levofloxacin / Generic mfg. 
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  • ||||||||||  FML, FML Forte (fluorometholone ophthalmic suspension) / AbbVie, Cytovene (ganciclovir) / Roche
    Review, Journal:  Topical pharmacologic interventions versus placebo for epidemic keratoconjunctivitis. (Pubmed Central) -  Apr 22, 2022   
    The currently available evidence is insufficient to determine whether any of the evaluated interventions confers an advantage over steroids or artificial tears with respect to virus eradication or its spread to initially uninvolved fellow eyes. Future updates of this review should provide evidence of high-level certainty from trials with larger sample sizes, enrollment of participants with similar durations of signs and symptoms, and validated methods to assess short- and long-term outcomes.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    IDIOPATHIC PULMONARY HEMOSIDEROSIS IN TWO YOUNG PRE-MENARCHAL FEMALES WITH IRON-DEFICIENCY ANEMIA () -  Apr 20, 2022 - Abstract #ASPHO2022ASPHO_213;    
    She was initiated on Rituximab, with stable course at ten months.Case 2: A seven-year-old female presented with fatigue, pallor, and dizziness... These cases illustrate the importance of IPH on the differential for recurrent iron-responsive IDA in young pre-menarchal females without respiratory symptoms, screening with CXR and bronchoscopy, and management based on clinical progression.
  • ||||||||||  Invanz (ertapenem) / Merck (MSD)
    Journal:  Nationwide surveillance of antimicrobial resistance in invasive isolates of Streptococcus pneumoniae in Taiwan from 2017 to 2019. (Pubmed Central) -  Apr 20, 2022   
    Empirical treatment with ceftriaxone monotherapy for pneumococcal meningitis should be carefully monitored owing to its high non-susceptibility rate. The susceptibility rates of most isolates to penicillin (used for treating non-meningitis pneumococcal diseases), carbapenems (ertapenem and doripenem), respiratory quinolones (moxifloxacin and levofloxacin), vancomycin, and linezolid suggested the potential of these antibiotics in treating pneumococcal diseases in Taiwan.
  • ||||||||||  levofloxacin / Generic mfg., amoxycillin/clavulanate / Generic mfg.
    Journal:  Drug-Induced Histiocytoid Sweet Syndrome: Two Cases With Levofloxacin and Amoxicillin-Clavulanate. (Pubmed Central) -  Apr 20, 2022   
    Clinicopathologic correlation led to diagnosis of drug-induced HSS, associated with the use of levofloxacin and amoxicillin-clavulanate, respectively. Both patients were then successfully treated with systemic corticosteroid therapy, and neither of them had recurrence during the period of 24-month follow-up.
  • ||||||||||  Trial completion, Enrollment change:  Topical Antibiotics in Chronic Rhinosinusitis (clinicaltrials.gov) -  Apr 20, 2022   
    P1/2,  N=19, Completed, 
    Both patients were then successfully treated with systemic corticosteroid therapy, and neither of them had recurrence during the period of 24-month follow-up. Recruiting --> Completed | N=40 --> 19
  • ||||||||||  Journal:  Pan-Genome Analysis of Laribacter hongkongensis: Virulence Gene Profiles, Carbohydrate-Active Enzyme Prediction, and Antimicrobial Resistance Characterization. (Pubmed Central) -  Apr 19, 2022   
    Thirty-two AMR genes were detected, susceptibility to 18 clinical used antibiotics including aminoglycoside, chloramphenicol, trimethoprim, and sulfa was checked to evaluate the availability of clinical medicines. Resistance to Rifampicin, Cefazolin, ceftazidime, Ampicillin, and ceftriaxone is prevalent in most strains, resistance to tetracycline, trimethoprim-sulfamethoxazole, ciprofloxacin, and levofloxacin are aggregated in nearly half of frog-derived strains, suggesting that drug resistance of frog-derived strains is more serious, and clinical treatment for L. hongkongensis infection should be more cautious.
  • ||||||||||  linezolid oral / Generic mfg.
    Journal:  Oral and Stool Microbiome Coalescence and Its Association With Antibiotic Exposure in Acute Leukemia Patients. (Pubmed Central) -  Apr 19, 2022   
    Levofloxacin receipt was associated with a lower risk of microbiome community coalescence (HR 0.75, 95% CI 0.61 - 0.93, P = 0.009)...Exhibiting oral-stool community coalescence was associated with the occurrence of infections prior to neutrophil recovery (P=0.002), as well as infections during the 90 days post neutrophil recovery (P=0.027). This work elucidates specific antimicrobial effects on microbial ecology and furthers the understanding of oral/intestinal microbial biogeography and its implications for adverse clinical outcomes.
  • ||||||||||  ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
    Observational data, Retrospective data, Journal:  Comparing outcomes among outpatients treated for pyelonephritis with oral cephalosporins versus first-line agents. (Pubmed Central) -  Apr 15, 2022   
    Our findings indicate that AMR-related genes in the BigD region could produce trade-off effects between phages and drug sensitivity and thereby contribute to a potential strategy to control and prevent phage-resistant variants in phage therapy. There was no significant difference in UTI recurrence rates between oral cephalosporins and first-line agents in the treatment of acute pyelonephritis in the outpatient setting.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Comparative study on characteristics and mechanism of levofloxacin adsorption on swine manure biochar. (Pubmed Central) -  Apr 14, 2022   
    Characterization and adsorption experiments indicated that pore-filling, π-π stacking interaction, π-π electron donor-acceptor, H-bonding, and hydrophobic interactions each played a critical role in the adsorption of LEV on SM-derived BC. Collectively, this study confirms the potential utility of SM-derived BC for the removal of antibiotics.
  • ||||||||||  levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., minocycline / Generic mfg.
    Review, Journal:  Overcoming Stenotrophomonas maltophilia Resistance for a More Rational Therapeutic Approach. (Pubmed Central) -  Apr 14, 2022   
    Novel agents such as cefiderocol have exhibited promising activity in preclinical investigations, though additional outcomes data are needed to determine its place in therapy for S maltophilia. Combination therapy is often employed despite the dearth of adequate supporting data.
  • ||||||||||  Journal:  Emergence of a Multidrug-Resistant Escherichia coli Co-Carrying a New mcr-1.33 Variant and bla Genes Recovered from a Urinary Tract Infection. (Pubmed Central) -  Apr 13, 2022   
    coli 779 was resistant to aztreonam, levofloxacin, fosfomycin, cefoxitin, cefepime, cefotaxime, imipenem, meropenem, polymyxin, and tigecycline...The colistin resistance gene mcr-1.33 (located in a 242,460 bp IncHI2/IncHI2A plasmid) and the β-lactam resistance gene bla (located in a 46,161 bp IncX3 plasmid) were among the 27 antimicrobial resistance genes discovered...We discovered the first multidrug-resistant ST101 E. coli strain with plasmid-mediated mcr-1.33 variant and bla gene in China. These findings would help us to better understanding the genomic traits, antimicrobial resistance mechanisms and epidemiological aspects of this bacterial pathogen.
  • ||||||||||  clarithromycin / Generic mfg.
    Journal:  Biofilm Formation of Helicobacter pylori in Both Static and Microfluidic Conditions Is Associated With Resistance to Clarithromycin. (Pubmed Central) -  Apr 12, 2022   
    Additionally, it was noticed that strong biofilm producers had higher tendency for autoaggregation and presented morphostructural differences (a greater cellular packing, shorter cells and a higher amount of both OMVs and flagella) in relation to weak biofilm counterparts. In conclusion, resistance to CLR in clinical H. pylori strains was associated with a broad array of phenotypical features translating to the ability of strong biofilm formation.
  • ||||||||||  Orapenem (tebipenem pivoxil) / Spero Therap, Meiji Seika
    Tebipenem In vitro Activity Against a Collection of Pathogens Responsible for Urinary Tract Infections in the United States (Room 255) -  Apr 10, 2022 - Abstract #AUA2022AUA_2229;    
    The oral agents, cefuroxime, amoxicillin-clavulanate, TMP-SMX, and levofloxacin showed susceptibility rates ranging from 63.1% to 87.1% against ENT, EC, and KPN...In addition, these data showed compromised activity of intravenous and oral agents used for treating UTI. This data supports the development of tebipenem as an oral option for management of UTI in the US.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Antibacterial Activity and Synergetic Mechanism of Carbon Dots against Gram-Positive and -Negative Bacteria. (Pubmed Central) -  Apr 9, 2022   
    Here, a compact antibacterial activity of CDs from levofloxacin hydrochloride is reported...Surprisingly, CDs exert moderate cytotoxicity on mammalian cells at the equivalent bactericidal concentration, in which the cell viability is more than 80% at 100 μg/mL of CDs. The investigation of antibacterial CDs may provide a useful avenue for further exploiting CD-based nano-bactericides in biomedical applications.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Ultra-sensitive detection of hydrogen peroxide and levofloxacin using a dual-functional fluorescent probe. (Pubmed Central) -  Apr 9, 2022   
    Moreover, when introducing LVF into the system, the fluorescent intensities of MoOx QDs increased along with the aggregation of themselves while that of OxOPD remained unchanged, which was explained by the joint behavior of FRET and photo-induced electron transfer (PET) instead of the conventional aggregation-induced emission enhancement (AIEE). With these observation, the proposed probe was employed for HO and LVF determination in biological samples with the limit of detection (LOD) of 32.60 pmol/L and 0.85 μmol/L, respectively, suggesting the method holds great promises for trace HO and LVF monitoring in eco-environment.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals. (Pubmed Central) -  Apr 8, 2022   
    Here, we report the development of dry powder formulations for nanocarriers containing benzothiazinone 043 (BTZ) or levofloxacin (LVX), respectively...While the colloidal stability of silica NPs was improved after spray drying, MPs encapsulating either BTZ nanosuspensions or LVX-loaded liposomes showed the highest respirable fractions and active pharmaceutical ingredient loads. Importantly, for the BTZ nanosuspension, biocompatibility and in vitro uptake by a macrophage model cell line were improved even further after spray drying.
  • ||||||||||  linezolid oral / Generic mfg.
    Journal:  Assessment of Intravenous versus Oral Antimicrobials in a Large Regional Health Authority. (Pubmed Central) -  Apr 8, 2022   
    Two hundred charts were randomly selected for patients who had received either azithromycin, ciprofloxacin, clindamycin, fluconazole, levofloxacin, linezolid, moxifloxacin, metronidazole, sulfamethoxazole-trimethoprim, or voriconazole...More than half of patients who received IV therapy were eligible to receive the PO formulation of antimicrobials known to have high oral bioavailability; relative to earlier studies, this proportion has not improved over time. This finding highlights the need for continued vigilance in encouraging the use of PO rather than IV formulations for hospitalized patients.
  • ||||||||||  levofloxacin / Generic mfg., doxycycline / Generic mfg., acetylcysteine solution / Generic mfg.
    Preclinical, Journal:  Antimicrobial coating prevents ventilator-associated pneumonia in a 72 hour large animal model. (Pubmed Central) -  Apr 7, 2022   
    This finding highlights the need for continued vigilance in encouraging the use of PO rather than IV formulations for hospitalized patients. Endotracheal tubes coated with antimicrobial lipids plus mucolytic and antimicrobial lipids with antibiotics plus mucolytic reduced bacterial colonization of pig lungs after prolonged mechanical ventilation and may be an effective strategy to reduce ventilator-associated pneumonia.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Accumulation of chiral pharmaceuticals (ofloxacin or levofloxacin) onto polyethylene microplastics from aqueous solutions. (Pubmed Central) -  Apr 7, 2022   
    The excitation-emission matrix (EEM) spectra confirmed the enantioselective behaviors of chiral pharmaceuticals under UV light due to the different optical activity and humic acid-like and fulvic acid-like molecular structure of the enantiomers. These findings imply that the enantioselectivity of drug enantiomers should be considered in presence of microplastics, leading to a more accurate environmental fate and risks assessments of chiral pharmaceuticals.
  • ||||||||||  clarithromycin / Generic mfg.
    Journal:  Biofilm and Planktonic Antibiotic Resistance in Patients With Acute Exacerbation of Chronic Rhinosinusitis. (Pubmed Central) -  Apr 6, 2022   
    Biofilm-forming bacteria from AECRS patients are prevalent, and biofilm forms are highly resistant to antibiotics compared to their planktonic counterparts. Antibiotic resistance observed in planktonic forms is a good indicator of biofilm resistance, although near 20% of susceptible planktonic bacteria can produce antibiotic tolerant biofilms.