- |||||||||| Journal: An overview of drugs for the treatment of Mycobacterium kansasii pulmonary disease. (Pubmed Central) - May 6, 2022
The success rate of 7-days concomitant therapy encountered an approximately 5% decrease across 4-year time interval (2013-2017) with the changes of clarithromycin resistance from 11.8% to 17.8% in Taiwan. We report preclinical data on the efficacy and potency of drugs that can potentially be repurposed to create safe, effective and likely shorter duration regimen for the treatment of Mkn pulmonary disease.
- |||||||||| levofloxacin / Generic mfg., azithromycin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Review, Journal: Legionnaires' Disease: Update on Diagnosis and Treatment. (Pubmed Central) - May 6, 2022
Most published studies evaluating antibiotic treatment for Legionnaires' disease are observational and consequently susceptible to bias and confounding. Well-designed studies are needed to assess the usefulness of diagnostic tests regarding clinical outcomes, as well as randomized trials comparing fluoroquinolones and macrolides or combination therapy that evaluate outcomes and adverse events.
- |||||||||| levofloxacin / Generic mfg., gentamicin sulfate / Generic mfg.
Scalable Generation and Tailored Design of Human iPSC-Macrophages for Novel Immunotherapies Targeting Bacterial Infections (Room 206) - May 6, 2022 - Abstract #ASGCT2022ASGCT_1783;
In contrast, Levofloxacin was quickly released from iMac into the medium, suggesting a possibility to utilize preloaded iMac as a carrier to deliver drugs to the site of infection - in addition to the intrinsic antimicrobial potential of the cell. In summary, we demonstrate the scalable generation and tailored design of human iPSC-macrophages as a new immunotherapy targeting bacterial infections.
- |||||||||| levofloxacin / Generic mfg., cephalexin / Generic mfg.
Preclinical, Journal: Comparative effects of systemic administration of levofloxacin and cephalexin on fracture healing in rats. (Pubmed Central) - May 3, 2022
However, this difference was significant at 4 weeks (P=0.018), and the mean score in the saline group was significantly higher compared to that in the levofloxacin group (P=0.015). It is recommended not to prescribe levofloxacin for more than 1 week after surgical management of bone fractures due to its possible adverse effects on fracture healing.
- |||||||||| vancomycin / Generic mfg., levofloxacin / Generic mfg.
Journal: Enhanced antimicrobial treatment by a clay-based drug nanocarrier conjugated to a guanidine-rich cell penetrating peptide. (Pubmed Central) - May 3, 2022
Moreover, in vitro antimicrobial assessments (optical density, zone of inhibition, and minimum inhibitory concentration) have revealed that the bacterial cell growth rate is significantly inhibited by suggested nanocargoes, in comparison with the individual drugs in the same dosage. Hence, administration of the presented nanocargoes is recommended for the clinical treatment of the infected target organ.
- |||||||||| Journal: Multicenter Evaluation of a Gradient Diffusion Method for Antimicrobial Susceptibility Testing of Helicobacter pylori. (Pubmed Central) - Apr 30, 2022
Applying EUCAST levofloxacin breakpoints to interpret ciprofloxacin results, 60.2% of isolates were R by AD; ARUP CA was 97.6% (1 ME (3%), 1 VME (2%)) and CC CA was 96.3% (1 ME (3%), 2 VMEs (4%))...The Etest gradient diffusion method can be a reliable alternative for H. pylori AST with the advantage of being a less laborious quantitative method. This work reveals that an optimized Etest method can provide acceptable performance for H. pylori AST and describes the challenges associated with this methodology.
- |||||||||| Taigexyn (nemonoxacin) / TaiGen
Clinical, Journal, HEOR: Economic Evaluation of Nemonoxacin, Moxifloxacin and Levofloxacin in the Treatment of Early Community-Acquired Pneumonia with Possible Pulmonary Tuberculosis. (Pubmed Central) - Apr 30, 2022
Regarding patients with PTB who were misdiagnosed with CAP, taking nemonoxacin could save $290.76 and $205.51 when compared with moxifloxacin and levofloxacin and resulted in a gain of 2.83 QALDs. Our findings demonstrate that nemonoxacin is the more economical compared with moxifloxacin and levofloxacin, and non-fluoroquinolone antibiotics are cost-saving and utility-increasing compared to fluoroquinolones in the differential diagnosis of PTB, which can help healthcare system in making optimal policies and help clinicians in the medication of patients.
- |||||||||| levofloxacin / Generic mfg.
Journal: The relationship between nasal and conjunctival cultures of antimicrobial-resistant isolates of methicillin-resistant Staphylococcus aureus. (Pubmed Central) - Apr 29, 2022
The bacterial composition, the proportion of multi-drug resistant bacteria among the pathogens, and the high risk for amputation should be fully considered in the initial empirical medication, and broad-spectrum antibacterials are recommended. This study showed a significant relationship between conjunctival and nasal cultures of MRSA, MRCNS, and LVFX-R Corynebacterium spp., suggesting that nasal cavity culture is a potentially useful screening method for detecting resistant bacteria, especially MRSA, in the conjunctiva.
- |||||||||| Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie
Retrospective data, Journal: Emergence of Hypervirulent ST11-K64 Klebsiella pneumoniae Poses a Serious Clinical Threat in Older Patients. (Pubmed Central) - Apr 29, 2022
In conclusion, higher MICs of the last line antibiotic agents (ceftazidime-avibactam, tigecycline) might be a critical consideration in the clinical management of older patients where the concentration of these toxic antibiotics matters because of underlying comorbidities. Caution regarding KPC-2-producing ST11-K64 CR-hvKP as being new significant "superbugs" is required as they are widespread, and infection control measures should be strengthened to curb further dissemination in nosocomial settings in China.
- |||||||||| levofloxacin / Generic mfg., azithromycin / Generic mfg., erythromycin / Generic mfg.
Review: Legionella micdadei Aquaticum Infection: a Case Report and Literature Review. (Pubmed Central) - Apr 28, 2022
The detection of Legionella should be strengthened in patients with pneumonia whose symptoms have no obvious improvement after antibiotic treatment. Azithromycin, erythromycin or levofloxacin are effective in the treatment of Legionella spp.
- |||||||||| ceftriaxone / Generic mfg., levofloxacin / Generic mfg.
Journal: Lumbar osteomyelitis and knee septic arthritis caused by Streptococcus agalactiae bacteraemia. (Pubmed Central) - Apr 27, 2022
Aspirate and blood cultures grew Streptococcus agalactiae Transthoracic echocardiogram showed no vegetations; however, an MRI of lumbar spine showed L2-L3 and L4-L5 osteomyelitis. He was treated with intravenous ceftriaxone for 3 weeks and then oral levofloxacin for 3 weeks, for a total 6 week course of antibiotics.
- |||||||||| levofloxacin / Generic mfg.
Journal: A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea. (Pubmed Central) - Apr 27, 2022
Armored probiotics have shown the ability to colonize inside the gastrointestinal tracts of levofloxacin-treated rats, which significantly reduced antibiotic-associated diarrhea (AAD) resulting from the levofloxacin-treatment and improved some of the pre-inflammatory symptoms caused by AAD. This nanoarmor strategy represents a robust platform to enhance the potency of therapeutic bacteria in the gastrointestinal tracts of patients receiving antibiotics and to avoid the negative effects of antibiotics in the gastrointestinal tract.
- |||||||||| Cubicin (daptomycin) / Merck (MSD)
Journal: Amphiphilic cyclic peptide [WKR]-Antibiotics combinations as broad-spectrum antimicrobial agents. (Pubmed Central) - Apr 26, 2022
Cyclic [WKR] was subjected to combination (physical mixture or covalent conjugation) with meropenem as a model antibiotic to study the impact of the combination on antimicrobial activity...Combinations studies of [WKR] with an additional 9 commercially available antibiotics showed significant enhancement in antibacterial activity for all tested combinations, especially with tetracycline, tobramycin, levofloxacin, clindamycin, daptomycin, polymyxin, kanamycin, and vancomycin...These data indicate that [WKR] improves the antibacterial activity, presumably by facilitating the internalization of antibiotics and their interaction with the intracellular targets. This study introduces a potential strategy for treating multidrug-resistant pathogens by combining [WKR] and a variety of classical antibiotics to improve the antibacterial effectiveness.
- |||||||||| MASS SCREENING AND ERADICATION OF HELICOBACTER PYLORI INFECTION TO REDUCE GASTRIC CANCER FOR INDIGENOUS TAIWANESE PEOPLES: A FEASIBILITY STUDY (ePoster - DDW Virtual) - Apr 25, 2022 - Abstract #DDW2022DDW_6592;
P=N/A
Those who failed initial treatment were retreated with a 10-day bismuth-based quadruple treatment or levofloxacin-based triple treatment...Conclusion s: Mass screening and eradication of H. pylori infection is acceptable and feasible for populations with a high risk of gastric cancer, such as indigenous peoples living in remote areas in Taiwan. Expanded programs can accelerate progress toward the elimination of the health disparity in H. pylori-related diseases.Funding: Health Promotion Administration, Ministry of Health and Welfare (A1091010).
- |||||||||| Takecab (vonoprazan) / Takeda, Phathom Pharma
HIGH EFFICACY OF 14-DAY VONOPRAZAN-BASED QUADRUPLE THERAPY FOR HELICOBACTER PYLORI ERADICATION IN AREAS WITH HIGH CLARITHROMYCIN RESISTANCE: A PROSPECTIVE RANDOMIZED STUDY (VQ-HP TRIAL) (Poster Hall - San Diego Convention Center) - Apr 25, 2022 - Abstract #DDW2022DDW_6058;
Methods This preliminary prospective randomized study was operated to compare H. pylori eradication between 7-day and 14-day vonoprazan-based quadruple therapy containing vonoprazan 20 mg twice daily, bismuth subsalicylate 1,024 mg twice daily, metronidazole 400 mg 3 times daily and tetracycline 500 mg 4 times daily...Antibiotic resistance was 37.5% for clarithromycin, 28.5% for metronidazole and 37.5% for levofloxacin...Conclusion 14-day vonoprazan-based quadruple therapy provide an excellent cure rate for H. pylori infection in areas with high clarithromycin resistance regardless of CYP3A4/5 genotype. This 14-day regimen could be use as alternative first line treatment for H. pylori eradication.Keywords: Helicobacter pylori, Vonoprazan, Quadruple therapy.
- |||||||||| THE SHORT-TERM AND LONG-TERM IMPACTS OF H. PYLORI ERADICATION ON THE ANTIBIOTIC RESISTANCE AND RESISTOME OF GUT MICROBIOTA- A MULTICENTER RANDOMIZED TRIAL (29CD - San Diego Convention Center) - Apr 25, 2022 - Abstract #DDW2022DDW_5444;
Methods : H. pylori infected patients who failed after one treatment were eligible in this open labeled, multicenter, randomized trial, and were randomized to receive (1) Levofloxacin sequential therapy (EAML): esomeprazole 40 mg and amoxicillin 1 g for the first 7 days, followed by esomeprazole 40 mg, metronidazole 500 mg, and levofloxacin 250 mg for another 7 days (all twice daily); or (2) Bismuth quadruple therapy (BQ): esomeprazole 40mg twice daily, bismuth tripotassium dicitrate 300 mg four times a day, tetracycline 500mg four times a day, and metronidazole 500mg three times a day, for 10 days...The resistance rates to levofloxacin, ciprofloxacin, ampicillin and various cephalosporins of E. coli were significantly increased in the EAML group than in the BQ group at week 2, which were restored to basal state at week 8 and 1 year (Figure 1)...Conclusion : Levofloxacin sequential therapy and bismuth quadruple therapy are similarly effective in the second-line treatment of H. pylori infection. The transient increase of antibiotic resistance/ resistome and perturbation of diversity of fecal microbiota can be restored to basal state months after treatment, supporting the safety of H. pylori eradication for gastric cancer prevention.
- |||||||||| Mycobutin (rifabutin) / Pfizer, Lupin, Pylera (bismuth subcitrate potassium/ metronidazole/tetracycline) / AbbVie
SUCCESS OF HELICOBACTER PYLORI GUIDELINE-BASED TREATMENT OF NEWLY DIAGNOSED AND PREVIOUSLY TREATED PATIENTS (Poster Hall - San Diego Convention Center) - Apr 25, 2022 - Abstract #DDW2022DDW_3154;
Second and/or third line therapies are PBMT or PPI-amoxicillin-levofloxacin (PAL) and the fourth line PPI-amoxicillin-rifabutin (PAR) for 10 days...PAR performs well as rescue therapy and may be considered as an appropriate 3rd-line treatment. Antibiotic resistance in H. pylori is common to clarithromycin, metronidazole, and levofloxacin and frequently accounts for treatment failures.
- |||||||||| A RETROSPECTIVE 8 YEAR ANALYSIS OF HELICOBACTER PYLORI RESISTANCE PATTERNS IN A TERTIARY CENTRE – EVOLVING PARADIGMS IN SALVAGE THERAPY (ePoster - DDW Virtual) - Apr 25, 2022 - Abstract #DDW2022DDW_1404;
There was a decline in Amoxicillin and Clarithromycin resistance rates, from 9% and 63% respectively in the year 2013-2017 to 0% and 50% respectively in the year 2018-2021...There was no significant difference in resistance rates with gender. Conclusion Given the extremely low amoxicillin resistance rate of Helicobacter pylori locally, we suggest using high dose dual therapy (amoxicillin + PPI) as the next line salvage therapy following failure of at least 2 empirical eradication therapies, particularly in patients who either have an inconclusive culture result or declined gastroscopy for culture directed eradication therapy.
- |||||||||| levofloxacin / Generic mfg.
Treatment delivery and outcomes in elderly myeloma patients at The Royal Bournemouth hospital; Real-life data () - Apr 25, 2022 - Abstract #BSH2022BSH_124;
Eleven patients had documented use of Levofloxacin...With 63% of patients not going on to receive second-line therapy, the choice of treatment at diagnosis should be the best possible for that individual acknowledging many will not receive treatment beyond this line. Infection prophylaxis, close initial monitoring and regular clinical review to manage early toxicities are keys in this group of vulnerable patients.
- |||||||||| Omnicef (cefdinir) / Abbott
Journal: Evaluation of the Correspondence between the Concentration of Antimicrobials Entering Sewage Treatment Plant Influent and the Predicted Concentration of Antimicrobials Using Annual Sales, Shipping, and Prescriptions Data. (Pubmed Central) - Apr 24, 2022
The correspondence ratio on the basis of shipping volume was, for CFX, 0.1; CTM, 2.9; LFX, 0.5; MCL, 1.9; and VMC, 1.7, and on the basis of NDB volume the measured concentration was CFX, 0.1; CTM, 3.7; DCL, 0.4; LFX, 0.7; MCL, 1.9; TCL, 0.6; and VMC, 1.6. To our knowledge, this is the first report to evaluate the accuracy of predicted concentrations based on sales, shipping, NDB statistics and measured concentrations for antimicrobials in the STP influent.
- |||||||||| Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie
Journal: Evaluation of the EUCAST Rapid Antimicrobial Susceptibility Test for Enterobacterales-Containing Blood Cultures in China. (Pubmed Central) - Apr 23, 2022
In addition, we developed potential breakpoints for a recently introduced antimicrobial, 30/20 μg ceftazidime-avibactam, which has high potential for treating multidrug-resistant Enterobacterales...The breakpoints developed in this study can categorize the isolates sampled in this study with an accuracy of 93%. Results from our experiments can be applied to clinically determine the microbial susceptibility of BSI-causing bacteria within 8 h and benefit clinical diagnostics for BSI patients.
- |||||||||| Journal: Molecular epidemiology of antimicrobial-resistant Pseudomonas aeruginosa in a veterinary teaching hospital environment. (Pubmed Central) - Apr 23, 2022
The MLST approach and single nucleotide polymorphism analysis revealed a link between resistant strains from ward rooms and those from examination, wound care, and operating rooms. The improvement of routine cleaning, especially of sink environments, and the continued monitoring of antimicrobial resistance of P. aeruginosa in veterinary hospitals are necessary to prevent the spread of resistant clones and ensure infection control.
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