rapid turnaround time. The method was applied to clinical samples collected from four ICUs.
- | levofloxacin / Generic mfg.
Journal: A Microbe-Derived Efflux Pump Inhibitor of the Resistance-Nodulation-Cell Division Protein Restores Antibiotic Susceptibility in Escherichia coli and Pseudomonas aeruginosa. (Pubmed Central) - Mar 24, 2022
Furthermore, the RP1-levofloxacin combination is nontoxic, well-tolerated, and notably effective in a murine lung infection model. In sum, RP1 is a potent EPI and worthy of further consideration as a potentiator to improve the effectiveness of existing antibiotics.
- | New trial, Adherence: Short-Term Use of Antibiotics and Adherence Level (clinicaltrials.gov) - Mar 23, 2022
P=N/A, N=589, Completed, Sponsor: Jordan University of Science and Technology
- | levofloxacin / Generic mfg.
Preclinical, Journal: Synthesis of Novel Hydrazones of Levofloxacin related molecule and their In Vitro evaluation as antioxidant, and Molecular Docking Studies. (Pubmed Central) - Mar 23, 2022
In vitro preliminary antioxidant screening results in support by in Silico binding affinity data of novel hydrazones of levofloxacin related molecules BK-24 to BK-41 reported here have emerged as excellent antioxidant agents. The inference derived from the in vitro antioxidant screening data and the quantitative insights derived from the per-residue interaction analysis with MPO enzyme, are now being fruitfully utilized for site specific mutation around the nucleus to identify selective and potent antioxidants.
- | Cedax (ceftibuten dihydrate) / Currax
Preclinical, Journal: In Vitro Activity of Ceftibuten/VNRX-5236 against Urinary Tract Infection Isolates of Antimicrobial-Resistant Enterobacterales. (Pubmed Central) - Mar 23, 2022
The potency of ceftibuten/VNRX-5236 (MIC, 2 μg/ml) was similar (within one doubling-dilution) to intravenous-only agents ceftazidime-avibactam (MIC 2 μg/ml) and meropenem-vaborbactam (MIC 1 μg/ml). Continued investigation of ceftibuten/VNRX-5236 is warranted.
- | ceftriaxone / Generic mfg., clarithromycin / Generic mfg.
Journal: Linear regression equations to predict β-lactam, macrolide, lincosamide and fluoroquinolone minimum inhibitory concentrations from molecular antimicrobial resistance determinants in Streptococcus pneumoniae. (Pubmed Central) - Mar 23, 2022
Accuracy of predicted MICs to the phenotypically determined MICs was similar to phenotype-only MIC comparison studies. The ability to acquire detailed antimicrobial resistance information directly from molecular determinants will facilitate the transition from routine phenotypic testing to whole genome sequencing analysis and can fill the surveillance gap in an era of increased reliance on nucleic acid assay diagnostics to better monitor the dynamics of S. pneumoniae.
- | Zerbaxa (ceftolozane /tazobactam) / Merck (MSD)
Preclinical, Journal: In vitro susceptibility of ceftolozane/tazobactam against typhoidal, non-typhoidal and extended spectrum β-lactamase-producing Salmonella. (Pubmed Central) - Mar 23, 2022
All the 10 ESBL-producing Salmonella (all non-typhoidal) isolates, of which 8 were CTX-M-55-producers and 2 were CTX-M-65-producers, were sensitive to ceftolozane/tazobactam albeit with a higher MIC value (1/2 mg/L) than non-ESBL-producers (0.25/0.5 mg/L). In summary, our data indicate that ceftolozane/tazobactam is active against most strains of both typhoidal and non-typhoidal salmonellae and also active against ESBL-producing salmonellae.
- || ampicillin / Generic mfg.
Clinical, Journal: Prediction of antimicrobial resistance in clinical Enterococcus faecium isolates using a rules-based analysis of whole genome sequences. (Pubmed Central) - Mar 23, 2022
The prediction rules demonstrated generalizability when tested on an external dataset. Known AMR genes and mutations can predict E. faecium phenotypic susceptibility with high accuracy for most routinely tested antibiotics, providing opportunities for advancing molecular diagnostics.
- | rifampicin / Generic mfg.
Journal: Adaptive responses of Pseudomonas aeruginosa to treatment with antibiotics. (Pubmed Central) - Mar 23, 2022
A mathematical comparison of these response profiles based on upregulated marker proteins revealed similarities of responses to antibiotics acting on the same target area. This study provides insights into the effects of commonly used antibiotics on P. aeruginosa and lays the foundation for the comparative analysis of the impact of novel compounds with precedented and unprecedented modes of action.